Crystal structures of the apoAequorin complex with (S)-daCTZ and (S)-HM-daCTZ.
A. a) Superposition of native aequorin (A form, gray color) and the apoAequorin/(S)-daCTZ complex (A form, blue color). b) Superposition of (S)-2-peroxycoelenterazine (gray color) and (S)-daCTZ (yellow color). B. a) Superposition of native aequorin (A form, gray color) and the apoAequorin/(S)-HM-daCTZ complex (A form, red color). b) Superposition of (S)-2-peroxycoelenterazine (gray color) and (S)-HM-daCTZ (green color). The labeled N and C in the structures indicate the amino and carboxyl terminus, respectively. The numbers 2, 6, and 8 indicate the positions of C2, C6, and C8 in the imidazopyrazinone ring of coelenterazine, respectively.
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