CN103751709A - Traditional Chinese medicinal composition for treating chloasma and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicinal composition for treating chloasma. The traditional Chinese medicinal composition comprises an internal medicine and an external medicine, wherein the internal medicine comprises the following components in parts by weight: 10-20 parts of white poria, 10-20 parts of Chinese angelica, 10-20 parts of geranium, 10-20 parts of ligusticum wallichii, 10-20 parts of astragalus membranaceus, 10-20 parts of peach kernel, 10-20 parts of rhizoma atractylodis, 10-20 parts of radix polygonati officinalis, 10-20 parts of coix seed, 10-20 parts of multiflower knotweed vine, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of red peony root, 10-20 parts of smoked plum, 10-20 parts of rhizoma acori graminei, 10-20 parts of mulberry, 10-20 parts of motherwort, 10-20 parts of raw rehmannia, 10-20 parts of white gourd seed, 10-20 parts of glossy privet fruit, 10-20 parts of rhizoma sparganic, 10-20 parts of bupleurum, 10-20 parts of curcuma zedoary, 10-20 parts of gynostemma pentaphyllum and 10-20 parts of white mulberry root-bark; the external medicine comprises the following components in parts by weight: 10-20 parts of silkworm larva, 10-20 parts of white peony root, 10-20 parts of ligusticum wallichii, 10-20 parts of flos magnoliae, 10-20 parts of bletilla striata, 10-20 parts of white lilac, 10-20 parts of asarum, 10-20 parts of Japanese ampelopsis root, 10-20 parts of angelica pubescens, 10-20 parts of mongolian snakegourd root, 10-20 parts of angelica root, 10-20 parts of prepared rhizoma typhonii, 10-20 parts of smoked plum and 10-20 parts of luffa. The traditional Chinese medicinal composition is used by combination of internal and external use, can be used for accelerating treatment of chloasma caused by stagnation of liver qi, can perform treatment from theory of qi and stasis, and also can be used for tonifying deficiency and strengthening body resistance.

Description

A kind of Chinese medicine composition for the treatment of chloasma and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of Chinese medicine composition for the treatment of chloasma and preparation method thereof.

Background technology

Chloasma is a kind of facial metabolism of pigment abnormity dermatosis that betides, and shows as the yellowish-brown or light black patch of symmetry that facial area size do not wait, divides on skin, and that comforts is not in the way.Motherland's medical science is called primary disease " chloasma ", " chloasma hepaticum ", " dusty face " etc.Because the cause of disease of the functional disorders such as the existing obvious endocrine of generation, nervous system or digestive system of primary disease can be followed, the chemical factors that is subject to again many external worlds is as the impact of Exposure to Sunlight, thermal radiation, wound (scratch, friction etc.), contact photosensitizer or compound, the agent of external silvery, mercurial etc., therefore generally advocates treatment of the inside combined with the outside.

The traditional Chinese medical science said ailment said due to cold or exposure in the etiology and pathogenesis of chloasma, like understanding from the angle of broad sense, as Exposure to Sunlight, thermal radiation, contact photosensitizer or the compound of modern medicine understanding, the agent of external silvery, mercurial etc., all can be summed up as ailment said due to cold or exposure.Therefore, the medicine for external use of controlling for ailment said due to cold or exposure can also be in conjunction with modern pharmacology result of study, compatibility anti-ultraviolet, radiation-resistant medicine.In formula, also should take the circumstances into consideration to add said medicine so that treatment have something to base in conjunction with the achievement in research of modern pharmacology.In addition, for exfoliative medicine, as Radix Aconiti Lateralis Preparata, Fructus Mume etc., because its Skin peeling effect meeting causes skin injury, thereby easily cause the pigmentation of skin to increase the weight of symptom, should be cautious use of.

At present, most research thinks, chloasma is that melanocyte and melanosome all increase, and then show mottle due to patient with chloasma skin lesion position melanocyte increased activity.Under pathological state, intradermal macrophage can be engulfed the melanosome that is dropped into corium, or calm in corium upper strata, or degrades in cell, and a part is through lymph metastasis.The generation of pigment and excretion disequilibrium, and superfluous be gathered in the part in epidermis cell, just form pigmentation.Melanic excretion has two approach: the one, in kidney, to drain, and another is to discharge through skin, melanin is transferred in keratoprotein, with the epidermal growth horny layer of dividing a word with a hyphen at the end of a line, finally with the horny layer cycle, renews and comes off.The method for the treatment of chloasma comprises acupuncture and tuina-massage (as local acupuncture, body acupuncture, acupoint injection therapy, cup, scrape therapy, massage, SHENQUE acupoint stick, sunken cord, imbedding needle, the ear acupoint etc.), external treatment (as cream, facial film, lotion, stifling side) and decoction for the treatment etc.Existing square medicated bag is drawn together XIAOYAO POWDER, JIAWEI XIAOYAO SAN, LIUWEI DIHUANG TANG, TAOHONG SIWU TANG, decoction for removing blood stasis, ERZHI WAN, GUIPI TANG etc.; The most frequently used Chinese medicine is followed successively by Radix Angelicae Sinensis, Poria, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Bupleuri, Fructus Ligustri Lucidi, Radix Glycyrrhizae, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, Semen Persicae, Cortex Moutan, the Radix Rehmanniae, Radix Paeoniae Rubra, Radix Salviae Miltiorrhizae, the Radix Angelicae Dahuricae, Fructus Corni, Herba Leonuri, Rhizoma Dioscoreae, Fructus Ligustri Lucidi, Rhizoma Cyperi etc.But the effect of these Therapeutic Method is not very desirable, can not fundamentally treats chloasma, and also have certain side effect.Therefore the medicine of preventing and treating chloasma that, improves a kind of highly effective and safe has become people's urgent needs.Prevalence is on the rise in recent years, gives current many people's spirit of liking to be beautiful and has in lifely caused great misery.

Chloasma belongs to dermatology common disease, and pathogenesis it be not immediately clear.Modern medicine is thought may excessively the many factors such as irradiation be relevant with endocrine disturbance, heredity, D&C, some chronic disease, ultraviolet.Wherein endocrine disturbance is primary pathogenic factors.Pigmented spots can be multiple at first, tend to merge form not of uniform size, irregular patch, are symmetrically distributed in the face that exposure is exposed.The most outstanding with cheekbone portion, forehead, two cheeks, be sometimes butterfly wing, occasionally in upper lip.Clear-cut margin or be diffusivity, local NIP and squama.No conscious sympton, pigment can slightly change with factors such as season, Exposure to Sunlight, hormonal changes, does not often prolongedly move back, and a part can slowly disappear in minute puerperium or after withdrawing contraceptive.

The treatment of relevant chloasma, Western medicine is mainly cracking-off agent (as retinoic acid, salicylic acid), Donisolone, plumbous mercurial, oxidant or reducing agent (as hydroquinone, hydrogen peroxide), has side effect in various degree or causes some complication.Chinese medicine product because of its draw materials natural, safety good, low side effect, documents and materials abundant, clinical efficacy is good enjoys favor.Theory of Chinese medical science is thought " have Zhu Neibi shape all outer ", and " vital organs of the human body 12 are through QI and blood, all up in face." stop in the generation of chloasma and human body depression of liver-QI, stagnation of blood stasis, caused by liver and kidney deficiency, insufficiency of vital energy and blood, expectorant are turbid etc. multiple because of Suo Youguan.Its pathogenesis or by depression of liver-QI, with the passing of time heat-transformation, fumigates in face and give birth to; Or because of qi depression to blood stasis, battalion defends and becomes estranged, and stops up stagnant channels, ties in face and sends out; Or because of Liver and kidney deficient, Chong and Ren channel disorder, asthenia of essence and blood, can not go up and flourish in face, form; Or be that insufficiency of the spleen mistake is strong, raw in phlegm-damp, turbid pathogen blocks in face and causes.It is clinical adopts the treatment approach such as treatment by oral administration of medicines, external treatment, acupuncture, massage more, lays particular emphasis on from liver,spleen,kidney and starts with, and corrects function disorderly, eliminates gas, the stasis of blood, expectorant, the pathological factor such as wet, hot.

Summary of the invention

Technical problem to be solved by this invention is, tunes up part and use hormone in the relevant doctor trained in Western medicine of chloasma, and it is main improving endocrine; External treatment medicine, though clinical Western medicine has certain curative effect, but it is satisfied that effect is still owed, be mainly cracking-off agent (as retinoic acid, salicylic acid), Donisolone, plumbous mercurial, oxidant or reducing agent (as hydroquinone, hydrogen peroxide), investigation mission outside the city or town for oral administration has side effect in various degree or causes some complication; And oral medicinal herb medicine has some curative effects, but higher at drug manufacture cost, and also manufacturing cycle is longer, and preparation method is loaded down with trivial details; External used medicine specific aim is poor, and chloasma can not be fundamentally treated in individual dispenser, and also has certain side effect.Therefore the medicine of, finding a kind for the treatment of chloasma of highly effective and safe has become people's urgent needs.

For solving these technical barriers, the invention provides a kind of Chinese medicine composition for the treatment of chloasma, by endo-medicine and external used medicine, formed, in described endo-medicine, the parts by weight of various crude drug are: 10～20 parts of Porias, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Pelargoniis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of the Radixs Astragali, 10～20 parts, Semen Persicae, 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Rhizoma Polygonati Odorati, 10～20 parts of Semen Coicis, 10～20 parts of Caulis Polygoni Multiflori, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Fructus Mumes, 10～20 parts of Rhizoma Acori Graminei, 10～20 parts of Fructus Mori, 10～20 parts of Herba Leonuris, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Semen Benincasaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Rhizoma Sparganii, 10～20 parts of Radix Bupleuri, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Herb Gynostemmae Pentaphylli, 10～20 parts of Cortex Mori,

In external used medicine, the parts by weight of various crude drug are: 10～20 parts of Bombyx Batryticatus, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Flos Magnoliaes, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Faeces Passeriss, 10～20 parts of Herba Asaris, 10～20 parts of Radix Ampelopsis, 10～20 parts of Radix Angelicae Pubescentiss, 10～20 parts of Radix Trichosanthis, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Rhizoma Typhonii (processed), 10～20 parts of Fructus Mumes, 10～20 parts of Retinervus Luffae Fructuss.

The Chinese medicine composition of described treatment chloasma, described in it, in endo-medicine, the parts by weight of various crude drug can be: 10～15 parts of Porias, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Flos Pelargoniis, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of the Radixs Astragali, 10～15 parts, Semen Persicae, 10～15 parts of Rhizoma Atractylodis, 10～15 parts of Rhizoma Polygonati Odorati, 10～15 parts of Semen Coicis, 10～15 parts of Caulis Polygoni Multiflori, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Radix Paeoniae Rubra, 10～20 parts of Fructus Mumes, 10～20 parts of Rhizoma Acori Graminei, 10～20 parts of Fructus Mori, 10～20 parts of Herba Leonuris, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Semen Benincasaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Rhizoma Sparganii, 10～20 parts of Radix Bupleuri, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Herb Gynostemmae Pentaphylli, 10～20 parts of Cortex Mori,

In described external used medicine, the parts by weight of various crude drug can be: 10～15 parts of Bombyx Batryticatus, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Flos Magnoliaes, 10～15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～15 parts of Faeces Passeriss, 10～15 parts of Herba Asaris, 10～20 parts of Radix Ampelopsis, 10～20 parts of Radix Angelicae Pubescentiss, 10～20 parts of Radix Trichosanthis, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Rhizoma Typhonii (processed), 10～20 parts of Fructus Mumes, 10～20 parts of Retinervus Luffae Fructuss.

