WO2022058877A1 - Novel picolinamide compounds for combating phytopathogenic fungi - Google Patents

Novel picolinamide compounds for combating phytopathogenic fungi Download PDF

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Publication number
WO2022058877A1
WO2022058877A1 PCT/IB2021/058343 IB2021058343W WO2022058877A1 WO 2022058877 A1 WO2022058877 A1 WO 2022058877A1 IB 2021058343 W IB2021058343 W IB 2021058343W WO 2022058877 A1 WO2022058877 A1 WO 2022058877A1
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Prior art keywords
bis
carbamoyl
methoxypyridin
oxopropan
amino
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PCT/IB2021/058343
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French (fr)
Inventor
Sachin Baban NARUTE
Rahul Deshmukh
Vinoth PERUMAL
Rohit Saxena
Ruchi GARG
Alexander G.M. KLAUSENER
Santosh Shridhar AUTKAR
Vishal A. MAHAJAN
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Pi Industries Limited
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Publication of WO2022058877A1 publication Critical patent/WO2022058877A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Definitions

  • transitional phrase “consisting of” excludes any element, step or ingredient not specified. If in the claim, such would close the claim to the inclusion of materials other than those recited except for impurities ordinarily associated therewith.
  • the phrase “consisting of” appears in a clause of the body of a claim, rather than immediately following the preamble, it limits only the element set forth in that clause; other elements are not excluded from the claim as a whole.
  • the transitional phrase “consisting essentially of” is used to define a composition or method that includes materials, steps, features, components or elements, in addition to those literally disclosed, provided that these additional materials, steps, features, components or elements do not materially affect the basic and novel characteristic(s) of the claimed invention.
  • invertebrate pest includes arthropods, gastropods, nematodes, helminths, fungi, bacteria and viruses of economic importance as pests.
  • arthropod includes insects, mites, spiders, scorpions, centipedes, millipedes, pill bugs and symphylans.
  • gastropod includes snails, slugs and other Stylommatophora.
  • nematode refers to a living organism of the Phylum Nematoda.
  • helminths includes roundworms, heartworms, phytophagous nematodes (Nematoda), flukes (Tematoda), acanthocephala and tapeworms (Cestoda).
  • invertebrate pest control means inhibition of invertebrate pest development (including mortality, feeding reduction, and/or mating disruption), and related expressions are defined analogously.
  • agronomic refers to the production of field crops such as for food, feed and fiber and includes the growth of corn, soybeans and other legumes, rice, cereal (e.g., wheat, oats, barley, rye, rice, maize), leafy vegetables (e.g., lettuce, cabbage, and other cole crops), fruiting vegetables (e.g., tomatoes, pepper, eggplant, crucifers and cucurbits), potatoes, sweet potatoes, grapes, cotton, tree fruits (e.g., pome, stone and citrus), small fruit (berries, cherries) and other specialty crops (e.g., canola, sunflower, olives).
  • wheat e.g., wheat, oats, barley, rye, rice, maize
  • leafy vegetables e.g., lettuce, cabbage, and other cole crops
  • fruiting vegetables e.g., tomatoes, pepper, eggplant, crucifers and cucurbits
  • potatoes e.g., sweet potatoes, grapes, cotton, tree fruits (e.
  • nonagronomic refers to other than field crops, such as horticultural crops (e.g., greenhouse, nursery or ornamental plants not grown in a field), residential, agricultural, commercial and industrial structures, turf (e.g., sod farm, pasture, golf course, lawn, sports field.), wood products, stored product, agro-forestry and vegetation management, public health (i.e. human) and animal health (e.g., domesticated animals such as pets, livestock and poultry, undomesticated animals such as wildlife) applications.
  • Nonagronomic applications include protecting an animal from an invertebrate parasitic pest by administering a parasiticidally effective (i.e.
  • a compound of the present invention typically in the form of a composition formulated for veterinary use, to the animal to be protected.
  • parasitic and “parasiticidally” refers to observable effects on an invertebrate parasite pest to provide protection of an animal from the pest. Parasiticidal effects typically relate to diminishing the occurrence or activity of the target invertebrate parasitic pest. Such effects on the pest include necrosis, death, retarded growth, diminished mobility or lessened ability to remain on or in the host animal, reduced feeding and inhibition of reproduction.
  • alkyl used either alone or in compound words such as “alkylthio” or “haloalkyl” or - N(alkyl) or alkylcarbonylalkyl or alkylsuphonylamino includes straight-chain or branched C 1 to C 24 alkyl, preferably C 1 to C 15 alkyl, more preferably C 1 to C 10 alkyl, most preferably C 1 to C 6 alkyl.
  • the alkyl is at the end of a composite substituent, as, for example, in alkylcycloalkyl
  • the part of the composite substituent at the start for example the cycloalkyl
  • other radicals for example alkenyl, alkynyl, hydroxy, halogen, carbonyl, carbonyloxy and the like, are at the end.
  • alkynyl as a part of a composite substituent, for example haloalkynyl etc., unless specifically defined elsewhere.
  • alkynyl can also include moieties comprised of multiple triple bonds such as 2,5-hexadiynyl.
  • cycloalkyl means alkyl closed to form a ring. Non-limiting examples include cyclopropyl, cyclopentyl and cyclohexyl. This definition also applies to cycloalkyl as a part of a composite substituent, for example cycloalkylalkyl etc., unless specifically defined elsewhere.
  • cycloalkenyl means alkenyl closed to form a ring including monocyclic, partially unsaturated hydrocarbyl groups. Non-limiting examples include cyclopropenyl, cyclopentenyl and cyclohexenyl. This definition also applies to cycloalkenyl as a part of a composite substituent, for example cycloalkenylalkyl etc., unless specifically defined elsewhere.
  • cycloalkynyl means alkynyl closed to form a ring including monocyclic, partially unsaturated groups. Non-limiting examples include cyclopropynyl, cyclopentynyl and cyclohexynyl.
  • cycloalkynyl as a part of a composite substituent, for example cycloalkynylalkyl etc., unless specifically defined elsewhere.
  • cycloalkoxy “cycloalkenyloxy” and the like are defined analogously. Non limiting examples of cycloalkoxy include cyclopropyloxy, cyclopentyloxy and cyclohexyloxy. This definition also applies to cycloalkoxy as a part of a composite substituent, for example cycloalkoxy alkyl etc., unless specifically defined elsewhere.
  • halogen either alone or in compound words such as “haloalkyl”, includes fluorine, chlorine, bromine or iodine.
  • haloalkyl when used in compound words such as “haloalkyl”, said alkyl may be partially or fully substituted with halogen atoms which may be the same or different.
  • haloalkyl include chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoroethyl, 2- fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, 1,1-dichloro
  • Non-limiting examples of haloalkylthio include chloromethylthio, bromomethylthio, dichloromethylthio, trichloromethylthio, fluoromethylthio, difluoromethylthio, trifluoromethylthio, chlorofluoromethylthio, dichlorofluoromethylthio, chlorodifluoromethylthio, 1-chloroethylthio, 1- bromoethylthio, 1- fluoroethylthio, 2-fluoroethylthio, 2,2-difluoroethylthio, 2,2,2-trifluoroethylthio, 2- chloro-2-fluoroethylthio, 2-chloro-2,2-difluoroethylthio, 2,2-dichloro-2-fluoroethylthio, 2,2,2- trichloroethylthio, pentafluoroethylthio and 1,1,l-triflu
  • hydroxy means —OH
  • Amino means —NRR, wherein R can be H or any possible substituent such as alkyl.
  • sulfinyl means SO
  • sulfonyl means S(O) 2 .
  • alkoxy used either alone or in compound words included C 1 to C 24 alkoxy, preferably C 1 to C 15 alkoxy, more preferably C 1 to C 10 alkoxy, most preferably C 1 to C 6 alkoxy.
  • alkoxyalkyl denotes alkoxy substitution on alkyl.
  • alkoxyalkyl include CH 3 OCH 2 , CH 3 OCH 2 CH 2 , CH 3 CH 2 OCH 2 , CH 3 CH 2 CH 2 CH 2 OCH 2 and CH 3 CH 2 OCH 2 CH 2 .
  • alkoxyalkoxy denotes alkoxy substitution on alkoxy.
  • alkylthio includes branched or straight-chain alkylthio moieties such as methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio, 1,1- dimethylethylthio, pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 2,2- dimethylpropylthio, 1-ethylpropylthio, hexylthio, 1,1-dimethylpropylthio, 1,2-dimethylpropylthio, 1- methylpentylthio, 2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1,1-dimethylbutylthio, 1,2-dimethylbutylthio, 1,3-dimethylbutylthio, 2,2-dimethylbutylthio,
  • Halocycloalkyl, halocycloalkenyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, haloalkylcarbonyl, cycloalkylcarbonyl, haloalkoxylalkyl, and the like, are defined analogously to the above examples.
  • alkylthioalkyl denotes alkylthio substitution on alkyl.
  • alkylthioalkyl include -CH 2 SCH 2 , -CH 2 SCH 2 CH 2 , CH 3 CH 2 SCH 2 , CH 3 CH 2 CH 2 CH 2 SCH 2 and CH 3 CH 2 SCH 2 CH 2 .
  • Alkylthioalkoxy denotes alkylthio substitution on alkoxy.
  • cycloalkylalkylamino denotes cycloalkyl substitution on alkyl amino.
  • alkoxyalkoxyalkyl is an alkoxy group bonded to a skeleton via a carbonyl group (-CO-). This definition also applies to alkoxycarbonyl as a part of a composite substituent, for example cycloalkylalkoxycarbonyl and the like, unless specifically defined elsewhere.
  • alkoxycarbonylalkylamino denotes alkoxy carbonyl substitution on alkyl amino.
  • Alkylcarbonylalkylamino denotes alkyl carbonyl substitution on alkyl amino.
  • alkylthioalkoxycarbonyl, cycloalkylalkylaminoalkyl and the like are defined analogously.
  • alkylsulfinyl include methylsulphinyl, ethylsulphinyl, propylsulphinyl, 1- methylethylsulphinyl, butylsulphinyl, 1-methylpropylsulphinyl, 2-methylpropylsulphinyl, 1,1- dimethylethylsulphinyl, pentylsulphinyl, 1-methylbutylsulphinyl, 2-methylbutylsulphinyl, 3- methylbutylsulphinyl, 2,2-dimethylpropylsulphinyl, 1-ethylpropylsulphinyl, hexylsulphinyl, 1,1- dimethylpropylsulphinyl, 1,2-dimethylpropylsulphinyl, 1-methylpentylsulphinyl, 2- methylpentylsulphinyl, 3-methylpentylsulphinyl, 4-methylp
  • arylsulfinyl includes Ar-S(O), wherein Ar can be any carbocyle or heterocylcle. This definition also applies to alkylsulphinyl as a part of a composite substituent, for example haloalkylsulphinyl etc., unless specifically defined elsewhere.
  • alkylsulfonyl include methylsulphonyl, ethylsulphonyl, propylsulphonyl, 1-methylethylsulphonyl, butylsulphonyl, 1-methylpropylsulphonyl, 2-methylpropylsulphonyl, 1,1- dimethylethylsulphonyl, pentylsulphonyl, 1-methylbutylsulphonyl, 2-methylbutylsulphonyl, 3- methylbutylsulphonyl, 2,2-dimethylpropylsulphonyl, 1-ethylpropylsulphonyl, hexylsulphonyl, 1,1- dimethylpropylsulphonyl, 1,2-dimethylpropylsulphonyl, 1-methylpentylsulphonyl, 2- methylpentylsulphonyl, 3-methylpentylsulphonyl, 4-methylpentylsulphony
  • arylsulfonyl includes Ar-S(O) 2 , wherein Ar can be any carbocyle or heterocylcle. This definition also applies to alkylsulphonyl as a part of a composite substituent, for example alkylsulphonylalkyl etc., unless defined elsewhere. “Alkylamino”, “dialkylamino”, and the like, are defined analogously to the above examples.
  • non-aromatic heterocycle or “non-aromatic heterocyclic” means three- to fifteen- membered, preferably three- to twelve- membered, saturated or partially unsaturated heterocycle containing one to four heteroatoms from the group of oxygen, nitrogen and sulphur: mono, bi- or tricyclic heterocycles which contain, in addition to carbon ring members, one to three nitrogen atoms and/or one oxygen or sulphur atom or one or two oxygen and/or sulphur atoms; if the ring contains more than one oxygen atom, they are not directly adjacent; non-limiting examples thietanyl, oxetanyl, oxiranyl, azetidinyl, aziridinyl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydrothienyl, 3- tetrahydrothienyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 3-pyr
  • heterocyclyl as a part of a composite substituent, for example heterocyclylalkyl etc., unless specifically defined elsewhere.
  • heteroaryl or “aromatic heterocyclic” means 5 or 6-membered, fully unsaturated monocyclic ring system containing one to four heteroatoms from the group of oxygen, nitrogen and sulphur; if the ring contains more than one oxygen atom, they are not directly adjacent; 5-membered heteroaryl containing one to four nitrogen atoms or one to three nitrogen atoms and one sulphur or oxygen atom; 5-membered heteroaryl groups which, in addition to carbon atoms, may contain one to four nitrogen atoms or one to three nitrogen atoms and one sulphur or oxygen atom as ring members, non-limiting examples furyl, thienyl, pyrrolyl, isoxazolyl, isothiazolyl, pyrazolyl, oxazolyl, thiazolyl, imidazoly
  • 6-membered heteroaryl which contains one to four nitrogen atoms: 6-membered heteroaryl groups which, in addition to carbon atoms, may contain, respectively, one to three and one to four nitrogen atoms as ring members, non-limiting examples 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 3-pyridazinyl, 4- pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyrazinyl, 1,3,5-triazin-2-yl, 1,2,4-triazin- 3-yl and 1,2,4,5-tetrazin-3-yl; benzofused 5-membered heteroaryl containing one to three nitrogen atoms or one nitrogen atom and one oxygen or sulphur atom: non-limiting examples indol-1-yl, indol- 2-yl, indol-3-yl, indol-4-yl, indol-5-yl, indol
  • trialkylsilyl includes 3 branched and/or straight-chain alkyl radicals attached to and linked through a silicon atom such as trimethylsilyl, triethylsilyl and t-butyl-dimethylsilyl.
  • “Halotrialkylsilyl” denotes at least one of the three alkyl radicals is partially or fully substituted with halogen atoms which may be the same or different.
  • alkoxytrialkylsilyl denotes at least one of the three alkyl radicals is substituted with one or more alkoxy radicals which may be the same or different.
  • trialkylsilyloxy denotes a trialkylsilyl moiety attached through oxygen.
  • the total number of carbon atoms in a substituent group is indicated by the “C i -C j ” prefix where i and j are numbers from 1 to 21.
  • C 1 -C 3 alkylsulfonyl designates methylsulfonyl through propylsulfonyl
  • C 2 alkoxyalkyl designates CH 3 OCH 2
  • C 3 alkoxyalkyl designates, for example, CH 3 CH(OCH 3 ), CH 3 OCH 2 CH 2 or CH 3 CH 2 OCH 2
  • C 4 alkoxyalkyl designates the various isomers of an alkyl group substituted with an alkoxy group containing a total of four carbon atoms, examples including CH 3 CH 2 CH 2 OCH 2 and CH 3 CH 2 OCH 2 CH 2 .
  • the inventive compound of the present invention may, if appropriate, be present as mixtures of different possible isomeric forms, especially of stereoisomers, for example E and Z, threo and erythro, and also optical isomers, but if appropriate also of tautomers. Both the E and the Z isomers, and also the threo and erythro isomers, and the optical isomers, any desired mixtures of these isomers and the possible tautomeric forms are disclosed and claimed.
  • polymorph refers to a particular crystalline form of a chemical compound that can crystallize in different crystalline forms, these forms having different arrangements and/or conformations of the molecules in the crystal lattice.
  • the preparation and isolation of a particular polymorph of a compound represented by formula (I) can be achieved by methods known to those skilled in the art including, for example, crystallization using selected solvents and temperatures.
  • the term “pest” for the purpose of the present disclosure includes but is not limited to fungi, stramenopiles (oomycetes), bacteria, nematodes, mites, ticks, insects and rodents.
  • the term “plant” is understood here to mean all plants and plant populations, such as desired and undesired wild plants or crop plants (including naturally occurring crop plants).
  • sugar beet or fodder beet fruits and fruit trees, such as pomes, stone fruits or soft fruits, e.g. apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, blackberries or gooseberries; leguminous plants, such as lentils, peas, alfalfa or soybeans; oil plants, such as rape, mustard, olives, sunflowers, coconut, cocoa beans, castor oil plants, oil palms, ground nuts or soybeans; cucurbits, such as squashes, cucumber or melons; fiber plants, such as cotton, flax, hemp or jute; citrus fruit and citrus trees, such as oranges, lemons, grapefruits or mandarins; any horticultural plants, vegetables, such as spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, cucurbits or paprika; lauraceous plants, such as avocados, cinnamon or camphor; cucurbitaceae; oleaginous plants; energy and raw material plants, such as
  • the plant for the purpose of the present invention includes but is not limited to cereals, corn, rice, soybean and other leguminous plants, fruits and fruit trees, grapes, nuts and nut trees, citrus and citrus trees, any horticultural plants, cucurbitaceae, oleaginous plants, tobacco, coffee, tea, cacao, sugar beet, sugar cane, cotton, potato, tomato, onions, peppers and vegetables, ornamentals, any floricultural plants and other plants for use of human and animals.
  • plant parts is understood to mean all parts and organs of plants above and below the ground.
  • plant parts includes but is not limited to cuttings, leaves, twigs, tubers, flowers, seeds, branches, roots including taproots, lateral roots, root hairs, root apex, root cap, rhizomes, slips, shoots, fruits, fruit bodies, bark, stem, buds, auxillary buds, meristems, nodes and internodes.
  • locus thereof includes soil, surroundings of plant or plant parts and equipment or tools used before, during or after sowing/planting a plant or a plant part.
  • compositions optionally comprising other compatible compounds to a plant or a plant material or locus thereof include application by a technique known to a person skilled in the art which include but is not limited to spraying, coating, dipping, fumigating, impregnating, injecting and dusting.
  • applied means adhered to a plant or plant part either physically or chemically including impregnation.
  • the present invention provides a novel compound of formula (I), wherein, R 1 is selected from the group consisting of hydroxy, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 3 -C 6 - cycloalkyl, C 1 -C 6 -alkoxy, C 3 -C 6 -cycloalkyloxy, C 1 -C 6 -alkylthio, C 1 -C 6 -cycloalkylthio, -NHR 13 and - N(R 13 ) 2 ; R 1a is selected from the group consisting of hydroxy, halogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 6 - haloalkyl and C 1 -C 6 -alkoxy; R 2 is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 halo
  • the compound of formula (I) is represented by compound of formula (IA); In one embodiment, the compound of formula (I) is represented by compound of formula (IB); In one embodiment, the compound of formula (I) is represented by compound of formula (IC); In one embodiment, the compound of formula (I) is represented by compound of formula (ID); In a preferred embodiment, the present invention provides a compound of formula (I), wherein R 1 is selected from the group consisting of hydroxy, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 3 -C 6 - cycloalkyl, C 3 -C 6 -cycloalkyloxy and C 1 -C 6 -alkoxy; R 2 is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 -alkoxy-C 1 - C 6 -alkyl, -C(O)-
  • the present invention provides a compound of formula (I), wherein R 1 is selected from the group consisting of hydroxy, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 3 -C 6 - cycloalkyl and C 1 -C 6 -alkoxy; R 2 is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 -alkoxy-C 1 - C 6 -alkyl, -C(O)-R 13 , -C(O)-OR 13 and –(CH 2 ) m -O-C(O)-R 13 ; R 3 is selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 - C 6 -alkoxy-
  • R 1 is selected from the group consisting of hydroxy, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 3 -C 6 -cycloalkyl and C 1 -C 6 -alkoxy.
  • R 2 is selected from the group consisting of hydrogen, C 1 -C 6 - alkyl, C 1 -C 6 haloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, -C(O)-R 13 , -C(O)-OR 13 and –(CH 2 ) m -O-C(O)-R 13 .
  • R 3 is selected from the group consisting of hydrogen, C 1 -C 6 - alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkyl- C 1 -C 6 -alkyl and -(CH 2 ) m -C(O)-OR 13 .
  • W represents O.
  • R 4 and R 5 are independently selected from the group consisting of hydrogen, halogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 - C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkyl-C 1 -C 6 -alkyl, C 6 -C 10 -aryl, C 7 -C 14 -aralkyl and C 3 -C 10 -heterocyclyl; each group of R 4 and R 5 may be optionally substituted by one or more groups selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C 1 -C 6 -alkyl, C
  • R 4 and R 5 together with the atoms to which they are attached may form a 3 to 6 membered non-aromatic carbocyclic ring; the ring may be optionally substituted with one or more identical or different groups selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio and C 1 -C 6 - haloalkoxy.
  • R 6 and R 6a are independently selected from the group consisting of hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl and C 3 -C 6 -cycloalkyl-C 1 -C 6 -alkyl.
  • R 7 is selected from the group consisting of hydrogen, C 1 -C 6 - alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl and C 3 -C 6 cycloalkyl-C 1 -C 6 alkyl; each group of R 7 may be optionally substituted by one or more groups selected from halogen, cyano, nitro, hydroxyl, thiol, amino.
  • R 8 , R 8a , R 9 and R 9a are independently selected from the group consisting of C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 alkoxy-C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 cycloalkyl-C 1 -C 6 -alkyl, phenyl, benzyl, phenyloxy, phenylthio; each group of R 8 , R 8a , R 9 and R 9a may be optionally substituted by one or more groups selected from R 10 ; or R 8 and R 9 together with the atoms to which they are attached may form a 3- to 6- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N,
  • R 10 is selected from the group consisting of cyano, halogen, nitro, hydroxyl, thiol, amino, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 1 -C 6 -haloalkyl, C 1 -C 6 - alkoxy, C 1 -C 6 alkoxy-C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkyl-C 1 -C 6 -alkyl.
  • R 11 is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio and C 3 -C 8 -cycloalkyl.
  • R 12 is selected from the group of hydrogen, halogen, hydroxy, C 1 -C 6 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 6 -haloalkyl and C 1 -C 4 -haloalkoxy.
  • R 13 is selected from the group consisting of hydrogen, formyl, C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, C 1 -C 4 -haloalkyl, C 3 -C 5 -cycloalkyl, C 3 -C 5 -cycloalkyl-C 1 - C 3 -alkyl, C 6 -C 10 -aryl, C 7 -C 14 -aralkyl and C 3 -C 10 -heterocyclyl.
  • the compound of formula (I) is selected from N-((S)-1-(((S)-1,1-bis(4- methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1- (((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl acetate, N-((2S,3S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan- 2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((2S,3S)-1-(((S)-1,1-bis(4-methoxyphenyl)propyl)a
  • the agriculturally acceptable salts of the compounds of formula (I) encompass especially the salts of those cations or the acid addition salts of those acids whose cations and anions, respectively have no adverse effect on the fungicidal action of the compounds of formula (I).
  • Suitable cations are thus in particular the ions of the alkali metals, preferably sodium and potassium; of the alkaline earth metals, preferably calcium, magnesium and barium; of the transition metals, preferably manganese, copper, zinc and iron and also the ammonium ion which, if desired, may carry one to four C 1 -C 4 -alkyl substituents and/or one phenyl or benzyl substituent, preferably diisopropylammonium, tetramethylammonium, tetrabutylammonium, trimethylbenzylammonium, furthermore phosphonium ions, sulfonium ions, preferably tri(C 1 -C 4 -alkyl)sulf
  • the salts obtainable in this way likewise have fungicidal properties.
  • Anions of useful acid addition salts are primarily chloride, bromide, fluoride, hydrogensulfate, sulfate, dihydrogenphosphate, hydrogenphosphate, phosphate, nitrate, bicarbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate, and the anions of C 1 -C 4 -alkanoic acids, preferably formate, acetate, propionate and butyrate. They can be formed by reacting a compound of formula (I) with an acid of the corresponding anion, preferably of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid or nitric acid.
  • the compounds of the present invention may be present either in pure form or as mixtures of different possible isomeric forms such as stereoisomers e.g., a racemate, individual stereoisomers, or constitutional isomers or as an optically active form.
  • the various stereoisomers include enantiomers, diastereomers, chiral isomers, atropisomers, conformers, rotamers, tautomers, optical isomers, polymorphs, and geometric isomers. Any desired mixtures of these isomers fall within the scope of the claims of the present disclosure.
  • one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other isomer(s) or when separated from the other isomer(s).
  • the compounds of formula (I) can be present in different crystal modifications whose biological activity may differ. They also form part of the subject matter of the present invention.
  • the compounds of formula (I) can be present in atropisomers arising from restricted rotation about a single bond of asymmetric groups. They also form part of the subject matter of the present invention.
  • the compound selected from formula (I), (including all stereoisomers, N-oxides, and salts thereof), typically may exist in more than one form.
  • the compounds of formula (I) thus includes all crystalline and non-crystalline forms of the compound that formula (I) represents.
  • Non-crystalline forms include embodiments which are solids such as waxes and gums as well as embodiments which are liquids such as solutions and melts.
  • Crystalline forms include embodiments which represent essentially a single crystal type and embodiments which represent a mixture of polymorphs (i.e. different crystalline types).
  • the following schemes illustrate approaches for preparing compounds of formula (I). The following descriptions and examples are provided for illustrative purposes and should not be construed as limiting in terms of substituents or substitution patterns. Further, the mentioned reagents, solvents and reaction conditions are intended for the purpose of exemplification only and should not be construed as limiting. In one embodiment, the present invention provides a process for synthesis of compounds of formula (I).
  • the compound of formula (I) can be prepared by one or other of the following methods.
  • the definitions of W, Z, R 1 , R 1a , R 2 , R 3 , R 4 , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , R 9 , and R 12 in the compounds of formula (I) and compounds of formula 1–21 are as defined above in the detailed description of the invention unless otherwise stated specifically.
  • a compound of formula (I), wherein W is O involves coupling of an acid of formula 4 (or it’s salt) with an amine (or its acid salt) of formula 3 in the presence of a suitable coupling reagent such as hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3- dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride and the like, or alkyl chloroformates such as ethyl chloroformate, isobutyl chloroformate and the like, and optionally in a suitable solvent such as dichloromethane, tetrahydrofuran and the like.
  • a suitable coupling reagent such as hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3- dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride and the like, or al
  • an acid of formula 4 can be prepared employing a reported protocol (US2016/0009650A1) and an amine of formula 3 can be obtained by coupling of protected amino acid of formula 1 and suitable coupling partner (Z) using coupling reagents and or a solvent such as dichloromethane, tetrahydrofuran and the like.
  • a suitably substituted amine of formula 27 can be prepared by deprotection of protecting group in compound of formula 26 using a suitable reagent such as trifluoroacetic acid, HCl, oxalyl chloride/MeOH and the like. These transformations are typically carried out at a temperature between 0°C to 25°C.
  • the desired compound of formula 26 can be obtained by N-alkylation of an amine of formula 25 using a suitable alkyl halide (R 6a -X).
  • the compound of formula 29 can be subsequently equipped by treating suitably substituted hydrazine of formula 22 with a ketone of formula 18 under suitable conditions.
  • the compound of formula (I-z 1 ), wherein W is O was obtained by coupling of an acid of formula 4 (or it’s salt) with an amine of formula 14 (or it’s acid salt) in the presence of a suitable coupling reagent such as hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3- dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride and the like, or alkyl chloroformates such as ethyl chloroformate, isobutyl chloroformate and the like, and optionally in a suitable solvent such as dichloromethane, tetrahydrofuran and the like.
  • a suitable coupling reagent such as hexafluorophosphate azabenzotriazole
  • An agrochemical composition comprises a fungicidally effective amount of a compound of formula (I).
  • the term "effective amount” denotes an amount of the composition or of the compound of formula (I), which is sufficient for controlling harmful fungi on cultivated plants or in the protection of materials and which does not result in a substantial damage to the treated plants. Such an amount can vary in a broad range and is dependent on various factors, such as the fungal species to be controlled, the treated cultivated plant or material, the climatic conditions and the specific compound of formula (I) used.
  • the present invention provides a composition comprising at least one compound of formula (I) and seed.
  • compositions are prepared in a known manner, such as described by Mollet and Grubemann, Formulation technology, Wiley VCH, Weinheim, 2001; or Knowles, New developments in crop protection product Formulation, Agrow Reports DS243, T&F Informa, London, 2005.
  • Suitable surfactants are surface-active compounds, such as anionic, cationic, nonionic and amphoteric surfactants, block polymers, polyelectrolytes, and mixtures thereof. Such surfactants can be used as emulsifier, dispersant, solubilizer, wetter, penetration enhancer, protective colloid, or adjuvant. Examples of surfactants are listed in McCutcheon's, Vol.1: Emulsifiers & Detergents, McCutcheon's Directories, Glen Rock, USA, 2008 (International Ed. or North American Ed.).
  • xanthan gum carboxymethyl cellulose
  • inorganic clays organic clays (organically modified or unmodified), polycarboxylates, and silicates.
  • Suitable bactericides are bronopol and isothiazolinone derivatives such as alkylisothiazolinones and benzisothiazolinones.
  • Suitable anti-freezing agents are ethylene glycol, propylene glycol, urea and glycerin.
  • Suitable anti-foaming agents are silicones, long chain alcohols, and salts of fatty acids.
  • Suitable colorants e. g. in red, blue, or green
  • examples are inorganic colorants (e. g.
  • binder e. g. polyvinyl alcohol
  • binder e. g. polyvinyl alcohol
  • dispersants and wetting agents e. g. sodium lignosulfonate and alcohol ethoxylate
  • Microcapsules An oil phase comprising 5-50 wt% of a compound of formula (I), 0-40 wt% water insoluble organic solvent (e. g. aromatic hydrocarbon), 2-15 wt% acrylic monomers (e. g. methylmethacrylate, methacrylic acid and a di- or triacrylate) are dispersed into an aqueous solution of a protective colloid (e.
  • a protective colloid e.
  • an oil phase comprising 5-50 wt% of a compound of Formula (I) according to the invention, 0-40 wt% water insoluble organic solvent (e. g. aromatic hydrocarbon), and an isocyanate monomer (e. g. diphenylmethene-4,4'-diisocyanatae) are dispersed into an aqueous solution of a protective colloid (e. g. polyvinyl alcohol).
  • a polyamine e. g. hexamethylenediamine
  • the monomers amount to 1-10 wt%.
  • compositions in question give, after two-to-tenfold dilution, active substance concentrations from 0.01 to 60% by weight, preferably from 0.1 to 40%, in the ready-to-use preparations.
  • the amounts of active substances applied are, depending on the kind of effect desired, from 0.001 to 2 kg per ha, preferably from 0.005 to 2 kg per ha, more preferably from 0.05 to 1.0 kg per ha, and in particular from 0.1 to 1.0 kg per ha.
  • amounts of active substance from 0.1 to 1000 g, preferably from 1 to 1000 g, more preferably from 1 to 100 g and most preferably from 5 to 100 g, per 100 kg of plant propagation material (preferably seeds) are generally required.
  • the amount of active substance applied depends on the kind of application area and on the desired effect.
  • Amounts customarily applied in the protection of materials are 0.001 g to 2 kg, preferably 0.005 g to 1 kg, of active substance per cubic meter of treated material.
