CN113453552A

CN113453552A - Composition of ifenesin and pyraclostrobin

Info

Publication number: CN113453552A
Application number: CN202080006427.6A
Authority: CN
Inventors: 沙伊伦德拉·米塔拉姆·巴兰比; 普什彭德·辛格·古翰; 阿希姆·库马尔·杜塔; 阿舒特什·阿科哈里亚; 维什瓦纳·加德; 桑托什·什里达尔·奥特加; 拉维库马尔·瑟亚纳拉亚纳·萨拉古; 鲁芝·加尔嘉
Original assignee: PI Industries Ltd
Current assignee: PI Industries Ltd
Priority date: 2019-01-17
Filing date: 2020-01-15
Publication date: 2021-09-28
Also published as: WO2020148660A8; ZA202104998B; MA54005A1; WO2020148660A1; KR20210116466A; MX2021006534A; CO2021006225A2; MA54005B1; TN2021000134A1

Abstract

Disclosed are synergistic combinations of fenarimat and pyraclostrobin and compositions thereof and methods for controlling a variety of harmful pathogenic microorganisms, pests and mites of plants comprising treating the plant/plant part and the area surrounding the plant. The invention also discloses enhanced efficacy against pests compared to the individual components of the combination. The combination also expands the spectrum, and is said to have a longer residual effect on harmful pathogenic microorganisms, pests and mites.

Description

Composition of ifenesin and pyraclostrobin

Technical Field

The invention relates to a combination of fen-ruit and pyraclostrobin, a composition thereof and a preparation method thereof. In particular, the present invention relates to synergistic compositions comprising ifenprodil and pyraclostrobin, methods of preparation of the compositions and their use in controlling a variety of harmful phytopathogenic microorganisms, pests and mites.

Background

In many important commercial crops, such as rice, pepper, tomato, grape, pea, cotton and other agricultural and horticultural crops, fungal infections and insect pests may occur simultaneously, and the grower applies control measures to these crops individually or simply by mixing various insecticides and fungicides together. This combination of pesticides may result in poor efficacy and damage to the crop due to compatibility issues, and therefore, the optimal formulation premix for the pesticide and fungicide combination will help the grower control these important diseases and insects/mites at these crop stages.

A typical problem arising in the field of pest control is to reduce the dosage rate of the active composition in order to reduce or avoid adverse environmental or toxicological effects, while still allowing effective control of the disease/pest. Therefore, it is a practical necessity to apply an effective amount of the bactericide and the insecticide in combination as a uniform composition.

It is known in the art that certain pyrazole carboxamide derivatives have insecticidal and fungicidal properties, such as ifenprinol. Deferarin is a contact insecticide and fungicide, developed by Mitsubishi chemical company (now Nihon Nohyaku), as described in U.S. Pat. No. 5,039,693. It is useful for controlling or inhibiting a variety of pests and diseases, including lepidopteran, coleopteran, dipteran, hemipteran, orthopteran, and thysanopteran insects, as well as downy mildew and powdery mildew. It can effectively control all stages of development of most target pests. It is classified into 21A group for IRAC mode of action and 39 group for FRAC mode of action. Deferarin is a MET1 inhibitor that inhibits cellular respiration when contacted with a target pest.

The chemical name is 4-chloro-3-ethyl-1-methyl-N- [4- (p-tolyloxy) benzyl ] -1H-pyrazole-5-carboxamide, and the structure is as follows.

Strobilurin derivatives have fungicidal activity, such as pyraclostrobin, azoxystrobin, fluoxastrobin, trifloxystrobin, pyraclostrobin or pyraclostrobin. As described in us patent 5,869,517, pyraclostrobin is a broad spectrum foliar fungicide developed by basf. It is classified into FRAC mode of action of group 11, blocking mitochondrial electron transport, thereby inhibiting energy supply of the fungus, resulting in death of the target fungus. Currently, it is currently used to control a variety of fungal diseases such as downy mildew, powdery mildew, black stalk disease, black spot, melon rust, post-anthesis fruit drop, anthracnose, alternating brown spot, scab or oil spot, leaf rust, black spot, net spot, burn, sieve and glume spots, blotch, stem rust, stripe rust, yellow leaf spot, eye spot, gray spot, northern corn leaf spot, chytrid, rust, southern corn leaf blight or yellow leaf blight.

The chemical name is 2- [1- (4-chlorphenyl) -1H-pyrazol-3-yloxymethyl ] -N-methoxy carbamic acid methyl ester, and the structure is as follows.

Various patent applications disclose mixtures of fungicides and insecticides as in US20120322654, US20080261811 and WO 2011144593. There is no effective composition that can act on multiple fungi and pests simultaneously.

It has been found by analysis that a composition comprising a pyrazole carboxamide compound and a streptourea compound provides an effective composition for controlling a wide variety of harmful phytopathogenic microorganisms, insect pests and mites, as a solution to the above-mentioned problems. More specifically, the combination includes ifenprodil and pyraclostrobin.

The compositions of the combinations of the invention have similar sites of action. Apophlegmatism acts by inhibiting complex I in the mitochondrial electron transport chain of mitochondria, whereas pyraclostrobin acts by inhibiting complex III in mitochondrial respiration. The present invention provides a combination of ifenprodil and pyraclostrobin with enhanced efficacy and range compared to the use of tofafield and pyraclostrobin alone.

Disclosure of Invention

In one aspect, the present invention provides a composition comprising:

a) an effective amount of a tolfenpyrate or salt,

b) an effective amount of pyraclostrobin or a salt thereof,

c) optionally adding one or more insecticides or fungicides or acaricides or nematicidal or herbicidal or plant growth regulator compounds or any other combination,

d) an agriculturally acceptable additive.

In one particular aspect, the present invention provides a synergistic combination of fenarimat and pyraclostrobin to control a variety of harmful phytopathogenic microorganisms, pests and mites.

In another aspect, the present invention provides a synergistic fungicidal and insecticidal combination of ifenprodil and pyraclostrobin.

In another aspect, the present invention provides a synergistic fungicidal combination of ifenprodil and pyraclostrobin.

In another aspect, the present invention provides a synergistic insecticidal combination of ifenprodil and pyraclostrobin.

In another aspect, the present invention provides longer residual control of harmful phytopathogenic microorganisms, pests and mites treated with a combination of desinferamide and pyrrolnitrin.

In another aspect, the present invention provides a synergistic composition comprising:

a) an effective amount of a tolfenpyrate or salt,

b) an effective amount of pyraclostrobin or a salt thereof,

c) optionally, adding one or more insecticidal or fungicidal or acaricidal or nematicidal or herbicidal or plant growth regulator compounds or any combination,

d) an agriculturally acceptable additive.

In one aspect, the present invention provides synergistic compositions of fenarimol and pyraclostrobin for controlling a variety of harmful phytopathogenic microorganisms, pests and mites.

In another aspect, the present invention provides a synergistic composition comprising ifenprodil and pyraclostrobin; and the composition has fungicidal and/or insecticidal activity.

In another aspect, the present invention provides a method of preparing a composition comprising ifenprodil and pyraclostrobin.

In another aspect, the present invention provides a method of improving crop health (antinociception) comprising treating plants with an effective amount of a combination of tolfenfluride and pyrazoline.

The above aspects and other objects will also become more apparent in view of the following description.

Detailed Description

Abbreviations

AE: aerosol formulation	ME microemulsion
		CS: capsule suspension	OD water-dispersible oil suspension
DC: water dispersible emulsions	SC: suspending agent
		DP: powder preparation	Su Ultra Low Volume (ULV) suspensions
EC: emulsifiable concentrate	UL: ultra Low Volume (ULV) liquids
		EG emulsifiable granules	WDG: water dispersible granule
For example: examples of the present invention	WP wettable powder
		EP: milk powder preparation	WT: water dispersible tablet
EW oil-in-water emulsion

Definition of

The above definitions provided herein for terms used in the present disclosure are for illustrative purposes only and do not limit the scope of the invention disclosed in the disclosure.

It is to be understood that the terminology used herein is for the purpose of describing embodiments only and is not intended to be limiting. As used in this specification, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, reference to "a surfactant" includes one or more such surfactants.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. Although other methods and materials similar or equivalent to those described herein can be used in the practice of the present invention, the preferred materials and methods are described herein.

As used herein, the terms "comprises" and "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, but with any limitation explicitly stated. For example, a composition or method that includes a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition or method.

The terms "composition" or "formulation" as used herein are used interchangeably and, unless otherwise indicated, refer to a composition or formulation including, but not limited to, a combination comprising desinferant and pyraclostrobin.

The term "pesticidal" as used herein refers to the ability of a composition or substance to increase the mortality rate or inhibit the growth rate of an insect.

The term "fungicidal" as used herein refers to the ability of a composition or substance to reduce the rate of fungal growth or increase the mortality of fungi.

The term "nematicidal" as used herein refers to the ability of a composition or substance to increase nematode mortality or inhibit growth rate.

The term "acaricidal" as used herein refers to the ability of a component or substance belonging to the class arachnids to increase the mortality rate of an ectoparasite named acari or its ability to inhibit the growth rate.

The term "herbicidal" as used herein refers to the ability of a composition or substance to be applied to an area of interest (e.g., a field or area under cultivation) before the plant emerges apparently from the soil and/or before the seed germinates, or after the plant emerges apparently from the soil.