The Chinese medicine composition of described treatment chloasma, described in it, in endo-medicine, the parts by weight of various crude drug can also be: 10～20 parts of Porias, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Pelargoniis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of the Radixs Astragali, 10～20 parts, Semen Persicae, 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Rhizoma Polygonati Odorati, 10～20 parts of Semen Coicis, 10～20 parts of Caulis Polygoni Multiflori, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Radix Paeoniae Rubra, 10～15 parts of Fructus Mumes, 10～15 parts of Rhizoma Acori Graminei, 10～15 parts of Fructus Mori, 10～15 parts of Herba Leonuris, 10～15 parts, the Radix Rehmanniae, 10～15 parts of Semen Benincasaes, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Rhizoma Sparganii, 10～15 parts of Radix Bupleuri, 10～15 parts of Rhizoma Curcumae, 10～15 parts of Herb Gynostemmae Pentaphylli, 10～15 parts of Cortex Mori,

In described external used medicine, the parts by weight of various crude drug can also be: 10～20 parts of Bombyx Batryticatus, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Flos Magnoliaes, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Faeces Passeriss, 10～20 parts of Herba Asaris, 10～15 parts of Radix Ampelopsis, 10～15 parts of Radix Angelicae Pubescentiss, 10～15 parts of Radix Trichosanthis, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Rhizoma Typhonii (processed), 10～15 parts of Fructus Mumes, 10～15 parts of Retinervus Luffae Fructuss.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine composition of described treatment chloasma, and described in it, the dosage form of oral preparations is capsule, and its preparation method comprises:

A, get crude drug and put into ethanol and soak, heat is extracted 2 times, becomes paste, is component 1;

B, medicinal residues extracting in water 2 times, thickening filtration is paste, is component 2;

C, above-mentioned two kinds of components are merged, be condensed into powder and incapsulate.

In described step a, can get in the ethanol that crude drug adds 5-10 doubly to measure and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid,, after standing, remove supernatant, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, stand for standby use, becomes component 1.

In described step b, the medicinal residues of the crude drug of can above-mentioned ethanol extraction crossing add 10 times of water gagings, heating and refluxing extraction 2 times, and each 1～2 hour, 2 extracting solution are merged standing, become component 2.

In described step c, then the merging of component 1 and component 2 can be put into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 ℃ 1.06; After the macroporous adsorptive resins absorption that above-mentioned filtrate is 10L through volume, with deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain after medicated powder is dried incapsulating.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method of Chinese medicine composition of described treatment chloasma again, and described in it, the dosage form of oral preparations is electuary, and preparation method comprises:

Described crude drug roguing can be dried, be ground into granule, soak 1 hour; Soaked raw material is put and in multi-function extractor, decocted with water secondary; Add up for the first time the water of 10 times of amounts of medical material, decoct 1.5～2 hours, get decocting liquid, filter; The water that adds for the second time 7 times of amounts of total amount, decocts 1～1.2 hour, gets twice decocting liquid and mixes, and filters; The filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator to the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, after convection drying powdered, and mediation Mel or dextrin granulation electuary.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine composition of described treatment chloasma, and the dosage form of described external preparation is face film agent, and its preparation method comprises the following steps:

According to described umber, first will wear the Radix Angelicae Dahuricae, Herba Asari and Pseudobulbus Bletillae (Rhizoma Bletillae) and distill with steam method, obtain crystal, standby as component 1; Get the 60-90% soak with ethanol 1-2 hour that the medicinal residues mixing surplus stock after distillation adds 5-10 doubly to measure, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid,, 80-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated, 30 minutes～45 minutes, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, and stand for standby use, becomes component 2; The component of the component of distillation extraction 1 and ethanol extraction 2 is mixed to adding preservative agent spice furnishing facial film.

The Chinese medicine composition of described treatment chloasma, described in it, the endo-medicine dosage form of compositions can be: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution or injection; The external used medicine dosage form of described compositions can be: face film agent, unguentum, spray, liniment, gauze agent and ointment.

When the present invention uses, water decoction can be once-a-day, within 15th, is a course for the treatment of.When tablet, pill and capsule are used, three times on the one, each 2 to 3 or ball; When face film agent is used, clean after face just before going to bed every night, smeared to chloasma place, one as a child washed.

The present invention, in line with the treatment rule for the treatment of must aim at the pathogenesis of disease, controls from gas, stasis of blood opinion, holds concurrently with tonify deficiency righting.By vital energy regualting and blood circulation-promoting, adjust smooth QI and blood, dredging the meridian, hold concurrently with nourishing the liver and kidney, human body is adjusted to lastingly, stable equilibrium between yin and yang, the unobstructed state of QI and blood.Thereby reach spot-removing beautifying face, beautify the object of appearance.Oral administration and externally of the present invention is used in conjunction with, and can accelerate the chloasma that treatment depression of liver-QI causes, from gas, stasis of blood opinion, controls, and holds concurrently with tonify deficiency righting.By vital energy regualting and blood circulation-promoting, adjust smooth QI and blood, dredging the meridian, hold concurrently with nourishing the liver and kidney, human body is adjusted to lastingly, stable equilibrium between yin and yang, the unobstructed state of QI and blood.Thereby reach spot-removing beautifying face, blood circulation promoting and blood stasis dispelling, beautify the object of appearance.Therapeutic effect is more satisfactory, and cheap, and preparation method is simple and easy to do, can create good social benefit and economic benefit.

The specific embodiment

Chloasma also claims " chloasma hepaticum " " butterfly spot ", is the common chromatopathy that betides face.Be a kind of facial metabolism of pigment abnormity dermatosis that betides, show as the yellowish-brown or light black patch of symmetry that facial area size do not wait, divide on skin, that comforts is not in the way.Primary disease men and women all can occur, more with women.Its pathomechanism is complicated, and endocrine disturbance, ultraviolet radiation, D&C, Nervous and Mental Factors etc. all can cause the generation of primary disease.Chloasma and liver, kidney is relevant and lack of proper care after one's birth, dysfunction of the spleen in transportation, and QI-blood failing to nourish upward is in face, also raw brown patch.In a word, primary disease and liver,spleen,kidney three are dirty, especially in close relations with liver.Chloasma has another name called chloasma, shows as dark complexion, dark, dusty face, dough cover, chloasma hepaticum, the symptoms such as black speck of looking unfamiliar, and for a kind of how sick because of property pigmentation, affects patient's appearance, to it, causes serious mental pressure.But the pathogenic factor of chloasma and complicated mechanism, wherein irritability stasis, kidney water (sun) deficiency and blood stasis internal resistance are its most common pattern of syndrome, are secondly spleen soil virtual loss.

Pathogen and pathology of tcm is analyzed: in the classical documents of the traditional Chinese medical science, the etiology and pathogenesis of primary disease is had to following discussion.< < General Treatise on the Cause and Symptoms of Diseases > > says: " dark complexion person, or internal organs have phlegm retention, or skin is subject to ailment said due to cold or exposure, all makes qi and blood disorder, causes raw black.The vital organs of the human body 12 menses, all go up in face, the trip of husband's blood, all flourish the exterior and the interior.People or phlegm retention waterlogging possession, or space between skin and muscles wind-engaging hyperamization gas discord, puckery or turbid, can not be flourish in skin, therefore become raw black ".< < Yizong Jinjian > > says: " depressed by being worried, not magnificent a little less than blood, fiery dryness accumulated in the stomach and intestine is stagnant and be born on face, and women has it more." < < surgery great achievement > > says: " and chloasma is born in woman's face more, and by not magnificent a little less than blood, fiery dryness accumulated in the stomach and intestine becomes, doubtful thing certainly due to." < < Waike Zhengzong, Orthodox Manual of External Diseases > > says: " and chloasma person, water thanks to can not fire processed, can not magnificent meat a little less than blood, so that fiery dryness accumulated in the stomach and intestine spotting is black, and color is withered not damp." motherland's medical science thinks, this pathogenetic endogenous cause of ill is with liver,spleen,kidney three is dirty and QI-blood circulation not normal in close relations, so treatment by oral administration of medicines controls from liver spleen kidney opinion internal organs are many, starts with QI and blood is many from the nourshing blood and promoting blood circulation of regulating the flow of vital energy; This pathogenetic exopathogenic factor is because " space between skin and muscles wind-engaging hyperamization gas discord, puckery or turbid, can not be flourish in skin ", or " not magnificent a little less than blood, fiery dryness accumulated in the stomach and intestine becomes ", because blood deficiency or skin are lost by not smooth the caused passages through which vital energy circulates of ailment said due to cold or exposure or QI-blood circulation, supports.Therefore, external treatment should carry out prescription from the angle of the promoting the circulation of blood wind dispelling of enriching blood.

Theory of Chinese medical science is thought " have Zhu Neibi shape all outer ", and " vital organs of the human body 12 are through QI and blood, all up in face." stop in the generation of chloasma and human body depression of liver-QI, stagnation of blood stasis, caused by liver and kidney deficiency, insufficiency of vital energy and blood, expectorant are turbid etc. multiple because of Suo Youguan.Its pathogenesis or by depression of liver-QI, with the passing of time heat-transformation, fumigates in face and give birth to; Or because of qi depression to blood stasis, battalion defends and becomes estranged, and stops up stagnant channels, ties in face and sends out; Or because of Liver and kidney deficient, Chong and Ren channel disorder, asthenia of essence and blood, can not go up and flourish in face, form; Or be that insufficiency of the spleen mistake is strong, raw in phlegm-damp, turbid pathogen blocks in face and causes.It is clinical adopts the treatment approach such as treatment by oral administration of medicines, external treatment, acupuncture, massage more, lays particular emphasis on from liver,spleen,kidney and starts with, and corrects function disorderly, eliminates gas, the stasis of blood, expectorant, the pathological factor such as wet, hot.Conventional method for the treatment of has that dispersing the stagnated live-QI to relieve the stagnation of QI, vital energy regualting and blood circulation-promoting, nourishing the liver and kidney, soothing liver and strengthening spleen, warming YANG activating the spleen, dampness removing reduce phlegm, eliminating damp-heat etc.

Traditional Chinese medical science QI and blood theory is thought, qi-blood circulating process is the material base that all histoorgans of human body carry out work, the smooth balance of QI-blood circulating regularly is expensive, if QI and blood is smooth, will not produce blood stasis, blood stasis hinders in body, will further cause the deterioration of qi-blood circulating, cause more serious stasis of blood plug, therefore the traditional Chinese medical science be take QI and blood as guiding principle, makes it smooth balance by regulating qi and activating blood, can disease-relieving and physique enhancing, the beauty treatment of nourishing blood.Skin speckle at all in the stasis of blood, moving back speckle must first blood stasis dispelling, blood stasis dispelling be when invigorating blood circulation, invigorating blood circulation more must QI invigorating, regulate the flow of vital energy, qi being the governor of blood, blood moves thereupon; Blood is keeping of gas, be so incensed that and quiet, depressed blood clotting, the deficiency of vital energy is blood prostration, gas is compeled blood and is walked.QI and blood and all and.And regulate the flow of vital energy liver, QI invigorating is at lung kidney, lung governing skin and hair.Because of qi depression to blood stasis, have influence on the QI-blood circulation function of lung spleen Liver and kidney, and cause face, occur even occurring alopecia, alopecia areata by the mottles such as chloasma, freckle.The present invention mainly identifies and corrects according to Chinese medicine the principle treating, and collects many doctor chiefs, extensively adopts the rich strange medicine wonderful recipe in area of receiving, and skims the cream off milk; Pathogenetic understanding and Therapeutic Principle based on Chinese medicine to facial colour spot, reference is Chinese medicine pharmacological research achievement at all times, the natural Chinese medicine of screening inrigorating qi and promoting blood circulation, tonifying Qi and lifting yang, dispersing the stagnated live-QI to relieve the stagnation of QI, suppressing the hyperactive liver and subsiding YANG, enriching yin and nourishing kidney, heat-clearing and toxic substances removing, clearing away heat-fire, strengthening vital QI to eliminate pathogenic factors, purging FU-organs is let out poison, promoting blood circulation to remove blood stasis, the metabolism function of adjusting human body, improve blood circulation of human body and liver detoxification ability, and sum up and form through the clinical practice of long-term diagnosis and treatment case.