  • Various types of oils, wetters, adjuvants, fertilizer, or micronutrients, and further pesticides e. g. herbicides, insecticides, fungicides, growth regulators, safeners, biopesticides
  • pesticides e. g. herbicides, insecticides, fungicides, growth regulators, safeners, biopesticides
  • These agents can be mixed with the composition according to the invention in a weight ratio of 1:100 to 100:1, preferably 1:20 to 20:1.
  • a pesticide is generally a chemical or biological agent (such as pesticidally active ingredient, compound, composition, virus, bacterium, antimicrobial or disinfectant) that through its effect deters, incapacitates, kills or otherwise discourages pests.
  • Target pests can include insects, plant pathogens, weeds, mollusks, birds, mammals, fish, nematodes (roundworms), and microbes that destroy property, cause nuisance, spread disease or are vectors for disease.
  • pesticide includes also plant growth regulators that alter the expected growth, flowering, or reproduction rate of plants; defoliants that cause leaves or other foliage to drop from a plant, usually to facilitate harvest; desiccants that promote drying of living tissues, such as unwanted plant tops; plant activators that activate plant physiology for defense against certain pests; safeners that reduce unwanted herbicidal action of pesticides on crop plants; and plant growth promoters that affect plant physiology e.g. to increase plant growth, biomass, yield or any other quality parameter of the harvestable goods of a crop plant.
  • the user applies the composition according to the invention usually from a predosage device, a knapsack sprayer, a spray tank, a spray plane, or an irrigation system.
  • the agrochemical composition is made up with water, buffer, and/or further auxiliaries to the desired application concentration and the ready-to-use spray liquor or the agrochemical composition according to the invention is thus obtained.
  • 20 to 2000 liters, preferably 50 to 400 liters, of the ready-to-use spray liquor are applied per hectare of agricultural useful area.
  • the present invention provides a combination comprising the compound of formula (I) and at least one further pesticidally active substance selected from the group consisting of fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, safeners, plant growth regulators, antibiotics, fertilizers and nutrients.
  • the compound of formula (I), the combination and the composition thereof comprising them in the use as fungicides with other fungicides may result in an expansion of the fungicidal spectrum of activity being obtained or in a prevention of fungicide resistance development. Furthermore, in many cases, extraordinary and unexpected effects are obtained.
  • the present invention also relates to the combination comprising at least one compound of formula (I) and at least one further pesticidally active substance selected from the group of fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, safeners, plant growth regulators, antibiotics, fertiliers and nutrients.
  • the pesticidally active substances reported in WO2015185485 pages 36-43 and WO2017093019 pages 42-56 can be used in conjunction with the compound of formula (I).
  • the active substances referred to as component 2 their preparation and their activity e. g. against harmful fungi is known (cf.: http://www.alanwood.net/pesticides/); these substances are commercially available.
  • the compounds described by IUPAC nomenclature, their preparation and their pesticidal activity are also known (cf. Can. J.
  • the present invention furthermore relates to agrochemical mixtures comprising at least one compound of formula (I) (component 1) and at least one further active substance useful for plant protection.
  • agrochemical mixtures comprising at least one compound of formula (I) (component 1) and at least one further active substance useful for plant protection.
  • an additional effect can be obtained.
  • This can be obtained by applying the compound of formula (I) and at least one further pesticidally active substance simultaneously, either jointly (e. g. as tank-mix) or separately, or in succession, wherein the time interval between the individual applications is selected to ensure that the active substance applied first still occurs at the site of action in a sufficient amount at the time of application of the further pesticidally active substance(s).
  • the order of application is not essential for working of the present invention.
  • the time between both applications may vary e. g. between 2 hours to 7 days. Also a broader range is possible ranging from 0.25 hour to 30 days, preferably from 0.5 hour to 14 days, particularly from 1 hour to 7 days or from 1.5 hours to 5 days, even more preferred from 2 hours to 1 day.
  • the weight ratio of the component 1) and the component 2) generally depends on the properties of the active components used, usually it is in the range of 1:1000 to 1000:1, often in the range of 1:100 to 100:1, regularly in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1, even more preferably in the range of 1:4 to 4:1 and in particular in the range of 1:2 to 2:1.
  • the weight ratio of the component 1) and the component 2) usually is in the range of 1000:1 to 1:1000, often in the range of 100:1 to 1:100, regularly in the range of 50:1 to 1:50, preferably in the range of 20:1 to 1:20, more preferably in the range of 10:1 to 1:10, even more preferably in the range of 4:1 to 1:4 and in particular in the range of 2:1 to 1:2.
  • the ternary mixtures i.e.
  • the weight ratio of component 1) and component 2) depends from the properties of the active substances used, usually it is in the range of 1:100 to 100:1, regularly in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1 and in particular in the range of 1:4 to 4:1, and the weight ratio of component 1) and component 3) usually it is in the range of 1:100 to 100:1, regularly in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1 and in particular in the range of 1:4 to 4:1.
  • any further active components are, if desired, added in a ratio of 20:1 to 1:20 to the component 1. These ratios are also suitable for inventive mixtures applied by seed treatment.
  • individual components of the composition according to the invention such as parts of a kit or parts of a binary or ternary mixture may be mixed by the user himself in a spray tank or any other kind of vessel used for applications (e. g. seed treater drums, seed pelleting machinery, knapsack sprayer) and further auxiliaries may be added, if appropriate.
  • one embodiment of the invention is a kit for preparing a usable pesticidal composition, the kit comprising a) a composition comprising component 1) as defined herein and at least one auxiliary; and b) a composition comprising component 2) as defined herein and at least one auxiliary; and optionally c) a composition comprising at least one auxiliary and optionally a further active component 3) as defined herein.
  • Application of the compound of formula (I), the combination and the composition thereof can be carried out before or during sowing.
  • Methods for applying the compound of formula (I), the combination and the composition thereof, respectively, are application onto plant propagation material, especially seeds, include dressing, coating, pelleting, dusting, and soaking as well as in- furrow application methods.
  • Oomycetes Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes (syn. Fungi imperfecti).
  • Some are systemically effective and they can be used in crop protection as foliar fungicides, fungicides for seed dressing and soil fungicides. Moreover, they are suitable for controlling harmful fungi, which inter alia occur in wood or roots of plants.
  • the compound of formula (I) and the composition according to the invention are particularly important in the control of a multitude of phytopathogenic fungi on various cultivated plants, such as cereals, e. g. wheat, rye, barley, triticale, oats or rice; beet, e. g.
  • the compound of formula (I) and the composition according to the invention are important in the control of phytopathogenic fungi on soybeans and on the plant propagation material, such as seeds, and the crop material of soybeans.
  • the compound of formula (I) and composition thereof, respectively are used for controlling a multitude of fungi on field crops, such as potatoes sugar beets, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybeans, rape, legumes, sunflowers, coffee or sugar cane; fruits; vines; ornamentals; or vegetables, such as cucumbers, tomatoes, beans or squashes.
  • one or more genes have been integrated into the genetic material of a genetically modified plant in order to improve certain properties of the plant.
  • Such genetic modifications also include but are not limited to targeted post-translational modification of protein(s), oligo-or polypeptides e. g. by glycosylation or polymer additions such as prenylated, acetylated or farnesylated moieties or PEG moieties.
  • toxins produced by animals such as scorpion toxins, arachnid toxins, wasp toxins, or other insect-specific neurotoxins
  • toxins produced by fungi such Streptomycetes toxins, plant lectins, such as pea or barley lectins; agglutinins
  • proteinase inhibitors such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin or papain inhibitors
  • ribosome-inactivating proteins (RIP) such as ricin, maize-RIP, abrin, luffin, saporin or bryodin
  • steroid metabolism enzymes such as 3-hydroxysteroid oxidase, ecdysteroid-IDP-glycosyl-transferase, cholesterol oxidases, ecdysone inhibitors or HMG-CoA- reductase
  • ion channel blockers such as blockers of sodium or calcium channels
  • these insecticidal proteins or toxins are to be understood expressly also as pre-toxins, hybrid proteins, truncated or otherwise modified proteins.
  • Hybrid proteins are characterized by a new combination of protein domains, (see, e. g. WO02/015701).
  • Further examples of such toxins or genetically modified plants capable of synthesizing such toxins are disclosed, e. g., in EP374753, WO93/007278, WO95/34656, EP427529, EP451878, WO03/18810 und WO03/52073.
  • the methods for producing such genetically modified plants are generally known to the person skilled in the art and are described, e. g. in the publications mentioned above.
  • plants that contain a modified amount of substances of content or new substances of content, by the use of recombinant DNA techniques, to improve human or animal nutrition e. g. oil crops that produce health-promoting long-chain omega-3 fatty acids or unsaturated omega-9 fatty acids (e. g. Nexera ® rape, DOW Agro Sciences, Canada) are also within the scope of the present invention.
  • Non-limiting examples of pathogens of fungal diseases which can be treated in accordance with the invention include the diseases caused by rust disease pathogens, for example Gymnosporangium species, for example Gymnosporangium sabinae; Hemileia species, for example Hemileia vastatrix; Phakopsora species, for example Phakopsora pachyrhizi or Phakopsora meibomiae; Puccinia species, for example Puccinia recondita, Puccinia graminis oder Puccinia striiformis; Uromyces species, for example Uromyces appendiculatus.
  • rust disease pathogens for example Gymnosporangium species, for example Gymnosporangium sabinae
  • Hemileia species for example Hemileia vastatrix
  • Phakopsora species for example Phakopsora pachyrhizi or Phakopsora meibomiae
  • Cronartium ribicola White pine blister rust
  • Gymnosporangium juniperi-virginianae Cedar-apple rust
  • Hemileia vastatrix Coffee rust
  • Phakopsora meibomiae and P. pachyrhizi Soybean rust
  • Puccinia coronata Crown Rust of Oats and Ryegrass
  • Puccinia graminis Stetem rust of wheat and Kentucky bluegrass, or black rust of cereals
  • Puccinia hemerocallidis Daylily rust
  • Puccinia persistens subsp.
  • phytophthora rot (Phytophthora megasperma), brown stem rot (Phialophora gregata), pythium rot (Pythium aphanidennatum, Pythium irregulare, Pythium debaryanum, Pythium myriotylum, Pythium ultimum), rhizoctonia root rot, stem decay, and damping-off (Rhizoctonia solani), sclerotinia stem decay (Sclerotinia sclerotiorum), sclerotinia southern blight (Sclerotinia rolfsii), thielaviopsis root rot (Thielaviopsis basicola).
  • graminicola Anthracnose stalk rot
  • soft fruits e. g. C. coccodes: black dot
  • beans e. g. C. lindemuthianum
  • soybeans e. g. C. truncatum or C. gloeosporioides
  • Corticium spp. e. g. C. sasakii (sheath blight) on rice
  • Corynespora cassiicola leaf spots
  • Cycloconium spp. e. g. C. oleaginum on olive trees
  • Cylindrocarpon spp. e. g.
  • R. solani root and stem rot
  • S. solani silk and stem rot
  • S. solani silk and stem rot
  • S. solani silk blight
  • R. cerealis Rhizoctonia spring blight
  • Rhizopus stolonifer black mold, soft rot
  • Rhynchosporium secalis scald
  • Sarocladium oryzae and S. attenuatum sheath rot) on rice
  • Sclerotinia spp e. g.
  • R. solani root and stem rot
  • S. solani silk blight
  • R. cerealis Rhizoctonia spring blight
  • Rhizopus stolonifer black mold, soft rot
  • Rhynchosporium secalis scald
  • Sarocladium oryzae and S. attenuatum sheath rot
  • Sclerotinia spp Sclerotinia spp.
  • Example-2 Preparation of 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3- methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate (Compound no.23): To a stirred solution of 3-hydroxy-4-methoxypicolinic acid (0.2 g, 1.2 mmol) in dichloromethane (2 mL), triethylamine (0.8 mL, 5.9 mmol) was added at 25 °C and the resulting reaction mixture was cooled to 0 °C.
  • Example 4 Colletotrichum capsici (anthracnose): Compounds were dissolved in 0.3% dimethyl sulfoxide and then added to potato dextrose agar medium just prior to dispensing it into petri dishes. 5 mL medium with the compound in the desired concentration was dispensed into 60 mm sterile petri-plates. After solidification, each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate. Plates were incubated in growth chambers at 25 °C temperature and 60% relative humidity for seven days and the radial growth was measured and compared to the one of the untreated control.
  • test media-solution 100 ⁇ l of the test media-solution was added to a 96-well microtiter plate, consequently, the same volume (100 ⁇ l) of spore suspension was added to each well providing the final test concentration and the plate was incubated at 22 °C for 15-18 days.
  • the growth inhibition was evaluated by measuring the OD600.

Abstract

The present invention relates to a compound of formula (I), Formula (I) wherein, R1, R1a, R2, W, R3, R4, R5, and Z are as defined in the detailed description and to a process for preparing the compound of formula (I). The present invention also relates to a method for combating phytopathogenic fungi.

Description

TITLE OF THE INVENTION:NOVEL PICOLINAMIDE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI FIELD OF THE INVENTION: The present invention relates to novel picolinamide compounds which are useful in combating phytopathogenic fungi, and a process for preparing these picolinamide compounds. The present invention also relates to a composition, a combination comprising these novel picolinamide compounds and a method for combating phytopathogenic fungi using the same. BACKGROUND OF THE INVENTION: Picolinamide compounds are described as fungicidal agents in WO2016109288, WO2016109289, WO2016109300, WO2016109301, WO2016109302, WO2016109303, WO200114339, and WO2016122802. The picolinamide compounds reported in the above cited literature have disadvantages in certain aspects, such as that they exhibit a narrow spectrum of efficacy or that they do not have satisfactory fungicidal activity, particularly at low application rates. Therefore, the need remains for the development of new fungicidal compounds, including such that are belonging to the class of the above cited picolinamides, so as to provide compounds being effective against a broader spectrum of fungi, having lower toxicity, higher selectivity, being used at lower dosage rate to reduce or avoid unfavorable environmental or toxicological effects whilst still allowing effective and long-lasting control. Therefore, it is an objective of the present invention to provide compounds having an improved/enhanced activity and/or a broader efficacy spectrum against phytopathogenic fungi. This objective is achieved by using a compound of formula (I) of the present invention for combating phytopathogenic fungi. SUMMARY OF THE INVENTION: The present invention relates to a compound of formula (I),
Figure imgf000002_0001
wherein, R1, R1a, R2, W, R3, R4, R5, and Z are as defined in the detailed description. The present invention also relates to a process for preparing the compound of formula (I). The compounds of formula (I) have been found to be advantageous over the compounds reported in the literature in either of improved fungicidal activity, broader spectrum of biological efficacy, lower application rates, more favourable biological, environmental properties or enhanced plant compatibility. The present invention further relates to an agrochemical composition comprising a compound of formula (I) or a compound of formula (I) in combination with a further pesticidally active substance for controlling and/or preventing plant diseases, particularly caused by phytopathogenic fungi. The present invention still further relates to a method for controlling or preventing infestation of useful plants by phytopathogenic microorganisms, wherein a fungicidally effective amount of a compound of formula (I), a composition or a combination thereof, is applied to the plants, to parts thereof or the locus thereof. DETAILED DESCRIPTION OF THE INVENTION: DEFINITIONS: The definitions provided herein for the terminologies used in the present disclosure are for illustrative purpose only and in no manner limit the scope of the present invention disclosed in the present disclosure. As used herein, the terms “comprises”, “comprising”, “includes”, “including”, “has”, “having”, “contains”, “containing”, “characterized by” or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation explicitly indicated. For example, a composition, mixture, process or method that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, mixture, process or method. The transitional phrase “consisting of” excludes any element, step or ingredient not specified. If in the claim, such would close the claim to the inclusion of materials other than those recited except for impurities ordinarily associated therewith. When the phrase “consisting of” appears in a clause of the body of a claim, rather than immediately following the preamble, it limits only the element set forth in that clause; other elements are not excluded from the claim as a whole. The transitional phrase “consisting essentially of” is used to define a composition or method that includes materials, steps, features, components or elements, in addition to those literally disclosed, provided that these additional materials, steps, features, components or elements do not materially affect the basic and novel characteristic(s) of the claimed invention. The term “consisting essentially of” occupies a middle ground between “comprising” and “consisting of”. Further, unless expressly stated to the contrary, “or” refers to an inclusive “or” and not to an exclusive “or”. For example, a condition A “or” B is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present). Also, the indefinite articles “a” and “an” preceding an element or component of the present invention are intended to be nonrestrictive regarding the number of instances (i.e. occurrences) of the element or component. Therefore “a” or “an” should be read to include one or at least one, and the singular word form of the element or component also includes the plural unless the number is obviously meant to be singular. As referred to in this disclosure, the term “invertebrate pest” includes arthropods, gastropods, nematodes, helminths, fungi, bacteria and viruses of economic importance as pests. The term “arthropod” includes insects, mites, spiders, scorpions, centipedes, millipedes, pill bugs and symphylans. The term “gastropod” includes snails, slugs and other Stylommatophora. The term “nematode” refers to a living organism of the Phylum Nematoda. The term “helminths” includes roundworms, heartworms, phytophagous nematodes (Nematoda), flukes (Tematoda), acanthocephala and tapeworms (Cestoda). In the context of this disclosure “invertebrate pest control” means inhibition of invertebrate pest development (including mortality, feeding reduction, and/or mating disruption), and related expressions are defined analogously. The term “agronomic” refers to the production of field crops such as for food, feed and fiber and includes the growth of corn, soybeans and other legumes, rice, cereal (e.g., wheat, oats, barley, rye, rice, maize), leafy vegetables (e.g., lettuce, cabbage, and other cole crops), fruiting vegetables (e.g., tomatoes, pepper, eggplant, crucifers and cucurbits), potatoes, sweet potatoes, grapes, cotton, tree fruits (e.g., pome, stone and citrus), small fruit (berries, cherries) and other specialty crops (e.g., canola, sunflower, olives). The term “nonagronomic” refers to other than field crops, such as horticultural crops (e.g., greenhouse, nursery or ornamental plants not grown in a field), residential, agricultural, commercial and industrial structures, turf (e.g., sod farm, pasture, golf course, lawn, sports field.), wood products, stored product, agro-forestry and vegetation management, public health (i.e. human) and animal health (e.g., domesticated animals such as pets, livestock and poultry, undomesticated animals such as wildlife) applications. Nonagronomic applications include protecting an animal from an invertebrate parasitic pest by administering a parasiticidally effective (i.e. biologically effective) amount of a compound of the present invention, typically in the form of a composition formulated for veterinary use, to the animal to be protected. As referred to in the present disclosure and claims, the terms “parasiticidal” and “parasiticidally” refers to observable effects on an invertebrate parasite pest to provide protection of an animal from the pest. Parasiticidal effects typically relate to diminishing the occurrence or activity of the target invertebrate parasitic pest. Such effects on the pest include necrosis, death, retarded growth, diminished mobility or lessened ability to remain on or in the host animal, reduced feeding and inhibition of reproduction. These effects on invertebrate parasite pests provide control (including prevention, reduction or elimination) of parasitic infestation or infection of the animal. The meaning of various terms used in the description shall now be illustrated. The term “alkyl”, used either alone or in compound words such as “alkylthio” or “haloalkyl” or - N(alkyl) or alkylcarbonylalkyl or alkylsuphonylamino includes straight-chain or branched C1 to C24 alkyl, preferably C1 to C15 alkyl, more preferably C1 to C10 alkyl, most preferably C1 to C6 alkyl. Non- limiting examples of alkyl include methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2- methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2- dimethylpropyl, 1-ethylpropyl, hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2- methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3- dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl and 1-ethyl-2-methylpropyl or the different isomers. If the alkyl is at the end of a composite substituent, as, for example, in alkylcycloalkyl, the part of the composite substituent at the start, for example the cycloalkyl, may be mono- or polysubstituted identically or differently and independently by alkyl. The same also applies to composite substituents in which other radicals, for example alkenyl, alkynyl, hydroxy, halogen, carbonyl, carbonyloxy and the like, are at the end. The term “alkenyl”, used either alone or in compound words includes straight-chain or branched C2 to C24 alkenes, preferably C2 to C15 alkenes, more preferably C2 to C10 alkenes, most preferably C2 to C6 alkenes. Non-limiting examples of alkenes include ethenyl, 1-propenyl, 2-propenyl, 1-methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 1-methyl-2 -propenyl, 2- methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-1-butenyl, 2-methyl-1- butenyl, 3-methyl-1-butenyl, 1-methyl-2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3- butenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-1-propenyl, 1,2-dimethyl-2 -propenyl, 1-ethyl-1-propenyl, 1-ethyl-2-propenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4- hexenyl, 5-hexenyl, 1-methyl-1-pentenyl, 2-methyl-1-pentenyl, 3-methyl-1-pentenyl, 4-methyl-1- pentenyl, 1-methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2-pentenyl, 1- methyl-3-pentenyl, 2-methyl-3-pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl, 1-methyl-4- pentenyl, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-1-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1,3- dimethyl-1-butenyl, 1,3-dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3- dimethyl-1-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 3,3-dimethyl-1-butenyl, 3,3- dimethyl-2-butenyl, 1-ethyl-1-butenyl, 1-ethyl-2-butenyl, 1-ethyl-3-butenyl, 2-ethyl- 1-butenyl, 2- ethyl-2-butenyl, 2-ethyl-3-butenyl, 1,1,2-trimethyl-2-propenyl, 1-ethyl-1-methyl-2-propenyl, 1-ethyl-2- methyl-1-propenyl and 1-ethyl-2-methyl-2-propenyl and the different isomers. “Alkenyl” also includes polyenes such as 1,2-propadienyl and 2,4-hexadienyl. This definition also applies to alkenyl as a part of a composite substituent, for example haloalkenyl and the like, unless defined specifically elsewhere. Non-limiting examples of alkynes include ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3- butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-2-butynyl, 1- methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-1-butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl -2- propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, 1-methyl-3- pentynyl, 1-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-1-pentynyl, 3- methyl-4-pentynyl, 4-methyl-1-pentynyl, 4-methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, 1,1-dimethyl-3- butynyl, 1,2-dimethyl-3-butynyl, 2,2-dimethyl-3-butynyl, 3,3-dimethyl-1-butynyl, 1-ethyl-2-butynyl, 1- ethyl-3-butynyl, 2-ethyl-3-butynyl and 1-ethyl-1-methyl-2-propynyl and the different isomers. This definition also applies to alkynyl as a part of a composite substituent, for example haloalkynyl etc., unless specifically defined elsewhere. The term “alkynyl” can also include moieties comprised of multiple triple bonds such as 2,5-hexadiynyl. The term “cycloalkyl” means alkyl closed to form a ring. Non-limiting examples include cyclopropyl, cyclopentyl and cyclohexyl. This definition also applies to cycloalkyl as a part of a composite substituent, for example cycloalkylalkyl etc., unless specifically defined elsewhere. The term “cycloalkenyl” means alkenyl closed to form a ring including monocyclic, partially unsaturated hydrocarbyl groups. Non-limiting examples include cyclopropenyl, cyclopentenyl and cyclohexenyl. This definition also applies to cycloalkenyl as a part of a composite substituent, for example cycloalkenylalkyl etc., unless specifically defined elsewhere. The term “cycloalkynyl” means alkynyl closed to form a ring including monocyclic, partially unsaturated groups. Non-limiting examples include cyclopropynyl, cyclopentynyl and cyclohexynyl. This definition also applies to cycloalkynyl as a part of a composite substituent, for example cycloalkynylalkyl etc., unless specifically defined elsewhere. The term “cycloalkoxy”, “cycloalkenyloxy” and the like are defined analogously. Non limiting examples of cycloalkoxy include cyclopropyloxy, cyclopentyloxy and cyclohexyloxy. This definition also applies to cycloalkoxy as a part of a composite substituent, for example cycloalkoxy alkyl etc., unless specifically defined elsewhere. The term “halogen”, either alone or in compound words such as “haloalkyl”, includes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as “haloalkyl”, said alkyl may be partially or fully substituted with halogen atoms which may be the same or different. Non- limiting examples of “haloalkyl” include chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1-fluoroethyl, 2- fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, 1,1-dichloro-2,2,2-trifluoroethyl, and 1,1,1-trifluoroprop-2-yl. This definition also applies to haloalkyl as a part of a composite substituent, for example haloalkylaminoalkyl etc., unless specifically defined elsewhere. The terms “haloalkenyl”, “haloalkynyl” are defined analogously except that, instead of alkyl groups, alkenyl and alkynyl groups are present as a part of the substituent. The term “haloalkoxy” means straight-chain or branched alkoxy groups where some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as specified above. Non-limiting examples of haloalkoxy include chloromethoxy, bromomethoxy, dichloromethoxy, trichloromethoxy, fluoromethoxy, difluoromethoxy, trifluoromethoxy, chlorofluoromethoxy, dichlorofluoromethoxy, chlorodifluoromethoxy, 1-chloroethoxy, 1-bromoethoxy, 1-fluoroethoxy, 2-fluoroethoxy, 2,2- difluoroethoxy, 2,2,2-trifluoroethoxy, 2-chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2- dichloro-2-fluoroethoxy, 2,2,2-trichloroethoxy, pentafluoroethoxy and 1,1,l-trifluoroprop-2-oxy. This definition also applies to haloalkoxy as a part of a composite substituent, for example haloalkoxyalkyl etc., unless specifically defined elsewhere. The term “haloalkylthio” means straight-chain or branched alkylthio groups where some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as specified above. Non-limiting examples of haloalkylthio include chloromethylthio, bromomethylthio, dichloromethylthio, trichloromethylthio, fluoromethylthio, difluoromethylthio, trifluoromethylthio, chlorofluoromethylthio, dichlorofluoromethylthio, chlorodifluoromethylthio, 1-chloroethylthio, 1- bromoethylthio, 1- fluoroethylthio, 2-fluoroethylthio, 2,2-difluoroethylthio, 2,2,2-trifluoroethylthio, 2- chloro-2-fluoroethylthio, 2-chloro-2,2-difluoroethylthio, 2,2-dichloro-2-fluoroethylthio, 2,2,2- trichloroethylthio, pentafluoroethylthio and 1,1,l-trifluoroprop-2-ylthio. This definition also applies to haloalkylthio as a part of a composite substituent, for example haloalkylthioalkyl etc., unless specifically defined elsewhere. Non-limiting examples of “haloalkylsulfinyl” include CF3S(O), CCl3S(O), CF3CH2S(O) and CF3CF2S(O). Non-limiting examples of “haloalkylsulfonyl” include CF3S(O)2, CCl3S(O)2, CF3CH2S(O)2 and CF3CF2S(O)2. The term “hydroxy” means –OH, Amino means –NRR, wherein R can be H or any possible substituent such as alkyl. Carbonyl means -C(=O)- , carbonyloxy means -OC(=O)-, sulfinyl means SO, sulfonyl means S(O)2. The term “alkoxy” used either alone or in compound words included C1 to C24 alkoxy, preferably C1 to C15 alkoxy, more preferably C1 to C10 alkoxy, most preferably C1 to C6 alkoxy. Examples of alkoxy include methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy, 1,1- dimethylethoxy, pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 2,2-dimethylpropoxy, 1- ethylpropoxy, hexoxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, 1-methylpentoxy, 2- methylpentoxy, 3-methylpentoxy, 4-methylpentoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3- dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2- ethylbutoxy, 1,1,2-trimethylpropoxy, 1,2,2-trimethylpropoxy, 1-ethyl-1-methylpropoxy and 1-ethyl-2- methylpropoxy and the different isomers. This definition also applies to alkoxy as a part of a composite substituent, for example haloalkoxy, alkynylalkoxy and the like, unless specifically defined elsewhere. The term “alkoxyalkyl” denotes alkoxy substitution on alkyl. Non-limiting examples of “alkoxyalkyl” include CH3OCH2, CH3OCH2CH2, CH3CH2OCH2, CH3CH2CH2CH2OCH2 and CH3CH2OCH2CH2. The term “alkoxyalkoxy” denotes alkoxy substitution on alkoxy. The term “alkylthio” includes branched or straight-chain alkylthio moieties such as methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio, 1,1- dimethylethylthio, pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 2,2- dimethylpropylthio, 1-ethylpropylthio, hexylthio, 1,1-dimethylpropylthio, 1,2-dimethylpropylthio, 1- methylpentylthio, 2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1,1-dimethylbutylthio, 1,2-dimethylbutylthio, 1,3-dimethylbutylthio, 2,2-dimethylbutylthio, 2,3-dimethylbutylthio, 3,3- dimethylbutylthio, 1-ethylbutylthio, 2-ethylbutylthio, 1,1,2-trimethylpropylthio, 1,2,2- trimethylpropylthio, 1-ethyl-1-methylpropylthio and 1-ethyl-2-methylpropylthio and the different isomers. Halocycloalkyl, halocycloalkenyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkoxyalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, haloalkylcarbonyl, cycloalkylcarbonyl, haloalkoxylalkyl, and the like, are defined analogously to the above examples. The term “alkylthioalkyl” denotes alkylthio substitution on alkyl. Non-limiting examples of “alkylthioalkyl” include -CH2SCH2, -CH2SCH2CH2, CH3CH2SCH2, CH3CH2CH2CH2SCH2 and CH3CH2SCH2CH2. “Alkylthioalkoxy” denotes alkylthio substitution on alkoxy. The term “cycloalkylalkylamino” denotes cycloalkyl substitution on alkyl amino. The terms “alkoxyalkoxyalkyl”, “alkylaminoalkyl”, “dialkylaminoalkyl”, “cycloalkylaminoalkyl”, “cycloalkylaminocarbonyl” and the like, are defined analogously to “alkylthioalkyl” or “cycloalkylalkylamino”. The term “alkoxycarbonyl” is an alkoxy group bonded to a skeleton via a carbonyl group (-CO-). This definition also applies to alkoxycarbonyl as a part of a composite substituent, for example cycloalkylalkoxycarbonyl and the like, unless specifically defined elsewhere. The term “alkoxycarbonylalkylamino” denotes alkoxy carbonyl substitution on alkyl amino. “Alkylcarbonylalkylamino” denotes alkyl carbonyl substitution on alkyl amino. The terms alkylthioalkoxycarbonyl, cycloalkylalkylaminoalkyl and the like are defined analogously. Non-limiting examples of “alkylsulfinyl” include methylsulphinyl, ethylsulphinyl, propylsulphinyl, 1- methylethylsulphinyl, butylsulphinyl, 1-methylpropylsulphinyl, 2-methylpropylsulphinyl, 1,1- dimethylethylsulphinyl, pentylsulphinyl, 1-methylbutylsulphinyl, 2-methylbutylsulphinyl, 3- methylbutylsulphinyl, 2,2-dimethylpropylsulphinyl, 1-ethylpropylsulphinyl, hexylsulphinyl, 1,1- dimethylpropylsulphinyl, 1,2-dimethylpropylsulphinyl, 1-methylpentylsulphinyl, 2- methylpentylsulphinyl, 3-methylpentylsulphinyl, 4-methylpentylsulphinyl, 1,1- dimethylbutylsulphinyl, 1,2-dimethylbutylsulphinyl, 1,3-dimethylbutylsulphinyl, 2,2- dimethylbutylsulphinyl, 2,3-dimethylbutylsulphinyl, 3,3-dimethylbutylsulphinyl, 1- ethylbutylsulphinyl, 2-ethylbutylsulphinyl, 1,1,2-trimethylpropylsulphinyl, 1,2,2- trimethylpropylsulphinyl, 1-ethyl-1-methylpropylsulphinyl and 1-ethyl-2-methylpropylsulphinyl and the different isomers. The term “arylsulfinyl” includes Ar-S(O), wherein Ar can be any carbocyle or heterocylcle. This definition also applies to alkylsulphinyl as a part of a composite substituent, for example haloalkylsulphinyl etc., unless specifically defined elsewhere. Non-limiting examples of “alkylsulfonyl” include methylsulphonyl, ethylsulphonyl, propylsulphonyl, 1-methylethylsulphonyl, butylsulphonyl, 1-methylpropylsulphonyl, 2-methylpropylsulphonyl, 1,1- dimethylethylsulphonyl, pentylsulphonyl, 1-methylbutylsulphonyl, 2-methylbutylsulphonyl, 3- methylbutylsulphonyl, 2,2-dimethylpropylsulphonyl, 1-ethylpropylsulphonyl, hexylsulphonyl, 1,1- dimethylpropylsulphonyl, 1,2-dimethylpropylsulphonyl, 1-methylpentylsulphonyl, 2- methylpentylsulphonyl, 3-methylpentylsulphonyl, 4-methylpentylsulphonyl, 1,1- dimethylbutylsulphonyl, 1,2-dimethylbutylsulphonyl, 