The term "plant growth regulator" as used herein refers to the ability of a composition or substance to change the growth and development of a treated plant to an agricultural mature state without killing the treated plant.

As used herein, the terms "one or more" or "adjuvant" or "one or more agriculturally acceptable carriers" are used interchangeably and refer to inert materials commonly used as diluents to provide stability or protect. The activity profile of the composition or formulation is enhanced with or without agrochemical activity or with direct effect on harmful pathogenic microorganisms, pests and mites.

The term "surfactant" as used herein refers to a compound that, when dissolved in a liquid, lowers the surface tension of the liquid, thereby lowering the interfacial tension between two liquids or lowering the surface tension between a liquid and a solid.

The term "stabilizer" as used herein refers to a substance capable of imparting resistance to physical or chemical deterioration or distortion.

The term "antifoam" as used herein refers to a chemical additive that reduces and retards foam formation during the course of a liquid, semi-solid or solid, highly potent liquid of a drug. The terms defoamer, defoamer and antifoamer may be used interchangeably.

The term "thickener" as used herein refers to a polymeric material that increases the viscosity of an aqueous solution at low concentrations and helps stabilize the composition.

Unless otherwise indicated,% refers to wt.%; and wt% means that the weight% of each component is based on the total weight of the composition.

The term "locus" as used herein refers to a plant, plant part, plant propagation material (preferably seed), soil, area, material or environment in which pests are growing or may grow.

The term "plant part" as used herein is understood to mean all parts and organs of plants above and below the ground, such as shoots, leaves, flowers and roots, examples including leaves, needles, stems, stalks, flowers, fruit bodies, fruits and seeds, but also roots, tubers and rhizomes. Plant parts also include harvested plants and vegetative propagation material, such as seedlings, tubers, rhizomes, cuttings and seeds.

The term "effective amount" as used herein refers to the amount of active in a composition to achieve an observable effect on growth, including the effects of necrosis, death, retardation, prevention and removal, destruction, or otherwise reducing the occurrence and activity of the target organism. Effective amounts of the various compositions used in the present invention may vary. The effective amount of the composition will also vary depending on the prevailing conditions, such as the desired pesticidal effect and duration, weather conditions, the target species, the locus, the mode of application, and the like.

The term "ifenprinol" as used herein includes ifenprinol or a pesticidally acceptable salt, ester, derivative or any other modification of ifenprinol.

The term "pyraclostrobin" as used herein includes pyraclostrobin or any other modification of its pesticidally acceptable salt, ester, derivative or pyraclostrobin.

In one embodiment, the present invention provides a composition comprising:

a) an effective amount of a tolfenpyrate or salt,

b) an effective amount of pyraclostrobin or a salt thereof,

d) an agriculturally acceptable additive.

In another embodiment, the present invention provides a synergistic composition comprising:

a) an effective amount of a tolfenpyrate or salt,

b) an effective amount of pyraclostrobin or a salt thereof,

d) an agriculturally acceptable additive.

In one embodiment, the present invention provides a synergistic combination of fenarimat and pyraclostrobin to control a variety of harmful phytopathogenic microorganisms, pests and mites.

In another embodiment, the present invention provides a fungicidal and insecticidal combination of ifenprodil and pyraclostrobin.

In another embodiment, the present invention provides a fungicidal combination of ifenprodil and pyraclostrobin.

In another embodiment, the present invention provides a pesticidal combination of ifenprodil and pyraclostrobin.

In another embodiment, the present invention provides longer residual control of harmful phytopathogenic microorganisms, pests and mites of plants treated with a combination of defenses and pyrrolecarboxamide.

The mixing ratio of the tolfenpyrate and the pyraclostrobin depends on various factors, such as undesirable phytopathogenic microorganisms, pests and mites to be controlled, degree of infestation, climatic conditions, soil characteristics and method of application, wherein the ratio of desinferant to pyraclostrobin is from 50:1 to 1:50, preferably from 20:1 to 1:20 or from 10:1 to 110, more preferably from 3:2 to 2: 3.

In one embodiment, the present invention also provides compositions of fenarimol and pyraclostrobin for controlling a plurality of harmful phytopathogenic microorganisms, pests and mites.

In another embodiment, the present invention provides a composition of fenarimol and pyraclostrobin, wherein the composition is used as a fungicidal and/or insecticidal composition.

The composition is selected from Wettable Powder (WP), Water Dispersible Granule (WDG), water dispersible tablet (WT), Suspension Concentrate (SC), Ultra Low Volume (ULV) liquid (UL), Ultra Low Volume (ULV) Suspension (SU), Emulsifiable Granule (EG), oil-in-water Emulsion (EW), Emulsifiable Concentrate (EC), powdered milk (EP), Dispersible Concentrate (DC), Microemulsion (ME), water dispersible oil suspension (OD), Capsule Suspension (CS), pulverizable powder (DP) or Aerosol (AE).

In a preferred embodiment, the present invention provides a water dispersible granular composition of ifenprodil and pyraclostrobin.

In another preferred embodiment, the present invention provides suspension concentrate compositions of desinfluent and pyraclostrobin.

These compositions may be manufactured by any procedure known in the art, for example, "pesticide formulation guide" (edited by the agricultural formulation and application committee of the japan pesticide science association, published by the japan plant protection association, 1997).

The composition of the invention consists of tolfenpyraclostrobin and tolfenpyraclostrobin in a wide ratio, which is dependent on various factors, such as the undesired phytopathogenic microorganisms, insect pests and mites to be controlled, the extent of insect pests, climatic conditions, soil characteristics and the method of application, wherein the weight ratio of tolfenpyraclostrobin to pyraclostrobin is from 50:1 to 1:50, preferably from 20:1 to 1. 20 or 10:1 to 110, more preferably 3:2 to 2: 3.

Accordingly, the present invention further provides a composition for controlling various undesired phytopathogenic microorganisms, insect pests and mites, where the weight percentage of tolfentrazone is from about 4% to 80%, preferably from about 10% to 60%, the weight percentage of pyraclostrobin is from 80% to 4%, preferably from about 60% to 10%, and the weight percentage of the additive is from about 5% to 95%, preferably from about 20% to 90%. The total content of ifenesin and pyraclostrobin in the composition is typically selected in the weight range of from 8% to 84%, preferably from 10% to 80%, more preferably from 12% to 75%.

A composition comprising an organic or inorganic carrier material, including agriculturally acceptable additives, selected from the group consisting of solid carriers, liquid carriers, gaseous carriers, surfactants, binders, disintegrants, pH adjusting agents, thickeners, preservatives, anti-freeze agents, anti-foaming agents, spreading agents, stabilizers and/or colorants or combinations thereof. If desired, the compositions may also comprise one or more adjuvants customary for crop protection compositions.

The solid carrier is selected from the group including, but not limited to, natural minerals quartz, talc, kaolin, pyrophyllite, montmorillonite, attapulgite, bentonite, chalk, zeolite, calcite, sericite, acid clay, diatomaceous earth, fuller's earth, medical stone, feldspar, dolomite or pumice; synthetic minerals such as precipitated silica, fumed silica, sodium silicate, alumina, and aluminum hydroxide. Inorganic salts such as calcium carbonate, ammonium sulfate, sodium sulfate, potassium chloride; organic materials such as urea, solid polyoxyethylene, solid polyoxypropylene, polyethylene, polypropylene, lactose, starch, lignin, cellulose, cottonseed hulls, wheat flour, soybean flour, wood flour, walnut shell flour, plant flour, sawdust, coconut shell flowers, corncobs, tobacco stems. These solid carriers may be used alone or in combination.

The liquid carrier is selected from the group including, but not limited to, water; alcohols, such as ethanol, propanol, butanol, n-octanol, isopropanol, ethylene glycol, diethylene glycol, propylene glycol, polyethylene glycol, benzyl alcohol, glycerol. Polyol ethers such as ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, dipropylene glycol dimethyl ether; ketones, such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone; ethers such as dipropyl ether, dioxane, tetrahydrofuran; aliphatic hydrocarbons such as normal paraffin, isopentane, kerosene, mineral oil. Aromatic hydrocarbons such as xylene, toluene, naphthene, solvent naphtha, solvent C9, solvent C10, solvent C12, solvent 100, solvent 150, solvent 200; chlorinated aliphatic or aromatic hydrocarbons, such as chlorobenzene, vinyl chloride, dichloromethane; esters, such as ethyl acetate, diisopropyl phthalate, dimethyl adipate, methyl oleate, methyl tallowate. Lactones, such as gamma-butyrolactone, gamma-valerolactone, epsilon-decalactone; amides such as dimethylformamide, N-methylpyrrolidone, N-octylpyrrolidone, N-dimethyldecanamide; nitriles, such as acetonitrile; organic sulfur compounds such as dimethyl sulfoxide; vegetable oils, such as soybean oil, rapeseed oil, and cottonseed oil. These liquid carriers may be used alone or in combination.

The gaseous carrier is selected from, but not limited to, liquefied petroleum gas, air, nitrogen, carbon dioxide or dimethyl ether. These gaseous carriers may be used alone or in combination.