Motherland's medical science is called primary disease " chloasma ", " chloasma hepaticum ", " dusty face " etc.In the classical documents that occur in the traditional Chinese medical science due to primary disease, the etiology and pathogenesis of primary disease is had to following discussion.< < General Treatise on the Cause and Symptoms of Diseases > > says: " dark complexion person, or internal organs have phlegm retention, or skin is subject to ailment said due to cold or exposure, all makes qi and blood disorder, causes raw black.The vital organs of the human body 12 menses, all go up in face, the trip of husband's blood, all flourish the exterior and the interior.People or phlegm retention waterlogging possession, or space between skin and muscles wind-engaging hyperamization gas discord, puckery or turbid, can not be flourish in skin, therefore become raw black ".< < Yizong Jinjian > > says: " depressed by being worried, not magnificent a little less than blood, fiery dryness accumulated in the stomach and intestine is stagnant and be born on face, and women has it more." < < surgery great achievement > > says: " and chloasma is born in woman's face more, and by not magnificent a little less than blood, fiery dryness accumulated in the stomach and intestine becomes, doubtful thing certainly due to." < < Waike Zhengzong, Orthodox Manual of External Diseases > > says: " and chloasma person, water thanks to can not fire processed, can not magnificent meat a little less than blood, so that fiery dryness accumulated in the stomach and intestine spotting is black, and color is withered not damp." motherland's medical science thinks; this pathogenetic endogenous cause of ill is with liver,spleen,kidney three is dirty and QI-blood circulation not normal in close relations; so treatment by oral administration of medicines controls from liver spleen kidney opinion internal organs are many, although be in the skin lesion on skin of face surface in gas chloasma, is also the external reflection of body interior dysequilibrium.So will be from integral body in treatment, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.Liver spleen essence and blood is full, punching appoints tune smooth, the money of the own medicine carrying of blood network.Liver controlling conveyance and dispersion, can adjust and reach QI and blood, happy feelings will.If depression of liver-QI is qi-blood disharmony. qi depression to blood stasis. stop up stagnant channels, on tie in face and cause speckle.Liver storing blood.Liver blood fill and, the strong face profit of body.If deficiency of the liver and kindey, blood and essence asthenia, can not go up easily raw speckle of Rong Ze.

The Radix Astragali be take tonify deficiency as main, energy invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.For insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst and do not hold back person for a long time.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows, the Radix Astragali includes and multiple antibiotic effective ingredient, and immunologic function that can enhancing body, therefore can also be for preventing the generation of some infectious disease.< < book on Chinese herbal medicine meets former > > to carry: " all void of Radix Astragali energy tonifying five ZANG-organs, controls stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly sends out, and has antiperspirant to stop." be the good medicine of promoting resistance and defence disease.

Radix Angelicae Sinensis: its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, thus again can promoting the circulation of blood, invigorating middle warmer has, in row, has benefit, really the gas medicine in blood, the also panacea in blood.About mending to mend of assistant, thus can support nutrition blood, QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack, therefore the pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, thus want its quiet person when keeping away it, the sliding benefaction of property, stool is not consolidated person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Rhizoma Chuanxiong is pungent, temperature.Return liver, gallbladder, pericardium channel.Function blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Rhizoma Chuanxiong is warm in nature, is gynecological's common drug, has the effect of activating blood cirulation to regulate QI flow, but can not be multiplex, and especially health has the people of bleeding to be not suitable for taking, as female menstrual period.Meanwhile, Rhizoma Chuanxiong is again one of medical material conventional in medicated diet, with Gallus Domesticus with food, can nourishing yin and activating blood, be women's excellent tonic product.

Semen Persicae is bitter, sweet, puts down the special medicine closing for blood stasis blood.Bitter to let out stagnant blood, sweet with tissue regeneration promoting blood.< < medicineization justice > >: Semen Persicae, bitter in the mouth can rush down heat in blood, and body profit can be grown dryness of the intestine.If it is multiplex that gross weight grinds, walk Liver Channel, main broken blood-retention, water, and pain all over month by month, extremity wood numbness, left hemiplegia, left sufficient patient, relaxes through the promoting the circulation of blood of invigorating blood circulation with it, the merit that has eliminating blood stasis to promote regeneration of blood, if few use is mashed in peeling, enters large intestine, controlling blood depletion just closes, the dry dyschezia of blood, with its make moist removing heat from blood and blood, has relieving accumulation of pathogens to lead to stagnant power.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil is to mice ehrlich carcinoma, lymphosarcoma ascitic type, esophageal carcinoma Ecal09), sarcoma 180 etc. has inhibitory action.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also there is remarkable inhibitory action.< < property of medicine opinion > > carries it: monarch, and sweet in the mouth, pungent, nontoxic.Can main large migratory arthralgia, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, removes sputum, except cold and heat, lets out under only.Interarea light is happy, preserves youthful looks, and de-black.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in abdomen is vomited and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.

Semen Coicis is conventional Chinese medicine. be again generally, the food often eaten, property slightly sweet flavor is slightly cold, and has the effects such as inducing diuresis to remove edema, spleen invigorating are dried, arthralgia relieving by relaxing muscles and tendons, clearing away heat and discharging pus, is conventional damp-clearing drug.Semen Coicis is again a kind of beauty food, and normal food can keep human body skin gloss fine and smooth, eliminates acne, speckle passeris montani saturati, senile plaque, cyasma, butterfly spot, to desquamation, acne, chap, pachylosis etc. has good efficacy.The kind Renhe root of Semen Coicis can be used as medicine and cure the disease again.Li Shizhen (1518-1593 A.D.) is recorded in < < Compendium of Materia Medica > >: " invigorating spleen and reinforcing stomach, tonifying the lung heat clearing away, removes wind prevailing over dampness to Semen Coicis energy.The food of cooking a meal, controls cold air.Decoct drink, diuresis pyretic stranguria." in recent years, a large amount of scientific research and clinical practices prove, Semen Coicis or a kind of cancer therapy drug, and Preliminary Identification, it can reach more than 35% the suppression ratio of cancer.

Radix Paeoniae Rubra: bitter in the mouth, cold nature.Return Liver Channel.The function with clearing away heat and cooling blood, eliminating stasis to stop pain.Raw Radix Paeoniae Rubra wins with clearing away heat and cooling blood power.The fever of the body that is used for the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases is hemorrhage, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus.Wine Radix Paeoniae Rubra: with promoting blood circulation to remove blood stasis power victory, a little less than clearing away heat and cooling blood effect.Be used for amenorrhea or dysmenorrhea, traumatic injury.The Radix Paeoniae Rubra minute excess-heat that can purify the blood, dissipating blood stasis blood is detained.This product function and Cortex Moutan are close, therefore normal and Cortex Moutan mutual reinforcement between are use.But the effect of Cortex Moutan clearing away heat and cooling blood is better, minute excess-heat that can purify the blood, can control fever due to yin deficiency again; And Radix Paeoniae Rubra can only, for blood system excess-heat, be good at promoting blood circulation to remove blood stasis.

Poria: Poria sweet in the mouth, light, property are flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is flat, enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, reaches by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels due to insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy

Flos Pelargonii, Latin formal name used at school: Pelargonium hortorum, has hemostasis, vasoconstrictive, asthma, liver and expelling toxin, cholelithiasis, kidney toxin expelling, renal calculus, diuresis, muscular soreness, oily skin, aging skin activation, herpes, palor, fat-reducing, promotes to scab, eczema, the sunburn of burning, tinea, menstruation has some setbacks, and engorgement of breasts inflammation alleviates melancholy uneasiness, drives demon, mends body, deodorization, antibacterial, sterilization, smoking cessation (wine).The major function of Flos Pelargonii is to adjust skin, and the effective ingredient in Flos Pelargonii extracting solution and natural alicyclic organic have very strong affinity, and therefore, Flos Pelargonii is often combined with alicyclic organic and is made lipoid product.General cleaning supplies are after cleaning, most of can the loss by water flushing of functional components of skin protection, the scientific research personnel of Switzerland is on the basis of three-hypers fresh extractor technology, by interpolation, select to hands sections such as organized enzymes, make the effective ingredient of Flos Pelargonii also produce affinity with skin epidermal area in affine with lipoid, this affinity has surmounted the affinity with water, therefore, in the process of cleaning, most of effective ingredient of Flos Pelargonii still can be absorbed by the skin, play the effect of adjusting skin, Flos Pelargonii is almost applicable to various skins, because of its energy balance sebum secretion, make turgor.May be to eczema, burn, herpes zoster, herpes, tinea and chilblain useful.To slack and undisciplined, pore block and oily skin also fine, because Flos Pelargonii can pore refining, blood circulation promoting, can allow after use pale skin is comparatively ruddy a vigor, makes the glossy exquisiteness of skin.

Rhizoma Atractylodis are pungent, bitter, temperature.Return spleen, stomach, Liver Channel.Function cures mainly: drying damp and strengthening spleen, and expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Main the spleen and stomach being stranded by dampness; Asthenia drowsiness; Born of the same parents' painful abdominal mass abdominal distention; Inappetence; Tell and have loose bowels; Phlegm retention; Damp-edema; Exterior syndrome folder is wet; Heavy sensation of the body pain; Arthromyodynia warm nature; Podomere is ached and is being weighed; Flaccidity folds in a garment.Rhizoma Atractylodis have drying damp and strengthening spleen, the effect of wind-damp dispelling.Cure mainly retention of dampness in middle-JIAO, anemofrigid-damp arthralgia, foot swelling and pain in knee, flaccidity is soft unable, nyctalopia nyctalopia.< < pearl sac > > day: " can stomach invigorating pacify spleen, non-this of all damp-edema can not remove." < < Compendium of Materia Medica > > says: " control damp-phlegm prolonged fluid-retention ... and spleen is wet dirty, turbid drop leukorrhagia, the sliding hemorrhoidal hamorrhage that rushes down." < < Newly Revised Canon of Materia Medica > > claims that it can " diuresis ".

Rhizoma Polygonati Odorati: nourishing YIN and moistening the lung; Nourishing the stomach to promote the production of body fluid.Cough caused by dryness; Chronic cough; The dry throat and mouth of the cloudy liquid consumption of calentura wound; Interior-heat is quenched one's thirst; Deficiency of YIN diseases caused by exogenous pathogenic factor; Dizzy dizzy; Muscle arteries and veins spasm and pain.Rhizoma Polygonati Odorati sweet in the mouth greasiness, matter is soft and moisten, and is the good medicine of YIN nourishing and the production of body fluid promoting simply.Contained vitamin A in Rhizoma Polygonati Odorati, improves dry and cracked, rough skin situation, makes it soft lubricated.Play the effect of beauty and skin care." stem is tetanic, like bamboo arrow shaft, has joint for < < Collective Notes to Canon of Materia Medica > > cloud.Therefore " there is the name of Rhizoma Polygonati Odorati.The rhizome of plant can hyoscine, and Chinese medicine name is also Rhizoma Polygonati Odorati, and excavate autumn, cleans, and shines to softness, repeatedly rubs, and dry in the sun, to without hard-core, is dried, or after steaming thoroughly, rubs to translucent, dries, and cuts sheet or section is used.The just > > of < < book on Chinese herbal medicine: " controlling lung dryness of the stomach heat, the disease such as body fluid dries up, thirsty dry sensation in the pharynx, and excessiveness of stomach-fire, dry thirsty rapid digestion of food, polyorexia person, You Youjie effect ".

Prunus mume is called dark plum, yellow son, closes Chinese prunus mume (sieb.) sieb.et zucc., is done a branch prunus mume (sieb.) sieb.et zucc., for the almost ripe fruit of the prunus mume (sieb.) sieb.et zucc. Prunus mume of rosaceae plant deciduous tree, through pyrotechnics, smokes and forms.If soak night with saline Exposure to Sunlight with Armeniaca mume Sieb., after 10 days, there is bloom to form, be called bloom prunus mume (sieb.) sieb.et zucc., its effect is similar, and compatibility and incompatibility of drugs is identical.According to modern study. Armeniaca mume Sieb. or Fructus Armeniacae Mume juice.Less containing sodium containing potassium is many in Fructus Mume, therefore, need long-term taking row potassium diuretic person should eat it; Fructus Armeniacae Mume China can promote enterokinesia containing catechuic acid, so the people of constipation should eat it.In Fructus Armeniacae Mume, containing multiple organic acid, be improved the effect of liver function, therefore hepatopath should eat it.Prunus mume (sieb.) sieb.et zucc. acid in Fructus Armeniacae Mume can vessel softening, postpones sclerosis of blood vessels, has anti-senility effect.It is not outward that purified diet is as pure white frumentum, pure white bread, pure white noodles, pure white sugar, chemical seasoning and animal food that modern likes the food of eating.Eaten these foods and can cause the toxin in blood to increase severely, the date is of a specified duration, and blood circulation worsens and product acidifer.Eat a Fructus Mume every day and can help to clean blood, make blood flow momentum normalization, get rid of excessive acid element.