1,3-dimethylbutylsulphonyl, 2,2- dimethylbutylsulphonyl, 2,3-dimethylbutylsulphonyl, 3,3-dimethylbutylsulphonyl, 1- ethylbutylsulphonyl, 2-ethylbutylsulphonyl, 1,1,2-trimethylpropylsulphonyl, 1,2,2- trimethylpropylsulphonyl, 1-ethyl-1-methylpropylsulphonyl and 1-ethyl-2-methylpropylsulphonyl and the different isomers. The term “arylsulfonyl” includes Ar-S(O)2, wherein Ar can be any carbocyle or heterocylcle. This definition also applies to alkylsulphonyl as a part of a composite substituent, for example alkylsulphonylalkyl etc., unless defined elsewhere. “Alkylamino”, “dialkylamino”, and the like, are defined analogously to the above examples. The term “carbocycle or carbocyclic” includes “aromatic carbocyclic ring system” and “non-aromatic carbocylic ring system” or polycyclic or bicyclic (spiro, fused, bridged, nonfused) ring compounds in which ring may be aromatic or non-aromatic (where aromatic indicates that the Huckel rule is satisfied and non-aromatic indicates that the Huckel rule is not statisfied). The term “heterocycle or heterocyclic” includes “aromatic heterocycle or heteroaryl ring system” and “non-aromatic heterocycle ring system” or polycyclic or bicyclic (spiro, fused, bridged, nonfused) ring compounds in which ring may be aromatic or non-aromatic, wherein the heterocycle ring contains at least one heteroatom selected from N, O, S(O)0-2, and or C ring member of the heterocycle may be replaced by C(=O), C(=S), C(=CR*R*) and C=NR*, * indicates integers. The term “non-aromatic heterocycle” or “non-aromatic heterocyclic” means three- to fifteen- membered, preferably three- to twelve- membered, saturated or partially unsaturated heterocycle containing one to four heteroatoms from the group of oxygen, nitrogen and sulphur: mono, bi- or tricyclic heterocycles which contain, in addition to carbon ring members, one to three nitrogen atoms and/or one oxygen or sulphur atom or one or two oxygen and/or sulphur atoms; if the ring contains more than one oxygen atom, they are not directly adjacent; non-limiting examples thietanyl, oxetanyl, oxiranyl, azetidinyl, aziridinyl, 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydrothienyl, 3- tetrahydrothienyl, 1-pyrrolidinyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 3-isoxazolidinyl, 4-isoxazolidinyl, 5- isoxazolidinyl, 3-isothiazolidinyl, 4-isothiazolidinyl, 5-isothiazolidinyl, 1-pyrazolidinyl, 3- pyrazolidinyl, 4-pyrazolidinyl, 5-pyrazolidinyl, 2-oxazolidinyl, 4-oxazolidinyl, 5-oxazolidinyl, 2- thiazolidinyl, 4-thiazolidinyl, 5-thiazolidinyl, 1-imidazolidinyl, 2-imidazolidinyl, 4-imidazolidinyl, 1,2,4-oxadiazolidin-3-yl, 1,2,4-oxadiazolidin-5-yl, 1,2,4-thiadiazolidin-3-yl, 1,2,4-thiadiazolidin-5-yl, 1,2,4-triazolidin-1-yl, 1,2,4-triazolidin-3-yl, 1,3,4-oxadiazolidin-2-yl, 1,3,4-thiadiazolidin-2-yl, 1,3,4- triazolidin-1-yl, 1,3,4-triazolidin-2-yl, 2,3-dihydrofur-2-yl, 2,3-dihydrofur-3-yl, 2,4-dihydrofur-2-yl, 2,4-dihydrofur-3-yl, 2,3-dihydrothien-2-yl, 2,3-dihydrothien-3-yl, 2,4-dihydrothien-2-yl, 2,4- dihydrothien-3-yl, pyrrolinyl, 2-pyrrolin-2-yl, 2-pyrrolin-3-yl, 3-pyrrolin-2-yl, 3-pyrrolin-3-yl, 2- isoxazolin-3-yl, 3-isoxazolin-3-yl, 4-isoxazolin-3-yl, 2-isoxazolin-4-yl, 3-isoxazolin-4-yl, 4- isoxazolin-4-yl, 2-isoxazolin-5-yl, 3-isoxazolin-5-yl, 4-isoxazolin-5-yl, 2-isothiazolin-3-yl, 3- isothiazolin-3-yl, 4-isothiazolin-3-yl, 2-isothiazolin-4-yl, 3-isothiazolin-4-yl, 4-isothiazolin-4-yl, 2- isothiazolin-5-yl, 3-isothiazolin-5-yl, 4-isothiazolin-5-yl, 2,3-dihydropyrazol-1-yl, 2,3-dihydropyrazol- 2-yl, 2,3-dihydropyrazol-3-yl, 2,3-dihydropyrazol-4-yl, 2,3-dihydropyrazol-5-yl, 3,4-dihydropyrazol- l-yl, 3,4-dihydropyrazol-3-yl, 3,4-dihydropyrazol-4-yl, 3,4-dihydropyrazol-5-yl, 4,5-dihydropyrazol-1- yl, 4,5-dihydropyrazol-3-yl, 4,5-dihydropyrazol-4-yl, 4,5-dihydropyrazol-5-yl, 2,3-dihydrooxazol-2- yl, 2,3-dihydrooxazol-3-yl, 2,3-dihydrooxazol-4-yl, 2,3-dihydrooxazol-5-yl, 3,4-dihydrooxazol-2-yl, 3,4-dihydrooxazol-3-yl, 3,4-dihydrooxazol-4-yl, 3,4-dihydrooxazol-5-yl, 3,4-dihydrooxazol-2-yl, 3,4- dihydrooxazol-3-yl, 3,4-dihydrooxazol-4-yl, piperidinyl, 2-piperidinyl, 3-piperidinyl, 4-piperidinyl, pyrazynyl, morpholinyl, thiomorphlinyl, 1,3-dioxan-5-yl, 2-tetrahydropyranyl, 4-tetrahydropyranyl, 2- tetrahydrothienyl, 3-hexahydropyridazinyl, 4-hexahydropyridazinyl, 2-hexahydropyrimidinyl, 4- hexahydropyrimidinyl, 5-hexahydropyrimidinyl, 2-piperazinyl, 1,3,5-hexahydrotriazin-2-yl, 1,2,4- hexahydrotriazin-3-yl, cycloserines, 2,3,4,5-tetrahydro[1H]azepin-1- or -2- or -3- or -4- or -5- or -6- or -7- yl, 3,4,5,6-tetra-hydro[2H]azepin-2- or -3- or -4- or -5- or -6- or-7-yl, 2,3,4,7- tetrahydro[1H]azepin-1- or -2- or -3- or -4- or -5- or -6- or-7- yl, 2,3,6,7-tetrahydro[1H]azepin-1- or - 2- or -3- or -4- or -5- or -6- or -7- yl, hexahydroazepin-1- or -2- or -3- or -4- yl, tetra- and hexahydrooxepinyl such as 2,3,4,5-tetrahydro[1 H]oxepin-2- or -3- or -4- or -5- or -6- or -7- yl, 2,3,4,7-tetrahydro[1H]oxepin-2- or -3- or -4- or -5- or -6- or -7- yl, 2,3,6,7-tetrahydro[1H]oxepin-2- or -3- or -4- or -5- or -6- or -7- yl, hexahydroazepin-1- or -2- or -3- or -4- yl, tetra- and hexahydro-1,3- diazepinyl, tetra- and hexahydro-1,4-diazepinyl, tetra- and hexahydro-1,3-oxazepinyl, tetra- and hexahydro-1,4-oxazepinyl, tetra- and hexahydro-1,3-dioxepinyl, tetra- and hexahydro-1,4-dioxepinyl. This definition also applies to heterocyclyl as a part of a composite substituent, for example heterocyclylalkyl etc., unless specifically defined elsewhere. The term “heteroaryl” or “aromatic heterocyclic” means 5 or 6-membered, fully unsaturated monocyclic ring system containing one to four heteroatoms from the group of oxygen, nitrogen and sulphur; if the ring contains more than one oxygen atom, they are not directly adjacent; 5-membered heteroaryl containing one to four nitrogen atoms or one to three nitrogen atoms and one sulphur or oxygen atom; 5-membered heteroaryl groups which, in addition to carbon atoms, may contain one to four nitrogen atoms or one to three nitrogen atoms and one sulphur or oxygen atom as ring members, non-limiting examples furyl, thienyl, pyrrolyl, isoxazolyl, isothiazolyl, pyrazolyl, oxazolyl, thiazolyl, imidazolyl, 1,2,4-oxadiazolyl, 1,2,4-thiadiazolyl, 1,2,4-triazolyl, 1,3,4-oxadiazolyl, 1,3,4-thiadiazolyl, 1,3,4-triazolyl, tetrazolyl; nitrogen-bonded 5-membered heteroaryl containing one to four nitrogen atoms, or benzofused nitrogen-bonded 5-membered heteroaryl containing one to three nitrogen atoms: 5-membered heteroaryl groups which, in addition to carbon atoms, may contain one to four nitrogen atoms or one to three nitrogen atoms as ring members and in which two adjacent carbon ring members or one nitrogen and one adjacent carbon ring member may be bridged by a buta-1,3-diene-l,4-diyl group in which one or two carbon atoms may be replaced by nitrogen atoms, where these rings are attached to the skeleton via one of the nitrogen ring members, non-limiting examples 1-pyrrolyl, 1- pyrazolyl, 1,2,4-triazol-1- yl, 1-imidazolyl, 1,2,3-triazol-1-yl and 1,3,4-triazol-1-yl. 6-membered heteroaryl which contains one to four nitrogen atoms: 6-membered heteroaryl groups which, in addition to carbon atoms, may contain, respectively, one to three and one to four nitrogen atoms as ring members, non-limiting examples 2-pyridinyl, 3-pyridinyl, 4-pyridinyl, 3-pyridazinyl, 4- pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl, 5-pyrimidinyl, 2-pyrazinyl, 1,3,5-triazin-2-yl, 1,2,4-triazin- 3-yl and 1,2,4,5-tetrazin-3-yl; benzofused 5-membered heteroaryl containing one to three nitrogen atoms or one nitrogen atom and one oxygen or sulphur atom: non-limiting examples indol-1-yl, indol- 2-yl, indol-3-yl, indol-4-yl, indol-5-yl, indol-6-yl, indol-7-yl, benzimidazol-1-yl, benzimidazol-2-yl, benzimidazol-4-yl, benzimidazol-5-yl, indazol-1-yl, indazol-3-yl, indazol-4-yl, indazol-5-yl, indazol- 6-yl, indazol-7-yl, indazol-2-yl, 1-benzofuran-2-yl, 1-benzofuran-3-yl, 1-benzofuran-4-yl, 1-benzofuran- 5-yl, 1-benzofuran- 6-yl, 1- benzofuran-7-yl, 1- benzothiophen-2-yl, 1- benzothiophen-3-yl, 1- benzothiophen-4-yl, 1- benzothiophen-5-yl, 1- benzothiophen-6-yl, 1- benzothiophen-7-yl, 1,3- benzothiazol-2-yl, 1,3- benzothiazol-4-yl, 1,3-benzothiazol-5-yl, 1,3-benzothiazol-6-yl, 1,3- benzothiazol-7-yl, 1,3-benzoxazol-2-yl, 1,3-benzoxazol-4-yl, 1,3-benzoxazol-5-yl, 1,3-benzoxazol-6-yl and 1,3-benzoxazol-7-yl; benzofused 6-membered heteroaryl which contains one to three nitrogen atoms: non-limiting examples quinolin-2-yl, quinolin-3-yl, quinolin-4-yl, quinolin-5-yl, quinolin-6-yl, quinolin-7-yl, quinolin-8-yl, isoquinolin-1-yl, isoquinolin-3-yl, isoquinolin-4-yl, isoquinolin-5-yl, isoquinolin-6-yl, isoquinolin-7-yl and isoquinolin-8-yl. The term “trialkylsilyl” includes 3 branched and/or straight-chain alkyl radicals attached to and linked through a silicon atom such as trimethylsilyl, triethylsilyl and t-butyl-dimethylsilyl. “Halotrialkylsilyl” denotes at least one of the three alkyl radicals is partially or fully substituted with halogen atoms which may be the same or different. The term”alkoxytrialkylsilyl” denotes at least one of the three alkyl radicals is substituted with one or more alkoxy radicals which may be the same or different. The term “trialkylsilyloxy” denotes a trialkylsilyl moiety attached through oxygen. Non-limiting examples of “alkylcarbonyl” include C(=O)CH3, C(=O)CH2CH2CH3 and C(=O)CH(CH3)2. Non-limiting examples of “alkoxycarbonyl” include CH3OC(=O), CH3CH2OC(=O), CH3CH2CH2OC(=O), (CH3)2CHOC(=O) and the different butoxy -or pentoxycarbonyl isomers. Non- limiting examples of “alkylaminocarbonyl” include CH3NHC(=O), CH3CH2NHC(=O), CH3CH2CH2NHC(=O), (CH3)2CHNHC(=O) and the different butylamino -or pentylaminocarbonyl isomers. Non-limiting examples of “dialkylaminocarbonyl” include (CH3)2NC(=O), (CH3CH2)2NC(=O), CH3CH2(CH3)NC(=O), CH3CH2CH2(CH3)NC(=O) and (CH3)2CHN(CH3)C(=O). Non-limiting examples of “alkoxyalkylcarbonyl” include CH3OCH2C(=O), CH3OCH2CH2C(=O), CH3CH2OCH2C(=O), CH3CH2CH2CH2OCH2C(=O) and CH3CH2OCH2CH2C(=O). Non-limiting examples of “alkylthioalkylcarbonyl” include CH3SCH2C(=O), CH3SCH2CH2C(=O), CH3CH2SCH2C(=O), CH3CH2CH2CH2SCH2C(=O) and CH3CH2SCH2CH2C(=O). The term haloalkylsulfonylaminocarbonyl, alkylsulfonylaminocarbonyl, alkylthioalkoxycarbonyl, alkoxycarbonylalkyl amino and the like are defined analogously Non-limiting examples of “alkylaminoalkylcarbonyl” include CH3NHCH2C(=O), CH3NHCH2CH2C(=O), CH3CH2NHCH2C(=O), CH3CH2CH2CH2NHCH2C(=O) and CH3CH2NHCH2CH2C(=O). The term “amide” means A-R'C=ONR''-B, wherein R' and R'' indicates substituents and A and B indicate any group. The term “thioamide” means A-R'C=SNR''-B, wherein R' and R'' indicates substituents and A and B indicate any group. The total number of carbon atoms in a substituent group is indicated by the “Ci-Cj” prefix where i and j are numbers from 1 to 21. For example, C1-C3 alkylsulfonyl designates methylsulfonyl through propylsulfonyl; C2 alkoxyalkyl designates CH3OCH2; C3 alkoxyalkyl designates, for example, CH3CH(OCH3), CH3OCH2CH2 or CH3CH2OCH2; and C4 alkoxyalkyl designates the various isomers of an alkyl group substituted with an alkoxy group containing a total of four carbon atoms, examples including CH3CH2CH2OCH2 and CH3CH2OCH2CH2. In the above recitations, when a compound of Formula (I) is comprised of one or more heterocyclic rings, all substituents are attached to these rings through any available carbon or nitrogen by replacement of a hydrogen on said carbon or nitrogen. When a compound is substituted with a substituent bearing a subscript that indicates the number of said substituents can exceed 1, said substituents (when they exceed 1) are independently selected from the group of defined substituents. Further, when the subscript m in (R)m indicates an integer ranging from for example 0 to 4 then the number of substituents may be selected from the integers between 0 and 4 inclusive. When a group contains a substituent which can be hydrogen, then, when this substituent is taken as hydrogen, it is recognized that said group is being un-substituted. Optionally substituted groups may be mono- or polysubstituted, where the substituents in the case of polysubstitutions may be the same or different. The embodiments herein and the various features and advantageous details thereof are explained with reference to the non-limiting embodiments in the description. Descriptions of well-known components and processing techniques are omitted so as to not unnecessarily obscure the embodiments herein. The examples used herein are intended merely to facilitate an understanding of ways in which the embodiments herein may be practiced and to further enable those of skilled in the art to practice the embodiments herein. Accordingly, the examples should not be construed as limiting the scope of the embodiments herein. The description of the specific embodiments will so fully reveal the general nature of the embodiments herein that others can, by applying current knowledge, readily modify and/or adapt for various applications such specific embodiments without departing from the generic concept, and, therefore, such adaptations and modifications should and are intended to be comprehended within the meaning and range of equivalents of the disclosed embodiments. It is to be understood that the phraseology or terminology employed herein is for the purpose of description and not of limitation. Therefore, while the embodiments herein have been described in terms of preferred embodiments, those skilled in the art will recognize that the embodiments herein can be practiced with modification within the spirit and scope of the embodiments as described herein. Any discussion of documents, acts, materials, devices, articles and the like that has been included in this specification is solely for the purpose of providing a context for the disclosure. It is not to be taken as an admission that any or all of these matters form a part of the prior art base or were common general knowledge in the field relevant to the disclosure as it existed anywhere before the priority date of this application. The numerical values mentioned in the description and the description/claims though might form a critical part of the present invention of the present invention, any deviation from such numerical values shall still fall within the scope of the present invention if that deviation follows the same scientific principle as that of the present invention disclosed in the present invention. The inventive compound of the present invention may, if appropriate, be present as mixtures of different possible isomeric forms, especially of stereoisomers, for example E and Z, threo and erythro, and also optical isomers, but if appropriate also of tautomers. Both the E and the Z isomers, and also the threo and erythro isomers, and the optical isomers, any desired mixtures of these isomers and the possible tautomeric forms are disclosed and claimed. The term "polymorph" refers to a particular crystalline form of a chemical compound that can crystallize in different crystalline forms, these forms having different arrangements and/or conformations of the molecules in the crystal lattice. Although polymorphs can have the same chemical composition, they can also differ in composition due to the presence or absence of co- crystallized water or other molecules, which can be weakly or strongly bound in the lattice. Polymorphs can differ in such chemical, physical and biological properties as crystal shape, density, hardness, color, chemical stability, melting point, hygroscopicity, suspensibility, dissolution rate and biological availability. One skilled in the art will appreciate that a polymorph of a compound represented by formula (I) can exhibit beneficial effects (e.g., suitability for preparation of useful formulations, improved biological performance) relative to another polymorph or a mixture of polymorphs of the same compound represented by formula (I). The preparation and isolation of a particular polymorph of a compound represented by formula (I) can be achieved by methods known to those skilled in the art including, for example, crystallization using selected solvents and temperatures. The term “pest” for the purpose of the present disclosure includes but is not limited to fungi, stramenopiles (oomycetes), bacteria, nematodes, mites, ticks, insects and rodents. The term “plant” is understood here to mean all plants and plant populations, such as desired and undesired wild plants or crop plants (including naturally occurring crop plants). Crop plants may be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including the transgenic plants and including the plant cultivars which are protectable and non-protectable by plant breeders’ rights. For the purpose of the present disclosure the term “plant” includes a living organism of the kind exemplified by trees, shrubs, herbs, grasses, ferns, and mosses, typically growing in a site, absorbing water and required substances through its roots, and synthesizing nutrients in its leaves by photosynthesis. Examples of “plant” for the purpose of the present invention include but are not limited to agricultural crops such as wheat, rye, barley, triticale, oats or rice; beet, e.g. sugar beet or fodder beet; fruits and fruit trees, such as pomes, stone fruits or soft fruits, e.g. apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, blackberries or gooseberries; leguminous plants, such as lentils, peas, alfalfa or soybeans; oil plants, such as rape, mustard, olives, sunflowers, coconut, cocoa beans, castor oil plants, oil palms, ground nuts or soybeans; cucurbits, such as squashes, cucumber or melons; fiber plants, such as cotton, flax, hemp or jute; citrus fruit and citrus trees, such as oranges, lemons, grapefruits or mandarins; any horticultural plants, vegetables, such as spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, cucurbits or paprika; lauraceous plants, such as avocados, cinnamon or camphor; cucurbitaceae; oleaginous plants; energy and raw material plants, such as cereals, corn, soybean, other leguminous plants, rape, sugar cane or oil palm; tobacco; nuts; coffee; tea; cacao; bananas; peppers; vines (table grapes and grape juice grape vines); hop; turf; sweet leaf (also called Stevia); natural rubber plants or ornamental and forestry plants, such as flowers, shrubs, broad-leaved trees or evergreens, e.g. conifers; and on the plant propagation material, such as seeds, and the crop material of these plants. Preferably, the plant for the purpose of the present invention includes but is not limited to cereals, corn, rice, soybean and other leguminous plants, fruits and fruit trees, grapes, nuts and nut trees, citrus and citrus trees, any horticultural plants, cucurbitaceae, oleaginous plants, tobacco, coffee, tea, cacao, sugar beet, sugar cane, cotton, potato, tomato, onions, peppers and vegetables, ornamentals, any floricultural plants and other plants for use of human and animals. The term “plant parts” is understood to mean all parts and organs of plants above and below the ground. For the purpose of the present disclosure the term plant parts includes but is not limited to cuttings, leaves, twigs, tubers, flowers, seeds, branches, roots including taproots, lateral roots, root hairs, root apex, root cap, rhizomes, slips, shoots, fruits, fruit bodies, bark, stem, buds, auxillary buds, meristems, nodes and internodes. The term “locus thereof” includes soil, surroundings of plant or plant parts and equipment or tools used before, during or after sowing/planting a plant or a plant part. Application of the compounds of the present disclosure or the compound of the present disclosure in a composition optionally comprising other compatible compounds to a plant or a plant material or locus thereof include application by a technique known to a person skilled in the art which include but is not limited to spraying, coating, dipping, fumigating, impregnating, injecting and dusting. The term “applied” means adhered to a plant or plant part either physically or chemically including impregnation. Accordingly, the present invention provides a novel compound of formula (I),
Figure imgf000016_0001
wherein, R1 is selected from the group consisting of hydroxy, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6- cycloalkyl, C1-C6-alkoxy, C3-C6-cycloalkyloxy, C1-C6-alkylthio, C1-C6-cycloalkylthio, -NHR13 and - N(R13)2; R1a is selected from the group consisting of hydroxy, halogen, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6- haloalkyl and C1-C6-alkoxy; R2 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6 haloalkyl, C1-C6-alkoxy-C1- C6-alkyl, -SOn-C1-C6-alkyl, -C(O)-R13, -C(O)-OR13, –(CH2)m-O-C(O)-R13, -C(O)-N(R13)2 and - (CH2)m-O-C(O)-N(R13)2; R3 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1- C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl, -(CH2)m-OR13, –(CH2)m- C(O)-R13, -(CH2)m-C(O)-OR13, -(CH2)m-C(O)-N(R13)2, -(CH2)m-O-C(O)-OR13, -(CH2)m-O-C(O)- N(R13)2 and –(CH2)m-C(O)-C1-C6-alkoxy ; or R2 and R3 together with the atoms to which they are attached may form a six membered heterocyclic ring; and one or more C atom/s of the ring may be optionally replaced by C(=O), C(=S), C=NR2a or CR2aN(R2a)2; wherein the heterocyclic ring may be optionally substituted with one or more identical or different groups of R2a; or R3 and R4 together with the atoms to which they are attached may form a 5 to 6 membered non- aromatic heterocyclic ring; wherein further heteroatom of said ring is selected from N, O or S(=O)0-2 and one or more C atom/s of the ring may be optionally replaced by C(=O) or C(=S); the ring may be optionally substituted with one or more identical or different groups of R3a; R2a is selected from the group consisting of halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6- alkoxy, C3-C8-cycloalkyl and C1-C4-alkoxy-C1-C4-alkyl; R3a is selected from the group consisting of halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6- alkoxy, C3-C8-cycloalkyl and C1-C4-alkoxy-C1-C4-alkyl; W represents O or S; R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C2- C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6- cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl; each group of R4 and R5 may be optionally substituted by one or more groups selected from R4a; or R4 and R5 together with the atoms to which they are attached may form a 3 to 6 membered non- aromatic carbocyclic ring, or non-aromatic heterocyclic ring; wherein one or more heteroatoms of said ring are selected from N, O or S(=O)0-2 and one or more C atom/s of the ring may be optionally replaced by C(=O), C(=S) or C(=NR13); the ring may be optionally substituted with one or more identical or different groups of R4a; R4a is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1- C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6- haloalkylthio, C3-C8-cycloalkyl and C1-C4-alkoxy-C1-C4-alkyl; Z is selected from Z1 to Z5;
Figure imgf000017_0001
* represents point of attachment; R6 and R6a are independently selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6- haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl, - C(O)-R13, –(CH2)m-C(O)-R13 and –(CH2)m-C(O)-C1-C6-alkoxy; R7 is selected from the group consisting of hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1- C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6 cycloalkyl-C1-C6 alkyl, C1-C6-alkoxycarbonyl, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl; each group of R7 may be optionally substituted by one or more groups selected from halogen, cyano, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6- haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C3-C8-cycloalkyl and C1-C4-alkoxy-C1-C4-alkyl; R7a is selected from the group consisting of hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6 cycloalkyl- C1-C6-alkyl; or R7 and R7a together with the atoms to which they are attached may form a 3- to 6- membered non- aromatic carbocyclic ring or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2 and one or more C atom/s of the ring may be optionally replaced by C(=O), C(=S) or C(=NR13); the ring may be optionally substituted with one or more identical or different groups of R7b; R7b is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1- C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C4-alkoxy-C1-C4-alkyl, C1-C6-haloalkoxy, C1-C6- alkylthio, C1-C6-haloalkylthio, C3-C8-cycloalkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10- heterocyclyl; R8, R8a, R9 and R9a are independently selected from the group consisting of hydrogen, hydroxy, halogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6 alkoxy-C1- C6-alkyl, C3-C6-cycloalkyl, C3-C6 cycloalkyl-C1-C6-alkyl, C6-C10-aryl, C7-C14-aralkyl, C6-C10-aryloxy, C6-C10-arylthio, C6-C10-aryl-C1-C6-alkoxy, C3-C10-heterocyclyl and C3-C10-heterocyclyloxy; each group of R8, R8a, R9 and R9a may be optionally substituted by one or more groups selected from R10; or R8 and R9 together with the atoms to which they are attached may form a 3- to 10- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2 and one or more C atom/s of the ring may be optionally replaced by C(=O), C(=S) or C(=NR13); the ring may be optionally substituted with one or more identical or different groups of R11; provided that when R8 and R9 forms an aromatic ring then R12 is absent; or R7 and R9 together with the atoms to which they are attached may form a 3- to 10- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2 and one or more C atom/s of the ring may be optionally replaced by C(=O), C(=S) or C(=NR13); the ring may be optionally substituted with one or more identical or different groups of R11; R10 is selected from the group consisting of cyano, halogen, nitro, hydroxyl, thiol, amino, C1- C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6 alkoxy-C1-C6- alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl, phenyl, benzyl, phenylthio, phenyl-C1- C6-alkoxy, C3-C10-heterocyclyl and C3-C10-heterocyclyloxy; R11 is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1- C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C4-alkoxy-C1-C4-alkyl, C1-C6-haloalkoxy, C1-C6- alkylthio, C1-C6-haloalkylthio, C3-C8-cycloalkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10- heterocyclyl; R12 is selected from the group of hydrogen, halogen, hydroxy, C1-C6-alkyl, C1-C4-alkoxy, C1-C6- haloalkyl and C1-C4-haloalkoxy; R13 is selected from the group consisting of hydrogen, formyl, C1-C4-alkyl, C2-C4-alkenyl, C2-C4- alkynyl, C1-C4-haloalkyl, C3-C5-cycloalkyl, C3-C5-cycloalkyl-C1-C3-alkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl; each group of R1 to R13 and R1a, R2a, R3a, R4a, R5a, R6a, R7a, R7b, R8a, R9a may be optionally substituted by one or more groups selected from the group consisting of halogen, cyano, nitro, R’, OR’, SR’, N(R’)2, COR’ and CON(R’)2; R’ are independently selected from the group consisting of hydrogen, halogen, cyano, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl, C2-C4-haloalkenyl, C2-C4-haloalkynyl, C1-C4- alkoxy, C1-C4-haloalkoxy, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C6-C10-aryl-C1-C4-alkoxy, C6- C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl; n is an integer selected from 0 to 2 and m is an integer selected from 0 to 3; and/or N-oxides, metal complexes, isomers, polymorphs or the agriculturally acceptable salts thereof; provided that the following compounds are excluded from the definition of Formula (I), 2-(((2S)-1-((1-(4-cyclohexylphenyl)ethyl)(methyl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate; N-((2S)-1-((1-(4-cyclohexylphenyl)ethyl)(methyl)amino)-1-oxopropan- 2-yl)-3-hydroxy-4-methoxypicolinamide; (S)-N-(1-(benzylamino)-1-oxo-3-phenylpropan-2-yl)-3,4- dihydroxypicolinamide; (S)-3,4-dihydroxy-N-(1-(isobutylamino)-1-oxo-3-phenylpropan-2- yl)picolinamide; (S)-N-(1-(benzylamino)-1-oxopropan-2-yl)-3,4-dihydroxypicolinamide; N-(2- (benzylamino)-2-oxoethyl)-3,4-dihydroxypicolinamide; (S)-3,4-dihydroxy-N-(1-(isobutylamino)-1- oxopropan-2-yl)picolinamide; 3,4-dihydroxy-N-(2-(isobutylamino)-2-oxoethyl)picolinamide; (S)-N- (1-(benzylamino)-1-oxo-3-phenylpropan-2-yl)-3,4-dihydroxypicolinamide hydrochloride; (S)-3,4- dihydroxy-N-(1-(isobutylamino)-1-oxo-3-phenylpropan-2-yl)picolinamide hydrochloride; (S)-N-(1- (benzylamino)-1-oxopropan-2-yl)-3,4-dihydroxypicolinamide hydrochloride; N-(2-(benzylamino)-2- oxoethyl)-3,4-dihydroxypicolinamide hydrochloride; (S)-3,4-dihydroxy-N-(1-(isobutylamino)-1- oxopropan-2-yl)picolinamide hydrochloride and 3,4-dihydroxy-N-(2-(isobutylamino)-2- oxoethyl)picolinamide hydrochloride. In one embodiment, the compound of formula (I) is represented by compound of formula (IA);
Figure imgf000020_0001
In one embodiment, the compound of formula (I) is represented by compound of formula (IB);
Figure imgf000020_0002
In one embodiment, the compound of formula (I) is represented by compound of formula (IC);
Figure imgf000020_0003
In one embodiment, the compound of formula (I) is represented by compound of formula (ID);
Figure imgf000020_0004
In a preferred embodiment, the present invention provides a compound of formula (I), wherein R1 is selected from the group consisting of hydroxy, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6- cycloalkyl, C3-C6-cycloalkyloxy and C1-C6-alkoxy; R2 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6 haloalkyl, C1-C6-alkoxy-C1- C6-alkyl, -C(O)-R13, -C(O)-OR13, –(CH2)m-O-C(O)-R13 and -C(O)-N(R13)2; R3 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1- C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl, -(CH2)m-OR13, -(CH2)m- C(O)-OR13 and –(CH2)m-C(O)-R13; R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C2- C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6- cycloalkyl, C3-C6 -cycloalkyl-C1-C6-alkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl; each group of R4 and R5 may be optionally substituted by one or more groups selected from R4a; or R4 and R5 together with the atoms to which they are attached may form a 3 to 6 membered non- aromatic carbocyclic ring, or non-aromatic heterocyclic ring; wherein one or more heteroatoms of said ring are selected from N, O or S(=O)0-2; the ring may be optionally substituted with one or more identical or different groups of R4a; R4a is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio and C3-C8- cycloalkyl; R6 and R6a are independently selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6- haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6-cycloalkyl-C1-C6- alkyl; R7 is selected from the group consisting of hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1- C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6 cycloalkyl-C1-C6 alkyl, C1-C6-alkoxycarbonyl, C1-C6-alkylsulfinyl and C1-C6-alkylsulfonyl; each group of R7 may be optionally substituted by one or more groups selected from halogen, cyano, nitro, hydroxyl, thiol and amino; R7a is selected from the group consisting of hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6 cycloalkyl-C1-C6-alkyl; or R7 and R9 together with the atoms to which they are attached may form a 3- to 10- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2 and one or more C atom/s of the ring may be optionally replaced by C(=O), C(=S) or C(=NR13); the ring may be optionally substituted with one or more identical or different groups of R11; R8, R8a, R9 and R9a are independently selected from the group consisting of C1-C6-alkyl, C1-C6- haloalkyl, C1-C6-alkoxy, C1-C6 alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6 cycloalkyl-C1-C6-alkyl, phenyl, benzyl, phenyloxy and phenylthio; each group of R8, R8a, R9 and R9a may be optionally substituted by one or more groups selected from R10; or R8 and R9 together with the atoms to which they are attached may form a 3- to 6- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2 ; the ring may be optionally substituted with one or more identical or different groups of R11; provided that when R8 and R9 forms a ring then R12 is absent; R10 is selected from the group consisting of cyano, halogen, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6 alkoxy-C1-C6-alkyl, C3-C6- cycloalkyl and C3-C6-cycloalkyl-C1-C6-alkyl; R11 is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C4-alkoxy-C1-C4-alkyl, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6- haloalkylthio and C3-C8-cycloalkyl; R12 is selected from the group of hydrogen, halogen, hydroxy, C1-C6-alkyl, C1-C4-alkoxy, C1-C6- haloalkyl and C1-C4-haloalkoxy; R13 is selected from the group consisting of hydrogen, formyl, C1-C4-alkyl, C2-C4-alkenyl, C2-C4- alkynyl, C1-C4-haloalkyl, C3-C5-cycloalkyl, C3-C5-cycloalkyl-C1-C3-alkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl; and/or N-oxides, metal complexes, isomers, polymorphs or the agriculturally acceptable salts thereof. In another preferred embodiment, the present invention provides a compound of formula (I), wherein R1 is selected from the group consisting of hydroxy, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6- cycloalkyl and C1-C6-alkoxy; R2 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6 haloalkyl, C1-C6-alkoxy-C1- C6-alkyl, -C(O)-R13, -C(O)-OR13 and –(CH2)m-O-C(O)-R13; R3 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1- C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl and -(CH2)m -C(O)-OR13; or W represents O; R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C2- C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6- cycloalkyl, C3-C6 -cycloalkyl-C1-C6-alkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl; each group of R4 and R5 may be optionally substituted by one or more groups selected from R4a; or R4 and R5 together with the atoms to which they are attached may form a 3 to 6 membered non- aromatic carbocyclic ring; the ring may be optionally substituted with one or more identical or different groups of R4a; R4a is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkylthio and C1-C6-haloalkoxy; R6 and R6a are independently selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6- haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6-cycloalkyl-C1-C6- alkyl; R7 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1- C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6 cycloalkyl-C1-C6 alkyl; each group of R7 may be optionally substituted by one or more groups selected from halogen, cyano, nitro, hydroxyl, thiol, amino; R7a is selected from the group consisting of hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6 cycloalkyl-C1-C6-alkyl; or R7 and R9 together with the atoms to which they are attached may form a 3- to 10- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2; the ring may be optionally substituted with one or more identical or different groups of R11; R8, R8a, R9 and R9a are independently selected from the group consisting of C1-C6-alkyl, C1-C6- haloalkyl, C1-C6-alkoxy, C1-C6 alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6 cycloalkyl-C1-C6-alkyl, phenyl, benzyl, phenyloxy, phenylthio; each group of R8, R8a, R9 and R9a may be optionally substituted by one or more groups selected from R10; or R8 and R9 together with the atoms to which they are attached may form a 3- to 6- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2; the ring may be optionally substituted with one or more identical or different groups of R11; provided that when R8 and R9 forms a ring then R12 is absent; R10 is selected from the group consisting of cyano, halogen, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6 alkoxy-C1-C6-alkyl, C3-C6- cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl; R11 is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C4-alkoxy-C1-C4-alkyl, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6- haloalkylthio and C3-C8-cycloalkyl; R12 is selected from the group of hydrogen, halogen, hydroxy, C1-C6-alkyl, C1-C4-alkoxy, C1-C6- haloalkyl and C1-C4-haloalkoxy; R13 is selected from the group consisting of hydrogen, formyl, C1-C4-alkyl, C2-C4-alkenyl, C2-C4- alkynyl, C1-C4-haloalkyl, C3-C5-cycloalkyl, C3-C5-cycloalkyl-C1-C3-alkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl; n