Surfactants (dispersants, wetting agents, dusting agents, adjuvants to enhance penetration, rain resistance, soil leaching control, etc.) are nonionic or anionic surfactants or combinations of these surfactants. Using one or more than one surfactantIt is particularly preferred. Surfactants are selected from the group including, but not limited to, sugar esters such as sorbitol monolaurate, polyoxyethylene sorbitol monolaurate; alkyl polyglucosides such as decyl glucoside; polyoxyethylene alkyl ethers, such as polyoxyethylene lauryl ether, or polyoxyethylene coconut fatty alcohol ethers. Polyoxyethylene alkynyl ethers such as polyoxyethylene 2, 4, 7, 9-tetramethyl-5-decyne-4, 7-diol ether; polyoxyethylene aryl ethers, such as polyoxyethylene nonylphenyl ether or polyoxyethylene tristyrylphenyl ether. Polyoxyethylene vegetable oil ethers such as polyoxyethylene castor oil or polyoxyethylene hydrogenated castor oil; a vegetable oil ethoxylate; C12-C15 alcohol ethoxylate; polyoxyethylene fatty acid esters, such as polyoxyethylene monooleate, polyoxyethylene distearate or polyoxyethylene resinate. Polyoxyethylene polyoxypropylene (EO-PO) block copolymers, e.g.

Polyoxyethylene polyoxypropylene alkyl ethers such as polyoxyethylene polyoxypropylene lauryl ether; polyoxyethylene polyoxypropylene aryl ethers, such as polyoxyethylene polyoxypropylene styryl phenyl ether. Polyoxyethylene alkylamines, such as polyoxyethylene stearylamine; polyoxyethylene fatty acid amides such as lauric acid diethanolamine; a fluorinated surfactant; alkyl sulfates, such as sodium lauryl sulfate; sodium alkyl benzene sulfonate, calcium alkyl benzene sulfonate; polyoxyethylene alkyl ether sulfates, such as sodium polyoxyethylene lauryl ether sulfate; polyoxyethylene aryl ether sulfates, such as sodium polyoxyethylene nonylphenyl ether sulfate or ammonium polyoxyethylene triphenylethylene phenyl ether sulfate. Aryl sulfonates such as calcium dodecylbenzenesulfonate, sodium naphthalenesulfonate or sodium naphthalenesulfonate formaldehyde condensates; a polyarylphenyl ether sulfate ammonium salt; 'alpha' -olefin sulfonate; alkyl sulfosuccinates, such as sodium dioctyl sulfosuccinate; sodium lignosulfonate; sodium salt of polycarboxylic acid. Sarcosine, N-methyl fatty acid; polyoxyethylene alkyl ether phosphate ester; polyoxyethylene aryl ether phosphate esters such as polyoxyethylene phenyl ether phosphate ester; polyoxyethylene alkylphenyl ether phosphate; graft copolymers, such as polymethyl methacrylate-polyethylene glycol graft copolymers; or a combination thereof.

The binder or binder promoter is selected from the group including, but not limited to, polyvinyl alcohol, dextrin, modified dextrin, soluble starch, guar gum, xanthan gum, sucrose, polyvinylpyrrolidone, gum arabic, polyvinyl acetate, sodium polyacrylate. Carboxymethyl cellulose or its salt, carboxymethyl cellulose dextrin, bentonite, polyethylene glycol with average molecular weight of 6000 to 20000, polyethylene oxide with average molecular weight of 100000 to 5000000, and natural phospholipid such as cephalosporanic acid or lecithin. These binders or binder-imparting agents may be used alone or in combination.

Disintegrants are selected from the group including, but not limited to: sodium tripolyphosphate, metal stearate, cellulose powder, dextrin, methacrylate copolymer and polyvinylpyrrolidone. Polyamide carboxylic acid chelate, styrene sulfonate/isobutylene/maleic anhydride copolymer, starch/polyacrylonitrile graft copolymer, sodium hexametaphosphate, carboxymethyl cellulose, sodium polycarbonate and bentonite. These disintegrants may be used alone or in combination.

The pH adjusting agent is selected from the group including, but not limited to, sodium or potassium carbonate, sodium or potassium bicarbonate, sodium or potassium dihydrogen phosphate, disodium or dipotassium hydrogen phosphate, citric acid, malic acid, and triethanolamine. These pH adjusters may be used alone or in combination.

The thickener is selected from, but not limited to, water-soluble polymers such as xanthan gum, welan gum, guar gum, polyvinyl alcohol, carboxymethyl cellulose, polyvinyl pyrrolidone, carboxyvinyl polymers, acrylic acid graft copolymers, starch derivatives or polysaccharides, and inorganic fine powders; or inorganic fine powder selected from high purity silica, bentonite, white carbon. These thickeners may be used alone or in combination.

The preservative is selected from the group consisting of, but not limited to, potassium sorbate, 4-hydroxybenzoate, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, 1, 2-benzisothiazolin-3-one (B-methyl-ethyl-4-isothiazolin-3-one)

GXL). These preservatives may be used alone or in combinationCan be used together.

The antifreeze agent is selected from the group including, but not limited to, polyhydric alcohols such as ethylene glycol, diethylene glycol, propylene glycol, polyethylene glycol, and glycerin. These antifreeze agents may be used alone or in combination.

The defoaming agent is selected from the group including, but not limited to, organosilicon compounds such as polysiloxane, polydimethylsiloxane, and organofluorine compounds. These antifoaming agents may be used alone or in combination.

The extender is selected from the group including, but not limited to, silicone based surfactants, cellulose powders, dextrins, processed starches, polyaminocarboxylic acid chelates, crosslinked polyvinylpyrrolidone, maleic and styrene, methacrylic acid copolymers, half ester polymers of polyols and dicarboxylic anhydrides, water soluble salts of polystyrene sulfonic acid. These extenders may be used alone or in combination.

Stabilizers are selected from the group including but not limited to desiccants such as zeolite, quicklime or magnesia; antioxidants, such as phenols, amines, sulfur or phosphorus; or UV absorbers, such as salicylic acids or benzophenones. These stabilizers may be used alone or in combination.

The colorant is selected from the group including, but not limited to, inorganic pigments such as iron oxide, titanium oxide or prussian blue; organic dyes such as alizarin dyes, azo dyes, metal phthalocyanine dyes. These colorants may be used alone or in combination.

When the additive composition is added to the composition of the present invention, the carrier is generally selected in an amount ranging from about 5% to about 95% by weight, preferably from about 20% to about 90%; the surfactant content is generally selected to be in the range of about 0.1% to 30%, preferably about 0.5% to 10%, while the other additives are generally selected to be in the range of about 0.1% to 30%, preferably about 0.5% to 10%.

The composition of the present invention can be applied by any one method selected from atomization, scattering, dusting, spraying, spreading, soaking, irrigation, injection, mixing, spraying (immersion in water), foaming, dressing, coating, spraying, fumigation, smoking and painting.

In one embodiment, the present invention provides a method of controlling a variety of harmful phytopathogenic microorganisms, pests and mites with an effective amount of a combination of desinserin and pyraclostrobin.

In one embodiment, the present invention provides a method of controlling harmful phytopathogenic microorganisms with an effective amount of a composition of desinserin and pyraclostrobin.