Caulis Polygoni Multiflori is sweet, flat.GUIXIN, Liver Channel.Function with cure mainly: nourishing blood to tranquillize the mind, dispelling wind and removing obstruction in the collateral.For insomnia and dreamful sleep, blood deficiency general pain, rheumatic arthralgia; External treatment skin pruritus.Blood deficiency general pain, rheumatic arthralgia.This product nourishing blood to expel wind, collaterals and relieving pain, with controlling blood deficiency general pain, the compatibilities such as normal and Caulis Spatholobi, Radix Angelicae Sinensis, Rhizoma Chuanxiong, use dispelling the wind and dampness pathogens arthralgia pain, and wind-damp dispelling, the stopping numbness pain medicines such as normal and Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Herba Taxilli, Radix Gentianae Macrophyllae be use together.For malasia.The existing effect of nourishing blood of Caulis Polygoni Multiflori, also can tonneau meridians, control blood deficiency malasia, can coordinate Radix Angelicae Sinensis, Radix Rehmanniae, Caulis Spatholobi, Caulis Trachelospermi to be equal to use.

Its slightly warm in nature of Rhizoma Acori Graminei, acrid in the mouth, have have one's ideas straightened out, eliminating phlegm, regulate the flow of vital energy, invigorate blood circulation, loose wind, the effect of drying, be usually used in treating the diseases such as epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition unhappiness, stomachache, stomachache, rheumatic arthralgia, swollen ulcer drug, traumatic injury.Removing dampness appetizing, the eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.< < herbal classic > >: main anemofrigid-damp arthralgia, cough with dyspnea, happy hole, tonifying five ZANG-organs, logical nine orifices, improve visual and auditory acuity, goes out speech.< < does not record > >: " warming intestines and stomach, stops normal urination for main deafness, carbuncle skin ulcer, and extremity arthralgia chiefly caused by damp pathogen, must not bend and stretch, children's's pyrexial malaria, body accumulated heat is not understood, and can bathe soup.Audition improvement order, beneficial intelligence." < < property of medicine opinion > >: " dispelling the wind and dampness pathogens insensitive impediment, tinnitus, wind syndrome of head, under tear, kills parasites, controls malignant boil scabies scabies.

Fructus Mori nourishing YIN and benefiting blood medicine; Medicine promotes the production of body fluid; Aperitive.The YIN nourishing of enriching blood, promotes the production of body fluid and moisturizes.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.Tonifying liver, kidney tonifying, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid.Control hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Both can food, can be used as medicine again, the traditional Chinese medical science is thought the acid of Fructus Mori sweet in the mouth, cold nature, enters the heart, liver, kidney channel, is strengthening by means of tonics, the good fruit of the heart nourishing and intellengence improving.There is the YIN nourishing of enriching blood, promoting the production of body fluid to quench thirst, the effect such as intestine moistening is dry, cures mainly deficiency of YIN-blood and having a dizzy spell of causing, tinnitus cardiopalmus, irritated insomnia, soreness of the waist and knees, early whitening of beard and hair, the xerostomia of quenching one's thirst, the diseases such as constipation with dry stool.

Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, dispel silt, regulating menstruation, water disappears.Treatment menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Herba Leonuri, containing materials such as leonurine, Fumaric acids, has the effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema.

Semen Benincasae is sweet, cool.< < herbal classic > >: sweet in the mouth is flat.Removing heat from the lung and dissipating phlegm; Eliminating carbuncle evacuation of pus; Dampness removing.Main phlegm-heat cough; Lung abscess; Intestinal carbuncle; Nebulousurine; Leukorrhagia; Foot gas; Edema; Stranguria.< < Japan hanako materia medica > >: peeling skin wind stripping casting skin, profit skin.< < detailed outline > >: control acute appendicitis.< < Bencao Jingshu > >: the Pi that wakes up can whet the appetite.

The Radix Rehmanniae: the Radix Rehmanniae is also Radix Rehmanniae, the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosaLibosch..Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; The effect of Radix Rehmanniae and Radix Rehmanniae is different.Radix Rehmanniae clearing away heat and promoting production of body fluid, can stop blooding and removing heat from blood, is often for consumption of YIN caused by febrile disease, the diseases such as haematemesis, laryngopharynx swelling and pain, crimson tongue excessive thirst, a speckle dermexanthesis and nosebleed heat.With respect to Radix Rehmanniae, Radix Rehmanniae is heat clearing and blood cooling, also can promote the production of body fluid, and all right yin nourishing is used for treating yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, crimson tongue excessive thirst, sends out the problems such as speckle dermexanthesis.The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.Not only promoting the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect, every blood system to have the people of thermal burn the moon to metrorrhagia, menoxenia, frequent fetal movement, constipation etc., can often take.If want to treat epidemic febrile disease, can do qingying decoction with the Radix Rehmanniae; If the later stage for the treatment of epidemic febrile disease, because She's heat does not also disappear to the greatest extent, should be used for boiling QINGHAOBIEJIATANG the Radix Rehmanniae; In addition, for heat in blood poison, contain, macule purple is black, and the serious heat of epidemic febrile disease enters the symptom of nutrient blood, can take the Sisheng Wan that the Radix Rehmanniae is made; The general YIN nourishing and the production of body fluid promoting of wanting treats that interior-heat quenches one's thirst with constipation, should eat the once liquid soup that the Radix Rehmanniae boils

Fructus Ligustri Lucidi is for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to use, controls early whitening of beard and hair, often joins the same use of Fructus Mori, and fever due to yin deficiency, often joins Cortex Lycii.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.Protective effect research to liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, give rat skin lower injection, can reduce serum glutamic pyruvic transminase, the hepatic injury of Carbon Tetrachloride Induced being had to obvious protective effect, and can promote liver cell regeneration. oleanolic acid also can make in liver triglyceride accumulate that minimizings, hepatocellular degeneration necrosis obviously alleviate, glycogen is accumulated increase, serum γglobulin decline; Mitochondrial swelling and the degeneration of endoplasmic reticulum vesicle alleviates, the inflammatory reaction of hepatic tissue interstitial weakens in the visible hepatocyte of ultrastructure.

Rhizoma Sparganii rhizoma scirpi has another name called belt leather Rhizoma Sparganii.Tuber for sedge cyperus iria L. rhizoma scirpi Scirpusflaviatilis (Torr.) A.Gray.Below all take matter heavily fortified point, body weight, be dried, remove crust, surperficial yellow-white person as good.Controlling swollen pain, amenorrhea, postnatal blood stasis stomachache, traumatic injury, skin ulcer under lump in the abdomen, coagulation of QI-blood, trusted subordinate's pain, the side of body swells hard.. < < Japan hanako materia medica > >: control married woman's blood vessels uncomfortable, cardiac and abdominal pain, tire falls, the stagnant blood that disappears, mends labor, logical menstruation, control flatulence, disappear and flutter damage blood stasis, puerperal abdonimal pain, blood fortune stagnated blood not under.< < Kaibao Bencao > >: main old addiction lump in the abdomen caking.

Rhizoma Curcumae is pungent, bitter, temperature.Return liver, spleen channel.Cure mainly " lump in the abdomen, gathers for coagulation of QI-blood, trusted subordinate's distending pain, and dyspepsia does not disappear, women's blood stasis amenorrhea, and traumatic injury is had a pain." there are promoting QI circulation for relieving depression, removing blood stasis with potent drugs, the function of pain relieving.The mice alanine aminotransferase (ALT) that curcumenol extract and volatile oil cause carbon tetrachloride (CCI4) thioacetamide (TAA) raises obvious reducing effect, sulfobromophthalein sodium (BSP) retention amount is reduced, and corresponding liver tissue lesions alleviates.

Cortex Mori is the root bark of moraceae plants Mulberry Morus alba L..Main product in Anhui, the ground such as Henan, Zhejiang, Jiangsu, Hunan.Effect: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.< < property of medicine opinion > >: make, flat.Can control lung qi dyspnea with fullness of the chest, aqueous vapor edema, main wound is exhausted, dredging water passages, the aqueous vapor that disappears, the headache of asthenia exopathogenic heat, interior tonifying for the deficiency.< < Japan hanako materia medica > >: temperature, in tune, the therapeutic method to keep the adverse QI flowing downwards.Expectorant is quenched the thirst, sharp intestine and small intestine, and appetizing, lower food, kills abdomen and hides worm, and only cholera is vomited and diarrhoea.

Herb Gynostemmae Pentaphylli: through pharmacology, toxicity and clinical proof, Herb Gynostemmae Pentaphylli has adaptive capacity widely, and multiple cancerous cell is had to significant inhibitory action; In addition, Herb Gynostemmae Pentaphylli also has blood fat reducing, blood pressure lowering, blood sugar lowering, calmness, hypnosis, antitonic, antiulcer, resisting fatigue, prolongation cell survival and appetite stimulator, build up resistance, unobstructed stool, antiasthmatic-antitussive, the hemorrhoid that disappear, fat-reducing, treatment deficient syndrome, inhibition cholelithiasis form, prevent and treat glucocorticoid side effect, the anti-ageing multiple efficacies of waiting for a long time.Except having the effect of Radix Ginseng, also there is the multiple effect that Radix Ginseng does not possess, and there is no reaction and any other toxic and side effects of Radix Ginseng excessive use.

Radix Bupleuri clearind deficient heat Chinese medicine, for cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus come off, menoxenia.Return Liver Channel, gallbladder meridian.Function: evacuate and bring down a fever, yang invigorating soothing liver-QI.Cure mainly: cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus comes off, menoxenia.Treatment viral hepatitis: injection of Radix Bupleuri (every 1ml containing crude drug 2g) 10～20ml adds quiet of the quiet note of 50% Glucose Liquid or 5% Glucose Liquid 250～500ml, every day 1 time, was for 10 times 1 course for the treatment of, treatment viral hepatitis 120 examples, acute case 97 examples wherein, effective percentage is 98.4%; Chronic case 23 examples, effective percentage is 100%, to improving symptom, retraction liver spleen, recovery liver function and hepatitis B antigen negative conversion rate, all has better effect.

External used medicine has:

Retinervus Luffae Fructus is cool in nature, sweet in the mouth.Function cures mainly dredging collateral, invigorates blood circulation, and dispels the wind.For arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis.Fructus Luffae begins to be loaded in < < Compendium of Materia Medica > >, lists dish portion, vegetable category in.Li Shizhen (1518-1593 A.D.) is said: " this melon always muscle silk frame up, therefore there is the name of a network "." Fructus Luffae the old, grain runs through, and atrial septum affiliation, therefore can pass into venation internal organs, and removes to see poison, and detumescence is reduced phlegm, the pain parasite killing and control all disorders of blood also of dispelling." < < book on Chinese herbal medicine just reads > >: Retinervus Luffae Fructus, enter meridians, separate pathogenic heat.Evanescence of heat wind goes, and in network, the unlikely knot of body fluid, combined into expectorant, becomes all diseases of toxic swelling, therefore cloud removing toxic substances ear.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood.< < Japan hanako materia medica > >: control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, logical month water, brings down a fever, relieving restlessness, QI invigorating, the hot disease of it row, pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage, rush down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, skin ulcer scabies, headache, improving eyesight, conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Pseudobulbus Bletillae (Rhizoma Bletillae) property is bitter, sweet, puckery, is slightly cold.Return lung, liver, stomach warp.Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation.For hemoptysis, spit blood, traumatic hemorrhage, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage.< < Sheng Nong's herbal classic > >: " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach "; < < Compendium of Materia Medica > >: " abnormal smells from the patient (root) is bitter, flat, nontoxic.