is an integer selected from 0 to 1 and m is an integer selected from 0 to 2; and/or N-oxides, metal complexes, isomers, polymorphs or the agriculturally acceptable salts thereof. In yet another preferred embodiment, R1 is selected from the group consisting of hydroxy, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl and C1-C6-alkoxy. In yet another preferred embodiment, R2 is selected from the group consisting of hydrogen, C1-C6- alkyl, C1-C6 haloalkyl, C1-C6-alkoxy-C1-C6-alkyl, -C(O)-R13, -C(O)-OR13 and –(CH2)m-O-C(O)-R13. In yet another preferred embodiment, R3 is selected from the group consisting of hydrogen, C1-C6- alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl- C1-C6-alkyl and -(CH2)m-C(O)-OR13. In yet another preferred embodiment, W represents O. In yet another preferred embodiment, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1- C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6 -cycloalkyl-C1-C6-alkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl; each group of R4 and R5 may be optionally substituted by one or more groups selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C1- C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkylthio and C1-C6-haloalkoxy. In yet another preferred embodiment, R4 and R5 together with the atoms to which they are attached may form a 3 to 6 membered non-aromatic carbocyclic ring; the ring may be optionally substituted with one or more identical or different groups selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkylthio and C1-C6- haloalkoxy. In yet another preferred embodiment, R6 and R6a are independently selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6-cycloalkyl-C1-C6-alkyl. In yet another preferred embodiment, R7 is selected from the group consisting of hydrogen, C1-C6- alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6 cycloalkyl-C1-C6 alkyl; each group of R7 may be optionally substituted by one or more groups selected from halogen, cyano, nitro, hydroxyl, thiol, amino. In yet another preferred embodiment, R7 and R9 together with the atoms to which they are attached may form a 3- to 10- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non- aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2; the ring may be optionally substituted with one or more identical or different groups of R11. In yet another preferred embodiment, R8, R8a, R9 and R9a are independently selected from the group consisting of C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6 alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6 cycloalkyl-C1-C6-alkyl, phenyl, benzyl, phenyloxy, phenylthio; each group of R8, R8a, R9 and R9a may be optionally substituted by one or more groups selected from R10; or R8 and R9 together with the atoms to which they are attached may form a 3- to 6- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2; the ring may be optionally substituted with one or more identical or different groups of R11; provided that when R8 and R9 forms a ring then R12 is absent. In yet another preferred embodiment, R10 is selected from the group consisting of cyano, halogen, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6- alkoxy, C1-C6 alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl. In yet another preferred embodiment, R11 is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C4-alkoxy-C1-C4-alkyl, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio and C3-C8-cycloalkyl. In yet another preferred embodiment, R12 is selected from the group of hydrogen, halogen, hydroxy, C1-C6-alkyl, C1-C4-alkoxy, C1-C6-haloalkyl and C1-C4-haloalkoxy. In yet another preferred embodiment, R13 is selected from the group consisting of hydrogen, formyl, C1-C4-alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl, C3-C5-cycloalkyl, C3-C5-cycloalkyl-C1- C3-alkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl. In more preferred embodiment, the compound of formula (I) is selected from N-((S)-1-(((S)-1,1-bis(4- methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1- (((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl acetate, N-((2S,3S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan- 2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((2S,3S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2- yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((2S,3S)-1-(((S)- 1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate, N-((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, N-((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan- 2-yl)amino)-4-methyl-1-oxopentan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1- bis(4-methoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((2S,3S)-1-(((S)-1,1- bis(4-ethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3- yl acetate, N-((2S,3S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2- yl)-3-hydroxy-4-methoxypicolinamide, 2-(((2S,3S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2- yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((2S,3S)-1- (((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-4- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(4- methoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2- yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((2S,3S)-1- (((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(4- ethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4- methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan- 2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, ethyl (3-((ethoxycarbonyl)oxy)-4- methoxypicolinoyl)((2S)-1-(((2S)-1-(4-ethoxyphenyl)-1-(4-methoxyphenyl)propan-2-yl)amino)-4- methyl-1-oxopentan-2-yl)carbamate, ethyl ((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)- 4-methyl-1-oxopentan-2-yl)(3-((ethoxycarbonyl)oxy)-4-methoxypicolinoyl)carbamate, N-((S)-1- (((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((2S,3S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-3- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((2S,3S)-1-(((S)-1,1-bis(3,4- dimethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((2S,3S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-3- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((2S,3S)-1-(((S)-1,1- bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl ethyl carbonate, 2-((1-((1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, 2-((1-((1,1-bis(4- methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-((1-((1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-4-methyl-1- oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(3,4- dimethoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1- oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((2S,3S)-1-((1,1-bis(4- fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxopentan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxopentan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en- 2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, 2-(((S)- 1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate, N-((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-4- methyl-1-oxopentan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(3,4- dimethoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, N-((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan- 2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((2S,3S)-1-((1,1- bis(4-chlorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl acetate, 2-(((2S,3S)-1-((1,1-bis(4-chlorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxopentan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, N-((2S,3S)-1-((1,1-bis(4-chlorophenyl)prop-1-en- 2-yl)amino)-3-methyl-1-oxopentan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((2S,3S)-1-((1,1- bis(4-chlorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-3-methyl-1- oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-N-(1-((1,1-bis(4- chlorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2- ((1-((1,1-bis(4-chlorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2- yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate , 2-(((S)-1-(((S)-1,1- bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl acetate, (S)-2-((1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxobutan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4-fluorophenyl)prop-1-en-2- yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1- bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2- yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1- bis(4-chlorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2- yl)-3-hydroxy-4-methoxypicolinamide, N-((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2- yl)amino)-3-methyl-1-oxobutan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1-bis(4- fluorophenyl)prop-1-en-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(3-fluoro-4-methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((S)-1-(((S)-1,1-bis(3-fluoro-4- methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1- (((S)-1,1-bis(3-fluoro-4-methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-4-methyl- 1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4- fluorophenyl)prop-1-en-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N-(1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-4-methyl-1-oxopentan- 2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)- 4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, 2-(((S)-1-(((S)- 1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyl carbonate, 2-(((S)-1-(((S)-1,1-bis(3-fluoro-4-methoxyphenyl)propan-2- yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, N-((S)-1-(((S)- 1,1-bis(3-fluoro-4-methoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(3-fluoro-4-methoxyphenyl)propan-2-yl)amino)-4- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(4- chlorophenyl)prop-1-en-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-N-(1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3- hydroxy-4-methoxypicolinamide, (S)-2-((2-((1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-2- oxoethyl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4-chlorophenyl)prop-1- en-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1- ((1,1-bis(4-chlorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4- methoxypyridin-3-yl ethyl carbonate, (S)-N-(1-((1,1-bis(4-chlorophenyl)prop-1-en-2-yl)amino)-4- methyl-1-oxopentan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1-bis(4- fluorophenyl)prop-1-en-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate , (S)-2-((1-((1,1-bis(4-chlorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxobutan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-N-(2-((1,1-bis(4-methoxyphenyl)propan-2- yl)amino)-2-oxoethyl)-3-hydroxy-4-methoxypicolinamide, (S)-N-(1-((1,1-bis(4-chlorophenyl)prop-1- en-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1- bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4-chlorophenyl)-1-hydroxypropan-2- yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, 2-(((S)- 1-(((S)-1,1-bis(4-chlorophenyl)-1-hydroxypropan-2-yl)amino)-4-methyl-1-oxopentan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4-methoxyphenyl)propan-2- yl)carbamoyl)cyclopropyl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(4- methoxyphenyl)propan-2-yl)amino)-2-methyl-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, N-(1-((1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4- methoxypicolinamide, (S)-2-((1-((1,1-bis(4-methoxyphenyl)propan-2- yl)carbamoyl)cyclopropyl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-N-(1-((1,1-bis(4- methoxyphenyl)propan-2-yl)carbamoyl)cyclopropyl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1- ((1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-2-methyl-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate, (S)-N-(1-((1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-2-methyl-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1-hydroxy-1,1-bis(4- (trifluoromethoxy)phenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(4-methoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate, (S)-N-(1-((1,1-bis(4-methoxyphenyl)prop-1-en-2-yl)amino)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1-bis(4-methoxyphenyl)prop-1-en- 2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4- fluorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-N-(1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4- methoxypicolinamide, (S)-2-((1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4-(trifluoromethyl)phenyl)prop- 1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1- hydroxy-1,1-diphenylpropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1-hydroxy-1,1-diphenylpropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyl carbonate, 3-hydroxy-N-((S)-1-(((S)-1-hydroxy-1,1-diphenylpropan-2- yl)amino)-1-oxopropan-2-yl)-4-methoxypicolinamide, isobutyl (4-methoxy-2-(((2S)-1-((3- methylbutan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)pyridin-3-yl) carbonate, 2-(((S)-1-(((S)-1- hydroxy-1,1-diphenylpropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 3-hydroxy-N-((S)-1-(((S)-1-hydroxy-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1- oxopropan-2-yl)-4-methoxypicolinamide, (S)-2-((1-(2-(diphenylmethylene)hydrazinyl)-1-oxopropan- 2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-2-((1-(2- (diphenylmethylene)hydrazinyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2- ((1-(2-(bis(4-methoxyphenyl)methylene)hydrazinyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(4-chlorophenyl)-1-hydroxypropan-2-yl)amino)- 1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(4-chlorophenyl)- 1-hydroxypropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-4-(methylthio)-1-oxobutan- 2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2- yl)amino)-4-(methylthio)-1-oxobutan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1- bis(4-methoxyphenyl)propan-2-yl)amino)-4-(methylthio)-1-oxobutan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-4- (methylthio)-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl benzoate, (S)-N-(1-(2-(bis(4- methoxyphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 4- methoxy-2-(((2S)-1-((3-methylbutan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)pyridin-3-yl isobutyrate, 2-(((2S)-1-(((1s,3R)-adamantan-1-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate, (S)-N-(1-((4-(tert-butyl)cyclohexyl)amino)-1-oxopropan-2-yl)-3- hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(4-fluorophenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((4-(tert- butyl)cyclohexyl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1- ((3,3-difluorocyclobutyl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2- (((S)-1-(((S)-1,1-bis(4-fluorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate, (S)-2-((1-((3,3-difluorocyclobutyl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 4-methoxy-2-(((2S)-1-((3-methylbutan-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)pyridin-3-yl butyrate, ethyl (4-methoxy-2-(((2S)-1-((3- methylbutan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)pyridin-3-yl) carbonate, (S)-2-((1-((4-(tert- butyl)cyclohexyl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1- (((S)-1-hydroxy-1,1-bis(4-(trifluoromethoxy)phenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, N-((S)-1-(((S)-1,1-bis(4-chlorophenyl)-1- hydroxypropan-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-(2- (bis(4-methoxyphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((R)-1,1-bis(4-fluorophenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, N-((S)-1-(((R)-1,1-bis(4-fluorophenyl)propan-2- yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((R)-1,1-bis(4- fluorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl benzoate, 2- (((S)-1-(((R)-1,1-bis(4-fluorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate, 2-(((S)-1-(((R)-1,1-bis(4-fluorophenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-((4,4- dimethylcyclohexyl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-N- (1-((4,4-dimethylcyclohexyl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1- ((4,4-dimethylcyclohexyl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)- N-(1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)- 2-((1-(2-(bis(4-fluorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyl carbonate, (S)-2-((1-(2-(bis(4-fluorophenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-(2-(bis(4- chlorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-2-((1-(2-(bis(4-methoxyphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl isobutyl carbonate, 2-(((S)-1-(((S)-1,1-diphenylpropan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, N-((S)-1-(((S)-1,1-diphenylpropan-2- yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1-diphenylpropan- 2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl benzoate, 2-(((S)-1-(((S)-1,1- diphenylpropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1- (((S)-1,1-diphenylpropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-N-(1-(2-(bis(4-fluorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4- methoxypicolinamide, (S)-2-((1-((4,4-dimethylcyclohexyl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl butyrate, 2-(((2S)-1-(((1s,3R)-adamantan-1-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((2S)-1-(((1s,3R)-adamantan-1-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, 2-(((S)-1-(((S)-1,1-bis(4- fluorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl benzoate, 2- (((S)-1-(((S)-1,1-bis(4-fluorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl butyrate, (S)-2-((1-((4-(tert-butyl)cyclohexyl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(4- fluorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(4-fluorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl butyrate, N-((S)-1-(((S)-1,1-bis(4-fluorophenyl)propan-2-yl)amino)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(4-chlorophenyl)propan-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((S)-1-(((S)-1,1-bis(4- chlorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1- (((S)-1,1-bis(4-chlorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3- yl butyrate, 2-(((S)-1-(((S)-1,1-bis(4-chlorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(4-chlorophenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl benzoate, (S)-2-((1-(2-(bis(4- chlorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(4-chlorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(4-fluorophenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-2-((1-(2-(bis(4- chlorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate, (S)-N-(1-(2-(bis(4-chlorophenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-(2-(diphenylmethylene)hydrazineyl)- 1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-2-((1-(2-benzhydryl-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-(2- benzhydryl-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N-(1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4- methoxypicolinamide, (S)-2-((1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(4-fluorophenyl)methyl)-2-methylhydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-(2-(bis(4-fluorophenyl)methyl)- 2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)- N-(1-(2-(bis(4-fluorophenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4- methoxypicolinamide N-((S)-1-(((S)-1,1-bis(3-cyclopropylphenyl)propan-2-yl)amino)-1-oxopropan- 2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(3-cyclopropylphenyl)propan-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(3- cyclopropylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, 2-(((S)-1-(((S)-1,1-bis(3-cyclopropylphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, 2-(((S)-1-(((S)-1,1-bis(3-cyclopropylphenyl)propan-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(3- cyclopropylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N-((S)-1,1-bis(3-cyclopropylphenyl)propan-2-yl)-2-(8-methoxy-2,4-dioxo-2H- pyrido[2,3-e][1,3]oxazin-3(4H)-yl)propanamide , 2-(((S)-1-(((S)-1,1-bis(4-isopropylphenyl)propan-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(4- isopropylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, 2-(((S)-1-(((S)-1,1-bis(4-isopropylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate , N-((S)-1-(((S)-1,1-bis(3-isopropylphenyl)propan-2-yl)amino)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(3- isopropylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(3-isopropylphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate , (S)-N-((S)-1,1-bis(3- isopropylphenyl)propan-2-yl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)- yl)propanamide , 2-(((S)-1-(((S)-1,1-bis(4-methylphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, 2-(((S)-1-(((S)-1,1-bis(4-methylphenyl)propan-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(4- methylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(3-methylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl propionate, 2-(((S)-1-(((S)-1,1-bis(3-methylphenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(3- methylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, 2-(((S)-1-(((S)-1,1-bis(3,5-difluorophenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl propionate, 2-(((S)-1-(((S)-1,1-bis(3,5-difluorophenyl)propan- 2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N-((S)-1,1- bis(3,5-difluorophenyl)propan-2-yl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)- yl)propanamide, 2-(((S)-1-(((S)-1,1-bis(3,5-dichlorophenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl propionate, 2-(((S)-1-(((S)-1,1-bis(3,5-dichlorophenyl)propan- 2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N-((S)-1,1- bis(3,5-dichlorophenyl)propan-2-yl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)- yl)propanamide, (S)-N-(1-((1,1-bis(3-cyclopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)-3- hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1-bis(3-cyclopropylphenyl)prop-1-en-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(3- cyclopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-((1,1-bis(3-cyclopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-((1,1-bis(3-cyclopropylphenyl)prop-1-en-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(3- cyclopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N-(1,1-bis(3-cyclopropylphenyl)prop-1-en-2-yl)-2-(8-methoxy-2,4-dioxo-2H- pyrido[2,3-e][1,3]oxazin-3(4H)-yl)propanamide, (S)-2-((1-((1,1-bis(4-isopropylphenyl)prop-1-en-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(4- isopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-((1,1-bis(4-isopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl isobutyrate, (S)-N-(1-((1,1-bis(3-isopropylphenyl)prop-1-en-2-yl)amino)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1-bis(3-isopropylphenyl)prop-1-en- 2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(3- isopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N-(1,1-bis(3-isopropylphenyl)prop-1-en-2-yl)-2-(8-methoxy-2,4-dioxo-2H- pyrido[2,3-e][1,3]oxazin-3(4H)-yl)propanamide, (S)-2-((1-((1,1-bis(4-methylphenyl)prop-1-en-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-((1,1-bis(4- methylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4-methylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl ethyl carbonate, (S)-2-((1-((1,1-bis(3-methylphenyl)prop-1-en-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-((1,1-bis(3- methylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(3-methylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl isobutyl carbonate, (S)-2-((1-((1,1-bis(3,5-difluorophenyl)prop-1-en-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-((1,1-bis(3,5- difluorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N-(1,1-bis(3,5-difluorophenyl)prop-1-en-2-yl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3- e][1,3]oxazin-3(4H)-yl)propanamide, (S)-2-((1-((1,1-bis(3,5-dichlorophenyl)prop-1-en-2-yl)amino)- 1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-((1,1-bis(3,5- dichlorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N-(1,1-bis(3,5-dichlorophenyl)prop-1-en-2-yl)-2-(8-methoxy-2,4-dioxo-2H- pyrido[2,3-e][1,3]oxazin-3(4H)-yl)propanamide, (S)-N-(1-(2-(bis(3-cyclopropylphenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-(2-(bis(3- cyclopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3- yl acetate, (S)-2-((1-(2-(bis(3-cyclopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(3-cyclopropylphenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2- (bis(3-cyclopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate , (S)-2-((1-(2-(bis(3-cyclopropylphenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N'- (bis(3-cyclopropylphenyl)methyl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)- N'-methylpropanehydrazide, (S)-2-((1-(2-(bis(4-isopropylphenyl)methyl)-2-methylhydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-(2-(bis(4- isopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(4-isopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-N-(1-(2-(bis(3-isopropylphenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-(2-(bis(3- isopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(3-isopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate , (S)-N'-(bis(3-isopropylphenyl)methyl)-2- (8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)-N'-methylpropanehydrazide, (S)-2-((1- (2-(bis(4-methylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(4-methylphenyl)methyl)-2-methylhydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(4- methylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-2-((1-(2-(bis(3-methylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(3-methylphenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2- (bis(3-methylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl isobutyl carbonate, (S)-2-((1-(2-(bis(3,5-difluorophenyl)methyl)-2-methylhydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(3,5- difluorophenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N'-(bis(3,5-difluorophenyl)methyl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3- e][1,3]oxazin-3(4H)-yl)-N'-methylpropanehydrazide, (S)-2-((1-(2-(bis(3,5-dichlorophenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2- (bis(3,5-dichlorophenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl ethyl carbonate, (S)-N'-(bis(3,5-dichlorophenyl)methyl)-2-(8-methoxy-2,4- dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)-N'-methylpropanehydrazide, (S)-N-(1-(2-(bis(3- cyclopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-(2-(bis(3-cyclopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate, (S)-2-((1-(2-(bis(3-cyclopropylphenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(3- cyclopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(3-cyclopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(3- cyclopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N'-(bis(3-cyclopropylphenyl)methylene)-2-(8-methoxy-2,4-dioxo-2H- pyrido[2,3-e][1,3]oxazin-3(4H)-yl)propanehydrazide, (S)-2-((1-(2-(bis(4- isopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-(2-(bis(4-isopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(4-isopropylphenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-N-(1-(2-(bis(3- isopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)- 2-((1-(2-(bis(3-isopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate , (S)-2-((1-(2-(bis(3-isopropylphenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N'-(bis(3- isopropylphenyl)methylene)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)- yl)propanehydrazide, (S)-2-((1-(2-(bis(4-methylphenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(4- methylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(4-methylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl ethyl carbonate, (S)-2-((1-(2-(bis(3-methylphenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(3- methylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(3-methylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl isobutyl carbonate, (S)-2-((1-(2-(bis(3,5- difluorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(3,5-difluorophenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N'-(bis(3,5-difluorophenyl)methylene)-2- (8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)propanehydrazide, (S)-2-((1-(2-(bis(3,5- dichlorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(3,5-dichlorophenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate , (S)-N'-(bis(3,5-dichlorophenyl)methylene)- 2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)propanehydrazide, (S)-N-(1-((1,1- bis(3,4-dimethoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4- methoxypicolinamide, (S)-2-((1-((1,1-bis(3,4-dimethoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan- 2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(3,4-dimethoxyphenyl)prop-1-en- 2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-((1,1-bis(3,4- dimethoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-((1,1-bis(3,4-dimethoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(3,4-dimethoxyphenyl)prop-1- en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N-(1,1- bis(3,4-dimethoxyphenyl)prop-1-en-2-yl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin- 3(4H)-yl)propanamide, (S)-2-((1-((1,1-bis(3-fluoro-4-methoxyphenyl)prop-1-en-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(3-fluoro-4- methoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-((1,1-bis(3-fluoro-4-methoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-N-(1-((1,1-bis(phenyl)prop-1-en-2-yl)amino)- 1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1-bis(phenyl)prop-1-en-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1- bis(phenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N-(1,1-bis(phenyl)prop-1-en-2-yl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3- e][1,3]oxazin-3(4H)-yl)propanamide, (S)-2-((1-(2-(bis(4-chlorophenyl)methyl)-2-methylhydrazineyl)- 1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(4- chlorophenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(4-chlorophenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-2-((1-(2-(bis(4-methoxyphenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2- (bis(4-methoxyphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate , (S)-2-((1-(2-(bis(4-methoxyphenyl)methyl)-2-methylhydrazineyl)- 1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-2-((1-(2-(bis(3-fluoro,5- methoxyphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(3-fluoro,5-methoxyphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan- 2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N'-(bis(3-fluoro,5- methoxyphenyl)methyl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)-N'- methylpropanehydrazide, (S)-2-((1-(2-(bis(4-ethoxyphenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(4- ethoxyphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate and (S)-N'-(bis(4-ethoxyphenyl)methylene)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3- e][1,3]oxazin-3(4H)-yl)propanehydrazide. The agriculturally acceptable salts of the compounds of formula (I) encompass especially the salts of those cations or the acid addition salts of those acids whose cations and anions, respectively have no adverse effect on the fungicidal action of the compounds of formula (I). Suitable cations are thus in particular the ions of the alkali metals, preferably sodium and potassium; of the alkaline earth metals, preferably calcium, magnesium and barium; of the transition metals, preferably manganese, copper, zinc and iron and also the ammonium ion which, if desired, may carry one to four C1-C4-alkyl substituents and/or one phenyl or benzyl substituent, preferably diisopropylammonium, tetramethylammonium, tetrabutylammonium, trimethylbenzylammonium, furthermore phosphonium ions, sulfonium ions, preferably tri(C1-C4-alkyl)sulfonium, and sulfoxonium ions, preferably tri(C1- C4-alkyl)sulfoxonium. The salts obtainable in this way likewise have fungicidal properties. Anions of useful acid addition salts are primarily chloride, bromide, fluoride, hydrogensulfate, sulfate, dihydrogenphosphate, hydrogenphosphate, phosphate, nitrate, bicarbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate, and the anions of C1-C4-alkanoic acids, preferably formate, acetate, propionate and butyrate. They can be formed by reacting a compound of formula (I) with an acid of the corresponding anion, preferably of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid or nitric acid. The compounds of the present invention may be present either in pure form or as mixtures of different possible isomeric forms such as stereoisomers e.g., a racemate, individual stereoisomers, or constitutional isomers or as an optically active form. The various stereoisomers include enantiomers, diastereomers, chiral isomers, atropisomers, conformers, rotamers, tautomers, optical isomers, polymorphs, and geometric isomers. Any desired mixtures of these isomers fall within the scope of the claims of the present disclosure. One skilled in the art will appreciate that one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other isomer(s) or when separated from the other isomer(s). Additionally, the person skilled in the art knows processes or methods or technology to separate, enrich, and/or to selectively prepare said isomers. The compounds of formula (I) can be present in different crystal modifications whose biological activity may differ. They also form part of the subject matter of the present invention. The compounds of formula (I) can be present in atropisomers arising from restricted rotation about a single bond of asymmetric groups. They also form part of the subject matter of the present invention. The compound selected from formula (I), (including all stereoisomers, N-oxides, and salts thereof), typically may exist in more than one form. The compounds of formula (I) thus includes all crystalline and non-crystalline forms of the compound that formula (I) represents. Non-crystalline forms include embodiments which are solids such as waxes and gums as well as embodiments which are liquids such as solutions and melts. Crystalline forms include embodiments which represent essentially a single crystal type and embodiments which represent a mixture of polymorphs (i.e. different crystalline types). The following schemes illustrate approaches for preparing compounds of formula (I). The following descriptions and examples are provided for illustrative purposes and should not be construed as limiting in terms of substituents or substitution patterns. Further, the mentioned reagents, solvents and reaction conditions are intended for the purpose of exemplification only and should not be construed as limiting. In one embodiment, the present invention provides a process for synthesis of compounds of formula (I). The compound of formula (I) can be prepared by one or other of the following methods. The definitions of W, Z, R1, R1a, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R9, and R12 in the compounds of formula (I) and compounds of formula 1–21 are as defined above in the detailed description of the invention unless otherwise stated specifically. As shown in scheme 1, a compound of formula (I), wherein W is O, involves coupling of an acid of formula 4 (or it’s salt) with an amine (or its acid salt) of formula 3 in the presence of a suitable coupling reagent such as hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3- dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride and the like, or alkyl chloroformates such as ethyl chloroformate, isobutyl chloroformate and the like, and optionally in a suitable solvent such as dichloromethane, tetrahydrofuran and the like. These reactions are typically carried out at a temperature between 0 °C to 25 °C. Subsequently, an acid of formula 4 can be prepared employing a reported protocol (US2016/0009650A1) and an amine of formula 3 can be obtained by coupling of protected amino acid of formula 1 and suitable coupling partner (Z) using coupling reagents and or a solvent such as dichloromethane, tetrahydrofuran and the like.