Harmful pathogenic microorganisms that can be treated with the present invention are selected from the group consisting of white rust (white rust) on ornamental plants, vegetables (e.g., candida), and sunflowers (e.g., chafer); alternaria on vegetables, rape (rape or canola), beet (alternaria tenuissima), fruits, rice, soybean, potatoes (such as alternaria solani), tomatoes (such as alternaria solani) and wheat; myceliophthora on beets and vegetables; chitobiosis on cereals and vegetables, e.g., wheat scab (anthracnose) on wheat and rye scab on barley; helminthosporium and helminthosporium endospora (allotrope: cochliobolus species), such as southern leaf blight (botrytis cinerea) or northern leaf blight (marssonia turcicola) on corn, such as leaf spot on cereals (wheat root rot), such as helminthosporium cucumerinum on rice, turf and oats; powdery mildew (formerly powdery mildew) of gramineae (powdery mildew) in cereal crops (e.g. wheat or barley); botrytis cinerea (allotrope: Botrytis cinerea: Gray mold) on fruits and berries (e.g., strawberry), vegetables (such as lettuce, carrot, celery, and cabbage), oilseed rape, flowers, grapes, forestry plants, and wheat; downy mildew on lettuce; long beak shells on broad-leaved trees and evergreens, such as inchworm on elms (elm disease in the netherlands); cercospora species on corn and cotton, corn (e.g., gray speck; corn-corn leaf spot), rice, sugar beet (e.g., areca), sugarcane, vegetables, coffee, soybean (e.g., soybean leaf spot or chicory), and purpura on rice, sunflower, and peanut; cladosporium (e.g. phyllosticta) on tomatoes and cereals, such as phoma graminearum (black ear) on wheat; ergot (ergot) on cereals; sporophytes on hickory (hickory sores); neurospora species on peanuts (Lilium nodosum: Neurospora species melasma); purple ergot (ergot) bacteria on cereals; coenospora immaturus (allotrope: dipolar nematode) of maize (corn orbicularia species), cereals (e.g., acacia verticillata, allotrope: root rot), and rice (e.g., leaf spot, allotrope: rice blast); anthrax (isoform: Pesticta) on cotton, corn (e.g., Oridole: anthracnose stalk rot), soft fruit, potato (e.g., colletotrichum: Nippon), legumes (e.g., Colletotrichum) and soybeans (e.g., colletotrichum or Colletotrichum) (anthracnose); revolutionary bacteria on rice, such as sheath blight; leaf spots on soybeans and ornamentals; bromelain disease on olive trees; podospora on fruit trees, grapevines (e.g., schefflera, sexually-shaped, Heilopoda) and ornamentals (canker disease of fruit trees or decline of young vines, allotrope: necrosis or primary spores); detoxified plant (amoeba: Rosa) necrotizing bacteria (root and stem rot) on soybean; alternaria phaseoloides on soybeans; corn, cereals such as barley (e.g.cylindrospermum, nettherospermum) and wheat (e.g.wheat: brown spot), rice and helminthosporium (helminthospores, cambium distachyum: nucleoporids) on turf; withering on grapevine caused by Anthrix (Phellinus linteus), Verbena officinalis, rehmanniae radix, Phaeodactylum chlamydosporia (precocious Phaeodactylum chlamydosporia), Phaeodactylum chlorophyllin and/or Bacillus platypus; elsinoe scabiosus on pome, soft fruit (anthracnose) and vine (anthracnose); rice black swelling on rice; wheat scab; powdery mildew on beet (beet black mold), vegetables (such as pea), such as gourd (such as chicory), cabbage, rape (such as cruciferous plants); bacterial blight (asexual ulcer or blight, asexual reproduction: cytomyces. meiococcus) on white birch on fruit trees, vines and ornamental forests; parasites on corn (e.g., turmeric); fusarium (wilting, root rot or stem rot) on various plants, such as gramineae or hamsters (root rot, scab or cephalosporium) on cereals (e.g. wheat or barley), oxysporum on tomatoes, fusarium wilt on eggplant (now glycine bacillus). Viral and histoplasmosis and brazilian protozoa cause sudden death syndrome on soybean and rotabacter on corn, respectively; bacillus graminis is caused on cereal crops (such as wheat or barley) and maize; gibberella on cereal crops (e.g. zea) and rice (bacana); chlorella cingulata on grapes, grapefruit and other plants; cotton bollworm on cotton; graminaceous complexes on rice; gibberella on grapes (black rot); gymnosperm on rosaceous plants and juniper, for example sabina (rust) on pears; helminthosporium on corn, cereals and rice; camelina rust on coffee, such as coffee rust (coffee leaf rust); cladosporium on the vine; macrophage diseases (root and stem rot) on soybeans and cotton; microsporidia (snow mold pink) on cereals (e.g. wheat or barley); microsporidia on soybean (powdery mildew); streptosclerotium species on stone fruits and other rosaceous plants, such as flowering and twig blight, brown rot; leaf spot on cereals, bananas, soft fruits and crushed nuts, such as kernel cola on wheat (morphosomes: rhizoctonia cerealis, septoria leaf spot) or feijomyces on bananas (smut); peronospora (peronospora) on brassica oleracea (e.g. cabbage), brassica napus (e.g. parasites), onions (e.g. broken phosphorus), tobacco (bemisia tabaci), and soybean (e.g. penicillium amansii); soybean rust on soybeans; botrytis on grapes (e.g. tracheonematode) and soybeans (e.g. botrytis stem rot); root rot (root rot and stem rot) on oilseed rape and cabbage, ophthalmia (root rot, leaf spot and damping) on sugar beet; phomopsis on sunflower, grapevine (downy mildew and leaf spot of grape) and soybean (stalk rot: adzuki bean, sexually-typed: phomopsis sojae); phytophthora maltosa (brown spots) on corn; phytophthora (blight, root, leaf, fruit and shoot root) on various plants, such as Capsicum and cucurbita (e.g. Phytophthora capsici), Glycine max (e.g. Phytophthora megathera, homologues) Phytophthora sojae, Solanum tuberosum and Lycopersicon esculentum (e.g. late blight) and broadleaf trees (e.g. Phytophthora robusta: sudden death); plasmodium brassicae (bulb root) on brassica oleracea, brassica napus, raphanus sativus and other plants; plasma parasites, such as plasmodium vitriol (plasmopara viticola) on grapes, plasmodium harderi on sunflowers; leptospira (powdery mildew) on rosaceous plants, hops, pomegranates and soft fruits, e.g. sogatella furcifera on apples; polymyxa, e.g., cereals such as barley and wheat (polymyxa) and sugar beet (beet diophores) and transmitted viral diseases; cercospora species on cereals, such as wheat or barley; pseudomonas on various plants (downy mildew), such as Bacillus cuneii on cucurbits or Pythium on hops; pseudomonas trachealis (red fire or rotifer, proteosome: genus Calycopsis) on grapes; puccinia (rust) on various plants, such as wheat (brown or leaf rust), stripe rust (stripe rust or yellow rust), dwarf rust (dwarf rust), gramineous rust (stem or black rust) or gramineous rust (brown or leaf rust), e.g. chrysosporium odoratum (orange rust) on wheat, barley or rye, sugar cane and asparagus; pyrophoromycetes (proteosome: helminthosporium endocordyceunderlying wheat), Gibberella graminis (brown spot) of wheat or Gibberella graminis (net spot) of barley; pyricularia oryzae on rice (telemorphic: Pyricularia oryzae) and Pyricularia oryzae on rice (Pyricularia oryzae), Pyricularia oryzae on lawn, rice, corn, wheat, cotton, grape, sunflower, soybean, sugar beet, vegetables and various other plants (e.g., Phytophthora infestans or Phytophthora infestans) (damping); podocarpus, such as leaf spot (physiological leaf spot) on barley and Neurospora griseofulensis on beet; rhizoctonia species on cotton, rice, potato, lawn, corn, canola, potato, sugar beet, vegetables and various other plants, such as rhizoctonia solani on soybean (rhizome rot), rhizoctonia solani on rice (sheath blight) or wheat or barley (sheath blight); rhizopus stolonifer (black mold, soft rot) on black mold, carrot, cabbage, vines, and tomatoes; barley leaf rot (scald) sample on barley, rye, and triticale; rice blast and streptococcus sparsus (sheath rot) on rice; sclerotinia (stalk rot or white mold) on vegetables and field crops, such as oilseed rape, sunflower (e.g. sclerotinia sclerotiorum) and soybean (e.g. sclerotinia sclerotiorum); septoria on various plants, such as streptococcus glycine on soybean (brown spot), speckles of wheat (alternaria leaf spot) on wheat, and sporotrichia on cereals; leptospermum (proteosome: powdery mildew) and ostertagia (powdery mildew, amophoma: trichosporium) on grapevine; leaf blight on corn (e.g., turmeric, Helminthosporium turcicum) and lawn; smut (smut) on corn (e.g., head smut: head smut), sorghum, and sugarcane; coccobacillus on cucurbit (powdery mildew); spongia (powdery scabies) on potatoes, thereby transmitting viral diseases; the genus ascochyta on cereals, such as septoria nodorum (ascochyta, teleomorph: pediococcus) on wheat [ allotropes: leptospira ]; endosomes on potatoes (potato verrucosis); such as proteobacteria on peaches (leaf curl disease) and excystia plum on plums (bag of plums); moniliforme (black root rot) on tobacco, grapefruit, vegetables, soybeans, and cotton, such as root black rot (proteosome. insidiosporium elegans); tilletia species (common fennel or stink smut) on grains, such as Tilletia tritici (allotrope. Tilletia foetida) and Tilletia controversa (Tilletia controversa) on wheat; sclerotinia rot (gray snow mold) on barley or wheat; smut, such as stem smut on rye; monascus (rust) on vegetables such as legumes (phakopsora phaseoloides) and sugar beets; smut genus on cereals (e.g., smut), maize (e.g., smut maize: smut maize) and sugarcane; scab (scab) on apples (e.g., scab) and pears; and verticillium wilt (blight) on various plants, such as fruits, ornamentals, grapevines, soft fruits, vegetables and field crops, for example, verticillium dahliae on strawberries, oilseed rape, potatoes and tomatoes.

In a preferred embodiment, the present invention provides a fungicidal composition consisting of tolfenpyrad and pyraclostrobin to control the following (but not limited to) harmful pathogenic microorganisms: downy mildew, powdery mildew, black stalk disease, black spot, melanosis, late-flowering fruit drop and anthracnose. Alternaria leaf spot, scab or oil stain, leaf rust, black spot, net blotch, burn, septicemia leaf and glume blotch, stem rust, stripe or yellow rust, yellow leaf spot, eye spot, gray leaf spot, northern corn leaf spot, Picrasma, rust, southern corn leaf blight, yellow leaf spot, leaf blast, or late blight.

