Debunking the Myth
of Fusarium poae T‑2/HT‑2 Toxin Production
Posted on 2024-02-20 - 11:03
Fusarium poae is commonly detected in
field surveys
of Fusarium head blight (FHB) of cereal crops and
can produce a range of trichothecene mycotoxins. Although experimentally
validated reports of F. poae strains producing T-2/HT-2
trichothecenes are rare, F. poae is frequently generalized
in the literature as a producer of T-2/HT-2 toxins due to a single
study from 2004 in which T-2/HT-2 toxins were detected at low levels
from six out of forty-nine F. poae strains examined.
To validate/substantiate the observations reported from the 2004 study,
the producing strains were acquired and phylogenetically confirmed
to be correctly assigned as F. poae; however, no
evidence of T-2/HT-2 toxin production was observed from axenic cultures.
Moreover, no evidence for a TRI16 ortholog, encoding
a key acyltransferase shown to be necessary for T-2 toxin production
in other Fusarium species, was observed in any of
the de novo assembled genomes of the F. poae strains. Our findings corroborate multiple field-based and in vitro studies on FHB-associated Fusarium populations which also do not support the production of T-2/HT-2
toxins with F. poae and therefore conclude that F. poae should not be generalized as a T-2/HT-2 toxin producing
species of Fusarium.
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Witte, Thomas
E.; Hicks, Carmen; Hermans, Anne; Shields, Sam; Overy, David P. (1753). Debunking the Myth
of Fusarium poae T‑2/HT‑2 Toxin Production. ACS Publications. Collection. https://doi.org/10.1021/acs.jafc.3c08437
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AUTHORS (5)
TW
Thomas
E. Witte
CH
Carmen Hicks
AH
Anne Hermans
SS
Sam Shields
DO
David P. Overy
KEYWORDS
key acyltransferase shownde novo 2 toxins duefusarium poae 2 toxin productionpoae fusarium 2 toxinsvitro tri16 ‑ 22 trichothecenestrichothecene mycotoxinstherefore concludesingle studyphylogenetically confirmedobservations reportedlow levelshead blightfield surveyscorrectly assignedcereal cropsaxenic culturesassembled genomes>; however