Figure imgf000038_0001
As shown in scheme 2, a compound of formula (I) can also be prepared by coupling of an acid of formula 7 (or it’s salt) with a suitable coupling partner (Z) in the presence of a suitable coupling reagent such as hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3- dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride and the like or a suitable alkyl chloroformates such as ethyl chloroformate, isobutyl chloroformate and the like, and optionally in a suitable solvent such as dichloromethane, N,N-dimethylformamide, tetrahydrofuran and the like. These reactions are typically run at a temperature between 0 °C to 25 °C.
Figure imgf000039_0001
The acid of formula 7 can be prepared by acidic or basic hydrolysis of corresponding methyl ester of formula 6. The ester of formula 6 can be constructed via coupling of an acid of formula 4 and an amine (or it’s acid salt) coupling partner of formula 5 in the presence of a suitable coupling reagent such as hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3-dimethylaminopropyl)-N′- ethylcarbodiimide hydrochloride and the like, or a suitable alkyl chloroformates such as ethyl chloroformate, isobutyl chloroformate and the like, and optionally in a suitable solvent such as dichloromethane, N,N-dimethylformamide and the like.
Figure imgf000039_0002
A suitably substituted amine of formula 11 can be prepared either via nucleophilic displacement of hydroxyl group in an alcohol of formula 10 in the presence of acid such as trifluoroacetic acid, borontrifluride diethyl ether complex and the like, and requisite nucleophile such as hydride, fluoride, alkoxide or via O-alkylation in the presence of a suitable alkyl halide or triflate such as methyl iodide. An alcohol of formula 10 can be afforded by addition of required Grignard reagent such as phenyl magnesium bromide, 4-methoxy phenyl magnesium bromide and the like, or organolithium species such as phenyl lithium to an ester of formula 9 which can be prepared by esterification of corresponding acid of formula 8 in presence of acid such as phosphoric acid, hydrochloric acid and the like, or acid chloride such as thionyl chloride, oxalyl chloride and the like, and in an alcoholic solvent such as methanol, ethanol and the like.
Figure imgf000040_0001
The acid salt of amine of formula 15 can be obtained from an amine of formula 14 by treatment with a solution of hydrohaloic acid such as hydrochloric acid in an organic solvent such as 1,4-dioxane, diethyl ether and the like. The amine of formula 14 can be obtained via acid mediated deprotection of the corresponding protected amine of formula 13, which in turn can be obtained by nucleophilic displacement or O-alkylation of hydroxyl group in amide of formula 12. The compound of formula 12 can be built from a protected amino acid of formula 1 and suitably substituted amine of formula 10 in the presence of a coupling reagent such as hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride and the like, or alkyl chloroformates such as ethyl chloroformate, isobutyl chloroformate and the like and optionally in a suitable solvent such as dichloromethane, N,N-dimethylformamide, tetrahydrofuran and the like.
Figure imgf000040_0002
As shown in scheme 5, the acid salt of amine of formula 17 can be prepared from corresponding free amine of formula 16 by treatment with a solution of hydrohaloic acid such as hydrochloric acid in an organic solvent such as 1,4-dioxane or diethyl ether. The suitably substituted amine of formula 16 can be obtained by dehydration of the corresponding alcohol of formula 12, which can be prepared as mentioned in scheme 4. Scheme: 6
Figure imgf000041_0001
Suitably substituted hydrazine of formula 21 can be obtained via Grignard addition to the corresponding hydrazinium compound of formula 20, which in turn can be obtained by reacting a substituted hydrazine 19 (or it’s salt) with a carbonyl compound of formula 18.
Figure imgf000041_0002
As shown in scheme 7, a suitably substituted amine of formula 27 can be prepared by deprotection of protecting group in compound of formula 26 using a suitable reagent such as trifluoroacetic acid, HCl, oxalyl chloride/MeOH and the like. These transformations are typically carried out at a temperature between 0°C to 25°C. The desired compound of formula 26 can be obtained by N-alkylation of an amine of formula 25 using a suitable alkyl halide (R6a-X). The desired amine of formula 25 can be synthesized by reduction of hydrazinamide compound of formula 24 using suitable reducing agent such as NaBH4, BH3.THF, BH3.DMS and the like, and optionally in a suitable solvent such as diethyl ether, tetrahydrofuran and the like. The reactions are typically run at a temperature between 0°C to 25°C. The hydrazinamide compound of formula 24 can be prepared by treating a ketone of formula 18 with hydrazide of formula 23 which was subsequently synthesized by reacting suitably substituted amino acid of formula 1 and hydrazine (or it’s acid salt) of formula 22 using suitable coupling reagent such as hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3-dimethylaminopropyl)-N′- ethylcarbodiimide hydrochloride and the like, or alkyl chloroformates such as ethyl chloroformate, isobutyl chloroformate and the like, and optionally in a suitable a solvent such as dichloromethane, N,N-dimethylformamide, tetrahydrofuran and the like. Scheme: 8
Figure imgf000042_0002
The amine of formula 28 can be prepared by removal of the N-protecting group in compound of formula 24 using suitable reagents such as trifluoroacetic acid, HCl, oxalyl chloride and the like, and optionally in a suitable solvent such as dichloromethane, methanol, tetrahydrofuran and the like.
Figure imgf000042_0001
Alternatively, the amine of formula 24 can also be prepared by coupling of an acid of formula 1 and an imine of formula 29 using a suitable coupling reagent such as hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3-dimethylaminopropyl)-N′- ethylcarbodiimide hydrochloride and the like, or alkyl chloroformates such as ethyl chloroformate, isobutyl chloroformate and the like, and optionally in a suitable solvent such as dichloromethane, N,N-dimethylformamide, tetrahydrofuran and the like. The compound of formula 29 can be subsequently equipped by treating suitably substituted hydrazine of formula 22 with a ketone of formula 18 under suitable conditions.
Figure imgf000042_0003
As shown in scheme 10, the compound of formula (I-z1), wherein W is O, was obtained by coupling of an acid of formula 4 (or it’s salt) with an amine of formula 14 (or it’s acid salt) in the presence of a suitable coupling reagent such as hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3- dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride and the like, or alkyl chloroformates such as ethyl chloroformate, isobutyl chloroformate and the like, and optionally in a suitable solvent such as dichloromethane, tetrahydrofuran and the like. These reactions are typically run at a temperature between 0 °C to 25 °C.
Figure imgf000043_0001
The compound of formula (I-z2), wherein W is O, was obtained by coupling of an acid of formula 4 (or it’s salt) with an amine of formula 27 (or it’s acid salt) in the presence of suitable coupling reagents such as hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3- dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride and the like, or alkyl chloroformates such as ethyl chloroformate, isobutyl chloroformate and the like, and optionally in a suitable solvent such as dichloromethane, tetrahydrofuran and the like. These reactions are typically run at 0 °C to 25 °C.
Figure imgf000043_0002
As shown in scheme 12, a compound of formula (I-z3), wherein W is O, was obtained by coupling of an acid of formula 4 (or it’s salt) with an amine of formula 16 (or it’s acid salt) in the presence of a suitable coupling reagent such as hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3- dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride and the like, or alkyl chloroformates such as ethyl chloroformate, isobutyl chloroformate and the like, and optionally in a suitable solvent such as dichloromethane, tetrahydrofuran and the like. These reactions are typically run at a temperature between 0 °C to 25 °C.
Figure imgf000043_0003
As shown in scheme 13, the compound of formula (I-z4), wherein W is O, is obtained by coupling of an acid of formula 4 (or it’s salt) with an amine of formula 28 (or it’s acid salt) in the presence of a suitable coupling reagent such as hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3- dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride and the like, or alkyl chloroformates such as ethyl chloroformate, isobutyl chloroformate and the like, and optionally in a suitable solvent such as dichloromethane, tetrahydrofuran and the like. These reactions are typically run at a temperature between 0 °C to 25 °C. The compounds of the present disclosure may be applied by any of a variety of known techniques, either as the compounds themselves or as formulations comprising these compounds. For example, the compounds may be applied to the roots or foliage of plants for the control of various fungi, without damaging the commercial value of the plants. The materials may be applied in the form of any of the generally used formulation types, for example, as solutions, dusts, wettable powders, flowable concentrate, or emulsifiable concentrates. Preferably, the compounds of the present disclosure are applied in the form of a formulation, comprising one or more of the compounds of formula (I) with a phytologically acceptable carrier. Concentrated formulations may be dispersed in water, or other liquids, for application, or formulations may be dust-like or granular, which may then be applied without further treatment. The formulations can be prepared according to procedures that are conventional in the agricultural chemical art. The present disclosure contemplates all vehicles by which one or more of the compounds may be formulated for delivery and use as a fungicide. Typically, formulations are applied as aqueous suspensions or emulsions. Such suspensions or emulsions may be produced from water-soluble, water-suspendible, or emulsifiable formulations which are solids, usually known as wettable powders; or liquids, usually known as emulsifiable concentrates, aqueous suspensions, or suspension concentrates. As will be readily appreciated, any material to which these compounds may be added may be used, provided it yields the desired utility without significant interference with the activity of these compounds as antifungal agents. In one embodiment, the present invention provides a agrochemical composition comprising the compound of formula (I), agriculturally acceptable salts, metal complexes, constitutional isomers, stereo-isomers, diastereoisomers, enantiomers, chiral isomers, atropisomers, conformers, rotamers, tautomers, optical isomers, polymorphs, geometric isomers, or N-oxides thereof, optionally with one or more additional active ingredient with the auxiliary such as inert carrier or any other essential ingredient such as surfactants, additives, solid diluents and liquid diluents. An agrochemical composition comprises a fungicidally effective amount of a compound of formula (I). The term "effective amount" denotes an amount of the composition or of the compound of formula (I), which is sufficient for controlling harmful fungi on cultivated plants or in the protection of materials and which does not result in a substantial damage to the treated plants. Such an amount can vary in a broad range and is dependent on various factors, such as the fungal species to be controlled, the treated cultivated plant or material, the climatic conditions and the specific compound of formula (I) used. In another embodiment, the present invention provides a composition comprising at least one compound of formula (I) and seed. The amount of the compound of formula (I) in the composition ranges from 0.1 g ai (gram per active ingredient) to 1 kg ai (kilogram per active ingredient) per 100 kg of seeds. The compound of formula (I), their oxides, metal complexes, isomers, polymorphs or the agriculturally acceptable salts thereof can be converted into customary types of agrochemical compositions, e. g. solutions, emulsions, suspensions, dusts, powders, pastes, granules, pressings, capsules, and mixtures thereof. Examples for composition types are suspensions (e. g. SC, OD, FS), emulsifiable concentrates (e. g. EC), emulsions (e. g. EW, EO, ES, ME), capsules (e. g. CS, ZC), pastes, pastilles, wettable powders or dusts (e. g. WP, SP, WS, DP, DS), pressings (e. g. BR, TB, DT), granules (e. g. WG, SG, GR, FG, GG, MG), insecticidal articles (e. g. LN), as well as gel Formulations for the treatment of plant propagation materials such as seeds (e. g. GF). These and further compositions types are defined in the "Catalogue of pesticide Formulation types and international coding system", Technical Monograph No.2, 6th Ed. May 2008, CropLife International. The compositions are prepared in a known manner, such as described by Mollet and Grubemann, Formulation technology, Wiley VCH, Weinheim, 2001; or Knowles, New developments in crop protection product Formulation, Agrow Reports DS243, T&F Informa, London, 2005. Examples for suitable auxiliaries for the formulations and/or the agrochemicals compositions according to the inventions are solvents, liquid carriers, solid carriers or fillers, surfactants, dispersants, emulsifiers, wetters, adjuvants, solubilizers, penetration enhancers, protective colloids, adhesion agents, thickeners, humectants, repellents, attractants, feeding stimulants, compatibilizers, bactericides, anti-freezing agents, anti-foaming agents, colorants, tackifiers and binders. Suitable solvents and liquid carriers are water and organic solvents, such as mineral oil fractions of medium to high boiling point, e. g. kerosene, diesel oil; oils of vegetable or animal origin; aliphatic, cyclic and aromatic hydrocarbons, e. g. toluene, paraffin, tetrahydronaphthalene, alkylated naphthalenes; alcohols, e. g. ethanol, propanol, butanol, benzyl alcohol, cyclohexanol; glycols; dimethyl sulfoxide; ketones, e. g. cyclohexanone; esters, e. g. lactates, carbonates, fatty acid esters, gamma-butyrolactone; fatty acids; phosphonates; amines; amides, e. g. N-methyl pyrrolidone, fatty acid dimethyl amides; and mixtures thereof. Suitable solid carriers or fillers are mineral earths, e. g. silicates, silica gels, talc, kaolins, limestone, lime, chalk, clays, dolomite, diatomaceous earth, bentonite, calcium sulphate, magnesium sulphate, magnesium oxide; polysaccharides, e. g. cellulose, starch; fertilizers, e. g. ammonium sulphate, ammonium phosphate, ammonium nitrate, ureas; products of vegetable origin, e. g. cereal meal, tree bark meal, wood meal, nutshell meal, and mixtures thereof. Suitable surfactants are surface-active compounds, such as anionic, cationic, nonionic and amphoteric surfactants, block polymers, polyelectrolytes, and mixtures thereof. Such surfactants can be used as emulsifier, dispersant, solubilizer, wetter, penetration enhancer, protective colloid, or adjuvant. Examples of surfactants are listed in McCutcheon's, Vol.1: Emulsifiers & Detergents, McCutcheon's Directories, Glen Rock, USA, 2008 (International Ed. or North American Ed.). Suitable anionic surfactants are alkali, alkaline earth or ammonium salts of sulfonates, sulphates, phosphates, carboxylates, and mixtures thereof. Examples of sulfonates are alkylaryl sulfonates, diphenyl sulfonates, alpha-olefin sulfonates, lignin sulfonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of alkoxylated arylphenols, sulfonates of condensed naphthalenes, sulfonates of dodecyl-and tridecylbenzenes, sulfonates of naphthalenes and alkyl naphthalenes, sulfosuccinates or sulfosuccinamates. Examples of sulphates are sulphates of fatty acids and oils, of ethoxylated alkylphenols, of alcohols, of ethoxylated alcohols, or of fatty acid esters. Examples of phosphates are phosphate esters. Examples of carboxylates are alkyl carboxylates, and carboxylated alcohol or alkylphenol ethoxylates. Suitable nonionic surfactants are alkoxylates, N-substituted fatty acid amides, amine oxides, esters, sugar-based surfactants, polymeric surfactants, and mixtures thereof. Examples of alkoxylates are compounds such as alcohols, alkylphenols, amines, amides, arylphenols, fatty acids or fatty acid esters which have been alkoxylated with 1 to 50 equivalents. Ethylene oxide and/or propylene oxide may be employed for the alkoxylation, preferably ethylene oxide. Examples of N-substituted fatty acid amides are fatty acid glucamides or fatty acid alkanolamides. Examples of esters are fatty acid esters, glycerol esters or monoglycerides. Examples of sugar-based surfactants are sorbitans, ethoxylated sorbitans, sucrose and glucose esters or alkylpolyglucosides. Examples of polymeric surfactants are home- or copolymers of vinyl pyrrolidone, vinyl alcohols, or vinyl acetate. Suitable cationic surfactants are quaternary surfactants, for example quaternary ammonium compounds with one or two hydrophobic groups, or salts of long-chain primary amines. Suitable amphoteric surfactants are alkylbetains and imidazolines. Suitable block polymers are block polymers of the A-B or A-B-A type comprising blocks of polyethylene oxide and polypropylene oxide, or of the A-B-C type comprising alkanol, polyethylene oxide and polypropylene oxide. Suitable polyelectrolytes are polyacids or polybases. Examples of polyacids are alkali salts of polyacrylic acid or polyacid comb polymers. Examples of polybases are polyvinyl amines or polyethylene amines. Suitable adjuvants are compounds, which have a negligible or even no pesticidal activity themselves, and which improve the biological performance of the compound of Formula (I) on the target. Examples are surfactants, mineral or vegetable oils, and other auxiliaries. Further examples are listed by Knowles, Adjuvants and additives, Agrow Reports DS256, T&F Informa UK, 2006, chapter 5. Suitable thickeners are polysaccharides (e. g. xanthan gum, carboxymethyl cellulose), inorganic clays (organically modified or unmodified), polycarboxylates, and silicates. Suitable bactericides are bronopol and isothiazolinone derivatives such as alkylisothiazolinones and benzisothiazolinones. Suitable anti-freezing agents are ethylene glycol, propylene glycol, urea and glycerin. Suitable anti-foaming agents are silicones, long chain alcohols, and salts of fatty acids. Suitable colorants (e. g. in red, blue, or green) are pigments of low water solubility and water-soluble dyes. Examples are inorganic colorants (e. g. iron oxide, titan oxide, iron hexacyanoferrate) and organic colorants (e. g. alizarin-, azo- and phthalocyanine colorants). Suitable tackifiers or binders are polyvinyl pyrrolidones, polyvinyl acetates, polyvinyl alcohols, polyacrylates, biological or synthetic waxes, and cellulose ethers. Examples for composition types and their preparation are: i) Water-soluble concentrates (SL, LS) 10-60 wt% of a compound of formula (I) and 5-15 wt% wetting agent (e. g. alcohol alkoxylates) are dissolved in water and/or in a water-soluble solvent (e. g. alcohols) ad 100 wt%. The active substance dissolves upon dilution with water. ii) Dispersible concentrates (DC) 5-25 wt% of a compound of formula (I) and 1-10 wt% dispersant (e. g. polyvinyl pyrrolidone) are dissolved in organic solvent (e. g. cyclohexanone) ad 100 wt%. Dilution with water gives a dispersion. iii) Emulsifiable concentrates (EC) 15-70 wt% of a compound of formula (I) and 5-10 wt% emulsifiers (e. g. calcium dodecylbenzenesulfonate and castor oil ethoxylate) are dissolved in water-insoluble organic solvent (e. g. aromatic hydrocarbon) ad 100 wt%. Dilution with water gives an emulsion. iv) Emulsions (EW, EO, ES) 5-40 wt% of a compound of formula (I) and 1-10 wt% emulsifiers (e. g. calcium dodecylbenzenesulfonate and castor oil ethoxylate) are dissolved in 20-40 wt% water-insoluble organic solvent (e. g. aromatic hydrocarbon). This mixture is introduced into water ad 100 wt% by means of an emulsifying machine and made into a homogeneous emulsion. Dilution with water gives an emulsion. v) Suspensions (SC, OD, FS) In an agitated ball mill, 20-60 wt% of a compound of formula (I) are comminuted with addition of 2- 10 wt% dispersants and wetting agents (e. g. sodium lignosulfonate and alcohol ethoxylate), 0.1-2 wt% thickener (e. g. xanthan gum) and water ad 100 wt% to give a fine active substance suspension. Dilution with water gives a stable suspension of the active substance. For FS type composition up to 40 wt% binder (e. g. polyvinyl alcohol) is added. vi) Water-dispersible granules and water-soluble granules (WG, SG) 50-80 wt% of a compound of formula (I) are ground finely with addition of dispersants and wetting agents (e. g. sodium lignosulfonate and alcohol ethoxylate) ad 100 wt% and prepared as water- dispersible or water-soluble granules by means of technical appliances (e. g. extrusion, spray tower, fluidized bed). Dilution with water gives a stable dispersion or solution of the active substance. vii) Water-dispersible powders and water-soluble powders (WP, SP, WS) 50-80 wt% of a compound of formula (I) are ground in a rotor-stator mill with addition of 1-5 wt% dispersants (e. g. sodium lignosulfonate), 1-3 wt% wetting agents (e. g. alcohol ethoxylate) and solid carrier (e. g. silica gel) ad 100 wt%. Dilution with water gives a stable dispersion or solution of the active substance. viii) Gel (GW, GF) In an agitated ball mill, 5-25 wt% of a compound of formula (I) are comminuted with addition of 3-10 wt% dispersants (e. g. sodium lignosulfonate), 1-5 wt% thickener (e. g. carboxymethyl cellulose) and water ad 100 wt% to give a fine suspension of the active substance. Dilution with water gives a stable suspension of the active substance. ix) Microemulsion (ME) 5-20 wt% of a compound of formula (I) are added to 5-30 wt% organic solvent blend (e. g. fatty acid dimethyl amide and cyclohexanone), 10-25 wt% surfactant blend (e. g. alcohol ethoxylate and arylphenol ethoxylate), and water ad 100 %. This mixture is stirred for 1 h to produce spontaneously a thermodynamically stable microemulsion. x) Microcapsules (CS) An oil phase comprising 5-50 wt% of a compound of formula (I), 0-40 wt% water insoluble organic solvent (e. g. aromatic hydrocarbon), 2-15 wt% acrylic monomers (e. g. methylmethacrylate, methacrylic acid and a di- or triacrylate) are dispersed into an aqueous solution of a protective colloid (e. g. polyvinyl alcohol). Radical polymerization results in the formation of poly(meth)acrylate microcapsules. Alternatively, an oil phase comprising 5-50 wt% of a compound of Formula (I) according to the invention, 0-40 wt% water insoluble organic solvent (e. g. aromatic hydrocarbon), and an isocyanate monomer (e. g. diphenylmethene-4,4'-diisocyanatae) are dispersed into an aqueous solution of a protective colloid (e. g. polyvinyl alcohol). The addition of a polyamine (e. g. hexamethylenediamine) results in the formation of polyurea microcapsules. The monomers amount to 1-10 wt%. The wt% relate to the total CS composition. xi) Dustable powders (DP, DS) 1-10 wt% of a compound of formula (I) are ground finely and mixed intimately with solid carrier (e. g. finely divided kaolin) ad 100 wt%. xii) Granules (GR, FG) 0.5-30 wt% of a compound of formula (I) are ground finely and associated with solid carrier (e. g. silicate) ad 100 wt%. Granulation is achieved by extrusion, spray-drying or fluidized bed. xiii) Ultra-low volume liquids (UL) 1-50 wt% of a compound of formula (I) are dissolved in organic solvent (e. g. aromatic hydrocarbon) ad 100 wt%. The compositions types i) to xiii) may optionally comprise further auxiliaries, such as 0.1-1 wt% bactericides, 5-15 wt% anti-freezing agents, 0.1-1 wt% anti-foaming agents, and 0.1-1 wt% colorants. The agrochemical compositions generally comprise between 0.01 and 95%, preferably between 0.1 and 90%, and in particular between 0.5 and 75%, by weight of active ingredient (ai). The active ingredients (ai) are employed in a purity of from 90% to 100%, preferably from 95% to 100% (according to NMR spectrum). For the purposes of treatment of plant propagation materials, particularly seeds, solutions for seed treatment (LS), suspoemulsions (SE), flowable concentrates (FS), powders for dry treatment (DS), water-dispersible powders for slurry treatment (WS), water-soluble powders (SS), emulsions (ES), emulsifiable concentrates (EC), and gels (GF) are usually employed. The compositions in question give, after two-to-tenfold dilution, active substance concentrations from 0.01 to 60% by weight, preferably from 0.1 to 40%, in the ready-to-use preparations. When employed in plant protection, the amounts of active substances applied are, depending on the kind of effect desired, from 0.001 to 2 kg per ha, preferably from 0.005 to 2 kg per ha, more preferably from 0.05 to 1.0 kg per ha, and in particular from 0.1 to 1.0 kg per ha. In the treatment of plant propagation materials such as seeds, e. g. by dusting, coating or drenching seed, amounts of active substance from 0.1 to 1000 g, preferably from 1 to 1000 g, more preferably from 1 to 100 g and most preferably from 5 to 100 g, per 100 kg of plant propagation material (preferably seeds) are generally required. When used in the protection of materials or stored products, the amount of active substance applied depends on the kind of application area and on the desired effect. Amounts customarily applied in the protection of materials are 0.001 g to 2 kg, preferably 0.005 g to 1 kg, of active substance per cubic meter of treated material. Various types of oils, wetters, adjuvants, fertilizer, or micronutrients, and further pesticides (e. g. herbicides, insecticides, fungicides, growth regulators, safeners, biopesticides) may be added to the active substances or the compositions comprising them as premix or, if appropriate not until immediately prior to use (tank mix). These agents can be mixed with the composition according to the invention in a weight ratio of 1:100 to 100:1, preferably 1:20 to 20:1. A pesticide is generally a chemical or biological agent (such as pesticidally active ingredient, compound, composition, virus, bacterium, antimicrobial or disinfectant) that through its effect deters, incapacitates, kills or otherwise discourages pests. Target pests can include insects, plant pathogens, weeds, mollusks, birds, mammals, fish, nematodes (roundworms), and microbes that destroy property, cause nuisance, spread disease or are vectors for disease. The term "pesticide" includes also plant growth regulators that alter the expected growth, flowering, or reproduction rate of plants; defoliants that cause leaves or other foliage to drop from a plant, usually to facilitate harvest; desiccants that promote drying of living tissues, such as unwanted plant tops; plant activators that activate plant physiology for defense against certain pests; safeners that reduce unwanted herbicidal action of pesticides on crop plants; and plant growth promoters that affect plant physiology e.g. to increase plant growth, biomass, yield or any other quality parameter of the harvestable goods of a crop plant. The user applies the composition according to the invention usually from a predosage device, a knapsack sprayer, a spray tank, a spray plane, or an irrigation system. Usually, the agrochemical composition is made up with water, buffer, and/or further auxiliaries to the desired application concentration and the ready-to-use spray liquor or the agrochemical composition according to the invention is thus obtained. Usually, 20 to 2000 liters, preferably 50 to 400 liters, of the ready-to-use spray liquor are applied per hectare of agricultural useful area. In one embodiment, the present invention provides a combination comprising the compound of formula (I) and at least one further pesticidally active substance selected from the group consisting of fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, safeners, plant growth regulators, antibiotics, fertilizers and nutrients. The compound of formula (I), the combination and the composition thereof comprising them in the use as fungicides with other fungicides may result in an expansion of the fungicidal spectrum of activity being obtained or in a prevention of fungicide resistance development. Furthermore, in many cases, extraordinary and unexpected effects are obtained. The present invention also relates to the combination comprising at least one compound of formula (I) and at least one further pesticidally active substance selected from the group of fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, safeners, plant growth regulators, antibiotics, fertiliers and nutrients. The pesticidally active substances reported in WO2015185485 pages 36-43 and WO2017093019 pages 42-56 can be used in conjunction with the compound of formula (I). The active substances referred to as component 2, their preparation and their activity e. g. against harmful fungi is known (cf.: http://www.alanwood.net/pesticides/); these substances are commercially available. The compounds described by IUPAC nomenclature, their preparation and their pesticidal activity are also known (cf. Can. J. Plant Sci.48(6), 587-94, 1968; EP141317; EP152031; EP226917; EP243970; EP256503; EP428941 ; EP532022; EP1028125; EP1035122; EP1201648; EP1122244, JP2002316902; DE19650197; DE10021412; DE102005009458; US3296272; US3325503; WO9846608; WO9914187; WO9924413; WO9927783; WO0029404; WO0046148; WO0065913; WO0154501 ; WO 0156358; WO0222583; WO0240431; WO0310149; WO0311853; WO0314103; WO0316286; WO0353145; WO0361388; WO0366609; WO0374491; WO0449804; WO0483193; WO05120234; WO05123689; WO05123690; WO0563721; WO0587772; WO0587773; WO0615866; WO0687325; WO0687343; WO0782098; WO0790624; WO11028657; WO2012168188; WO2007006670; WO201177514; WO13047749; WO10069882; WO13047441; WO0316303; WO0990181; WO13007767; WO1310862; WO13127704; WO13024009; WO13024010; WO13047441; WO13162072; WO13092224 and WO11135833. The present invention furthermore relates to agrochemical mixtures comprising at least one compound of formula (I) (component 1) and at least one further active substance useful for plant protection. By applying the compound of formula (I) together with at least one pesticidally active compound an additional