The combinations or compositions of the invention are also suitable for controlling harmful pathogenic microorganisms present in plant parts in the protection of materials, such as wood, paper, paint dispersions, fibers or textiles, and in the protection of stored products. The term "material protection" is understood to mean the protection of technical and non-biological materials, such as adhesives, glues, wood, paper and cardboard, textiles, leather, paint dispersions, plastics, cooling lubricants, fibers or fabrics, against the infestation and destruction by harmful pathogenic microorganisms, such as fungi and bacteria. With regard to the protection of wood and other materials, special attention should be paid to the following harmful pathogenic microorganisms: ascomycetes, such as Pectinophora, Pectinophyta, Aureobasidium, Chaetomium, Humicola, Pectinophyta, Phycomyces; basidiomycetes, such as the genera Phanerochaete, Coriolus, Pleurotus, Poria, Rakaomyces and Casimiomyces; deuteromycetes, such as Aspergillus, Cladosporium, Penicillium, Mucor, Alternaria, Paecilomyces, and Zygomycetes, such as Mucor. Furthermore, in protecting stored products, the following harmful pathogenic microorganisms are notable: candida and Saccharomyces cerevisiae.

The compositions of the present invention also provide non-agronomic (non-crop) applications such as in horticultural crops (e.g., greenhouses, nurseries or ornamentals not planted in the field), residential, commercial and industrial structures, turf (e.g., farms, rangelands, golf courses, lawns, sports fields, etc.).

In one embodiment, the present invention provides a method for controlling pests and mites with an effective amount of a combination of tolfenpyrad and pyraclostrobin.

The pests or mites are selected from moths and butterflies (lepidoptera), beetles (coleoptera), flies, mosquitoes (diptera), thrips (thysanoptera), termites (isoptera), cockroaches (blattaria-blattaria), stinkbugs (hemiptera), crickets, grasshoppers, locusts (orthoptera), arachnids (mites), fleas (fleas), silverfish, rangefinches (thysanoptera), millipedes (copepods), earwigs (dermaptera), lice (phthiridae), or plant parasitic nematodes.

In another embodiment of the invention, pests and mites are defined by the following orders:

lepidopteran insects, for example, agrotis microti, cutworm (cutworm), spodoptera littoralis, velvet bean moth, codling moth, spodoptera exigua, looper, fir leaf roller, tobacco leaf roller, winter moth, Diatra nubilalis, spruce leaf roller, fir color roller moth, armyworm, codling moth, European pine moth, cucumber cutworm, southwestern corn borer, cotton leaf spot moth, diamond-back moth, southern American corn seedling leaf roller, grape and apple leaf roller moth, spodoptera exigua, greater wax moth, leaf roller moth, oriental fruit moth, cotton bollworm, corn earworm, cabbage moth, American white moth, apple moth, tomato stem and leaf moth, iron scale moth, beet moth, coffee leaf roller, spiderworm, yellow leaf roller moth, diamond-back moth, gold leaf roller, grape moth, meadow moth, yellow leaf roller, yellow eared moth, white eared moth, black moth, cabbage looper, yellow earworm, black moth, black earworm, Spodoptera exigua, pink bollworm, armyworm, Autographa californica, tuber moth, citrus leaf miner, cabbage caterpillar, alfalfa green looper, diamond back moth, soybean looper, pine tip looper, yellow stem borer, scrotum flea, wheat moth, grape leaf roller moth, spodoptera frugiperda, spodoptera littoralis, prodenia litura, beet armyworm, pine rowfly, oak green looper, cabbage looper, solidago canadensis, yellow caterpillar (butterfly orange, grape berry moth), corn earworm, American cotton bollworm, yellow cutworm, cabbage looper, heart and moth, tomato cutworm, cabbage looper (cabbage looper), lissord beetle, cabbage looper, eastern moth (cabbage looper), lissorrel worm, winter worm, cabbage worm, etc., lyxofine worm, cabbage worm, orange borer, cabbage worm,

beetles (Coleoptera), for example pernicia littoralis, trichlorna lata, darkish beetles, juniper beetles, fennel species, bollworm weevil, pink weevil, aphididae, cryptogamia littoralis, pissodes radiata, beet chafer, bean beetles, golden beetles, cabbage seed beetles, cabbage shin beetles, tobacco wireworms, cunninghamia paniculata, longhorn beetles, diabrotica, cucumber beetles, southern American diabrotica, corn rootworm, Mexican bean beetles, tobacco beetles, elephant trunk, pine weevil, phylloxera, spruce beetles, lima, black hornworm, potato beetles, beet beetles, watercress beetles, rape beetles, golden beetles, gilles gibba, gilles castellana, rice beetles, grape beetles, rice beetles, etc., and rice beetles, etc., and other worms, rice beetles, etc., and other plants, etc., and other worms, and other plants, etc., and other plants, and the like, and other plants, and so for example, and the like, and so for example, and so as for example, and so that are included in the plant, and the order, Leaf-eating gill-tortoise species, garden Fascia sinensis, Leptosphaeria maculata, Phyllotreta striolata, Japanese beetle, grain weevil, weevil and plum weevil,

flies, mosquitoes (diptera), such as Aedes aegypti, Aedes albopictus, Eggera fly, Anopheles quinquefolius, Anopheles catarrhalis, Anopheles albus, Anopheles gambiae, Anopheles sphaericus, Anopheles viticola, Anopheles sanguinea, Chrysomya gibeli, Anopheles palustris, Anopheles maculata, Anopheles cupriformis, Anopheles macrorhynchus, Conophilus alpinus, Pectinatus dermalis, Cuicoides trichoides, Culex pipiensis, Culex nigricans, Culex fatigus, Culex tarsalis, Culex pipiensis, Cuctilus cucurbitae, Eulerus oleae, Culex oleifera, Ensifolius olgensis, Culex pipta indica, Cuctilus, Cuscuta indica, Piptotheca, Cuscuta indica, Pogostemminum, Pisca dora, Cuculus, Pacifoliomycopa, Cuculus, Pacifoliomycopa, Cuculus, Pacifolius, Cuculus, Pacifolius, Pacifoli, Liriomyza sativae, liriomyza trifoliae, liriomyza braziliana, liriomyza cuprina, lucilia sericata, myza magna, geckoo, cyckoo, barnyard fly, estragous, agromyzis, barnyard fly, turnip fly, tsetnamese fly, sandfly, columba palustris, tsetnamese fly, alepidotis, protognat, cherry wound rope, apple fruit fly, red tail fly, leprias, gnat, stable fly, cattle fly, black soldier fly, horse fly, and gadfly, mosquito genus, and marsh mosquito,

thrips (Thysanoptera), such as Frankliniella orchid, Frankliniella fusca, Frankliniella occidentalis, Frankliniella orientalis, Frankliniella citrifolia (Citrus thrips), thrips oryzae, thrips palmi, thrips gossypii and Frankliniella viridis

From the order of the termites (isoptera), such as yellow-crown termites, heterotermes, North-American Reticulitermes, south-European Coptotermes, Santalum album, Taiwan Lactotermes,

blatta Seu Periplaneta (Blatta order), such as Blatta Germanica, Blatta Asiatica, Blatta Periplaneta, Blattella japonica, Blattella fusca, Blattella fuliginosa, Blattella orientalis,

stinkbug (semipterides), such as diaphorina citri, lygus lucorum, lygus pratensis, lygus lucorum, tinctorius filiformis, lygus lucorum, codling moth, osmidge bugs, green pea aphid, green leaf pine aphid, cabbage aphid, beet aphid, strawberry aphid, yellow apple aphid, cotton aphid, tea bamboo basket seed aphid, schindyla, meadow bug, adonius, bean irridis netorum, green eggplant, aleyrodidymystis argentum, yellow leaf aphid, yellow tail aphid, plum short tail aphid, cabbage aphid, green apple tail aphid, yellow tail aphid, green apple tail aphid, yellow apple tail aphid, green beetle, etc., green beetle, etc., the plant can be selected from the group consisting of Leptospermum erythrosepala, Aphis graminicola, Aphis citricola, Aphis reticula, Myzus persicae, Aphis graminifolia, Aphis citricola, Aphis graminifolia, Aphis citrifolia, Aphis citricola, Aphis negundo, Aphis viridis, Aphis citricola, Aphis citrina zeae, Aphis graminifolia, Aphis citrifolia, Aphis buccinata, Aphis pomonella, Aphis citrina, Adhis cerifera, Aphis citrina, Poecia, Aphis graminifolia, Aphis citrifolia, Aphis citri, Aphis viridis, Adhis viridans, Adhis citrina, Adhis citri, Adhis viridis, Popula, Populus, Poecia, Populus, Podosa, Podosphanus terus, Podosphanus, Podosus, Podosphanus terus, Podosus, Podosphanus, Podosphaedodes teus, Podosphanus terus, Podosus, Podosphanus terus, Podosphanus, Podosus, Podos, Ceroplastes olepidus and lecanium brosuum,

ants, bees, wasps (hymenoptera), such as vespid, tropical leafy ants, cephalote american leafy ants, leaf-cutting ants, texas leaf-cutting ants, ventral ants, black ants, yellow house ants, fire ants, red fire ants, black fire ants, red harvest ants, harvester ants, big head ants, marsupium, bumblebee, yellow spot wasps, pennsylvania, wasps, quebracho, florida dora, and argentina,

cricket, grasshopper, locust (order orthoptera), such as cricket, mole cricket, locusta migratoria, grasshopper bivitta, black locusta mexicana, black locusta sanguinea, rocky mountain locusta, red wing locusta, queen desert, desert locusta, moringa locusta, carlo king, indian yellow sandalwood locusta, italian locusta, plague locusta, and brown locusta,