Radix Angelicae Dahuricae meridian distribution of property and flavor: pungent, temperature.Attach to the lung and stomach meridians.Expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping.< < Japan hanako materia medica > >: control conjunctival congestion bulbar conjunctiva polyp, and tire patching leaks landing, broken stagnated blood, mend fresh blood, acute mastitis, carbuncle on the back, scrofula, hemorrhoidal hamorrhage, hemorrhoid complicated by anal fistula, evacuation of pus, desolation, scabies, pain relieving granulation promoting, goes face Shao-defect scar.

Bombyx Batryticatus enters liver, lung, stomach warp.Expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Control apoplectic aphasia, infantile convulsion, wind syndrome of head, acute throat trouble.Sore throat, scrofula tuberculosis.Wind skin ulcer urticaria, erysipelas, mastitis.< < herbal classic > >: main pediatric epilepsy scared night cry, go three worms, Mie Hei über, the cloudy infections of man is sick.< < does not record > >: woman's metrorrhagia is red white, puerperal She's pain, all skin ulcer cicatrixs of going out.It, do not seal furuncle swollen, and root ought go out certainly.< < property of medicine opinion > >: control locked mouth, diaphoresis, housewife people's metrorrhagia hematochezia is more than.

Flos Magnoliae is warm in nature, the micro-hardship of acrid in the mouth.Gui Jing attaches to the lung and stomach meridians.Dispersing wind and cold, clearing the nasal passage.For headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge.< < herbal classic > >: main the five internal organs health cold and heat, public attention headache, face acid anhydride.< < does not record > >: warming middle-JIAO expelling pathogenic factors from muscles, sharp nine orifices, stuffy nose relieving plug, tears go out, control swelling of the face and draw toothache, dizziness, body several as on car and boat person.Raw beard and hair, removes tapeworm.< < property of medicine opinion > >: can control the acid anhydride of looking unfamiliar.Face fat use, key light China.

Herba Asari, Chinese medicine name, cures mainly: dispels the wind, cold expelling, row water, has one's ideas straightened out.Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.All herbal medicine, with being antipyretic, diuresis, analgesia, tranquilizer.Control headache, the effect of have diaphoresis, eliminating the phlegm.Exterior syndrome due to wind-cold; Headache, toothache; Rheumatic arthralgia; Phlegm retention cough with asthma; Nasal obstruction; Nasal sinusitis; Aphtha.Refrigeration function Herba Asari volatile oil gavages many reasons as Wen Cifa, tetrahydrochysene beta-naphthylamine, typhoid fever, the caused rabbit experiment heat pyrexia of paratyphoid fever mixed vaccine have obvious refrigeration function, and the rat fever due to beer yeast is also had to obvious solution thermal effect.Can also reduce the body temperature of normal rat.

Radix Ampelopsis returns through heart channel; Lung meridian; Liver Channel; Spleen channel.Function: heat-clearing and toxic substances removing; Removing obstruction for relieving pain; Promoting tissue regeneration and ulcer healing.Cure mainly: sore swollen toxin, scrofula, scalds eczema, pyrexial malaria, infantile convulsion, dysentery, hemorrhoidal hamorrhage, anal fistula, leucorrhea, traumatic injury, traumatic hemorrhage.Radix Ampelopsis is the root of vitaceae Radix Ampelopsis, and annual spring, autumn excavate, and removes stem and thin fibrous root, and after cleaning, many rip cuttings become two lobes, pintongs or oblique sheet, dry and can be used as medicine.It is cool in nature, and bitter but sweet flavor is pungent, has the effect of heat clearing away, removing toxic substances, eliminating stagnation, granulation promoting, pain relieving, is used for the treatment of the diseases such as carbuncle, furuncle, scrofula, scald, pyrexial malaria, infantile convulsion, dysentery, hemorrhoidal hamorrhage, anal fistula

Radix Trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, is clearing away heat-fire class medicine, and its concrete effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, evacuation of pus detumescence.Cure mainly: control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.For treatment diabetes, conventional it and drugs for nourishing yin are used in conjunction with, to reach the effect for the treatment of both the principal and secondary aspects of a disease.< < book on Chinese herbal medicine converges says > >: Radix Trichosanthis, move back the five internal organs hot and suffocating, as heart-fire, contain and dry tongue and mouth, lung-fire is contained and pharyngeal swelling sore throat, spleen-fire is contained and dispute tooth is swollen, and phlegm-fire is contained and cough is not peaceful.If the side of body of liver-fire is swollen migratory arthralgia caused by wind, the hectic fever due to YIN-deficiency dysphoria with smothery sensation of kidney fire, or carbuncle bursts and do not burst, and pyretic toxicity is loose, or five types of jaundice yellow skin and eye, and if if little water drenches puckeryly, be due to all burning hot pent-up, only phlegm-fire, falls in this agent energy relieving stagnation, and can control it.Its property is sweet cold again, kindly can control yearningly, controls empty yearningly from tonic, controls fire thirsty from the medicine of a cold nature, controls strongly fragrant yearningly from gas medicine, from blood medicine, controls excessive thirst, is to control thirsty key medicine also.

Rhizoma Typhonii (processed): Rhizoma Typhonii (processed) is got clean Rhizoma Typhonii, separately size, soaks, and change water 2-3 every day, after a few days as play a sticky foam, add Alumen (every Rhizoma Typhonii 100mg, uses Alumen 2mg) after changing water, steep and change again water after one day, to mouth, taste micro-numb feeling in the tongue degree of being that has, take out.Ginger slice, Alumen powder are put in pot and added suitable quantity of water, after boiling, pour Rhizoma Typhonii into and boil altogether to without the dry heart, pull out, remove ginger slice, dry in the air to six to seventy percent dry, cut sheet, dry.Every Rhizoma Typhonii 100mg, with Rhizoma Zingiberis Recens, each 12.5mg of Alumen.Meridian distribution of property and flavor: Rhizoma Typhonii acrid in the mouth, sweet, warm in nature, poisonous.Return stomach, Liver Channel.Effect: drying dampness to eliminate phlegm, expelling wind and relieving convulsion, detoxicating and resolving stagnation of pathogens pain relieving.Cure mainly: in due to wind-phlegm oblique, the middle wind-phlegm heap soil or fertilizer over and around the roots of air port eye, hemiplegia, tetanus, headache, rheumatic arthralgia, numb limbs and tense tendons, scrofula tuberculosis, carbuncle of yin nature toxic swelling peppery, venom, infantile convulsion epilepsy, swollen ulcer drug.

Radix Angelicae Pubescentis, Chinese medicine name.Dry root for samphire Angelica pubescens.Main product in Sichuan, the ground such as Hubei, Anhui.At the beginning of spring or autumn end excavate, remove fibrous root and silt, a heatable brick bed to half-dried, banked up 2～3 days, after feeling like jelly again a heatable brick bed to absolutely dry.Section, raw using.The positive > > of < < book on Chinese herbal medicine: " specially manage part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels rheumatism, two pain in foot numbness, pruritus due to damp pathogen contracture." modern study, Radix Angelicae Pubescentis has antiinflammatory, analgesia and sedation; Platelet aggregation is had to inhibitory action; And it is not have hypotensive effect, but lasting; Contained bergapten, xanthotoxin etc. have photosensitive and antitumor action.

Faeces Passeris: enter liver, kidney two warps.Function cures mainly eliminate indigestion, removing nebula.Control hernia abdominal mass, disease addiction, corneal nebula, bulbar conjunctiva polyp, dental caries.Treat ophthalmalgia, the carbuncle furuncle of determining, woman's leukorrhagia, drowns unfavorable, except hernia abdominal mass.< < day is with herbal > >: " remove freckle on face, whelk.”

Specific embodiment 1

The preparation of honey pill agent of the present invention: by Poria 1000g, Radix Angelicae Sinensis 1000g, Flos Pelargonii 1000g, Rhizoma Chuanxiong 1000g, Radix Astragali 1000g, Semen Persicae 1000g, Rhizoma Atractylodis 1000g, Rhizoma Polygonati Odorati 1000g, Semen Coicis 1000g, Caulis Polygoni Multiflori 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Paeoniae Rubra 1000g, Fructus Mume 1000g, Rhizoma Acori Graminei 1000g, Fructus Mori 1000g, Herba Leonuri 1000g, Radix Rehmanniae 1000g, Semen Benincasae 1000g, Fructus Ligustri Lucidi 1000g, Rhizoma Sparganii 1000g, Radix Bupleuri 1000g, Rhizoma Curcumae 1000g, Herb Gynostemmae Pentaphylli 1000g, Cortex Mori 1000g, soak, heated and boiled 3 times, each 1-2 hour, filter, filtrate for later use, to merge in the filtrate suction concentrating under reduced pressure tank of latter 3 times, being evaporated to relative density is 1.20, the extractum that temperature to 60 is ℃-70 ℃, put into baking oven, put into baking oven, be controlled at 75 ℃, after oven dry, be cooled to and be Powderedly twisted into slice together with being mixed in Mel, every 5g of take packs as a ball wax seal.

Specific embodiment 2

The manufacturing process of capsule of the present invention is: get Poria 1200g, Radix Angelicae Sinensis 1300g, Flos Pelargonii 1200g, Rhizoma Chuanxiong 1300g, Radix Astragali 1200g, Semen Persicae 1300g, Rhizoma Atractylodis 1200g, Rhizoma Polygonati Odorati 1300g, Semen Coicis 1100g, Caulis Polygoni Multiflori 1200g, Rhizoma Atractylodis Macrocephalae 1100g, Radix Paeoniae Rubra 1200g, Fructus Mume 1200g, Rhizoma Acori Graminei 1200g, Fructus Mori 1200g, Herba Leonuri 1100g, Radix Rehmanniae 1200g, Semen Benincasae 1200g, Fructus Ligustri Lucidi 1100g, Rhizoma Sparganii 1200g, Radix Bupleuri 1200g, Rhizoma Curcumae 1200g, Herb Gynostemmae Pentaphylli 1200g, Cortex Mori 1100g, get in the ethanol that crude drug adds 5-10 doubly to measure and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, after standing, remove supernatant, then 100-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, stand for standby use, become component 1.The medicinal residues of the crude drug that above-mentioned ethanol extraction is crossed add 10 times of water gagings, heating and refluxing extraction 2 times, and each 1～2 hour, 2 extracting solution merging is standing, become component 2.By the merging of component 1 and component 2, then put into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 ℃ 1.06; After the macroporous adsorptive resins absorption that above-mentioned filtrate is 10L through volume, with deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain after medicated powder is dried incapsulating.

Specific embodiment 3

By described crude drug Poria 1100g, Radix Angelicae Sinensis 1200g, Flos Pelargonii 1200g, Rhizoma Chuanxiong 1300g, Radix Astragali 1200g, Semen Persicae 1300g, Rhizoma Atractylodis 1200g, Rhizoma Polygonati Odorati 1100g, Semen Coicis 1100g, Caulis Polygoni Multiflori 1200g, Rhizoma Atractylodis Macrocephalae 1100g, Radix Paeoniae Rubra 1200g, Fructus Mume 1200g, Rhizoma Acori Graminei 1200g, Fructus Mori 1200g, Herba Leonuri 1300g, Radix Rehmanniae 1200g, Semen Benincasae 1100g, Fructus Ligustri Lucidi 1100g, Rhizoma Sparganii 1200g, Radix Bupleuri 1200g, Rhizoma Curcumae 1100g, Herb Gynostemmae Pentaphylli 1200g, Cortex Mori 1300g roguing, dries, be ground into granule, soak 1 hour; Soaked raw material is put and in multi-function extractor, decocted with water secondary; Add up for the first time the water of 10 times of amounts of medical material, decoct 1.5～2 hours, get decocting liquid, filter; The water that adds for the second time 7 times of amounts of total amount, decocts 1～1.2 hour, gets twice decocting liquid and mixes, and filters; The filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator to the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, after convection drying powdered, and mediation Mel or dextrin granulation electuary.