effect can be obtained. This can be obtained by applying the compound of formula (I) and at least one further pesticidally active substance simultaneously, either jointly (e. g. as tank-mix) or separately, or in succession, wherein the time interval between the individual applications is selected to ensure that the active substance applied first still occurs at the site of action in a sufficient amount at the time of application of the further pesticidally active substance(s). The order of application is not essential for working of the present invention. When applying the compound of formula (I) and a pesticidally active substance sequentially the time between both applications may vary e. g. between 2 hours to 7 days. Also a broader range is possible ranging from 0.25 hour to 30 days, preferably from 0.5 hour to 14 days, particularly from 1 hour to 7 days or from 1.5 hours to 5 days, even more preferred from 2 hours to 1 day. In the binary mixtures and the composition according to the invention the weight ratio of the component 1) and the component 2) generally depends on the properties of the active components used, usually it is in the range of 1:1000 to 1000:1, often in the range of 1:100 to 100:1, regularly in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1, even more preferably in the range of 1:4 to 4:1 and in particular in the range of 1:2 to 2:1. According to a further embodiment of the binary mixtures and the composition thereof, the weight ratio of the component 1) and the component 2) usually is in the range of 1000:1 to 1:1000, often in the range of 100:1 to 1:100, regularly in the range of 50:1 to 1:50, preferably in the range of 20:1 to 1:20, more preferably in the range of 10:1 to 1:10, even more preferably in the range of 4:1 to 1:4 and in particular in the range of 2:1 to 1:2. In the ternary mixtures, i.e. the composition according to the invention comprising the component 1) and component 2) and a compound III (component 3), the weight ratio of component 1) and component 2) depends from the properties of the active substances used, usually it is in the range of 1:100 to 100:1, regularly in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1 and in particular in the range of 1:4 to 4:1, and the weight ratio of component 1) and component 3) usually it is in the range of 1:100 to 100:1, regularly in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1 and in particular in the range of 1:4 to 4:1. Any further active components are, if desired, added in a ratio of 20:1 to 1:20 to the component 1. These ratios are also suitable for inventive mixtures applied by seed treatment. According to one embodiment, individual components of the composition according to the invention such as parts of a kit or parts of a binary or ternary mixture may be mixed by the user himself in a spray tank or any other kind of vessel used for applications (e. g. seed treater drums, seed pelleting machinery, knapsack sprayer) and further auxiliaries may be added, if appropriate. Consequently, one embodiment of the invention is a kit for preparing a usable pesticidal composition, the kit comprising a) a composition comprising component 1) as defined herein and at least one auxiliary; and b) a composition comprising component 2) as defined herein and at least one auxiliary; and optionally c) a composition comprising at least one auxiliary and optionally a further active component 3) as defined herein. Application of the compound of formula (I), the combination and the composition thereof can be carried out before or during sowing. Methods for applying the compound of formula (I), the combination and the composition thereof, respectively, are application onto plant propagation material, especially seeds, include dressing, coating, pelleting, dusting, and soaking as well as in- furrow application methods. Preferably, the compound of formula (I), the combination and the composition thereof, respectively, are applied on to the plant propagation material by a method such that germination is not induced, e. g. by seed dressing, pelleting, coating and dusting. In one embodiment, the present invention provides a method for controlling or preventing infestation of plants by phytopathogenic microorganisms in agricultural crops and/or horticultural crops wherein an effective amount of at least one compound of formula (I) or the combination or the composition, is applied to the plants, to parts thereof or locus thereof. In another embodiment, the present invention provides a method for controlling or preventing infestation of plants by phytopathogenic microorganisms in agricultural crops and or horticultural crops wherein an effective amount of at least one compound of formula (I) or the combination or the composition, is applied to the seeds of plants. The compound of formula (I) and the composition according to the invention, respectively, are suitable as fungicides. They are distinguished by an outstanding effectiveness against a broad spectrum of phytopathogenic fungi, including soil-borne fungi, which derive especially from the classes of the Plasmodiophoromycetes, Peronosporomycetes (syn. Oomycetes), Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes (syn. Fungi imperfecti). Some are systemically effective and they can be used in crop protection as foliar fungicides, fungicides for seed dressing and soil fungicides. Moreover, they are suitable for controlling harmful fungi, which inter alia occur in wood or roots of plants. The compound of formula (I) and the composition according to the invention are particularly important in the control of a multitude of phytopathogenic fungi on various cultivated plants, such as cereals, e. g. wheat, rye, barley, triticale, oats or rice; beet, e. g. sugar beet or fodder beet; fruits, such as pomes, stone fruits or soft fruits, e. g. apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, blackberries or gooseberries; leguminous plants, such as lentils, peas, alfalfa or soybeans; oil plants, such as rape, mustard, olives, sunflowers, coconut, cocoa beans, castor oil plants, oil palms, ground nuts or soybeans; cucurbits, such as squashes, cucumber or melons; fiber plants, such as cotton, flax, hemp or jute; citrus fruit, such as oranges, lemons, grapefruits or mandarins; vegetables, such as spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, cucurbits or paprika; lauraceous plants, such as avocados, cinnamon or camphor; energy and raw material plants, such as corn, soybean, rape, sugar cane or oil palm; corn; tobacco; nuts; coffee; tea; bananas; vines (table grapes and grape juice grape vines); hop; turf; sweet leaf (also called Stevia); natural rubber plants or ornamental and forestry plants, such as flowers, shrubs, broad-leaved trees or evergreens, e. g. conifers; and on the plant propagation material, such as seeds, and the crop material of these plants. Particularly, the compound of formula (I) and the composition according to the invention are important in the control of phytopathogenic fungi on soybeans and on the plant propagation material, such as seeds, and the crop material of soybeans. Preferably, the compound of formula (I) and composition thereof, respectively are used for controlling a multitude of fungi on field crops, such as potatoes sugar beets, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybeans, rape, legumes, sunflowers, coffee or sugar cane; fruits; vines; ornamentals; or vegetables, such as cucumbers, tomatoes, beans or squashes. The term "plant propagation material" is to be understood to denote all the generative or reproductive parts of the plant such as seeds and vegetative plant material such as cuttings and tubers (e. g. potatoes), which can be used for the multiplication of the plant. This includes seeds, roots, fruits, tubers, bulbs, rhizomes, shoots, sprouts, twigs, flowers, and other parts of plants, including seedlings and young plants, which are to be transplanted after germination or after emergence from soil. These young plants may also be protected before transplantation by a total or partial treatment by immersion or pouring. Preferably, treatment of plant propagation materials with the compound of formula (I), the combination and or the composition thereof, respectively, is used for controlling a multitude of fungi on cereals, such as wheat, rye, barley and oats; rice, corn, cotton and soybeans. The term "cultivated plants" is to be understood as including plants which have been modified by breeding, mutagenesis or genetic engineering including but not limiting to agricultural biotech products on the market or in development (cf. http://cera-gmc.org/, see GM crop database therein). Genetically modified plants are plants, which genetic material has been so modified by the use of recombinant DNA techniques that under natural circumstances cannot readily be obtained by cross breeding, mutations or natural recombination. Typically, one or more genes have been integrated into the genetic material of a genetically modified plant in order to improve certain properties of the plant. Such genetic modifications also include but are not limited to targeted post-translational modification of protein(s), oligo-or polypeptides e. g. by glycosylation or polymer additions such as prenylated, acetylated or farnesylated moieties or PEG moieties. Plants that have been modified by breeding, mutagenesis or genetic engineering, e. g. have been rendered tolerant to applications of specific classes of herbicides, such as auxin herbicides such as dicamba or 2,4-D; bleacher herbicides such as hydroxylphenylpyruvate dioxygenase (HPPD) inhibitors or phytoene desaturase (PDS) inhibitors; acetolactate synthase (ALS) inhibitors such as sulfonyl ureas or imidazolinones; enolpyruvylshikimate-3-phosphate synthase (EPSPS) inhibitors, such as glyphosate; glutamine synthetase (GS) inhibitors such as glufosinate; protoporphyrinogen-IX oxidase inhibitors; lipid biosynthesis inhibitors such as acetyl CoA carboxylase (ACCase) inhibitors; or oxynil (i. e. bromoxynil or ioxynil) herbicides as a result of conventional methods of breeding or genetic engineering. Furthermore, plants have been made resistant to multiple classes of herbicides through multiple genetic modifications, such as resistance to both glyphosate and glufosinate or to both glyphosate and a herbicide from another class such as ALS inhibitors, HPPD inhibitors, auxin herbicides, or ACCase inhibitors. These herbicide resistance technologies are e. g. described in Pest Managem. Sci. 61, 2005, 246; 61, 2005, 258; 61, 2005, 277; 61, 2005, 269; 61, 2005, 286; 64, 2008, 326; 64, 2008, 332; Weed Sci. 57, 2009, 108; Austral. J. Agricult. Res. 58, 2007, 708; Science 316, 2007, 1185; and references quoted therein. Several cultivated plants have been rendered tolerant to herbicides by conventional methods of breeding (mutagenesis), e. g. Clearfield® summer rape (Canola, BASF SE, Germany) being tolerant to imidazolinones, e. g. imazamox, or ExpressSun® sunflowers (DuPont, USA) being tolerant to sulfonyl ureas, e. g. tribenuron. Genetic engineering methods have been used to render cultivated plants such as soybean, cotton, corn, beets and rape, tolerant to herbicides such as glyphosate and glufosinate, some of which are commercially available under the trade names RoundupReady® (glyphosate-tolerant, Monsanto, U.S.A.), Cultivance® (imidazolinone tolerant, BASF SE, Germany) and LibertyLink® (glufosinate-tolerant, Bayer CropScience, Germany). Furthermore, plants capable to synthesize one or more insecticidal proteins, especially those known from the bacterial genus (Bacillus), by the use of recombinant DNA techniques are within the scope of the present invention. The Bacillus are particularly from Bacillus thuringiensis, such as δ- endotoxins, e. g. CrylA(b), CrylA(c), CrylF, CrylF(a2), CryllA(b), CrylllA, CrylllB(bl) or Cry9c; vegetative insecticidal proteins (VIP), e. g. VIP1, VIP2, VIP3 or VIP3A; insecticidal proteins of bacteria colonizing nematodes, e. g. Photorhabdus spp. or Xenorhabdus spp.; toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins, or other insect-specific neurotoxins; toxins produced by fungi, such Streptomycetes toxins, plant lectins, such as pea or barley lectins; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin or papain inhibitors; ribosome-inactivating proteins (RIP), such as ricin, maize-RIP, abrin, luffin, saporin or bryodin; steroid metabolism enzymes, such as 3-hydroxysteroid oxidase, ecdysteroid-IDP-glycosyl-transferase, cholesterol oxidases, ecdysone inhibitors or HMG-CoA- reductase; ion channel blockers, such as blockers of sodium or calcium channels; juvenile hormone esterase; diuretic hormone receptors (helicokinin receptors); stilbene synthase, bibenzyl synthase, chitinases or glucanases. In the context of the present invention these insecticidal proteins or toxins are to be understood expressly also as pre-toxins, hybrid proteins, truncated or otherwise modified proteins. Hybrid proteins are characterized by a new combination of protein domains, (see, e. g. WO02/015701). Further examples of such toxins or genetically modified plants capable of synthesizing such toxins are disclosed, e. g., in EP374753, WO93/007278, WO95/34656, EP427529, EP451878, WO03/18810 und WO03/52073. The methods for producing such genetically modified plants are generally known to the person skilled in the art and are described, e. g. in the publications mentioned above. These insecticidal proteins contained in the genetically modified plants impart to the plants, producing these proteins, tolerance to harmful pests from all taxonomic groups of arthropods, especially to beetles (Coeloptera), two-winged insects (Diptera), and moths (Lepidoptera) and to nematodes (Nematoda). Genetically modified plants capable to synthesize one or more insecticidal proteins are, e. g., described in the publications mentioned above, and some of which are commercially available such as YieldGard® (corn cultivars producing the CrylAb toxin), YieldGard® Plus (corn cultivars producing CrylAb and Cry3Bb1 toxins), Starlink® (corn cultivars producing the Cry9c toxin), Herculex® RW (corn cultivars producing Cry34Ab1, Cry35Ab1 and the enzyme phosphinothricin-N-acetyltransferase [PAT]); NuCOTN® 33B (cotton cultivars producing the CrylAc toxin), Bollgard® I (cotton cultivars producing the Cry1 Ac toxin), Bollgard® II (cotton cultivars producing CrylAc and Cry2Ab2 toxins); VIPCOT® (cotton cultivars producing a VIP-toxin); NewLeaf®(potato cultivars producing the Cry3A toxin); Bt-Xtra®, NatureGard®, KnockOut®, BiteGard®, Protecta®, Bt11 (e. g. Agrisure® CB) and Bt176 from Syngenta Seeds SAS, France, (corn cultivars producing the CrylAb toxin and PAT enyzme), MIR604 from Syngenta Seeds SAS, France (corn cultivars producing a modified version of the Cry3A toxin, c.f. WO 03/018810), MON 863 from Monsanto Europe S.A., Belgium (corn cultivars producing the Cry3Bb1 toxin), IPC 531 from Monsanto Europe S.A., Belgium (cotton cultivars producing a modified version of the CrylAc toxin) and 1507 from Pioneer Overseas Corporation, Belgium (corn cultivars producing the Cry1 F toxin and PAT enzyme). Furthermore, plants capable to synthesize one or more proteins to increase the resistance or tolerance of those plants to bacterial, viral or fungal pathogens by the use of recombinant DNA techniques are also within the scope of the present invention. Examples of such proteins are the so-called "pathogenesis-related proteins" (PR proteins, see, e. g. EP392225), plant disease resistance genes (e. g. potato cultivars, which express resistance genes acting against Phytophthora infestans derived from the Mexican wild potato Solanum bulbocastanum) or T4-lysozym (e. g. potato cultivars capable of synthesizing these proteins with increased resistance against bacteria such as Erwinia amylvora). The methods for producing such genetically modified plants are generally known to the person skilled in the art and are described, e. g. in the publications mentioned above. Furthermore, plants capable to synthesize one or more proteins, by the use of recombinant DNA techniques, to increase the productivity (e. g. bio mass production, grain yield, starch content, oil content or protein content), tolerance to drought, salinity or other growth-limiting environmental factors or tolerance to pests and fungal, bacterial or viral pathogens of those plants are within the scope of the present invention. Furthermore, plants that contain a modified amount of substances of content or new substances of content, by the use of recombinant DNA techniques, to improve human or animal nutrition, e. g. oil crops that produce health-promoting long-chain omega-3 fatty acids or unsaturated omega-9 fatty acids (e. g. Nexera® rape, DOW Agro Sciences, Canada) are also within the scope of the present invention. Furthermore, plants that contain a modified amount of substances of content or new substances of content, by the use of recombinant DNA techniques, to improve raw material production, e. g. potatoes that produce increased amounts of amylopectin (e. g. Amflora® potato, BASF SE, Germany) are also within the scope of the present invention. The compounds of formula (I) may be, for example, effective against fungi and fungal vectors of disease as well as phytopathogenic bacteria and viruses. These fungi and fungal vectors of disease as well as phytopathogenic bacteria and viruses are for example: Absidia corymbifera, Alternaria spp, Aphanomyces spp, Ascochyta spp, Aspergillus spp. including A. flavus, A. fumigatus, A. nidulans, A. niger, A. terms, Aureobasidium spp. including A. pullulans, Blastomyces dermatitidis, Blumeria graminis, Bremia lactucae, Botryosphaeria spp. including B. dothidea, B. obtusa, Botrytis spp. inclusing B. cinerea, Candida spp. including C. albicans, C. glabrata, C. krusei, C. lusitaniae, C. parapsilosis, C. tropicalis, Cephaloascus fragrans, Ceratocystis spp, Cercospora spp. including C. arachidicola, Cercosporidium personatum, Cladosporium spp, Claviceps purpurea, Coccidioides immitis, Cochliobolus spp, Colletotrichum spp. including C. musae, Cryptococcus neoformans, Colletotrichum capsici, Diaporthe spp, Didymella spp, Drechslera spp, Elsinoe spp, Epidermophyton spp, Erwinia amylovora, Erysiphe spp. including E. cichoracearum, Eutypa lata, Fusarium spp. including F. culmorum, F. graminearum, F. langsethiae, F. moniliforme, F. oxysporum, F. proliferatum, F. subglutinans, F. solani, Gaeumannomyces graminis, Gibberella fujikuroi, Gloeodes pomigena, Gloeosporium musarum, Glomerella cingulate, Guignardia bidwellii, Gym nosporangium juniperi-virginianae, Helminthosporium spp, Hemileia spp, Histoplasma spp. including H. capsulatum, Laetisaria fuciformis, Leptographium lindbergi, Leveillula taurica, Lophodermium seditiosum, Microdochium nivale, Microsporum spp, Monilinia spp, Mucor spp, Mycosphaerella spp. including M. graminicola, M. pomi, Oncobasidium theobromaeon, Ophiostoma piceae, Paracoccidioides spp, Penicillium spp. including P. digitatum, P. italicum, Petriellidium spp, Peronosclerospora spp. Including P. maydis, P. philippinensis and P. sorghi, Peronospora spp, Parastagonospora nodorum, Phaeosphaeria nodorum, Phakopsora pachyrhizi, Phellinus igniarus, Phialophora spp, Phoma spp, Phomopsis viticola, Phytophthora spp. including P. infestans, Plasmopara spp. including P. halstedii, P. viticola, Pleospora spp., Podosphaera spp. including P. leucotricha, Polymyxa graminis, Polymyxa betae, Pseudocercosporella herpotrichoides, Pseudomonas spp, Pseudoperonospora spp. including P. cubensis, P. humuli, Pseudopeziza tracheiphila, Puccinia spp. including P. hordei, P. recondita, P. striiformis, P. triticina, Pyrenopeziza spp, Pyrenophora spp, Pyricularia spp. including P. oryzae, Pythium spp. including P. ultimum, Ramularia spp, Rhizoctonia spp, Rhizomucor pusillus, Rhizopus arrhizus, Rhynchosporium spp, Scedosporium spp. including S. apiospermum and S. prolificans, Schizothyrium pomi, Sclerotinia spp, Sclerotium spp, Septoria spp, including S. nodorum, S. tritici, Septoria lycopersici, Sphaerotheca macularis, Sphaerotheca fusca (Sphaerotheca fuliginea), Sporothorix spp, Stagonospora nodorum, Stemphylium spp., Stereum hirsutum, Thanatephorus cucumeris, Thielaviopsis basicola, Tilletia spp, Trichoderma spp., including T. harzianum, T. pseudokoningii, T. viride, Trichophyton spp, Typhula spp, Uncinula necator, Urocystis spp, Ustilago spp, Venturia spp. including V. inaequalis, Verticillium spp., and Xanthomonas spp, Ustilaginales such as Ustilaginoidea virens, Ustilago nuda, Ustilago tritici, Ustilago zeae, Cerotelium fici, Chrysomyxa arctostaphyli, Coleosporium ipomoeae, Hemileia vastatrix, Puccinia arachidis, Puccinia cacabata, Puccinia graminis, Puccinia sorghi, Puccinia striiformis f.sp. Hordei, Puccinia striiformis f.sp. Secalis, Pucciniastrum coryli, or Uredinales such as Cronartium ribicola, Gymnosporangium juniperi-viginianae, Melampsora medusae, Phragmidium mucronatum, Physopella ampelosidis, Tranzschelia discolor and Uromyces viciae-fabae, Cryptococcus spp., Exobasidium vexans, Marasmiellus inoderma, Mycena spp., Sphacelotheca reiliana, Typhula ishikariensis, Urocystis agropyri, ltersonilia perplexans, Corticium invisum, Waitea circinata, Rhizoctonia solani, Thanetephorus cucurmeris, Entyloma dahliae, Entylomella microspora, Neovossia moliniae and Tilletia caries, Blastocladiomycetes, such as Physoderma maydis, Mucoromycetes, such as Choanephora cucurbitarum. Non-limiting examples of pathogens of fungal diseases which can be treated in accordance with the invention include the diseases caused by rust disease pathogens, for example Gymnosporangium species, for example Gymnosporangium sabinae; Hemileia species, for example Hemileia vastatrix; Phakopsora species, for example Phakopsora pachyrhizi or Phakopsora meibomiae; Puccinia species, for example Puccinia recondita, Puccinia graminis oder Puccinia striiformis; Uromyces species, for example Uromyces appendiculatus. In particular, Cronartium ribicola (White pine blister rust); Gymnosporangium juniperi-virginianae (Cedar-apple rust); Hemileia vastatrix (Coffee rust); Phakopsora meibomiae and P. pachyrhizi (Soybean rust); Puccinia coronata (Crown Rust of Oats and Ryegrass); Puccinia graminis (Stem rust of wheat and Kentucky bluegrass, or black rust of cereals); Puccinia hemerocallidis (Daylily rust); Puccinia persistens subsp. triticina (wheat rust or 'brown or red rust'); Puccinia sorghi (rust in corn); Puccinia striiformis ('Yellow rust' in cereals); Uromyces appendiculatus (rust of beans); Uromyces phaseoli (Bean rust); Puccinia melanocephala ('Brown rust' in sugarcane); Puccinia kuehnii ('Orange rust' in sugarcane). The present invention further relates to the use of the compound of formula (I), the combination or the composition thereof for controlling or preventing against phytopathogenic fungi such as Septoria spp., powdery mildews, Botrytis spp., anthracnose, Alternaria spp., scab and Monilinia spp. of agricultural crops and or horticultural crops. The present invention further relates to the use of the compound of formula (I), the combination or the composition thereof for controlling or preventing against phytopathogenic fungi such as Septoria spp., powdery mildews, Botrytis spp., anthracnose, Alternaria spp., scab and Monilinia spp. in cereals, grapevines, fruits, nuts and vegetables. Plants which can be treated in accordance with the invention include the following: cotton, flax, grapevine, fruits, vegetables, such as Rosaceae sp (for example pome fruits such as apples, pears, apricots, cherries, almonds and peaches), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for example banana trees and plantations), Rubiaceae sp. (for example coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for example lemons, oranges and grapefruit); Vitaceae sp. (for example grapes); Solanaceae sp. (for example tomatoes, peppers), Liliaceae sp., Asteraceae sp. (for example lettuce), Umbelliferae sp., Cruciferae sp., Chenopodiaceae sp., Cucurbitaceae sp. (for example cucumber), Alliaceae sp. (for example leek, onion), Papilionaceae sp. (for example peas); major crop plants, such as Poaceae/Gramineae sp. (for example maize, turf, cereals such as wheat, rye, rice, barley, oats, millet and triticale), Asteraceae sp. (for example sunflower), Brassicaceae sp. (for example white cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, pak choi, kohlrabi, radishes, and oilseed rape, mustard, horseradish and cress), Fabacae sp. (for example bean, peanuts), Papilionaceae sp. (for example soya bean), Solanaceae sp. (for example potatoes), Chenopodiaceae sp. (for example sugar beet, fodder beet, swiss chard, beetroot); Malvaceae (for example cotton); useful plants and ornamental plants for gardens and wooded areas; and genetically modified varieties of each of these plants. More preference is given to controlling the following diseases of soya beans: Fungal diseases on leaves, stems, pods and seeds caused, for example, by Altemaria leaf spot (Altemaria spec. atrans tenuissima), Anthracnose (Colletotrichum gloeosporoides dematium var. truncatum), brown spot (Septoria glycines ), cercospora leaf spot and blight ( Cercospora kikuchii), choanephora leaf blight (Choanephora infundibulifera trispora (Syn.)), dactuliophora leaf spot (Dactuliophora glycines), downy mildew (Peronospora manshurica), drechslera blight (Drechslera glycini), frogeye leaf spot (Cercospora sojina), leptosphaerulina leaf spot (Leptosphaerulina trifolii), phyllostica leaf spot (Phyllosticta sojaecola), pod and stem blight (Phomopsis sojae), powdery mildew (Microsphaera diffusa), pyrenochaeta leaf spot (Pyrenochaeta glycines), rhizoctonia aerial, foliage, and web blight (Rhizoctonia solani), rust (Phakopsora pachyrhizi, Phakopsora meibomiae), scab (Sphaceloma glycines), stemphylium leaf blight (Stemphylium botryosum), target spot (Corynespora cassiicola). Fungal diseases on roots and the stem base caused, for example, by black root rot (Calonectiia crotalariae), charcoal rot (Macrophomina phaseolina), fusarium blight or wilt, root rot, and pod and collar rot (Fusarium oxysporum, Fusarium orthoceras, Fusarium semitectum, Fusarium equiseti), mycoleptodiscus root rot (Mycoleptodiscus terrestris), neocosmospora (Neocosmospora vasinfecta), pod and stem blight (Diaporthe phaseolorum), stem canker (Diaporthe phaseolorum var. caulivora), phytophthora rot (Phytophthora megasperma), brown stem rot (Phialophora gregata), pythium rot (Pythium aphanidennatum, Pythium irregulare, Pythium debaryanum, Pythium myriotylum, Pythium ultimum), rhizoctonia root rot, stem decay, and damping-off (Rhizoctonia solani), sclerotinia stem decay (Sclerotinia sclerotiorum), sclerotinia southern blight (Sclerotinia rolfsii), thielaviopsis root rot (Thielaviopsis basicola). The present invention also relates to the use of the compound of formula (I), the combination or the composition thereof for controlling or preventing the following plant diseases: Puccinia spp. (rusts) on various plants, for example, but not limited to P. triticina (brown or leaf rust), P. striiformis (stripe or yellow rust), P. hordei (dwarf rust), P. graminis (stem or black rust) or P. recondita (brown or leaf rust) on cereals, such as e. g. wheat, barley or rye and Phakopsoraceae spp. on various plants, in particular Phakopsora pachyrhizi and P. meibomiae (soybean rust) on soybeans, Hemileia vastatrix (Coffee rust), Uromyces appendiculatus, Uromyces fabae and Uromyces phaseoli (rust of beans). The compound, the combination and the composition of the present invention can be used for controlling or preventing plant diseases. The compound of formula (I), the combination and/or the composition thereof, respectively, are particularly suitable for controlling the following plant diseases: Albugo spp. (white rust) on ornamentals, vegetables (e. g. A. Candida) and sunflowers (e. g. A. tragopogonis); Altemaria spp. (Alternaria leaf spot) on vegetables, rape (A. brassicola or brassicae), sugar beets (A. tenuis), fruits, rice, soybeans, potatoes (e. g. A. solani or A. alternata), tomatoes (e. g. A. solani or A. alternata) and wheat; Aphanomyces spp. on sugar beets and vegetables; Ascochyta spp. on cereals and vegetables, e. g. A. tritici (anthracnose) on wheat and A. hordei on barley; Bipolaris and Drechslera spp. (teleomorph: Cochliobolus spp.), e. g. Southern leaf blight (D. maydis) or Northern leaf blight (B. zeicola) on corn, e. g. spot blotch (C. sorokiniana) on cereals and e. g. B. oryzae on rice and turfs; Blumeria (formerly Erysiphe) graminis (powdery mildew) on cereals (e. g. on wheat or barley); Botrytis cinerea (teleomorph: Botryotinia fuckeliana: grey mold) on fruits and berries (e. g. strawberries), vegetables (e. g. lettuce, carrots, celery and cabbages), rape, flowers, vines, forestry plants and wheat; Bremia lactucae (downy mildew) on lettuce; Ceratocystis (syn. Ophiostoma) spp. (rot or wilt) on broad-leaved trees and evergreens, e. g. C. ulmi (Dutch elm disease) on elms; Cercospora spp. (Cercospora leaf spots) on corn (e. g. Gray leaf spot: C. zeae-maydis), rice, sugar beets (e. g. C. beticola), sugar cane, vegetables, coffee, soybeans (e. g. C. sojina or C. kikuchii) and rice; Cladosporium spp. on tomatoes (e. g. C. fulvum: leaf mold) and cereals, e. g. C. herbarum (black ear) on wheat; Claviceps purpurea (ergot) on cereals; Cochliobolus (anamorph: Helminthosporium of Bipolaris) spp. (leaf spots) on corn (C. carbonum), cereals (e. g. C. sativus, anamorph: B. sorokiniana) and rice (e. g. C. miyabeanus, anamorph: H. oryzae); Colletotrichum (teleomorph: Glomerella) spp. (anthracnose) on cotton (e. g. C. gossypii), corn (e. g. C. graminicola: Anthracnose stalk rot), soft fruits, potatoes (e. g. C. coccodes: black dot), beans (e. g. C. lindemuthianum) and soybeans (e. g. C. truncatum or C. gloeosporioides); Corticium spp., e. g. C. sasakii (sheath blight) on rice; Corynespora cassiicola (leaf spots) on soybeans and ornamentals; Cycloconium spp., e. g. C. oleaginum on olive trees; Cylindrocarpon spp. (e. g. fruit tree canker or young vine decline, teleomorph: Nectria or Neonectria spp.) on fruit trees, vines (e. g. C. liriodendri, teleomorph: Neonectria liriodendri: Black Foot Disease) and ornamentals; Dematophora (teleomorph: Rosellinia) necatrix (root and stem rot) on soybeans; Diaporthe spp., e. g. D. phaseolorum (damping off) on soybeans; Drechslera (syn. Helminthosporium, teleomorph: Pyrenophora) spp. on