arachnidae, such as the order arachnidae (order acarina), for example the families of Cryptorhynchopridae, Hymenoridae and Sarcophagidae, for example the families Amidophytes, Cauliflower ticks, spotted ticks, Persperitus, Boophilus annulatus, Achromobacter, Boophilus microplus, Ehreria satis, Dermacentor ampyrifos, Dermacentor Hyalocephalus, Rhizopus ricini, Amblyomma minor, Erythagotarcus, Ardisia shoulder, Ardisia pan, Iris pacificus, Iris gesii, Botrytis subulis, Dermanychus gallinae, Onychia gallinae, Hymenoptera, Onychirophagus ovirensis, Rhipicephalus rhipiens, Rhipicephalus everus eversus, and Acarinus, such as Stephania destructor, Phyllophytes citrina citrifolia (Trionycis citri), Phyllophytes citrina citri citrina; tarsontarsondae species, such as Tarsonemus cerasus and Tarsonemus laterosus; species of the family of the spider mites, such as, for example, Leptodermus violaceus; tetranychidae species such as Tetranychus cinnabarinus, Tetranychus mirabilis, Tetranychus pacificus, Tetranychus gossypii and Tetranychus urticae, Panonychus ulmi, Panonychus citri, and Tetranychus urticae; araneida, such as black widow spider and human crinkled Arthrones,

fleas (Siphonaptera), such as Ctenocephalides felis, Ctenocephalides canis, Xenopsylla cheopis, Prypoda, Dermatophagoides pteronyssinus, and Pectinops opheles,

silverfish, Chlamydomonas (Thysanoptera), such as the small range of Chlamydomonas,

centipedes (centipedes), such as ants,

polypodas (polypodas), such as earwigs,

earwigs (dermaptera), such as centipedes,

lice (lice-malloptera), such as pediculus humanus capitis, pediculus humanus corporis, pediculus humanus pubis, haemaphysalis, pediculus bovis, calx louse and caerulea aquatica,

plant parasitic nematodes, such as root-knot nematodes, northern root-knot nematodes, southern root-knot nematodes, root-knot nematodes javanica and other root-knot nematodes; cyst-forming nematodes, potato nematodes and other nematode species; oat cyst nematode, soybean cyst nematode, beet cyst nematode, clover cyst nematode and other xenodermatosis species; seed nematodes and snake bedding cutting seeds; stem and leaf nematodes, species of aphelenchoides; nematodes, nematodes of the celery and other species of nematodes; pine wood nematodes, bursaphelenchus xylophilus and other pine wood nematodes; cyclonematode, Cyclo species, Roylenchus species, Cyclo species; stem and bulb nematodes, sweetpotato stem nematodes, bulbar stem nematodes and other phyla species; conidia, conidia species; helicoid, banana helicoid and other helicoid species; sheath and coleoptera, coleoptera species, and hemitylenchus species; a root penetrating nematode species; spear nematodes, spear nematodes; rhizoid nematodes, pearl nematode species; nematodes, longilineae elongata and other longtylenchus species; heterodera maculata, Heterodera pseudomaculata, Heterodera punctata, Heterodera flexuosa, Heterodera pratensis and other species of Heterodera pratensis; (ii) cryptates, radopholus similis and other radopholus species; reniform, discoid, and discoid species; a peltate nematode species; praecox, chondronetia and other Bursaphelenchus species, Bursaphelenchus pseudo; dwarf nematodes, cleft dwarf nematodes, cis-trans dwarf nematodes and other dwarf nematode species; citrus nematodes, piercing nematode species; dagger nematodes, sword nematode species; and other plant parasitic nematode species.

In a preferred embodiment, the present invention provides a pesticidal combination/composition comprising desinserin and pyraclostrobin for controlling pests and mites of lepidopteran, coleopteran, dipteran, hemipteran, orthopteran, acarid and thysanopteran insects.

The compositions of the present invention for controlling a wide variety of harmful pathogenic microorganisms, pests and mites are advantageous for several purposes, for example:

help to address more types of pests and diseases, such as insecticidal, fungicidal and acaricidal activity;

providing a single use as a homogeneous composition, instead of using a fungicide and insecticide separately;

it improves crop health compared to application of fungicides and insecticides alone.

Longer residual control time after application of the composition.

In another embodiment, the present invention provides a composition/composition that exhibits enhanced effects on harmful pathogenic microorganisms, pests and mites compared to the control rates possible with the compounds alone and/or control rates suitable for improving plant health. Application to plants, parts of plants, plant propagation material or the locus thereof.

In another embodiment, the compositions or compositions of the present invention are particularly important for controlling a wide variety of undesirable pathogenic microorganisms, insect pests and mites on various cultivated plants or plant parts, such as cereals, e.g. wheat, rye, barley, clover, oats or rice; sugar beets, such as sugar beets or fodder beets; fruits such as fruits, stone fruits or soft fruits such as apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, nectarines, prunes, blackberries or gooseberries; leguminous plants, such as lentils, peas, alfalfa or soybeans. Oil plants, such as rape, mustard, olives, sunflowers, coconut, cocoa beans, castor oil plants, oil palm, ground nuts or soybeans; cucurbitaceae, such as pumpkin, cucumber or melon; fiber plants, such as cotton, flax, hemp or jute; citrus fruits such as oranges, lemons, grapefruits or mandarins. Vegetables, such as spinach, lettuce, asparagus, cabbage, carrots, onions, tomatoes, potatoes, cucurbits or peppers; lauraceae plants, such as avocado, cinnamon or camphor; energy and raw material plants, such as corn, soybean, rape, sugar cane or oil palm. Corn; tobacco; a nut; coffee; tea leaves; bananas; grapevines (fresh eating grapes and grape juice vines); hops; turf; stevia rebaudiana (also called stevia rebaudiana); natural rubber plants or ornamental and forestry plants, such as flowers, shrubs, broad-leaved trees or evergreens, such as conifers; as well as plant propagation material, such as seeds, and crop material of these plants.

In a preferred embodiment, the composition or composition of the present invention is particularly important for controlling a variety of harmful pathogenic microorganisms, pests and mites in cucumber crops.

In general, the rate of application depends on, for example, the mixing ratio of the active ingredients, metering conditions, dosage form, application time, application method, application site, pests to be controlled and the target crop.

The method for controlling harmful fungi depends on the type of compound and the desired effect, and the application rate of the mixtures according to the invention is preferably from 5 to 1000g/ha, most preferably from 10 to 750 g/ha, in particular from 20 to 500 g/ha.

In a method for controlling pests (insects, acarids or nematodes) according to the type of compound and the desired effect, the application rate of the mixtures according to the invention is preferably from 20 to 1000g/ha, more preferably from 10 to 750 g/ha, in particular from 20 to 500 g/ha.

In one embodiment, the present invention provides a method for improving crop health (phytotension effect) comprising treating a plant with an effective amount of a composition of desinfluent and pyraclostrobin.

The invention is further illustrated by the following examples. These examples describe possible preferred embodiments, which are for illustrative purposes only, and they do not limit the scope of the invention.

Example 1: emulsifiable Concentrates (EC)

Raw materials	％w/w	Function(s)
			DefenRui technical high-efficiency liquid (97.0%)	15.5	Effective composition
Pyraclostrobin ester efficient liquid (97.0%)	10.4	Effective composition
			Polyoxyethylene alkyl ethers	3.0	Emulsifier
Polyoxyethylene tristyryl phenyl ether	2.0	Emulsifier
			Alkyl calcium benzene sulfonate	4.0	Emulsifier
N-methyl-2-pyrrolidone	5.0	Solvent(s)
			Xylene	60.1	Solvent(s)
All of	100.0

The preparation method comprises the following steps: 3.0 parts of polyoxyethylene alkyl ether, 3 parts of polyoxyethylene tristyryl terpene ether and calcium alkylbenzenesulfonate were mixed with an overhead stirrer in a mixture of 5.0 parts of N-methyl-2-pyrrolidone and 60.1 parts of xylene, and thoroughly mixed. 15.5 parts of the original drug highly effective liquid of the tuofenpyrate is added into the mixture in batches, and then 10.4 parts of the original drug highly effective liquid of the pyraclostrobin. The mixture was mixed thoroughly until all materials were completely dissolved.

Example 2: oil-in-water Emulsion (EW)

The preparation method comprises the following steps: 7.80 parts of desinfruit technical high-efficiency liquid and 5.20 parts of pyraclostrobin are completely dissolved into 15.00 parts of dimethylbenzene. 4.00 parts of polyoxyethylene castor oil ether, 7.00 parts of polyoxyethylene polyoxypropylene block copolymer, 0.10 part of polydimethylsiloxane emulsion, 0.05 part of 1, 2-benzothiazolin-3-one, 5.00 parts of polyethylene glycol and 35.85 parts of water are fully mixed in a mixing type pulverizer. The xylene solutions of tolfenpyrate and pyraclostrobin were added in portions and emulsified until the median diameter of the oil droplets was less than 2 μm. To the emulsified mixture obtained, 20.00 parts of a 1% aqueous solution of xanthan gum was added and uniformly mixed.