Specific embodiment 4

The manufacturing process of external face film agent of the present invention is: according to described umber, first Radix Angelicae Dahuricae 1500g, Herba Asari 1500g and Pseudobulbus Bletillae (Rhizoma Bletillae) 1500g distilled with steam method, obtains crystal, and standby as component 1, get the medicinal residues mixing surplus stock Bombyx Batryticatus 1500g after distillation, Radix Paeoniae Alba 1500g, Rhizoma Chuanxiong 1500g, Fructus Mume 1500g, Flos Magnoliae 1500g, Faeces Passeris 1500g, Radix Ampelopsis 1500g, Radix Angelicae Pubescentis 1500g, Radix Trichosanthis 1500g, Rhizoma Typhonii (processed) 1500g, Retinervus Luffae Fructus 1500g, the 60-90% soak with ethanol 1-2 hour that adds 5-10 doubly to measure, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated, 30 minutes～45 minutes, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stand for standby use, become component 2, the component of the component of distillation extraction 1 and ethanol extraction 2 is mixed to CO60 irradiation dose 8k sterilizing bottling for adding preservative agent spice furnishing facial film.

Specific embodiment 5

The preparation method of externally used paste of the present invention comprises: according to described umber, first Radix Angelicae Dahuricae 1200g, Herba Asari 1300g and Pseudobulbus Bletillae (Rhizoma Bletillae) 1200g distilled with steam method, obtains crystal, and standby as component 1, get the medicinal residues mixing surplus stock Bombyx Batryticatus 1200g after distillation, Radix Paeoniae Alba 1200g, Rhizoma Chuanxiong 1300g, Fructus Mume 1200g, Flos Magnoliae 1200g, Faeces Passeris 1100g, Radix Ampelopsis 1200g, Radix Angelicae Pubescentis 1200g, Radix Trichosanthis 1100g, Rhizoma Typhonii (processed) 1200g, Retinervus Luffae Fructus 1200g, the 60-90% soak with ethanol 1-2 hour that adds 5-10 doubly to measure, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated, 30 minutes～45 minutes, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, stand for standby use, become component 2, the component of the component of distillation extraction 1 and ethanol extraction 2 is mixed, add vaseline paste making agent.

Pharmacology's toxicity test

Embodiment 1: acute toxicity testing

One, test material:

Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Experiment thing: granule is taken in the present invention orally.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, 10 every group, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of the maximum permission capacity of mice, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose is measured (MTD value): get 20 of mices, each 10 of male and female.Adding distil water of the present invention is dissolved, be made into maximum concentration, by the maximum tolerated dose of animal, to inject, fill with hello device and can twitch and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice (interval half an hour) in a day, each 0.5ml (every ml is containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.After administration, Continuous Observation is 7 days.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, do not measure LD50, ask only maximum tolerated dose, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normally, there are no death.Select 300 times of doses that are equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: long term toxicity test data

The decoction agent of the present invention's granule for oral administration is through the gastric infusion long-term toxicity test for animals result of 6 months: SD rat is divided into three groups, every group 30, male and female half and half (being divided into high, medium and low three dosage groups, 10 every group), wherein first group through gavage to normal saline; Second group is given dosage of the present invention through gavage is 0.25g, 2.5g and 12.5g/kg.d; The 3rd group is 0.5mg, 5.0mg and 50.0mg/kg.d through gavage to the dosage of lovastatin.During administration, the indexs such as clinical manifestation, hematology, blood biochemistry, organ coefficient and histopathology of observing respectively after each treated animal administration are carried out the evaluation of drug toxicity.Result of study: main toxic reaction shows lovastatin 50mg/kg.d and 5.0mg group, shows after administration that reaction and the symptoms such as sialorrhea, hair are fluffy, busy, diarrhoea, step have appearred in SD rat, total food ration and losing weight; Blood test shows that total white blood cells increases to some extent, erythrocyte sum, content of hemoglobin and platelet count obviously decline (the equal < 0.05 of P); Blood biochemistry checking shows ALT, AST, ALP and 1～8 times (equal < 0.05 of P) of CK rising, and creatinine and blood urea nitrogen raise (the equal < 0.05 of P) to some extent, but do not cause animal dead; Histopathological analysis result shows that the Liver and kidney pathological change similar to people appearred in lovastatin 50mg/kg.d group.And all there is not similar reaction in tri-dosage groups of normal saline group and 0.25g of the present invention, 2.5g and 12.5g/kg.d and lovastatin 0.5mg/kg.d dosage group during whole administration, at convalescent period viewing duration, the symptom that occurs each treated animal of the reaction recovery normal condition that fades away.Visible the present invention not only can reduce the toxic and side effects of lovastatin, and can make the clinical non-toxic of lovastatin be increased to 5～25 times (the equal < 0.01 of P).

Test example 3: cumulative toxicity experiment:

The present invention decoct agent to mice by 7.69,19.18 and 15 weeks (1.0ml/100g body weight of 43.21g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 3 weeks, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation oral capsule of the present invention is to rat long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Embodiment 4: skin irritation test

One, experimental technique

Guinea pig back spinal column both sides are evenly coated depilatory, make approximately 20 square centimeters of unhairing scopes.Clean depilatory returns cage to observe 24 hours, and every group of Cavia porcellus is coated with respectively externally used paste 4,8 of the present invention and 12g, and respectively containing crude drug 92mg, 184mg and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment finishes, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin are done pathological examination.

Two, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity activity, histopathologic examination, the administration group heart, liver, kidney and depilation skin with contrast more also no significant difference of word.Results suggest, the present invention, without local irritant effect, also has no general toxicity performance.Show that external preparation of the present invention is used safety.

Pharmacological experiment explanation:

1 material

1.1 animals: 60 of healthy 3 monthly age pure lines Kunming kind female mices, body weight 25～35g, the laboratory animal department of the Chinese Academy of Sciences of Shandong University provides.Animal feeding condition: every group of mice is by group sub-cage rearing.In the situation that natural conditions are identical, routine is raised food drinking-water, keeps natural lighting, and without undesirable element impact, raise and after adaptation experimental situation, start to test for 1 week,

1.2 experimental drugs: oral capsule of the present invention, by embodiment 2 method preparations, concentration: 0.12mg/ml, the court Pharmacy department produces.3% Hydrochinone Cream: the hospital of traditional Chinese hospital, Wuhan City Pharmacy department produces, lot number 20050905.Progesterone injection: Zhejiang Province XianJu Pharmacy stock Co., Ltd, lot number: 20050115.

1.3 reagent: sodium sulfide (NaS): the limited public affairs of extra large Ling Feng chemical reagent can, lot number: 20020118, be made into before use 10% aqueous solution.Superoxide dismutase (SOD), malonaldehyde (MDA) test kit: Bioengineering Research Institute is built up in Nanjing, lot number: 20059116.

1.4 key instruments: DY89-II type electric driven glass refiner: Xin Lan biotech inc, Ningbo.System biological microscope: OLYMPUS; BX50F4 Beijing Institute of Aeronautics pathological image analytical system.

2 experimental techniques

2.1 modellings: with reference to chloasma experimental animal model clone method.After mice 2.5% pentobarbital sodium anesthesia, with 0.4% progesterone injection, press the intramuscular injection of 0.02g/kg dosage mouse hind leg, 6 times weekly, continuous 4 weeks.Normal group is pressed 0.02g/kg intramuscular injection sterilized water for injection.

2.2 animal grouping and administrations: get 60 of Healthy female mices, 3 dosage groups, are divided into 6 groups at random, 10 every group.Normal group, model group, 3 dosage groups of capsule of the present invention (0.15,0.3,0.6mg/ml), 3% hydroquinone positive controls (0.6mg/ml).3 dosage treatment groups of the present invention are respectively in mice modeling medication on the same day, every day 2 times, 6 times weekly, continuous use 30 days.Normal group and model group give distilled water in the corresponding time; 3% hydroquinone positive drug control group started local application in modeling the same day, and time and the course for the treatment of are with spot-removing beautifying face oral liquid treatment group.

2.3 observation index and detection: medication is after 30 days, and mice, back unhairing are put to death in cervical vertebra dislocation, get rapidly hepatic tissue and coating position skin histology each 2, wherein with ice-cold normal saline flushing, remove blood for one, filter paper blots, cut each 0.5g of liver and skin, the beaker of putting into respectively the pre-cold saline of 2.0ml, shreds tissue, then pours in test tube, with high speed disperser 10r/min homogenate twice, each 10 seconds; With 3500r/min rotating speed centrifugal 15 minutes again, get supernatant.Adopt xanthine oxidase, by test kit, detect description method and measure SOD; Adopt thiobarbituricacidα-method, by test kit, detect description method and measure MDA value.Meanwhile, separating mouse skin of back, gets one of plucked skin histology (2cm*1cm left and right), and 10% paraformaldehyde is fixed, routine paraffin wax embedding, section, HE dyeing, conventional organization pathology detection, om observation, counting epithelial proliferation, corium blood vessel number and chorionitis cell number; Immunohistochemical staining, and the dyeing of observation melanocyte and number (positive cell: nothing, count 0 minute; < 15%, counts 0.5 minute, and < 30%, counts 1 minute; > 30% 2 minutes).

2.4 statistical methods: relatively t check between measurement data employing group; Layering calculating chart adopts rank test to carry out statistical disposition.

3 results

3.1 mensuration of respectively organizing mouse skin, hepatic tissue MDA, SOD content are in Table 1.

Table 1 is respectively organized the mensuration (x ± s) of mouse skin and hepatic tissue MDA, SOD content

Compare * P < 0.05, * * P < 0.01 with model group; Compare #**P < 0.05 with positive group

3.2 respectively organize that mouse skin Pathomorphologic is learned and immunohistochemistry to observe PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM visible: the epithelial layer cell arrangement of normal group mouse skin is neat, without hypertrophy, has no little vasodilation in skin corium, and inflammatory cell is rare.The epithelial layer hyperplasia of model group mouse skin is obvious, the large and arrangement disorder of core, and visible little vasodilation in skin corium, inflammatory cell is common.The epithelial layer hyperplasia of dosage group big or middle and positive controls mouse skin alleviates to some extent, and arrangement disorder alleviates, and in skin corium, little vasodilation alleviates, and inflammatory cell is rare.The results are shown in Table 2.

Immunohistochemical PATHOMORPHOLOGICAL OBSERVATION OF PULLORUM is visible: visible a little melanocyte in normal group mouse epithelial layer, the painted sepia of endochylema.Visible a large amount of melanocytes in model group mouse epithelial layer, the painted dark brown of endochylema, and positive cell number > 30%.Visible black color element cell in dosage group big or middle and positive controls mouse epithelial layer, the painted dark brown of endochylema, positive cell number reduces, in Table 2.

Table 2 is respectively organized the morphology of mouse skin histopathology and melanocyte observed result (n)

Rank test; Compare * P < 0.05, * * P < 0.01 with model group

4, the microcirculation experimental technique of topical agent:

4.1 materials and methods: get 50 mices, be divided at random 5 groups, 10 every group (male and female half and half), the every Mus auris dextra of matched group be coated with normal saline a little; The every Mus auris dextra of positive controls gives commercially available silk white speckle dispelling ointment (production of Nanjing Pharmaceutical), test component is dosage group 600mg/kg/h in externally used paste low dose group 400mg/kg/h of the present invention, externally used paste of the present invention, externally used paste high dose 800mg/kg/h of the present invention.15min pneumoretroperitoneum is injected 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, and tail vein injection 0.1% epinephrine 0.1mL/10g, observes mouse right ear fine motion vein bore (μ m) and 0.2mm immediately subsequently ²experimental data is processed in blood capillary net number .t check.