corn, cereals, such as barley (e. g. D. teres, net blotch) and wheat (e. g. D. tritici-repentis: tan spot), rice and turf; Esca (dieback, apoplexy) on vines, caused by Formitiporia (syn. Phellinus) punctata, F. mediterranea, Phaeomoniella chlamydospora (earlier Phaeoacremonium chlamydosporum), Phaeoacremonium aleophilum and/or Botryosphaeria obtusa; Elsinoe spp. on pome fruits (E. pyri), soft fruits (E. veneta: anthracnose) and vines (E. ampelina: anthracnose); Entyloma oryzae (leaf smut) on rice; Epicoccum spp. (black mold) on wheat; Erysiphe spp. (powdery mildew) on sugar beets (£. betae), vegetables (e. g. E. pisi), such as cucurbits (e. g. E. cichoracearum), cabbages, rape (e. g. E. cruciferarum); Eutypa lata (Eutypa canker or dieback, anamorph: Cytosporina lata, syn. Libertella blepharis) on fruit trees, vines and ornamental woods; Exserohilum (syn. Helminthosporium) spp. on corn (e. g. E. turcicum); Fusarium (teleomorph: Gibberella) spp. (wilt, root or stem rot) on various plants, such as F. graminearum or F. culmorum (root rot, scab or head blight) on cereals (e. g. wheat or barley), F. oxysporum on tomatoes, F. solani (f. sp. glycines now syn. F. virguliforme) and F. tucumaniae and F. brasiliense each causing sudden death syndrome on soybeans, and F. verticillioides on corn; Gaeumannomyces graminis (take-all) on cereals (e. g. wheat or barley) and corn; Gibberella spp. on cereals (e. g. G. zeae) and rice (e. g. G. fujikuroi: Bakanae disease); Glomerella cingulata on vines, pome fruits and other plants and G. gossypii on cotton; Grainstaining complex on rice; Guignardia bidwellii (black rot) on vines; Gymnosporangium spp. on rosaceous plants and junipers, e. g. G. sabinae (rust) on pears; Helminthosporium spp. (syn. Drechslera, teleomorph: Cochliobolus) on corn, cereals and rice; Hemileia spp., e. g. H. vastatrix (coffee leaf rust) on coffee; Isariopsis clavispora (syn. Cladosporium vitis) on vines; Macrophomina phaseolina (syn. phaseoli) (root and stem rot) on soybeans and cotton; Microdochium (syn. Fusarium) nivale (pink snow mold) on cereals (e. g. wheat or barley); Microsphaera diffusa (powdery mildew) on soybeans; Monilinia spp., e. g. M. laxa, M. fructicola and M. fructigena (bloom and twig blight, brown rot) on stone fruits and other rosaceous plants; Mycosphaerella spp. on cereals, bananas, soft fruits and ground nuts, such as e. g. M. graminicola (anamorph: Septoria tritici, Septoria blotch) on wheat or M. fijiensis (black Sigatoka disease) on bananas; Peronospora spp. (downy mildew) on cabbage (e. g. P. brassicae), rape (e. g. P. parasitica), onions (e. g. P. destructor), tobacco (P. tabacina) and soybeans (e. g. P. manshurica); Phakopsora pachyrhizi and P. meibomiae (soybean rust) on soybeans; Phialophora spp. e. g. on vines (e. g. P. tracheiphila and P. tetraspora) and soybeans (e. g. P. gregata: stem rot); Phoma lingam (root and stem rot) on rape and cabbage and P. betae (root rot, leaf spot and damping-off) on sugar beets; Phomopsis spp. on sunflowers, vines (e. g. P. viticola: can and leaf spot) and soybeans (e. g. stem rot: P. phaseoli, teleomorph: Diaporthe phaseolorum); Physoderma maydis (brown spots) on corn; Phytophthora spp. (wilt, root, leaf, fruit and stem root) on various plants, such as paprika and cucurbits (e. g. P. capsici), soybeans (e. g. P. megasperma, syn. P. sojae), soybeans, potatoes and tomatoes (e. g. P. infestans: late blight) and broad-leaved trees (e. g. P. ramorum: sudden oak death); Plasmodiophora brassicae (club root) on cabbage, rape, radish and other plants; Plasmopara spp., e. g. P. viticola (grapevine downy mildew) on vines and P. halstedii on sunflowers; Podosphaera spp. (powdery mildew) on rosaceous plants, hop, pome and soft fruits, e. g. P. leucotricha on apples; Polymyxa spp., e. g. on cereals, such as barley and wheat (P. graminis) and sugar beets (P. betae) and thereby transmitted viral diseases; Pseudocercosporella herpotrichoides (eyespot, teleomorph: Tapesia yallundae) on cereals, e. g. wheat or barley; Pseudoperonospora (downy mildew) on various plants, e. g. P. cubensis on cucurbits or P. humili on hop; Pseudopezicula tracheiphila (red fire disease or .rotbrenner', anamorph: Phialophora) on vines; Puccinia spp. (rusts) on various plants, e. g. P. triticina (brown or leaf rust), P. striiformis (stripe or yellow rust), P. hordei (dwarf rust), P. graminis (stem or black rust) or P. recondita (brown or leaf rust) on cereals, such as e. g. wheat, barley or rye, P. kuehnii (orange rust) on sugar cane and P. asparagi on asparagus; Pyrenophora (anamorph: Drechslera) tritici-repentis (tan spot) on wheat or P. teres (net blotch) on barley; Pyricularia spp., e. g. P. oryzae (teleomorph: Magnaporthe grisea, rice blast) on rice and P. grisea on turf and cereals; Pythium spp. (damping-off) on turf, rice, corn, wheat, cotton, rape, sunflowers, soybeans, sugar beets, vegetables and various other plants (e. g. P. ultimum or P. aphanidermatum); Ramularia spp., e. g. R. collo-cygni (Ramularia leaf spots, Physiological leaf spots) on barley and R. beticola on sugar beets; Rhizoctonia spp. on cotton, rice, potatoes, turf, corn, rape, potatoes, sugar beets, vegetables and various other plants, e. g. R. solani (root and stem rot) on soybeans, R. solani (sheath blight) on rice or R. cerealis (Rhizoctonia spring blight) on wheat or barley; Rhizopus stolonifer (black mold, soft rot) on strawberries, carrots, cabbage, vines and tomatoes; Rhynchosporium secalis (scald) on barley, rye and triticale; Sarocladium oryzae and S. attenuatum (sheath rot) on rice; Sclerotinia spp. (stem rot or white mold) on vegetables and field crops, such as rape, sunflowers (e. g. S. sclerotiorum) and soybeans (e. g. S. rolfsii or S. sclerotiorum); Septoria spp. on various plants, e. g. S. glycines (brown spot) on soybeans, S. tritici (Septoria blotch) on wheat and S. (syn. Stagonospora) nodorum (Stagonospora blotch) on cereals; Uncinula (syn. Erysiphe) necator (powdery mildew, anamorph: Oidium tuckeri) on vines; Setospaeria spp. (leaf blight) on corn (e. g. S. turcicum, syn. Helminthosporium turcicum) and turf; Sphacelotheca spp. (smut) on corn, (e. g. S. reiliana: head smut), sorghum und sugar cane; Sphaerotheca fuliginea (powdery mildew) on cucurbits; Spongospora subterranea (powdery scab) on potatoes and thereby transmitted viral diseases; Stagonospora spp. on cereals, e. g. S. nodorum (Stagonospora blotch, teleomorph: Leptosphaeria [syn. Phaeosphaeria] nodorum) on wheat; Synchytrium endobioticum on potatoes (potato wart disease); Taphrina spp., e. g. T. deformans (leaf curl disease) on peaches and T. pruni (plum pocket) on plums; Thielaviopsis spp. (black root rot) on tobacco, pome fruits, vegetables, soybeans and cotton, e. g. T. basicola (syn. Chalara elegans); Tilletia spp. (common bunt or stinking smut) on cereals, such as e. g. T. tritici (syn. T. caries, wheat bunt) and T. controversa (dwarf bunt) on wheat; Typhula incarnata (grey snow mold) on barley or wheat; Urocystis spp., e. g. U. occulta (stem smut) on rye; Uromyces spp. (rust) on vegetables, such as beans (e. g. U. appendiculatus, syn. U. phaseoli) and sugar beets (e. g. U. betae); Ustilago spp. (loose smut) on cereals (e. g. U. nuda and U. avaenae), corn (e. g. U. maydis: corn smut) and sugar cane; Venturia spp. (scab) on apples (e. g. V. inaequalis) and pears; and Verticillium spp. (wilt) on various plants, such as fruits and ornamentals, vines, soft fruits, vegetables and field crops, e. g. V. dahliae on strawberries, rape, potatoes and tomatoes. In one embodiment, the compounds of formula (I) have broad ranges of activity against fungal pathogens. Exemplary pathogens may include, but are not limited to, causing agent of wheat leaf blotch (Zymoseptoria tritici), wheat brown rust (Puccinia triticina), wheat stripe rust (Puccinia striiformis), scab of apple (Venturia inaequalis), powdery mildew of grapevine (Uncinula necator), barley scald (Rhynchosporium secalis), blast of rice (Pyricularia oryzae), rust of soybean (Phakopsora pachyrhizi), glume blotch of wheat (Leptosphaeria nodorum), powdery mildew of wheat (Blumeria graminis f. sp. tritici), powdery mildew of barley (Blumeria graminis f. sp. hordei), powdery mildew of cucurbits (Erysiphe cichoracearum), anthracnose of cucurbits (Colletotrichum lagenarium), leaf spot of beet and soybean (Cercospora beticola, Cercospora sojina), early blight of tomato (Alternaria solani), Gray mold (Botrytis cinerea), target spot (Corynespora cassiicola), Late blight of potato & tomato (Phytophthora infestans), rhizoctonia aerial, foliage, and web blight (Rhizoctonia solani), Septoria nodorum blotch on wheat (Parastagonospora nodorum), root rot, scab or head blight on cereals (e. g. wheat or barley) (Fusarium culmorum) and spot blotch of barley (Cochliobolus sativus). The exact amount of the active material to be applied is dependent not only on the specific active material being applied, but also on the particular action desired, the fungal species to be controlled, and the stage of growth thereof, as well as the part of the plant or other product to be contacted with the compound. Thus, all the compounds, and formulations containing the same, may not be equally effective at similar concentrations or against the same fungal species. The compound of formula (I), the combination and the composition thereof, respectively, are also suitable for controlling harmful fungi in the protection of stored products or harvest and in the protection of materials. The term "protection of materials" is to be understood to denote the protection of technical and non-living materials, such as adhesives, glues, wood, paper and paperboard, textiles, leather, paint dispersions, plastics, cooling lubricants, fiber or fabrics, against the infestation and destruction by harmful microorganisms, such as fungi and bacteria. As to the protection of wood and other materials, the particular attention is paid to the following harmful fungi: Ascomycetes such as Ophiostoma spp., Ceratocystis spp., Aureobasidium pullulans, Sclerophoma spp., Chaetomium spp., Humicola spp., Petriella spp., Trichurus spp.; Basidiomycetes such as Coniophora spp., Coriolus spp., Gloeophyllum spp., Lentinus spp., Pleurotus spp., Pora spp., Serpula spp. and Tyromyces spp., Deuteromycetes such as Aspergillus spp., Cladosporium spp., Penicillium spp., Trichoderma spp., Altemaria spp., Paecilomyces spp. and Zygomycetes such as Mucor spp., and in addition in the protection of stored products and harvest the following yeast fungi are worthy of note: Candida spp. and Saccharomyces cerevisae. In one embodiment, the present invention provides a method for controlling or preventing phytopathogenic fungi, wherein the method comprises treating the fungi or the materials, plants, plant parts, locus thereof, soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of formula (I) or a combination or a composition comprising at least one compound of formula (I). The method of treatment according to the invention can also be used in the field of protecting stored products or harvest against attack of fungi and microorganisms. According to the present invention, the term "stored products" is understood to denote natural substances of plant or animal origin and their processed forms, which have been taken from the natural life cycle and for which long-term protection is desired. Stored products of crop plant origin, such as plants or parts thereof, for example stalks, leafs, tubers, seeds, fruits or grains, can be protected in the freshly harvested state or in processed form, such as pre-dried, moistened, comminuted, ground, pressed or roasted, which process is also known as post-harvest treatment. Also falling under the definition of stored products is timber, whether in the form of crude timber, such as construction timber, electricity pylons and barriers, or in the form of finished articles, such as furniture or objects made from wood. Stored products of animal origin are hides, leather, furs, hairs and the like. The combination according the present invention can prevent disadvantageous effects such as decay, discoloration or mold. Preferably "stored products" is understood to denote natural substances of plant origin and their processed forms, more preferably fruits and their processed forms, such as pomes, stone fruits, soft fruits and citrus fruits and their processed forms. It is also possible to use the compounds of formula (I) as a fungicide. The term “fungicide” as used herein means a compound that controls, modifies, or prevents the growth of fungi. The compound of formula (I), the combination and the composition thereof, respectively, may be used for improving the health of a plant. The invention also relates to a method for improving plant health by treating a plant, its propagation material and/or the locus where the plant is growing or is to grow with an effective amount of compound of formula (I) and the composition thereof, respectively. The term "plant health" is to be understood to denote a condition of the plant and/or its products which is determined by several indicators alone or in combination with each other such as yield (e. g. increased biomass and/or increased content of valuable ingredients), plant vigor (e. g. improved plant growth and/or greener leaves ("greening effect")), quality (e. g. improved content or composition of certain ingredients) and tolerance to abiotic and/or biotic stress. The above identified indicators for the health condition of a plant may be interdependent or may result from each other. The compound of formula (I) are employed as such or in the form of composition for treating the fungi or the plants, plant propagation materials, such as seeds, soil, surfaces, materials or rooms to be protected from fungal attack with a fungicidally effective amount of the active substances. The application can be carried out both before and after the infection of the plants, plant propagation materials, such as seeds, soil, surfaces, materials or rooms by the fungi. Plant propagation materials may be treated with a compound of formula (I), the combination and the composition thereof protectively either at or before planting or transplanting. Any range or desired value given herein may be extended or altered without losing the effects sought, as is apparent to the skilled person for an understanding of the teachings herein. The invention disclosed in the present disclosure shall now be elaborated with the help of non-limiting examples. CHEMISTRY EXAMPLES: Example-1: Preparation of 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3- methyl-1-oxobutan-2-yl) carbamoyl)-4-methoxypyridin-3-yl isobutyrate (Compound no.24): a) Step-A: Preparation of (S)-2-amino-1,1-bis(4-methoxyphenyl) propan-1-ol hydrochloride: To a stirred solution of (S)-1-methoxy-1-oxopropan-2-aminium chloride (5.0 g, 35.8 mmol) in tetrahydrofuran (50 mL), a freshly prepared solution of (4-methoxyphenyl)magnesium bromide (30.3 g, 143 mmol) in 100 mL of tetrahydrofuran was added at 0 °C. The resulting reaction mixture was warmed to 25 °C and further stirred for 16 h. After completion of the reaction, the reaction mixture was quenched with saturated aqueous ammonium chloride solution (50 mL) at 0 °C and the crude product was extracted with ethyl acetate (2 x 250 mL). The combined organic layer was washed with brine solution (100 mL), dried over anhydrous sodium sulfate and evaporated under reduced pressure to isolate crude material. This crude material was dissolved in methyl tert-butyl ether (500 mL) and treated slowly with 4 M HCl in dioxane till pH 2-3. A precipitate formed was filtered and washed with methyl tert-butyl ether (2 x 100 mL) to obtain (S)-2-amino-1,1-bis(4-methoxyphenyl) propan-1- ol hydrochloride (7.0 g, 21.6 mmol, 60 % yield) as a pale-yellow solid. 1H-NMR (400 MHz, DMSO- D6): δ 7.59 (d, J = 34.5 Hz, 2H), 7.44–7.47 (m, 2H), 7.37–7.42 (m, 2H), 6.82–6.89 (m, 4H), 6.23 (s, 1H), 4.38 (q, J = 6.5 Hz, 1H), 3.68–3.77 (m, 6H), 1.09–1.14 (m, 3H); ESI MS (m/z) 287.80 [M+H]+. b) Step-B: Preparation of tert-butyl ((S)-1-(((S)-1-hydroxy-1,1-bis(4-methoxyphenyl)propan-2- yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate: To a stirred solution of (tert-butoxycarbonyl)-L-valine (3.4 g, 15.4 mmol), (S)-2-amino-1,1-bis(4- methoxyphenyl) propan-1-ol hydrochloride (5.0 g, 15.4 mmol) and O-(7-Azabenzotriazol-1-yl)- N,N,N',N'-tetramethyluronium hexafluorophosphate (7.0 g, 18.5 mmol) in dichloromethane (50 mL), N,N-diisopropylethylamine (13.4 mL, 77.0 mmol) was added at 25 °C and the resulting reaction mixture was stirred at 25 °C for 5 h. After completion of the reaction, the reaction mixture was diluted with dichloromethane (100 mL) and washed with water (50 mL) followed by brine solution (50 mL). The separated organic layer was dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate a crude material, which was purified by flash column chromatography to obtain tert-butyl ((S)-1-(((S)-1-hydroxy-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan- 2-yl)carbamate (6.0 g, 12.3 mmol, 80 % yield). 1H-NMR (400 MHz, DMSO-D6): δ 7.28–7.38 (m, 5H), 6.81 (dt, J = 9.7, 2.5 Hz, 2H), 6.73 (d, J = 8.9 Hz, 2H), 6.54–6.58 (m, 1H), 5.58 (s, 1H), 4.81– 4.87 (m, 1H), 3.68 (s, 3H), 3.64 (s, 3H), 3.58 (dd, J = 8.6, 6.7 Hz, 1H), 1.62–1.69 (m, 1H), 1.24–1.37 (m, 11H), 0.85–0.90 (m, 3H), 0.55 (t, J = 6.4 Hz, 6H). c) Step-C: Preparation of (S)-2-amino-N-((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)-3- methylbutanamide hydrochloride: To a stirred solution of tert-butyl ((S)-1-(((S)-1-hydroxy-1,1-bis(4-methoxyphenyl)propan-2- yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate (5.5 g, 11.3 mmol) and triethyl silane (18.0 mL, 113 mmol) in dichloromethane (55 mL), trifluoroacetic acid (8.6 mL, 113 mmol) was added at 0 °C. The resulting reaction mixture was allowed to warm to 25 °C and stirred for 16 h. After completion of the reaction, the reaction mixture was diluted with dichloromethane (100 mL) and washed with water (50 mL) followed by brine solution (50 mL). The organic layer was dried over anhydrous sodium sulphate and evaporated under reduced pressure. The residual material thus obtained was dissolved in methyl tert-butyl ether (50 mL) and treated with 4 M HCl in dioxane (20 mL) at 0 °C. The solid material formed was filtered, washed with methyl tert-butyl ether (50 mL) and dried under reduced pressure to isolate ((S)-2-amino-N-((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)-3-methylbutanamide hydrochloride (4.0 g, 9.8 mmol, 87 % yield) as an off white solid. The material obtained was used for next reaction without any characterization. d) Step-D: Preparation of 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3- methyl-1-oxobutan-2-yl) carbamoy l)-4-methoxypyridin-3-yl isobutyrate (Compound no. 24): To a stirred solution of 3-hydroxy-4-methoxypicolinic acid (0.1 g, 0.6 mmol) in dichloromethane (2 mL), triethylamine (0.4 mL, 3.0 mmol) was added at 25 °C. The resulting reaction mixture was cooled to 0 °C and isobutyryl chloride (0.16 g, 1.6 mmol) was added. After stirring at 0 °C for 30 min, (S)-2- amino-N-((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)-3-methylbutanamide hydrochloride (0.27 g, 0.6 mmol) was added and stirring was continued at same temperature for next 30 min. After completion of the reaction, the reaction mixture was diluted with dichloromethane (30 mL) and washed with water (10 mL). The separated organic layer dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate crude material, which was purified by flash column chromatography to obtain 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate (0.2 g, 0.3 mmol, 57 % yield) as a brown solid. 1H- NMR (400 MHz, DMSO-D6): δ 8.40 (d, J = 5.5 Hz, 1H), 8.30 (d, J = 9.5 Hz, 1H), 8.00 (d, J = 8.9 Hz, 1H), 7.38 (d, J = 5.5 Hz, 1H), 7.21 (dd, J = 12.8, 8.9 Hz, 4H), 6.82 (d, J = 8.9 Hz, 2H), 6.74 (d, J = 8.9 Hz, 2H), 4.72–4.55 (1H), 4.15 (dd, J = 9.2, 5.5 Hz, 1H), 3.88 (s, 3H), 3.73 (d, J = 11.3 Hz, 1H), 3.68 (s, 3H), 3.64 (s, 3H), 2.74–2.81 (m, 1H), 1.52 (d, J = 5.8 Hz, 1H), 1.20 (d, J = 7.0 Hz, 6H), 0.92 (d, J = 6.4 Hz, 3H), 0.50 (d, J = 6.7 Hz, 3H), 0.41 (d, J = 6.7 Hz, 3H); ESI MS (m/z) 592.70 [M+H]+. Example-2: Preparation of 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3- methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate (Compound no.23): To a stirred solution of 3-hydroxy-4-methoxypicolinic acid (0.2 g, 1.2 mmol) in dichloromethane (2 mL), triethylamine (0.8 mL, 5.9 mmol) was added at 25 °C and the resulting reaction mixture was cooled to 0 °C. To this cold reaction mixture, ethyl chloroformate (0.3 mL, 3.0 mmol) was added and stirring was continued at same temperature for 30 min. To this reaction mixture, (S)-2-amino-N-((S)- 1,1-bis(4-methoxyphenyl)propan-2-yl)-3-methylbutanamide hydrochloride (0.5 g, 1.2 mmol) was added at 0 °C and stirred for next 30 min. After completion of the reaction, the reaction mixture was diluted with dichloromethane (50 mL) and washed with water (2 x 10 mL). The separated organic layer was dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate crude material, which was purified by flash column chromatography using 50 % ethyl acetate in hexane as an eluent to obtain 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl- 1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate (0.6 g, 1.1 mmol, 85 % yield) as an off white solid. 1H-NMR (400 MHz, DMSO-D6): δ 8.42–8.45 (m, 1H), 8.34 (d, J = 9.3 Hz, 1H), 8.02 (d, J = 9.0 Hz, 1H), 7.42 (d, J = 5.6 Hz, 1H), 7.21 (dd, J = 12.8, 8.7 Hz, 4H), 6.82 (d, J = 8.8 Hz, 2H), 6.74 (d, J = 8.8 Hz, 2H), 4.63 (dd, J = 20.4, 6.5 Hz, 1H), 4.14–4.30 (m, 3H), 3.92 (d, J = 4.2 Hz, 3H), 3.73 (d, J = 11.2 Hz, 1H), 3.68 (s, 3H), 3.63 (s, 3H), 1.54 (dd, J = 12.3, 6.7 Hz, 1H), 1.22–1.29 (m, 4H), 0.92 (d, J = 6.6 Hz, 3H), 0.51 (d, J = 6.6 Hz, 3H), 0.41 (d, J = 6.8 Hz, 3H); ESI MS (m/z) 594.60 [M+H]+. Example-3: Preparation of N-((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3- methyl-1-oxobutan-2-yl)-3-hydroxy-4-methoxypicolinamide (Compound no.27): To a stirred solution of 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1- oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate (0.3 g, 0.5 mmol) in tetrahydrofuran (5 mL), concentrated HCl (5 mL, 165 mmol) was added at 0 °C. The resulting reaction mixture was warmed to 80 °C and stirred for 16 h. After completion of the reaction, the crude compound was isolated by complete evaporation of reaction mixture under reduced pressure. The residual material thus obtained was extracted in saturated aqueous sodium bicarbonate solution (50 mL) and ethyl acetate (100 mL). The separated organic layer was washed with water (20 mL) followed by brine solution (20 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure to afford crude material. This crude material was dissolved in methanol (0.2 mL) and diluted with water (5 mL). The precipitate formed was filtered off and dried under reduced pressure to obtain N-((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan- 2-yl)-3-hydroxy-4-methoxypicolinamide (0.2 g, 0.4 mmol, 76 % yield). 1H-NMR (400 MHz, DMSO- D6): δ 12.24 (s, 1H), 8.54 (d, J = 9.2 Hz, 1H), 8.09 (d, J = 8.9 Hz, 1H), 8.04 (d, J = 5.5 Hz, 1H), 7.17– 7.24 (m, 5H), 6.82 (d, J = 8.9 Hz, 2H), 6.71 (d, J = 8.9 Hz, 2H), 4.59–4.66 (m, 1H), 4.20 (dd, J = 9.3, 5.3 Hz, 1H), 3.85 (d, J = 15.3 Hz, 3H), 3.75 (s, 1H), 3.72 (s, 1H), 3.68 (s, 3H), 3.63 (s, 3H), 1.62 (dt, J = 19.2, 6.6 Hz, 1H), 0.93 (d, J = 6.4 Hz, 3H), 0.56 (dd, J = 15.1, 6.9 Hz, 3H), 0.47 (dd, J = 17.3, 6.6 Hz, 3H); ESI MS (m/z) 522.15 [M+H]+. Example-4: Preparation of 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3- methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate (Compound no.56): To a stirred solution of N-((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1- oxobutan-2-yl)-3-hydroxy-4-methoxypicolinamide (0.13 g, 0.3 mmol) and triethylamine (0.1 mL, 0.7 mmol) in dichloromethane (5 mL), acetyl chloride (0.03 mL, 0.4 mmol) was added at 0 °C. The resulting reaction mixture was stirred at same temperature for 1 h. After completion of the reaction, the reaction mixture was diluted with dichloromethane (10 mL) and washed with water (10 mL). The separated organic layer was dried over anhydrous sodium sulphate and evaporated under reduced pressure to afford crude material, which was purified by flash column chromatography to obtain 2- (((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate (125 mg, 0.2 mmol, 89 % yield) as an off white solid. 1H-NMR (400 MHz, DMSO-D6): δ 8.41 (d, J = 5.6 Hz, 1H), 8.35 (d, J = 9.5 Hz, 1H), 8.00 (d, J = 9.0 Hz, 1H), 7.39 (d, J = 5.6 Hz, 1H), 7.21 (dd, J = 12.5, 8.8 Hz, 4H), 6.82 (d, J = 8.8 Hz, 2H), 6.74 (d, J = 8.6 Hz, 2H), 4.59–4.66 (m, 1H), 4.14 (dd, J = 9.3, 5.4 Hz, 1H), 3.89 (s, 3H), 3.73 (d, J = 11.2 Hz, 1H), 3.68 (s, 3H), 3.64 (s, 3H), 2.23 (s, 3H), 1.54 (dd, J = 12.3, 7.0 Hz, 1H), 0.92 (d, J = 6.4 Hz, 3H), 0.51 (d, J = 6.8 Hz, 3H), 0.41 (d, J = 6.8 Hz, 3H); ESI MS (m/z) 564.25 [M+H]+. Example-5: Preparation of 2-(((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate (Compound no.38): a) Step-A: Preparation of (2S,3S)-2-amino-N-(1,1-bis(4-fluorophenyl)prop-1-en-2-yl)-3- methylpentanamide: To a stirred solution of trifluoroacetic acid (16.2 mL, 210 mmol) and anhydrous sodium sulphate (1.0 g) in dichloromethane (35 mL), tert-butyl ((2S,3S)-1-(((S)-1,1-bis(4-fluorophenyl)-1-hydroxypropan- 2-yl)amino)-3-methyl-1-oxopentan-2-yl) (5 g, 10.5 mmol) in dichloromethane (15 mL) was added slowly at 0 °C. The resulting reaction mixture was stirred at same temperature for 1 h and then at 25 °C for 12 h. After completion of the reaction, the reaction mixture was diluted with dichloromethane (100 mL) and quenched with saturated sodium bicarbonate solution till pH ~ 12. The separated organic layer was washed with brine solution (50 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure to obtain (2S,3S)-2-amino-N-(1,1-bis(4-fluorophenyl)prop-1-en-2- yl)-3-methylpentanamide (3.3 g, 9.2 mmol, 88 % yield). 1H-NMR (400 MHz, DMSO-D6): δ 7.02– 7.21 (m, 9H), 2.99 (d, J = 4.3 Hz, 1H), 2.03–2.06 (m, 3H), 1.58–1.75 (m, 2H), 1.10–1.33 (m, 1H), 0.74–0.84 (m, 6H); ESI MS (m/z) 359.20 [M+H]+. b) Step-B: Preparation of 2-(((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate (Compound no.38): To a stirred solution of 3-acetoxy-4-methoxypicolinic acid (0.8 g, 3.8 mmol) and N,N- diisopropylethylamine (1.41 g, 10.9 mmol) in tetrahydrofuran (20 mL), isobutyl chloroformate (0.55 g, 4.0 mmol) was added slowly at 0 °C under nitrogen atmosphere and stirred for 30 min. To this reaction mixture, (2S,3S)-2-amino-N-(1,1-bis(4-fluorophenyl)prop-1-en-2-yl)-3-methylpentanamide (1.3 g, 3.6 mmol) was added and allowed to stir at 25 °C for 2 h. After completion of the reaction, the reaction mixture was quenched with water (10 mL) and extracted with dichloromethane (3 x 10 mL). The combined organic layer was washed with brine (10 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure to obtain a crude compound which was purified by flash column chromatography using 45–55% ethyl acetate in hexane as an eluent to afford 2-(((2S,3S)-1- ((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate (1.25 g, 2.3 mmol, 63 % yield) as a white solid. 1H-NMR (400 MHz, DMSO-D6): δ 9.14 (s, 1H), 8.35–8.42 (m, 2H), 7.41 (d, J = 5.8 Hz, 1H), 7.11–7.21 (m, 4H), 7.01– 7.06 (m, 2H), 6.92–6.99 (m, 2H), 4.28 (dd, J = 9.2, 7.3 Hz, 1H), 3.87–3.91 (m, 3H), 2.22–2.26 (m, 3H), 1.89 (d, J = 13.4 Hz, 3H), 1.67–1.75 (m, 1H), 1.18–1.33 (m, 1H), 0.88–1.01 (m, 1H), 0.67–0.83 (m, 6H); ESI MS (m/z) 552.30 [M+H]+. Example-6: Preparation of N-((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3- methyl-1-oxopentan-2-yl)-3-hydroxy-4-methoxypicolinamide (Compound no.39): To a stirred solution of 2-(((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1- oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate (1.3 g, 2.4 mmol) in methanol (15 mL), potassium carbonate (1.0 g, 7.1 mmol) was added at 25 °C and the reaction mixture was stirred for 1 h. After completion of the reaction, the reaction mixture was evaporated under reduced pressure to dryness; residue was suspended in water (10 mL) and extracted with dichloromethane (3 x 20 mL). The combined organic layer was dried over anhydrous sodium sulphate and evaporated under reduced pressure to obtain a crude compound which was purified by flash column chromatography to afford N-((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxopentan-2-yl)-3- hydroxy-4-methoxypicolinamide (1.1 g, 2.2 mmol, 92 % yield) as a white solid. 1H-NMR (400 MHz, DMSO-D6): δ 12.23 (d, J = 18.3 Hz, 1H), 9.22 (d, J = 11.5 Hz, 1H), 8.61 (d, J = 9.5 Hz, 1H), 8.04 (dd, J = 5.3, 3.8 Hz, 1H), 7.15–7.22 (m, 5H), 6.90–7.09 (m, 4H), 4.33 (dd, J = 9.3, 7.1 Hz, 1H), 3.89 (s, 3H), 1.92 (dd, J = 15.0, 7.0 Hz, 3H), 1.73–1.82 (m, 1H), 1.21–1.35 (m, 1H), 0.91–1.08 (m, 1H), 0.73–0.89 (m, 5H), 0.69 (d, J = 6.8 Hz, 1H); ESI MS (m/z) 510.50 [M+H]+. Example-7: Preparation of 2-(((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate(Compound no.40): To a stirred solution of N-((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1- oxopentan-2-yl)-3-hydroxy-4-methoxypicolinamide (0.3 g, 0.6 mmol) in dichloromethane (5 mL), triethylamine (0.25 mL, 1.8 mmol) and isobutyryl chloride (0.07 mL, 0.67 mmol) were added sequentially at 0 °C. The resulting reaction mixture was stirred at 0 °C for 30 min. After completion of the reaction, the reaction mixture was quenched with water (10 mL) and extracted with dichloromethane (2 x 20 mL). The combined organic layers were dried over anhydrous sodium sulphate and evaporated under reduced pressure to obtain crude material which was purified by flash column chromatography to afford 2-(((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate (0.28 g, 0.5 mmol, 79 % yield) as a white solid. 