Example 3: wettable Powder (WP)

The preparation method comprises the following steps: 59.1 parts of kaolin and 6.0% precipitated silica are mixed thoroughly in a high shear mixer. After being fully mixed, 15.5 parts of desinfruit technical high-efficiency liquid, 10.4 parts of pyraclostrobin technical high-efficiency liquid, 3 parts of alkyl sodium sulfate, 2 parts of sodium lignosulfonate and 4.0 parts of sodium naphthalenesulfonate formaldehyde condensate are added and fully mixed in a high-shear mixer. The mixture was ground by an air jet mill under operating conditions to give a median diameter below 10 μm.

Example 4: water dispersible granule (WG)

The preparation method comprises the following steps: 16.7 parts of ammonium sulfate, 16.7 parts of kaolin and 2.0% fumed silica were thoroughly mixed in a high shear mixer. After fully mixing, 31.0 parts of desinfluent crude drug high-efficiency liquid, 20.6 parts of pyrrolysin crude drug high-efficiency liquid, 3.0 parts of sodium naphthalene sulfonate formaldehyde condensate, 8.0 parts of sodium lignin sulfate and 2.0 parts of alkyl sodium sulfonate are added and fully mixed in a high-shear mixer. The mixture was ground by an air jet mill under operating conditions to give a median diameter below 10 μm. The resulting mixture was kneaded with water, extruded through a screen (opening of 0.8mm in diameter) and dried.

Example 5: suspending agent (SC)

The preparation method comprises the following steps: 3.00 parts of polyoxyethylene alkyl ether, 4.00 parts of polymethacrylate-polyoxyethylene graft copolymer, 1.00 part of sodium naphthalenesulfonate formaldehyde condensate, 0.05 part of 1, 2-benzothiazoline-3-ketone and 0.30 part of polysiloxane emulsion are mixed into 44.75 parts of distilled water solution, and 6.00 parts of polyethylene glycol. And adding 15.50 parts of desinfecti and 10.40 parts of pyraclostrobin bulk drug high-efficiency liquid into the mixture, and pre-grinding in a colloid mill until the median diameters of the desinfecti and the pyraclostrobin bulk drug high-efficiency liquid are lower than 100 micrometers. The pre-ground mixture was ground in a bead mill until the median diameter of the bulk drug concentrate was below 5 μm. After milling, 15.00 parts of a 1% aqueous solution of xanthan gum were added to the milled solution and mixed uniformly.

The following test results illustrate the invention and are not intended to limit the invention.

Example (c): biological effects of the combination of ifenprinol and pyraclostrobin:

experiments were conducted to investigate the biological efficacy of the combinations of the invention in terms of disease, pest control, crop vigor and yield. Bioefficacy assessments were made of the control of downy mildew, powdery mildew, beetles and thrips in cucumber and its indirect impact on cucumber vigor and yield.

Serial number	products/Compounds	Type of formulation	Dose/hectare
				1 is provided with	Defen drug	AI	120
2 are provided with	Defen drug	AI	150
				3	Pyraclostrobin (Kresoxim-methyl)	AI	80
4	Pyraclostrobin (Kresoxim-methyl)	AI	100
				5	Deferan + pyraclostrobin	AI	120+80
6	Deferan + pyraclostrobin	AI	120+100
				7	Deferan + pyraclostrobin	AI	150+80
8	Deferan + pyraclostrobin	AI	150+100
				9	Untreated
	Composition into a tank-mix preparation

Experiments were conducted in the field to test the efficacy of fen-rui and pyraclostrobin at different test doses to control cucumber downy mildew, powdery mildew, thrips and jasmine.

Test compounds were applied 30 days after sowing at the given application rates with the aid of a backpack sprayer fitted with a hollow cone nozzle. The amount of water used for spraying was 500lts/ha, the size of each plot was 50sq.mt, and each treatment was repeated 3 times.

The severity of the pest was recorded one day prior to application and 10 days after application. Crop vigor was recorded 30 days after application. Cucumbers are harvested at weekly intervals according to the maturity index of raw cucumbers. Six picks were recorded.

When applied, the cucumber crop (gherkin) showed 8% downy mildew and 10% powdery mildew severity, whereas the average number of jasmine flowers was 3/leaf and thrips was 5/leaf. At the time of data recording, the disease severity of downy mildew was 25%, the severity of powdery mildew was 35%, while the jasmine population was 8/leaf and the thrips population was 15/leaf. The composition comprising the compound of component (1) and component (2) shows a synergistic effect. According to the invention, a synergistic effect of the combination is present each time when the insecticidal activity of the active compound combination exceeds the sum of the activities of the individual combination partners applied alone. The expected activity of a given combination of two active compounds (binary mixture) can be calculated using the formula of Colby (Colby, SR "calculate synergistic and antagonistic effects of herbicidal combinations", Weeds, volume 15, pages 20-22; 1967).

Formula of Colby:

the expected activity of a given combination of two active compounds (binary composition) can be calculated as follows:

where E represents the expected percent inhibition of disease at a given dose (e.g., equal to x and y, respectively) for the two pesticidal combinations, x is the percent inhibition of disease observed for compound (1) at the given dose (equal to x), and y is the percent inhibition of disease observed for compound (2) at the given dose (equal to y). When the percentage of inhibition observed for the combination is greater than E, then there is a synergistic effect.

Here, efficacy was determined by%. 0% indicates efficacy equivalent to the control; whereas 100% means no infection is observed.

If the actual combination exceeds the calculated value, the effect of the combination is super-additive, i.e. there is a synergistic effect, in which case the actual observed effect must exceed the expected effect (E) value calculated using the above formula. In the case of a purely supplementary increase in activity (expected activity), the difference (O-E) is zero. A negative value of the difference (OE) compared to the expected efficacy indicates a decreased activity. However, in addition to the actual synergistic effect in terms of fungicidal activity, the compositions according to the invention may also have further surprising advantages. Examples of such advantageous properties are: more favorable degradability; improved toxicology and ecotoxicology behavior; or improved characteristics of useful plants, including emergence, crop yield, more developed root system, increased tillering, increased plant height, larger leaves, stronger tillers, greener leaf color, early flowering, early maturity, increased shoot growth, increased plant vigor, and early germination.

The pesticidal composition of the present invention also shows vigorous growth in crops. Vigor refers to the early leaf area development and growth rate of a crop, and is often associated with increased competitiveness. Rapid crown closure enables crops to quickly shade ground and competing plants. Vigorous early growth may also promote larger root growth and improve water use efficiency (Siddique et al, 1990; Richards et al, 2007; Richards, 2008), which may contribute to improved yield in water and nutrient limited environments, with a powerful strengthening effect on plants generally observed. They can therefore be used to mobilize the defenses of plants against attack by harmful microorganisms. Enhancing plant vigor, including plant health/plant quality and seed vigor, reducing stand failure, improving appearance, increasing recovery rate after stress time, improving pigmentation (e.g., chlorophyll content, green-keeping effect, etc.), and increasing photosynthesis efficiency.

Table 1: subsequent viability index

Under optimal conditions, more fruit may develop initially from the 4 axilla of each leaf than can later be supported to full size, and therefore it may be desirable to reduce the number of fruits. Plants that are allowed to bear too many fruits can become depleted, giving up fruits, and over time, the productivity fluctuates greatly. The excess vigor of plants is manifested by rapid growth, thick and brittle stem, large leaves, long tendrils, dark green leaves, many fruits, large and deep yellow flowers. On the other hand, cucumbers are very sensitive to adverse conditions, and the slightest stress affects their growth and yield.

The following table lists the effect of these combinations on disease control, pest control, vigor and yield of cucumbers.

Table 2: activity of this combination against cucumber downy mildew

It was therefore concluded that the combination of the present invention has a surprisingly synergistically effective effect on controlling downy mildew.

Table 3: the composition has effect in treating cucumber powdery mildew

It was therefore concluded that the combination of the invention has a surprising synergistic activity for controlling powdery mildew.

Table 4: activity of this combination on cucumber Jassid

It was therefore concluded that the combinations of the present invention surprisingly demonstrate that jasmines control synergistic effects.

Table 5: the composition has cucumber thrips activity

The synergy of the combination in terms of thrips control is clearly reflected in the data.

Table 6: activity of combinations on crop vigor

It was therefore concluded that cucumber crops treated with the test compositions of the present invention surprisingly show a synergistic effect in terms of synergy, which can be caused by effective disease control, pest control and activation of certain beneficial physiological pathways. The combination of tests with 150+100 and 80g ai/ha of defenses plus pyraclostrobin showed the highest synergistic effect in terms of crop vigor. Delay in senescence onset in combination plots is one of the main observations of maturity, which results in a 10-day extension of the crop cycle.

Table 7: combination of activities on cucumber yield

The synergy seen in stimulation can be attributed to better pest control and delayed aging.

Thus, from the foregoing description, it will be apparent to those skilled in the art that many changes and modifications may be made thereto without departing from the spirit or scope of the invention as set forth in the description. Accordingly, it is not intended that the scope of the foregoing description be limited to the description set forth above, but rather that the description be construed as encompassing all of the features present in the present invention, including all the functions and embodiments which would be treated as equivalents thereof by those skilled in the pertinent art.

Claims

1. A composition comprising

a) An effective amount of a tolfenpyrate or salt,

b) an effective amount of pyraclostrobin or a salt thereof,

d) an agriculturally acceptable additive.