4.2 results and discussion

4.2.1. on microcirculatory impact

Compare with matched group, the tested group of open number of 1 pair of mice blood capillary has showed increased (P < 0.01); The open number of tested group of 2 pairs of venule bore and blood capillary has remarkable increase (P < 0.01); The tested group of open number of 3 pairs of mice fine motions, vein bore and blood capillary all has increase (P < 0.01); Illustrate and be subject to reagent can improve microcirculation, have function of promoting blood circulation to disperse blood clots (table 1).

Table 3, the impact of externally used paste of the present invention on the open number of mice fine motion, vein bore and blood capillary

4 discuss

The chloasma traditional Chinese medical science is called " chloasma hepaticum ", belongs to motherland's medical science " dark speckle " or " dusty face " category.It is generally acknowledged that primary disease occurs with liver,spleen,kidney three dirty in close relations.

Theory of Chinese medical science is thought " lung governing skin and hair ", as < < Plain Questions > > six saves state of internal organs opinion clouds: lung person, the dominator of QI, the position of storing soul are also, its Hua Mao, it fills at skin, points out that lung closes fur at body.When the function of lung is normal, lung yin is full, and normal lung-QI is peaceful, and body fluid is sufficient, could compress must be capable, skin metabolism product is excreted, make skin clean, naturally shine gloss.Therefore have from ancient times to the present many doctors, recipe to have from lung opinion, control, we think, and Chinese medicine color effect is relevant, the corresponding theory of people and the world is one of characteristic of Chinese therapeutics, lung governing skin and hair, and corresponding with white, this is the rule of our prescription just.

Chloasma, chloasma hepaticum are a kind of facial metabolism of pigment obstacle dermatosis that is common in, and are apt to occur in female middle-aged, and its cause of disease and pathogeny are illustrated not yet completely.It is generally acknowledged morbidity and the endocrine disturbance of chloasma, ultraviolet radiation, inherited genetic factors is relevant.But research in recent years thinks, the generation of chloasma, chloasma hepaticum also changes relevant with oxygen-derived free radicals.In normal physiological situation, free radical constantly produces, but is also constantly eliminated, and makes it in a kind of dynamic equilibrium.And chloasma, chloasma hepaticum patient's lipid peroxide (LPO) or Free Radical Level are when increase, or in body, antioxidase is as declines such as superoxide dismutase (SOD), catalase (CAT), glutathion (CSH), can not remove in time the oxidation products such as lipid peroxide, LPO is piled up in vivo.Thereby accelerate tyrosine series oxidation reaction.Blackening pigment cell produces melanin and increases; Extremely unstable its product malonaldehyde (MDA) of LPO can cause protein molecule to occur to be cross-linked simultaneously, forms fluorescent chromophore-pigment.

Point out thus the present invention can remove oxygen-derived free radicals and reduce free-radical generating; Histopathology is observed and is shown that it can obviously improve histiocytic pathological change, alleviates epithelial hyperplasia, alleviates the little vasodilation of skin corium, reduces inflammatory cell number; It can obviously reduce melanin positive cell number and optical density in epithelial layer SABC detection display.Show that the present invention has freckle removing and whitening effect.

Clinical data:

Chloasma and women's is in close relations through, band, tire, product and feelings will, therefore female middle-aged patient is comparatively common clinically.For reaching comparatively ideal therapeutic effect, from Chinese medicine aspect, take several different methods, the combination of inner and outside, to reach treating both the principal and secondary aspects of a disease.Chloasma claims again butterfly spot or cyasma, it is a kind of common facial pigmentation proliferative skin disorders, that the interior disease of body is at a kind of outward manifestation of face, with the cheekbone buccal of being everlasting, be the filbert or brown spot of symmetry distribution and name, part can betide around forehead, nose side and lip, is a kind of damage capacitive dermatosis chronic disease.The present invention, from intending oral medicinal herb decoction and outer smoked skin, adds the rear Traditional Chinese Medicine for external application facial film treatment of massage chloasma, evident in efficacy.Now be described below.

1 data and method

1.1 physical data

This group case is totally 40 examples, is women, 22～37 years old age, 17 examples; 37～45 years old 15 examples; 46 years old above 8 examples.The course of disease is the shortest 3 months, reaches 10 years most.

1.2 clinical symptoms

Patch that erythra shows as and differs in size, comes in every shape, the depth is indefinite, has to be dispersed in, and merges in flakes or strip.Mainly be distributed in buccal both sides or mouthful week or forehead.Skin lesion boundary is clear, and not swelling, nothing come off, and smooth surface, is not in the way.

1.3 method

1.3.1 side for oral administration is from intending, and main medicine is: Poria 15g, Radix Angelicae Sinensis 12g, Flos Pelargonii 13g, Rhizoma Chuanxiong 11g, Radix Astragali 12g, Semen Persicae 12g, Rhizoma Atractylodis 13g, Rhizoma Polygonati Odorati 12g, Semen Coicis 13g, Caulis Polygoni Multiflori 14g, Rhizoma Atractylodis Macrocephalae 13g, Radix Paeoniae Rubra 13g, Fructus Mume 12g, Rhizoma Acori Graminei 13g, Fructus Mori 13g, Herba Leonuri 13g, Radix Rehmanniae 12g, Semen Benincasae 12g, Fructus Ligustri Lucidi 11g, Rhizoma Sparganii 12g, Radix Bupleuri 11g, Rhizoma Curcumae 12g, Herb Gynostemmae Pentaphylli 12g, Cortex Mori 1g part.1 dose of every day, be decocted in water for oral dose.Also can be made into pill or granule, capsule.

1.3.2 external side: Bombyx Batryticatus 15g, Radix Paeoniae Alba 14g, Rhizoma Chuanxiong 14g, Flos Magnoliae 12g, Pseudobulbus Bletillae (Rhizoma Bletillae) 12g, Faeces Passeris 14g, Herba Asari 12g, Radix Ampelopsis 11g, Radix Angelicae Pubescentis 11g, Radix Trichosanthis 15g, Radix Angelicae Dahuricae 12g, Rhizoma Typhonii (processed) 14g, Fructus Mume 14g, Retinervus Luffae Fructus 13g makes face film agent.This side has the effect of benefiting QI for activating blood circulation, face-beautifying and spot-removing.

1.3.3 coordinating the main acupuncture point of acupoint massage is the sun, yang white, Zanzhu, Baihui, Yingxiang, Sibai, ShiShimonoseki, dicang, cheek car, cheekbone wine with dregs etc.Massage manipulation adopts the maneuver of Chinese and western combination, and wherein Chinese style maneuver be take acupoint massage as main, and Western-style maneuver be take and pacified massage, lympha toxin expelling as main.

The method treatment in every 2 days 1 time, 1 month was 1 course for the treatment of, and all the other carry out the moisturizing of skin of face, sun-proof, isolation every day time.

2 results

In 40 routine patients, recovery from illness, speckle 24 examples that entirely disappear, account for 60%; Effectively (skin lesion disappearance) 12 examples, account for 30%; Invalid (former skin lesion slightly improves) 4 examples, account for 10%.Total effective rate is 90%.

3 discuss

The traditional Chinese medical science thinks, chloasma is more common in and is educated menstrual woman, and this age women, because cause, housework are busy, breeds loss in addition, many depression of liver-QI, and stagnation of liver-QI is blood stasis.< < Yizong Jinjian > > says that " be worried depressed, not magnificent a little less than blood, fiery dryness accumulated in the stomach and intestine is stagnant and be born on face, and women has it more." therefore I take SIWU TANG as main, enrich blood and invigorate blood circulation, assistant is with the medicine of dispersing the stagnated live-QI to relieve the stagnation of QI.The most of pressure of women of this age level is excessive, the impetuous irritability of disposition, and Zhu Danxi says: through water person, also, the moon must be from sun, therefore its color is red for cloudy blood .... through joining for gas, because gas is capable, in bulk person is solidifying, will go and pain person's gas stagnant, the person of having a pain after row, also, also, reversed menstruation person gas is disorderly for the light also void of color for all void of QI and blood, purple person's gas stagnant, black heat very also.The store blood of liver, main catharsis.Irritability is not dredged, disorder of movement of QI, and qi depression to blood stasis, kidney is the congenital foundation, and punching is appointed is originally kidney, and collaterals of the uterus lies in kidney, and the directly impact punching of suffering from a deficiency of the kidney is appointed, disharmony of Chong and Conception Channels, qi depression to blood stasis, not smooth through water running.And the vital organs of the human body, it is all in face that the gas of extraordinary Fu-organ all can be gone up, and outside being revealed in, is gradually piebaldism.Radix Angelicae Sinensis is with hemopoietic, and the Radix Rehmanniae to be to grow blood, Radix Paeoniae yin fluid astringing, the logical upper and lower and gas in promoting the circulation of blood of Rhizoma Chuanxiong.Assistant is with Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI, and Ramulus Cinnamomi can harmonizing yingfen and weifen, warm promoting blood circulation." < < Yizong Jinjian surgery heart method > > cloud: " as in dirt dark, former in being worried, depressedly become ", stagnation of liver-QI blood stasis; strongly fragrant and fire-transformation; assistant is with Cortex Moutan clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, Fructus Gardeniae pathogenic fire purging relieving restlessness.

On the basis of endo-medicine, use face mask of traditional Chinese medicine external, except directly improving facial blood circulation, with the Chinese medicine blood circulation promoting and blood stasis dispelling such as the Radix Angelicae Dahuricae, Bombyx Batryticatus, heat-clearing and toxic substances removing.Give face mask of traditional Chinese medicine and directly act on skin, make it to absorb and reach the object of external treatment.Modern medicine study shows: tryrosinase is catalyst important in melanocyte production process, suppresses its activity and can control the generation of melanocyte, and Pseudobulbus Bletillae (Rhizoma Bletillae) can the effect of restraint of tyrosinase and the enzymatic reaction of participation thereof; In addition, according to herbal pharmacology effect, the Radix Angelicae Dahuricae has antityrosinase active, thereby stop tyrosine oxidation to form pigment, has the crease-resistant effect of skin care.In addition the maneuver such as ionspray, massage can blood circulation promoting, expansion blood capillary, accelerate infiltration and the absorption of medicine, thereby reach brighten, the effect of speckle dispelling.

Along with social development, increasing and the lack of standardization use of cosmetics, the pollution of atmospheric environment, chloasma sickness rate rises year by year, cosmetics lead, hydrargyrum, hormone severe overweight, use these type of cosmetics to be as good as " drinking poison to quench thirst ", Chinese traditional treatment chloasma origin stream is long, by the Chinese medicine of the traditional Chinese medical science, makes drug and nutriment matter in the situation that skin temperature raises, accelerate infiltration and absorb, thereby reach perfect therapeutic effect.

Specific embodiment 1: Bai, female, 34 years old, over 4 years there is yellowish-brown patch in cheeks and forehead portion, and scope is 5cm * 4cm, and skin lesion boundary is clear, without desquamation, patient coerces feeling of distension and oppression with breast, easily irritated, menstrual blood volume is general, and color secretly has clot, yellow urine, companion's cyclomastopathy, tongue falls, yellow and thin fur, stringy and rolling pulse.Give from the decoction of intending, side uses: Poria 13g, Radix Angelicae Sinensis 11g, Flos Pelargonii 11g, Rhizoma Chuanxiong 11g, Radix Astragali 12g, Semen Persicae 12g, Rhizoma Atractylodis 13g, Rhizoma Polygonati Odorati 12g, Semen Coicis 13g, Caulis Polygoni Multiflori 14g, Rhizoma Atractylodis Macrocephalae 13g, Radix Paeoniae Rubra 13g, Fructus Mume 12g, Rhizoma Acori Graminei 13g, Fructus Mori 13g, Herba Leonuri 13g, Radix Rehmanniae 11g, Semen Benincasae 12g, Fructus Ligustri Lucidi 11g, Rhizoma Sparganii 12g, Radix Bupleuri 11g, Rhizoma Curcumae 12g, Herb Gynostemmae Pentaphylli 12g, Cortex Mori 1g part.1 dose of every day, be decocted in water for oral dose.Also can be made into pill or granule, capsule.External side: Bombyx Batryticatus 12g, Radix Paeoniae Alba 13g, Rhizoma Chuanxiong 14g, Flos Magnoliae 12g, Pseudobulbus Bletillae (Rhizoma Bletillae) 12g, Faeces Passeris 14g, Herba Asari 12g, Radix Ampelopsis 11g, Radix Angelicae Pubescentis 11g, Radix Trichosanthis 15g, Radix Angelicae Dahuricae 12g, Rhizoma Typhonii (processed) 14g, Fructus Mume 14g, Retinervus Luffae Fructus 13g.Make face film agent.One and a half months for oral administration, coordinates facial face mask of traditional Chinese medicine massage.Continual cure is chloasma disappearance after one month, follows up a case by regular visits to 2 years without recurrence.