2. A synergistic composition comprising:

a) an effective amount of a tolfenpyrate or salt,

b) an effective amount of pyraclostrobin or a salt thereof,

d) an agriculturally acceptable additive.

3. The composition of claim 1, wherein the composition comprises from about 4% to 80%, preferably from about 10% to 60%, by weight of ifenprinate, from about 80% to 4%, preferably about 60%, by weight of pyraclostrobin, and from about 5% to 95%, preferably from about 20% to 90%, by weight of the additive.

4. The composition according to claim 1, wherein the ratio of desinferant to pyraclostrobin is from 50:1 to 1:50, preferably from 20:1 to 1:20 or from 10:1 to 1:10, more preferably from 3:2 to 2: 3.

5. The composition of claim 1, wherein the composition is formulated as Wettable Powder (WP), Water Dispersible Granule (WDG), water dispersible powder, water dispersible tablet (WT), Suspension (SC), Ultra Low Volume (ULV) liquid, Ultra Low Volume (ULV) Suspension (SU), water Soluble Granule (SG), cocoa Emulsifiable Granule (EG), Emulsifiable Powder (EP), Dispersible Concentrate (DC), oil-in-water Emulsion (EW), Emulsifiable Concentrate (EC), Microemulsion (ME), water dispersible oil suspension (OD), Capsule Suspension (CS), Dust (DP), or aerosol.

6. The composition of claim 1, wherein the composition further comprises an agriculturally acceptable formulation additive, the group comprising surfactants, liquid carriers, solid carriers, binders, disintegrants, pH adjusting agents, thickeners, preservatives, anti-freeze agents, anti-foam agents, colorants, or combinations thereof.

7. The composition of claim 6 wherein suitable surfactants are selected from the group consisting of sorbitol monolaurate, polyoxyethylene sorbitol monolaurate; alkylpolyglucoside (decylglucoside), polyoxyethylene alkyl ether (polyoxyethylene lauryl ether, or polyoxyethylene coconut fatty alcohol ether), polyoxyethylene alkynyl ether (polyoxyethylene 2, 4, 7, 9-tetramethyl-5-decyne-4, 7-diol ether), polyoxyethylene aryl ether (polyoxyethylene nonylphenyl ether or polyoxyethylene triphenylvinylphenyl ether), polyoxyethylene vegetable oil ether (polyoxyethylene castor oil or polyoxyethylene hydrogenated castor oil), vegetable oil ethoxylate, alcohol C12-C15 ethoxylate; polyoxyethylene fatty acid esters (polyoxyethylene monooleate, polyoxyethylene distearate or polyoxyethylene resinate); polyoxyethylene polyoxypropylene (EO-PO) Block copolymer (C)

) Polyoxyethylene polyoxypropylene alkyl ether (polyoxyethylene polyoxypropylene lauryl ether), polyoxyethylene polyoxypropylene aryl ether (polyoxyethylene polyoxypropylene styryl ether), polyoxyethylene alkylamine (polyoxyethylene stearyl amine), polyoxyethylene fatty acid amide (lauric acid diethanolamine), fluorinated surfactant, alkyl sulfate (sodium lauryl sulfate), sodium alkylbenzene sulfonate, calcium alkylbenzene sulfonate, polyoxyethylene alkyl ether sulfate (polyoxyethylene lauryl ether sodium sulfate), polyoxyethylene aryl ether sulfate (polyoxyethylene nonylphenyl ether sodium sulfate or polyoxyethylene triphenylether ammonium sulfate), arylsulfonate (calcium dodecylbenzenesulfonate, sodium naphthalenesulfonate or sodium naphthalenesulfonate formaldehyde condensate), polyarylphenyl ether sulfate ammonium salt, 'alpha' -olefinsulfonate, alkylsulfosuccinate (sodium dioctylsulfosuccinate) Sodium lignosulfonate, sodium polycarboxylate, N-methyl fatty acid sarcosinate, polyoxyethylene alkyl ether phosphate, polyoxyethylene aryl ether phosphate (polyoxyethylene phenyl ether phosphate), polyoxyethylene alkyl phenyl ether phosphate, graft copolymer (polymethyl methacrylate-polyethylene glycol graft copolymer), or a combination thereof.

8. The composition of claim 6 wherein the suitable liquid carrier is selected from the group consisting of water, alcohols (ethanol, propanol, butanol, n-octanol, isopropanol, ethylene glycol, diethylene glycol, propylene glycol, polyethylene glycol, benzyl alcohol, glycerol), polyol ethers (ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, dipropylene glycol dimethyl ether), ketones (acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone; ethers, such as dipropyl ether, dioxane, tetrahydrofuran), aliphatic hydrocarbons (normal paraffins, isopentane, kerosene, mineral oil), aromatic hydrocarbons (xylenes, toluene, naphthenes, solvent naphtha, solvent C, and mixtures thereof₉And solvent C₁₀And solvent C₁₂Solvent 100, solvent 150, solvent 200), chlorinated aliphatic or aromatic hydrocarbons (chlorobenzene, vinyl chloride, dichloromethane); esters (Ethyl acetate, ortho-esters)Diisopropyl phthalate, dimethyl adipate, methyl oleate, methyl tallate), lactones (γ -butyrolactone, γ -valerolactone, ε -caprolactone), amides (dimethylformamide, N-methylpyrrolidone, N-octylpyrrolidone, N-dimethyldecanamide), nitriles (acetonitrile), organic sulfur compounds (dimethyl sulfoxide), vegetable oils (soybean oil, rapeseed oil, cottonseed oil) or combinations thereof.

9. The composition of claim 6, wherein suitable solid carriers are selected from the group comprising natural minerals (quartz, talc, kaolin, pyrophyllite, montmorillonite, attapulgite, bentonite, diatomaceous earth, chalk, zeolites, calcite, sericite, acid clays, diatomaceous earth, fullers earth or pumice), synthetic minerals (precipitated silica, inorganic salts (calcium carbonate, ammonium sulfate, sodium sulfate, potassium chloride), organic materials (urea, lactose, starch, lignin, cellulose, cotton seed hulls, wheat flour, soybean flour, wood flour, walnuts, plant flour), plastic carriers polyethylene, polypropylene or polyvinylidene chloride or combinations thereof.

10. The composition of claim 6, wherein suitable binders are selected from the group comprising polyvinyl alcohol, dextrin, modified dextrin, soluble starch, guar gum, sucrose, polyvinylpyrrolidone, gum arabic, polyvinyl acetate, sodium polyacrylate, carboxymethyl cellulose or its salt, carboxymethyl cellulose dextrin, bentonite, polyethylene glycol having an average molecular weight of 6,000 to 20,000, polyethylene oxide having an average molecular weight of 100,000 to 5,000,000, natural phospholipids (cephalo acid or lecithin), or combinations thereof.

11. The composition of claim 6, wherein suitable disintegrants are selected from the group comprising sodium tripolyphosphate, metal stearates, cellulose powder, dextrin, methacrylate copolymers, polyvinylpyrrolidone, polyaminocarboxylic acid chelates, styrene sulfonate/isobutylene/maleic anhydride copolymers, starch/polyacrylonitrile graft copolymers, sodium hexametaphosphate, carboxymethylcellulose, sodium percarbonate, bentonite or combinations thereof.

12. The composition of claim 6, wherein suitable pH adjusting agents are selected from the group comprising sodium or potassium carbonate, sodium or potassium bicarbonate, sodium or potassium dihydrogen phosphate, disodium or dipotassium hydrogen phosphate, citric acid, malic acid, and triethanolamine, or combinations thereof.

13. The composition of claim 6, wherein suitable thickeners are selected from the group comprising xanthan gum, welan gum, guar gum, polyvinyl alcohol, carboxymethyl cellulose, polyvinyl pyrrolidone, carboxyvinyl polymers, acrylic acid polymers, starch derivatives or polysaccharides, silica, bentonite or white carbon or combinations thereof.

14. The composition of claim 6, wherein the suitable preservative is selected from the group consisting of 4-hydroxybenzoate, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, and 1, 2-benzisothiazolin-3-one, or a combination thereof.

15. The composition of claim 6, wherein suitable anti-freeze agents are selected from the group of glycerol, ethylene glycol, polyethylene glycol, propylene glycol, diethylene glycol, dipropylene glycol and urea, or combinations thereof.

16. The composition according to claim 6, wherein suitable antifoaming agents are selected from the group of silicone compounds and organofluorine compounds or combinations thereof.

17. The composition according to claim 6, wherein suitable colorants are selected from organic dyes (azo dyes, phthalocyanine dyes or alizarin dyes) and inorganic pigments (iron oxide) or combinations thereof.

18. A method of controlling pests, their habitat, breeding grounds, locus, treating soil or plant propagation material with an effective amount of a composition according to claim 1 in order to protect the plants from attack by the pests.

19. A method for controlling phytopathogenic harmful fungi, which comprises treating the fungi, the habitat of the fungi, the seed, the soil or the plants to be protected from fungal attack with an effective amount of a composition according to claim 1.

20. A method of improving the health of a plant, comprising treating the plant propagation material of the plant or the locus where the plant is growing or is to grow with an effective amount of a composition of claim 1.

21. A method of making the composition of claim 1, comprising mixing desinfluent and pyraclostrobin with agriculturally acceptable formulation additives.