Concrete enforcement 2: Zheng, 28 years old.Marry 3 years, readme menoxenia.Because of " facial skin jaundice brown macules 3 years ", medical in June, 2011.Within medical first 3 years, patient face starts to have a little brown spot point to occur, it does not give attention, and brown speckle increases gradually, until have a strong impact on its appearance, just seeks medical advice.Inquiry when medical: its menstrual cycle is normal, menstrual period 4～6d, on the low side through measuring, color is dim, time press from both sides stasis of blood piece, the fore udder distending pain of passing through, time have soreness of the waist and knees, the difficulty of falling asleep, two is just normal.Look into the visible brown spot of having one's face covered with, forehead, two cheeks and lip Zhou Juncheng patch.Pale tongue has petechia, white and thin fur, hesitant pulse.Dialectical genus: the network stasis of blood of suffering from a deficiency of the kidney hepatic depression and blood deficiency.Specifically treat: menstruation be take blood rearing interpolating kidney after finishing for 1 week and filled out punching and appoint as main, and midcycle be take eliminating blood stasis and removing ecchymoses for 1 week as main, within premenstrual 1 week, take by the moon support just take the photograph blood in case metrorrhagia as main, menstrual phase be take giving treatment in accordance with the tendency of pathological change, half and is mended and partly disappear as main.Side uses: Poria 12g, Radix Angelicae Sinensis 11g, Flos Pelargonii 11g, Rhizoma Chuanxiong 13g, Radix Astragali 12g, Semen Persicae 12g, Rhizoma Atractylodis 13g, Rhizoma Polygonati Odorati 12g, Semen Coicis 12g, Caulis Polygoni Multiflori 14g, Rhizoma Atractylodis Macrocephalae 13g, Radix Paeoniae Rubra 13g, Fructus Mume 12g, Rhizoma Acori Graminei 13g, Fructus Mori 13g, Herba Leonuri 13g, Radix Rehmanniae 11g, Semen Benincasae 12g, Fructus Ligustri Lucidi 11g, Rhizoma Sparganii 12g, Radix Bupleuri 11g, Rhizoma Curcumae 12g, Herb Gynostemmae Pentaphylli 12g, Cortex Mori 1g part.1 dose of every day, be decocted in water for oral dose.Also can be made into pill or granule, capsule.External side: Bombyx Batryticatus 12g, Radix Paeoniae Alba 13g, Rhizoma Chuanxiong 13g, Flos Magnoliae 13g, Pseudobulbus Bletillae (Rhizoma Bletillae) 12g, Faeces Passeris 14g, Herba Asari 12g, Radix Ampelopsis 11g, Radix Angelicae Pubescentis 11g, Radix Trichosanthis 15g, Radix Angelicae Dahuricae 11g, Rhizoma Typhonii (processed) 14g, Fructus Mume 14g, Retinervus Luffae Fructus 13g.Make face film agent treatment and by the swollen logical alleviation of fore udder, body of the tongue petechia, also have dissipation, menorrhagia in 1 month.For another example ruling by law is treated 2 months: menstrual blood volume is recovered normal, the no longer distending pain of fore udder of passing through, and sleep is also improved.Look into: patient face brown patch dissipates substantially, and body of the tongue is light red, faint and stringy pulse.Foxiness is not newborn again to follow up a case by regular visits to 2 years.

Claims (10)

1. a Chinese medicine composition for the treatment of chloasma, is characterized in that, by endo-medicine and external used medicine, formed,

In described endo-medicine, the parts by weight of various crude drug comprise: 10～20 parts of Porias, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Pelargoniis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of the Radixs Astragali, 10～20 parts, Semen Persicae, 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Rhizoma Polygonati Odorati, 10～20 parts of Semen Coicis, 10～20 parts of Caulis Polygoni Multiflori, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Radix Paeoniae Rubra, 10～20 parts of Fructus Mumes, 10～20 parts of Rhizoma Acori Graminei, 10～20 parts of Fructus Mori, 10～20 parts of Herba Leonuris, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Semen Benincasaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Rhizoma Sparganii, 10～20 parts of Radix Bupleuri, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Herb Gynostemmae Pentaphylli, 10～20 parts of Cortex Mori,

In described external used medicine, the parts by weight of various crude drug comprise: 10～20 parts of Bombyx Batryticatus, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Flos Magnoliaes, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Faeces Passeriss, 10～20 parts of Herba Asaris, 10～20 parts of Radix Ampelopsis, 10～20 parts of Radix Angelicae Pubescentiss, 10～20 parts of Radix Trichosanthis, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Rhizoma Typhonii (processed), 10～20 parts of Fructus Mumes, 10～20 parts of Retinervus Luffae Fructuss.

2. treat according to claim 1 the Chinese medicine composition of chloasma, it is characterized in that,

In described endo-medicine, the parts by weight of various crude drug comprise: 10～15 parts of Porias, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Flos Pelargoniis, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of the Radixs Astragali, 10～15 parts, Semen Persicae, 10～15 parts of Rhizoma Atractylodis, 10～15 parts of Rhizoma Polygonati Odorati, 10～15 parts of Semen Coicis, 10～15 parts of Caulis Polygoni Multiflori, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Radix Paeoniae Rubra, 10～20 parts of Fructus Mumes, 10～20 parts of Rhizoma Acori Graminei, 10～20 parts of Fructus Mori, 10～20 parts of Herba Leonuris, 10～20 parts, the Radix Rehmanniae, 10～20 parts of Semen Benincasaes, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Rhizoma Sparganii, 10～20 parts of Radix Bupleuri, 10～20 parts of Rhizoma Curcumae, 10～20 parts of Herb Gynostemmae Pentaphylli, 10～20 parts of Cortex Mori,

In described external used medicine, the parts by weight of various crude drug comprise: 10～15 parts of Bombyx Batryticatus, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Flos Magnoliaes, 10～15 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～15 parts of Faeces Passeriss, 10～15 parts of Herba Asaris, 10～20 parts of Radix Ampelopsis, 10～20 parts of Radix Angelicae Pubescentiss, 10～20 parts of Radix Trichosanthis, 10～20 parts of the Radixs Angelicae Dahuricae, 10～20 parts of Rhizoma Typhonii (processed), 10～20 parts of Fructus Mumes, 10～20 parts of Retinervus Luffae Fructuss.

3. treat according to claim 1 the Chinese medicine composition of chloasma, it is characterized in that,

In described endo-medicine, the parts by weight of various crude drug comprise: 10～20 parts of Porias, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Flos Pelargoniis, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of the Radixs Astragali, 10～20 parts, Semen Persicae, 10～20 parts of Rhizoma Atractylodis, 10～20 parts of Rhizoma Polygonati Odorati, 10～20 parts of Semen Coicis, 10～20 parts of Caulis Polygoni Multiflori, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Radix Paeoniae Rubra, 10～15 parts of Fructus Mumes, 10～15 parts of Rhizoma Acori Graminei, 10～15 parts of Fructus Mori, 10～15 parts of Herba Leonuris, 10～15 parts, the Radix Rehmanniae, 10～15 parts of Semen Benincasaes, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Rhizoma Sparganii, 10～15 parts of Radix Bupleuri, 10～15 parts of Rhizoma Curcumae, 10～15 parts of Herb Gynostemmae Pentaphylli, 10～15 parts of Cortex Mori,

In described external used medicine, the parts by weight of various crude drug comprise: 10～20 parts of Bombyx Batryticatus, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Flos Magnoliaes, 10～20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10～20 parts of Faeces Passeriss, 10～20 parts of Herba Asaris, 10～15 parts of Radix Ampelopsis, 10～15 parts of Radix Angelicae Pubescentiss, 10～15 parts of Radix Trichosanthis, 10～15 parts of the Radixs Angelicae Dahuricae, 10～15 parts of Rhizoma Typhonii (processed), 10～15 parts of Fructus Mumes, 10～15 parts of Retinervus Luffae Fructuss.

4. as described in any one in claim 1～3, treat a preparation method for the Chinese medicine composition of chloasma, it is characterized in that, the dosage form of described oral preparations is capsule, and its preparation method comprises:

A, get crude drug and put into ethanol and soak, heat is extracted 2 times, becomes paste, is component 1;

B, medicinal residues extracting in water 2 times, thickening filtration is paste, is component 2;

C, above-mentioned two kinds of components are merged, be condensed into powder and incapsulate.

5. treat according to claim 4 the preparation method of the capsule of chloasma, it is characterized in that, in described step a, get in the ethanol that crude drug adds 5-10 doubly to measure and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid,, after standing, remove supernatant, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, stand for standby use, becomes component 1.

6. treat according to claim 4 the preparation method of the capsule of chloasma, it is characterized in that, in described step b, the medicinal residues of the crude drug that above-mentioned ethanol extraction is crossed add 10 times of water gagings, heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging is standing, become component 2.

7. treat according to claim 4 the capsule preparation method thereof of chloasma, it is characterized in that, in described step c, by the merging of component 1 and component 2, then put into concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 ℃ 1.60; After the macroporous adsorptive resins absorption that above-mentioned filtrate is 10L through volume, with deionized water or the distilled water eluting of 10 times of resin column volumes, then use 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, obtain after medicated powder is dried incapsulating.

8. as described in any one in claim 1～3, treat a preparation method for the Chinese medicine composition of chloasma, it is characterized in that, the dosage form of described oral preparations is electuary, and preparation method comprises:

By described crude drug roguing, dry, be ground into granule, soak 1 hour; Soaked raw material is put and in multi-function extractor, decocted with water secondary; Add up for the first time the water of 10 times of amounts of medical material, decoct 1.5～2 hours, get decocting liquid, filter; The water that adds for the second time 7 times of amounts of total amount, decocts 1～1.2 hour, gets twice decocting liquid and mixes, and filters; The filtrate of filtration is inserted in economic benefits and social benefits vacuum concentrator to the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05, set to 0～5 ℃ of deepfreezes 24 hours; Cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, after convection drying powdered, and mediation Mel or dextrin granulation electuary.

9. as described in any one in claim 1～3, treat a preparation method for the Chinese medicine composition of chloasma, it is characterized in that, the preparation method that the dosage form of described external preparation is face film agent comprises the following steps:

According to described umber, first will wear the Radix Angelicae Dahuricae, Herba Asari and Pseudobulbus Bletillae (Rhizoma Bletillae) and distill with steam method, obtain crystal, standby as component 1; Get the 60-90% soak with ethanol 1-2 hour that the medicinal residues mixing surplus stock after distillation adds 5-10 doubly to measure, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid,, 80-120 order filters, through the molecular weight that dams, be the ultrafiltration post ultrafiltration of 5000-10000 again, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated, 30 minutes～45 minutes, concentrated solution is settled into extractum shape, mass continues heating and is concentrated into extractum shape, and stand for standby use, becomes component 2; The component of the component of distillation extraction 1 and ethanol extraction 2 is mixed to adding preservative agent spice furnishing facial film.

10. according to the Chinese medicine composition for the treatment of chloasma described in any one in claim 1～9, it is characterized in that, the endo-medicine dosage form of described compositions is: sugar coated tablet, film coated tablet, enteric coated tablet, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, sublimed preparation, solution or injection; The external used medicine dosage form of described compositions is: face film agent, unguentum, spray, liniment, gauze agent and ointment.