1H-NMR (400 MHz, DMSO-D6): δ 9.13 (s, 1H), 8.40 (dd, J = 5.5, 1.2 Hz, 1H), 8.30–8.36 (m, 1H), 7.40 (d, J = 5.5 Hz, 1H), 7.11–7.19 (m, 4H), 7.02–7.07 (m, 2H), 6.93–6.99 (m, 2H), 4.29 (dd, J = 9.2, 7.0 Hz, 1H), 3.88 (d, J = 12.2 Hz, 3H), 2.76–2.85 (m, 1H), 1.89 (d, J = 13.1 Hz, 3H), 1.64–1.75 (m, 1H), 1.16–1.34 (m, 7H), 0.88–1.03 (m, 1H), 0.66–0.86 (m, 6H); ESI MS (m/z) 580.60 [M+H]+. Example-8: Preparation of 2-(((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate (Compound no. 41): To a stirred solution of N-((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1- oxopentan-2-yl)-3-hydroxy-4-methoxypicolinamide (0.34 g, 0.7 mmol) in dichloromethane (5 mL), triethylamine (0.28 mL, 2.0 mmol) and ethyl chloroformate (0.08 g, 0.7 mmol) were added sequentially at 0 °C. The resulting reaction mixture was stirred at 0 °C for 30 min. After completion of the reaction, the reaction mixture wad quenched with water (10 mL) and extracted with dichloromethane (2 x 15 mL). The combined organic layer was dried over anhydrous sodium sulphate and evaporated under reduced pressure to obtain crude compound which was purified by flash column chromatography to afford 2-(((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1- oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate (0.24 g, 0.4 mmol, 62 % yield) as a white solid.1H-NMR (400 MHz, DMSO-D6): δ 9.16 (s, 1H), 8.35–8.44 (m, 2H), 7.44 (d, J = 5.8 Hz, 1H), 7.10–7.23 (m, 4H), 7.02–7.08 (m, 2H), 6.93–7.00 (m, 2H), 4.27–4.33 (m, 1H), 4.18–4.26 (m, 2H), 3.93 (s, 3H), 1.91 (s, 3H), 1.66–1.75 (m, 1H), 1.21–1.33 (m, 4H), 0.88–1.08 (m, 1H), 0.72–0.67 (m, 6H); ESI MS (m/z) 582.15 [M+H]+ Example-9: Preparation of (S)-2-((1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate (Compound no.175): a) Step-A: Preparation of tert-butyl (S)-(1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2- yl)carbamate: To a stirred solution of benzophenone (6 g, 32.9 mmol) in ethanol (60 mL), tert-butyl (S)-(1- hydrazineyl-1-oxopropan-2-yl)carbamate (10 g, 49.4 mmol) was added followed by addition of few drops of acetic acid at 25 °C . The resulting reaction mixture was stirred at 80 °C for 48 h and evaporated under reduced pressure. The residue thus obtained was diluted with dichloromethane (250 mL) and washed with water (500 mL) followed by brine solution (100 mL). The organic layer was dried over anhydrous sodium sulfate and evaporated to isolate crude material which was purified by CombiFlash® column chromatography to obtain tert-butyl (S)-(1-(2- (diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)carbamate (7 g, 19.1 mmol, 58 % yield) as a white solid. 1H-NMR (400 MHz, DMSO-D6): δ 9.72 (s, 1H), 7.60–7.55 (m, 5H), 7.45–7.36 (m, 5H), 4.98 (dd, J = 14.8, 7.0 Hz, 1H), 1.41–1.22 (m, 9H), 1.18–1.08 (m, 3H); ESI MS (m/z) 367.19 [M+H]+. b) Step-B: Preparation of tert-butyl (S)-(1-(2-benzhydrylhydrazineyl)-1-oxopropan-2- yl)carbamate: To a stirred solution of tert-butyl (S)-(1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2- yl)carbamate (2.2 g, 6.0 mmol) in tetrahydrofuran (25 mL), borane tetrahydrofuran complex solution (15.0 mL, 15 mmol) was added at 0 °C. The resulting reaction mixture was stirred at 0 °C for 1 h and at 25 °C for 3 h. After completion of the reaction, the reaction mixture was quenched with saturated ammonium chloride solution (50 mL) and extracted with ethyl acetate (2 x 100 mL each). The combined organic layers were washed with water (200 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure to obtain a crude material, which was purified by CombiFlash® column chromatography to obtain tert-butyl (S)-(1-(2-benzhydrylhydrazineyl)-1- oxopropan-2-yl)carbamate (850 mg, 2.3 mmol, 38 % yield). 1H-NMR (400 MHz, DMSO-D6): δ 9.21 (d, J = 5.4 Hz, 1H), 7.40–7.38 (m, 4H), 7.29 (dd, J = 8.1, 7.1 Hz, 4H), 7.22–7.18 (m, 2H), 6.74 (d, J = 7.8 Hz, 1H), 5.12 (s, 1H), 3.85 (q, J = 7.5 Hz, 1H), 1.28 (d, J = 33.7 Hz, 9H), 0.95 (d, J = 7.1 Hz, 3H); ESI MS (m/z) 369.21 [M+H]+. c) Step-C: Preparation of tert-butyl (S)-(1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2- yl)carbamate: To a stirred solution of tert-butyl (S)-(1-(2-benzhydrylhydrazineyl)-1-oxopropan-2-yl)carbamate (800 mg, 2.2 mmol) in N,N-imethyl formamide (7 mL), diisopropylethylamine (0.9 mL, 5.4 mmol) was added followed by methyl iodide (0.3 mL, 5.4 mmol). The resulting reaction mixture was stirred at 25 °C for 24 h. After completion of the reaction, the reaction mixture was poured into water (20 mL). The precipitate obtained was filtered to obtain tert-butyl (S)-(1-(2-benzhydryl-2-methylhydrazineyl)- 1-oxopropan-2-yl)carbamate (450 mg, 1.2 mmol, 54 % yield) and taken as such to the next step. 1H- NMR (400 MHz, DMSO-D6): δ 8.86 (s, 1H), 7.44–7.33 (m, 4H), 7.31–7.20 (m, 4H), 7.17–7.11 (m, 2H), 6.55 (d, J = 7.3 Hz, 1H), 5.02 (d, J = 16.6 Hz, 1H), 3.60 (dd, J = 14.1, 6.7 Hz, 1H), 2.43 (s, 3H), 1.49–1.13 (m, 9H), 0.50 (d, J = 7.1 Hz, 3H); ESI MS (m/z) 383.22 [M+H]+. d) Step-D: Preparation of (S)-1-(2-benzhydryl-2-methylhydrazineyl)-N-chloro-1-oxopropan-2- aminium: To a stirred solution of tert-butyl (S)-(1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2- yl)carbamate (450 mg, 1.2 mmol) in methanol (5 mL), oxalyl chloride (1 mL, 11.7 mmol) was added at 0 °C and the resulting reaction mixture was stirred at 25 °C for 1 h. After completion of the reaction, the reaction mixture was evaporated under reduced pressure to isolate a crude material which was washed with methyl tert-butyl ether (20 mL) to obtain (S)-1-(2-benzhydryl-2- methylhydrazineyl)-N-chloro-1-oxopropan-2-aminium (325 mg, 1.0 mmol, 87 % yield). 1H-NMR (400 MHz, DMSO-D6): δ 9.53 (s, 1H), 8.09 (d, J = 3.7 Hz, 3H), 7.48–7.45 (m, 4H), 7.31–7.14 (m, 4H), 4.98 (s, 1H), 3.44 (dd, J = 12.4, 5.7 Hz, 1H), 2.48 (s, 3H), 0.59 (d, J = 7.0 Hz, 3H). ESI MS (m/z) 283.17 [M+H]+. e) Step-E: Preparation of (S)-2-((1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate (Compound no.175): To a stirred solution of 3-acetoxy-4-methoxypicolinic acid (180 mg, 0.9 mmol) in dichloromethane (5 mL), triethylamine (0.1 mL, 0.9 mmol) and isobutyl chloroformate (0.1 mL, 0.9 mmol) was added at 0 °C. After stirring for 15 min at same temperature, a solution of (S)-1-(2-benzhydryl-2- methylhydrazineyl)-1-oxopropan-2-aminium chloride (286 mg, 0.9 mmol) in dichloromethane (2 mL) was added at 0 °C with continuous stirring for 15 mins. After completion of the reaction, the reaction mass was quenched with water (25 mL) and extracted with dichloromethane (2 x 50 mL each). The combined organic layers were washed with brine (25 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate a crude material, which was purified by prep HPLC to obtain (S)-2-((1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate (100 mg, 0.2 mmol, 25% yield).1H-NMR (400 MHz, DMSO-D6): δ 9.23 (s, 1H), 8.41 (d, J = 5.5 Hz, 2H), 7.46 (d, J = 7.3 Hz, 4H), 7.39 (d, J = 5.8 Hz, 1H), 7.25 (q, J = 7.6 Hz, 4H), 7.17–7.12 (m, 2H), 5.03 (s, 1H), 4.07 (t, J = 7.3 Hz, 1H), 3.89 (s, 3H), 2.47 (s, 3H), 2.23 (d, J = 5.2 Hz, 3H), 0.62 (d, J = 6.7 Hz, 3H). ESI MS (m/z) 476.21 [M+H]+ Example-10: Preparation of (S)-2-((1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate (Compound no.180): To a stirred solution of 3-hydroxy-4-methoxypicolinic acid (170 mg, 1.0 mmol) in dichloromethane (10 mL), triethylamine (0.3 mL, 2.0 mmol) and isobutyl chloroformate (0.3 mL, 2.0 mmol) were added at 0 °C. The resulting reaction mixture was stirred at 0 °C for 15 min. To this reaction mixture, a solution of (S)-2-amino-N'-benzhydryl-N'-methylpropanehydrazide (299 g, 1.0 mmol) in dichloromethane (2 mL) was added at 0 °C under continuous stirring for 15 mins. After completion of the reaction, the reaction mixture was diluted with dichloromethane (25 mL) and washed with water (20 mL) followed brine solution (10 mL). The separated organic layer was dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate crude material, which was purified by prep HPLC to obtain (S)-2-((1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl isobutyl carbonate (125 mg, 0.2 mmol, 23 % yield). 1H-NMR (400 MHz, DMSO-D6): δ 9.23 (s, 1H), 8.43 (d, J = 5.5 Hz, 1H), 8.40 (t, J = 3.8 Hz, 1H), 7.47–7.41 (m, 5H), 7.25 (q, J = 7.8 Hz, 4H), 7.17–7.12 (m, 2H), 5.03 (s, 1H), 4.07 (q, J = 7.1 Hz, 1H), 3.95–3.91 (m, 5H), 2.47 (s, 3H), 1.95–1.88 (m, 1H), 0.91–0.87 (m, 6H), 0.61 (d, J = 7.0 Hz, 3H); ESI MS (m/z) 534.25 [M+H]+. Example-11: Preparation of (S)-N-(1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2-yl)-3- hydroxy-4-methoxypicolinamide (Compound no.181): To a stirred solution of (S)-2-((1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl acetate (1.0 g, 2.1 mmol) in methanol (10 mL), potassium carbonate (0.9 g, 6.3 mmol) was added at 25 °C and stirring was continued for 1 h. After completion of the reaction, the solvent was evaporated; the residue was dissolved in dichloromethane (50 mL) and washed with water (20 mL). The organic layer was dried over anhydrous sodium sulphate and evaporated under reduced pressure to obtain a crude compound which was purified by Prep HPLC to obtain (S)-N-(1- (2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide (151 mg, 0.3 mmol, 17 % yield). 1H-NMR (400 MHz, DMSO-D6): δ 12.19 (s, 1H), 9.29 (s, 1H), 8.61 (d, J = 7.9 Hz, 1H), 8.03 (dd, J = 8.3, 5.2 Hz, 1H), 7.47–7.43 (m, 4H), 7.29–7.18 (m, 5H), 7.17–7.12 (m, 2H), 5.04 (d, J = 6.4 Hz, 1H), 4.18–4.11 (m, 1H), 3.90–3.86 (m, 4H), 2.47 (d, J = 4.3 Hz, 3H), 0.71 (d, J = 7.0 Hz, 3H); ESI MS (m/z) 434.20 [M+H]+. Example-12: Preparation of (S)-2-((1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate (Compound no.188): To a stirred solution of (S)-N-(1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2-yl)-3-hydroxy- 4-methoxypicolinamide (400 mg, 0.9 mmol) in dichloromethane (10 mL), triethylamine (0.1 mL, 0.9 mmol) and isobutyryl chloride (0.1 mL, 0.9 mmol) were added at 0 °C. The resulting reaction mixture was stirred at 0 °C for 30 mins. After completion of the reaction, the reaction mixture was diluted with dichloromethane (25 mL) and washed with water (30 mL) and brine solution (20 mL). The organic layer was dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate a crude material, which was purified by CombiFlash® column chromatography to obtain (S)- 2-((1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate (125 mg, 0.2 mmol, 27 % yield).1H-NMR (400 MHz, DMSO-D6): δ 9.20 (s, 1H), 8.40 (d, J = 5.4 Hz, 1H), 8.38–8.33 (m, 1H), 7.46–7.42 (m, 4H), 7.40–7.37 (m, 1H), 7.25 (q, J = 7.8 Hz, 4H), 7.17–7.12 (m, 2H), 5.03 (s, 1H), 4.11–4.04 (m, 1H), 3.89 (d, J = 11.0 Hz, 3H), 2.77 (td, J = 13.9, 7.1 Hz, 1H), 2.47 (s, 3H), 1.24–1.19 (m, 6H), 0.62 (d, J = 6.8 Hz, 3H); ESI MS (m/z) 504.24 [M+H]+. Example-13: Preparation of (S)-2-((1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate (Compound no.172): a) Step-A: Preparation of tert-butyl (S)-(1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2- yl)carbamate: To a stirred solution of benzophenone (6.0 g, 32.9 mmol) in ethanol (20 mL), tert-butyl (S)-(1- hydrazineyl-1-oxopropan-2-yl)carbamate (10.0 g, 49.4 mmol) was added followed by addition of few drops of acetic acid at 25 °C. The resulting reaction mixture was stirred at 80 oC for 48 h. After completion of the reaction, the solvent was evaporated, the residue obtained was dissolved in dichloromethane (250 mL) and washed with water (500 mL) followed by brine solution (100 mL). The organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure to isolate crude material which was purified by CombiFlash® column chromatography to obtain tert- butyl (S)-(1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)carbamate (7.0 g, 19.1 mmol, 58 % yield). 1H-NMR (400 MHz, DMSO-D6): δ 9.72 (s, 1H), 7.60–7.55 (m, 5H), 7.45–7.36 (m, 5H), 4.98 (dd, J = 14.8, 7.0 Hz, 1H), 1.41–1.22 (m, 9H), 1.18–1.08 (m, 3H); ESI MS (m/z) 367.19 [M+H]+. b) Step-B: Preparation of (S)-2-amino-N'-(diphenylmethylene)propanehydrazide: To a stirred solution of tert-butyl (S)-(1-(2-(diphenylmethylene)hydrazinyl)-1-oxopropan-2- yl)carbamate (3.0 g, 8.2 mmol) in dichloromethane (20 mL), trifluoroacetic acid (6.3 mL, 82 mmol) was added at 0 °C and the reaction mixture was stirred at 25 °C for 5 h. After completion of the reaction, the solvent was evaporated under reduced pressure to isolate a crude material, which was then basified (till pH 7.5) using saturated sodium bicarbonate solution and extracted with dichloromethane (3 x 100 mL each). The combined organic layers were dried over anhydrous sodium sulphate then concentrated to isolate a crude material, which was purified by CombiFlash® column chromatography to obtain (S)-2-amino-N'-(diphenylmethylene)propanehydrazide (1.1 g, 4.1 mmol, 50 % yield).1H-NMR (400 MHz, DMSO-D6): δ 7.69–8.18 (1H), 7.62–7.55 (m, 3H), 7.46–7.38 (m, 4H), 7.37–7.26 (m, 2H), 3.72 (d, J = 6.8 Hz, 1H), 1.36 (dd, J = 113.5, 7.1 Hz, 3H); ); ESI MS (m/z) m/z: 267.14 [M+H]+. c) Step-C: Preparation of (S)-2-((1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate (Compound no.172): To a stirred solution of (S)-N-(1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)-3-hydroxy- 4-methoxypicolinamide (300 mg, 0.7 mmol) in dichloromethane (10 mL), triethylamine (0.1 mL, 0.7 mmol) was added followed by isobutyryl chloride (0.1 mL, 0.7 mmol) at 0 °C. The resulting reaction mixture was stirred at 0 °C for 30 min. After completion of the reaction, the reaction mixture was diluted with water (50 mL) and extracted with dichloromethane (2 x 30 mL). The combined organic layers were washed with brine solution (25 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate a crude material, which was purified by prep HPLC to obtain (S)-2-((1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate (188 mg, 0.4 mmol, 54 % yield).1H-NMR (400 MHz, DMSO-D6): δ 9.86 (d, J = 95.1 Hz, 1H), 8.71 (dd, J = 14.1, 7.9 Hz, 1H), 8.40 (dd, J = 16.5, 5.5 Hz, 1H), 7.57–7.21 (m, 11H), 5.37–4.51 (m, 1H), 3.90 (d, J = 7.8 Hz, 3H), 2.86–2.76 (m, 1H), 1.49–1.15 (m, 9H); ESI MS (m/z) m/z: 488.21 [M+H]+. Example-14: Preparation of (S)-2-((1-(2-(diphenylmethylene)hydrazinyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate (Compound no.110): To a stirred solution of 3-hydroxy-4-methoxypicolinic acid (180 mg, 1.1 mmol) in dichloromethane (10 mL), triethylamine (0.3 mL, 2.1 mmol) and isobutyl chloroformate (0.3 mL, 2.1 mmol) were added at 0 °C and stirring was continued at same temperature for 15 min. To this reaction mixture, a solution (S)-2-amino-N'-(diphenylmethylene)propanehydrazide (0.3 g, 1.1 mmol) in dichloromethane (2 mL) was added at 0 °C with continuous stirring for 15 min. After stirring at same temperature for 30 min, the reaction mixture was diluted with water (30 mL) and extracted with dichloromethane (2 x 20 mL). The combined organic layers were washed with water (25 mL) and brine (25 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate a crude material, which was then purified by prep HPLC to obtain (S)-2-((1-(2-(diphenylmethylene)hydrazinyl)-1-oxopropan- 2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate (135 mg, 0.3 mmol, 24 % yield).1H-NMR (400 MHz, DMSO-D6): δ 9.88 (d, J = 105.4 Hz, 1H), 8.74 (d, J = 7.8 Hz, 1H), 8.43 (dd, J = 15.8, 5.5 Hz, 1H), 7.57–7.36 (m, 9H), 7.31–7.21 (m, 2H), 4.97 (dt, J = 330.2, 7.3 Hz, 1H), 3.98–3.92 (m, 5H), 1.98–1.87 (m, 1H), 1.38 (dd, J = 82.3, 7.0 Hz, 3H), 0.91–0.86 (m, 6H); ESI MS (m/z) m/z: 518.22 [M+H]+. Example-15: Preparation of (S)-N-(1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)-3- hydroxy-4-methoxypicolinamide (Compound no.142): To a stirred solution of (S)-2-amino-N'-(diphenylmethylene)propanehydrazide (0.7 g, 2.7 mmol) in dichloromethane (10 mL), 3-hydroxy-4-methoxypicolinic acid (450 mg, 2.7 mmol) was added followed by the addition of N,N-diisopropylethylamine (0.9 mL, 5.3 mmol) and benzotriazol-1- yloxytripyrrolidinophosphonium hexafluorophosphate (1.7 g, 3.2 mmol) at 0 °C. The resulting reaction mixture was stirred at 0 °C for 1 h and then at 25 °C for 16 h. After completion of the reaction, the reaction mixture was diluted with water (50 mL) and extracted with dichloromethane (3 x 20 mL). The combined organic layers were washed with brine solution (25 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate a crude material, which was purified by prep HPLC to obtain (S)-N-(1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2- yl)-3-hydroxy-4-methoxypicolinamide (129 mg, 0.3 mmol, 12 % yield).1H-NMR (400 MHz, DMSO- D6): δ 12.32 (s, 1H), 9.98 (s, 1H), 9.02 (dd, J = 18.2, 7.9 Hz, 1H), 8.05 (dd, J = 13.4, 5.1 Hz, 1H), 7.57–7.54 (m, 1H), 7.48–7.36 (m, 7H), 7.30 (d, J = 5.9 Hz, 1H), 7.20 (dd, J = 19.2, 4.5 Hz, 2H), 5.46– 4.60 (m, 1H), 3.90–3.86 (m, 3H), 1.56–1.22 (m, 3H); ESI MS (m/z) m/z: 418.16 [M+H]+. Example-16: Preparation of (S)-2-((1-(2-(diphenylmethylene)hydrazinyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate (Compound no.111): To a stirred solution of 3-acetoxy-4-methoxypicolinic acid (375 mg, 1.8 mmol) in dichloromethane (15 mL), triethylamine (0.2 mL, 1.8 mmol) and isobutyl chloroformate (0.2 mL, 1.8 mmol) were added sequentially at 0 °C. After stirring for 15 min at 0 °C, a solution of (S)-2-amino-N'- (diphenylmethylene)propanehydrazide (498 mg, 1.9 mmol) in dichloromethane (2 mL) was added with continuous stirring for 15 min. After completion of the reaction, the reaction mixture was diluted with water (50 mL) and extracted with dichloromethane (2 x 25 mL). The combined organic layer was washed with brine solution (25 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate a crude material, which was purified by prep HPLC to obtain (S)-2-((1-(2- (diphenylmethylene)hydrazinyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate (230 mg, 0.5 mmol, 28 % yield). 1H-NMR (400 MHz, DMSO-D6): δ 9.85 (d, J = 76.5 Hz, 1H), 8.75 (t, J = 7.2 Hz, 1H), 8.46–8.38 (m, 1H), 7.57–7.35 (m, 9H), 7.31–7.20 (m, 2H), 5.39–4.50 (m, 1H), 3.97–3.90 (m, 3H), 2.25 (d, J = 11.7 Hz, 3H), 1.38 (dd, J = 80.3, 7.0 Hz, 3H); ESI MS (m/z) m/z: 460.17 [M+H]+. Example-17: Preparation of (S)-2-((1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl butyrate (Compound no.171): To a stirred solution of (S)-N-(1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)-3-hydroxy- 4-methoxypicolinamide (300 mg, 0.7 mmol) in dichloromethane (10 mL), triethylamine (0.1 mL, 0.7 mmol) and butyroyl chloride (0.1 mL, 1.4 mmol) were added sequentially at 0 °C. The resulting reaction mixture was stirred at 25 °C for 24 h. After completion of the reaction, the reaction mixture was quenched with water (25 mL) and extracted with dichloromethane (2 x 25 mL). The combined organic layers were washed with brine solution (20 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate a crude material, which was purified by prep HPLC to obtain (S)-2-((1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl butyrate (128 mg, 0.3 mmol, 37 % yield). 1H-NMR (400 MHz, DMSO-D6): δ 9.88 (d, J = 81.7 Hz, 1H), 8.76–8.71 (m, 1H), 8.41 (dd, J = 17.6, 5.4 Hz, 1H), 7.57–7.34 (m, 9H), 7.31–7.20 (m, 2H), 5.37–4.51 (m, 1H), 3.89 (t, J = 8.3 Hz, 3H), 2.58–2.51 (m, 2H), 1.70–1.59 (m, 2H), 1.49–1.22 (m, 3H), 1.02–0.93 (m, 3H); ESI MS (m/z) m/z: 488.21 [M+H]+. Example-18: Preparation of (S)-2-((1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate (Compound no.174): To a stirred solution of (S)-N-(1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)-3-hydroxy- 4-methoxypicolinamide (375 mg, 0.9 mmol) in dichloromethane (10 mL), triethylamine (0.1 mL, 0.9 mmol) and ethyl chlorocarbonate (0.1 mL, 0.9 mmol) were added sequentially at 0 °C and stirring was continued at 0 °C. After completion of the reaction, the reaction mixture was quenched with water (50 mL) and extracted with dichloromethane (2 x 25 mL). The combined organic layers were washed with brine solution (20 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate a crude material, which was then purified by prep HPLC to obtain (S)-2-((1-(2- (diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate (79 mg, 0.2 mmol, 18 % yield). 1H-NMR (400 MHz, DMSO-D6): δ 9.99–9.77 (m, 1H), 8.75 (q, J = 3.9 Hz, 1H), 8.43 (dd, J = 17.4, 5.5 Hz, 1H), 7.57–7.36 (m, 10H), 7.32–7.15 (m, 1H), 5.39–4.52 (m, 1H), 4.25–4.18 (m, 2H), 3.95–3.86 (m, 3H), 1.53–1.19 (m, 6H); ESI MS (m/z) m/z: 490.19 [M+H]+. The following compounds in Table 1 were prepared by using analogous procedures as described in above examples 1 to 18. Table: 1
Figure imgf000077_0001
Figure imgf000078_0001
Figure imgf000079_0001
Figure imgf000080_0001
Figure imgf000081_0001
Figure imgf000082_0001
Figure imgf000083_0001
Figure imgf000084_0001
Figure imgf000085_0001
Figure imgf000086_0001
Figure imgf000087_0001
Figure imgf000088_0001
Figure imgf000089_0001
Figure imgf000090_0001
Figure imgf000091_0001
Figure imgf000092_0001
Figure imgf000093_0001
Figure imgf000094_0001
Figure imgf000095_0001
Figure imgf000096_0001
Figure imgf000097_0001
Figure imgf000098_0001
Figure imgf000099_0001
Figure imgf000100_0001
Figure imgf000101_0001
Figure imgf000102_0001
Figure imgf000103_0001
Figure imgf000104_0001
Figure imgf000105_0001
Figure imgf000106_0001
Figure imgf000107_0001
Figure imgf000108_0001
Figure imgf000109_0001
Figure imgf000110_0001
Figure imgf000111_0001
Figure imgf000112_0001
Figure imgf000113_0001
Figure imgf000114_0001
Figure imgf000115_0001
Figure imgf000116_0001
Figure imgf000117_0001
The following compounds in Table 2 were prepared by using analogous procedures as described in above examples 1 to 18. Table: 2
Figure imgf000117_0002
Figure imgf000118_0001
Figure imgf000119_0001
Figure imgf000120_0001
Figure imgf000121_0001
Figure imgf000122_0001
Figure imgf000123_0001
Figure imgf000124_0001
Figure imgf000125_0001
BIOLOGY EXAMPLES: As described herein, the compound of general formula (I) show fungicidal activities which are exerted with respect to numerous phytopathogenic fungi which attack on important agricultural crops. The compounds of the present invention were assessed for their activity as described in the following tests: Example 1: Pyricularia oryzae (Rice blast): Compounds were dissolved in 0.3% dimethyl sulfoxide and then added to potato dextrose agar medium just prior to dispensing it into petri dishes. 5 mL medium with the compound in the desired test concentration was dispensed into 60 mm sterile petri-plates. After solidification, each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate. Plates were incubated in growth chambers at 25 ℃ temperature and 60% relative humidity for seven days and the radial growth was measured and compared to the one of the untreated control. Compounds 1 2 6 10 11 12 17 18 27 34 39 46 49 52 53 54 56 57 58 59 61 62 64 65 66 68 70 77 80 81 83 85 91 92 94 95 96 97 98 100 101 102 103 107 110 111 113 114 119 121 122 123 126 130 134 135 136 137 138 139 140 141 142 143 144 148 150 151 152 157 158 159 160 161 162 163 164 165 166 167 168 170 171 172 173 174 191 at 300 ppm gave more than or equal to 70% control in these tests when compared to the untreated check which showed extensive pathogen growth. Example 2: Botrytis cinerea (Gray mold): Compounds were dissolved in 0.3% dimethyl sulfoxide and then added to potato dextrose agar medium just prior to dispensing it into petri dishes. 5 mL medium with the compound in the desired concentration was dispensed into 60 mm sterile petri-plates. After solidification, each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate. Plates were incubated in growth chambers at 22 ℃ temperature and 90% relative humidity for seven days and the radial growth was measured and compared to the one of the untreated control. Compounds 3 4 6 7 8 11 12 50 51 61 85 124 135 140 142 at 300 ppm gave more than or equal to 70% control in these tests when compared to the untreated check which showed extensive pathogen growth. Example 3: Alternaria solani (early blight of tomato/potato): Compounds were dissolved in 0.3% dimethyl sulfoxide and then added to potato dextrose agar medium just prior to dispensing it into petri dishes. 5 mL medium with the compound in the desired concentration was dispensed into 60 mm sterile petri-plates. After solidification, each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate. Plates were incubated in growth chambers at 25 ℃ temperature and 60% relative humidity for seven days and the radial growth was measured and compared to the one of the untreated control. Compounds 1 2 6 10 12 13 24 27 32 52 53 54 55 56 57 59 60 61 64 65 66 67 69 70 73 74 75 77 85 90 91 93 96 97 98 99 101 108 109 111 118 122 130 134 135 136 137 138 139 140 141 142 143 144 148 161 162 170 at 300 ppm gave more than or equal to 70% control in these tests when compared to the untreated check which showed extensive pathogen growth. Example 4: Colletotrichum capsici (anthracnose): Compounds were dissolved in 0.3% dimethyl sulfoxide and then added to potato dextrose agar medium just prior to dispensing it into petri dishes. 5 mL medium with the compound in the desired concentration was dispensed into 60 mm sterile petri-plates. After solidification, each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate. Plates were incubated in growth chambers at 25 ℃ temperature and 60% relative humidity for seven days and the radial growth was measured and compared to the one of the untreated control. Compounds 1 2 3 6 9 10 12 20 27 32 33 46 52 53 54 56 57 58 61 65 66 77 85 91 96 97 98 100 101 130 131 133 142 144 147 159 162 163 164 165 170 at 300 ppm gave more than or equal to 70% control in these tests when compared to the untreated check which showed extensive pathogen growth. Example 5: Corynespora cassiicola (Leaf spot of tomato): Compounds were dissolved in 0.3% dimethyl sulfoxide and then added to potato dextrose agar medium just prior to dispensing it into petri dishes. 5 mL medium with the compound in the desired concentration was dispensed into 60 mm sterile petri-plates. After solidification, each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate. Plates were incubated in growth chambers at 25 oC temperature and 70% relative humidity for seven days and the radial growth was measured and compared to the one of the untreated control. Compounds 1 52 58 59 60 61 62 98 142 144 at 300 ppm gave more than or equal to 70% control in these tests when compared to the untreated check which showed extensive pathogen growth. Example 6: Phytophthora infestans (Late blight of potato & tomato): The compounds were dissolved in 0.3% dimethyl sulfoxide and then added to Rye Agar medium just prior to dispensing it into petri dishes. 5 mL medium with the compound in the desired test concentration was dispensed into 60 mm sterile petri-plates. After solidification, each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate. Plates were incubated in growth chambers at 18 ºC temperature and 95% relative humidity for seven days and the radial growth was measured and compared to the one of the untreated control. Compounds 2 4 20 46 49 58 60 65 66 67 77 78 84 85 107 108 109 112 113 115 116 123 130 135 137 144 158 160 161 162 163 165 169 170 at 300 ppm gave more than or equal to 70% control in these tests when compared to the untreated check which showed extensive pathogen growth. Example 7: Botrytis cinerea (Gray mold): Yeast bacterial peptone and sodium acetate (YBA) liquid medium containing a BOTRCI (104 spores/ml) spore suspension was prepared. For the inhibition assay, each test compound was solved in dimethyl sulfoxide. 100 µl of the test media-solution was added to a 96-well microtiter plate, consequently, the same volume (100 µl) of spore suspension was added to each well providing the final test concentration and the plate was incubated at 22 °C for 15-18 days. The growth inhibition was evaluated by measuring the OD600. Percent inhibition was calculated with the below formula: I= (C-B)-(T-B)/(C-B)*100 Where T=treatment, C=control, and B=blank Compounds 6 7 10 11 12 52 54 58 61 70 77 83 91 96 97 98 100 101 113 114 122 124 130 142 152 158 161 162 163 at 300 ppm gave more than or equal to 70% control in these tests when compared to the untreated check which showed extensive pathogen growth. Example 8: Parastagonospora nodorum (PARANO) Potato dextrose (PDB) liquid medium (Difco) containing a PARANO (105 spores/ml) spore suspension was prepared. For the inhibition assay, each test compound was solved in dimethyl sulfoxide. 100 µl of the test media-solution was added to a 96-well microtiter plate, consequently, the same volume (100 µl) of spore suspension was added to each well providing the final test concentration and the plate was incubated at 18 °C for 15-18 days. The growth inhibition was evaluated by measuring the OD600. Percent inhibition was calculated with the below formula: I= (C-B)-(T-B)/(C-B)*100 Where T=treatment, C=control, and B=blank Compounds 1 2 6 12 21 23 25 27 38 39 42 43 46 47 48 49 50 51 52 53 57 58 61 64 77 79 80 81 83 84 85 91 93 95 101 103 105 106 107 110 119 122 123 131 135 140 142 147 148 149 150 151 152 157 158 159 161 164 165 169 171 172 173 180 188 189 191 at 300 ppm gave more than or equal to 70% control in these tests when compared to the untreated check which showed extensive pathogen growth. Example 9: Venturia inequalis (VENTIN) Potato dextrose (PDB) liquid medium containing a VENTIN (105 spores/ml) spore suspension was prepared. For the inhibition assay, each test compound was solved in dimethyl sulfoxide. 100 µl of test media-solution was added to a 96-well microtiter plate, consequently, the same volume (100 µl) of spore suspension was added to each well providing the final test concentration and the treated plate was incubated at 18 °C for 15-18 days. The growth inhibition was evaluated by measuring the OD600. Percent inhibition was calculated with the below formula: I= (C-B)-(T-B)/(C-B)*100 Where T=treatment, C=control, and B=blank Compounds 1 6 12 25 39 46 48 49 61 77 83 85 142 143 at 300 ppm gave more than or equal to 70% control in these tests when compared to the untreated check which showed extensive pathogen growth. Biological Test Examples in vivo on plants The compounds were further selected for in vivo (Greenhouse) testing. The methods followed to check the preventive efficacy of compounds on the respective pathogens were as following: Example1: Botrytis cinerea test on tomato Compounds were dissolved in 2% dimethyl sulfoxide/acetone and then mixed with water containing an emulsifier to the calibrated spray volume of 50 mL. Each spray solution was poured into a spray bottle for further application. To test the preventive activity of the compound, healthy young bean/chilli plants, raised in the greenhouse, were sprayed with the active compound preparation at the stated application rate inside the spray cabinets using hollow cone nozzles. One day after treatment, the plants were inoculated with a spore suspension containing 1.2 x 106 Botrytis cinerea inoculum. The inoculated plants were then kept in a greenhouse chamber at 18-20 °C temperature and 90-100 % relative humidity for disease expression. A visual assessment of the compound’s performance was carried out by rating the disease severity (0- 100% scale) on treated plants 3, 7, 10 and 15 days after application. Efficacy (% control) of the compound was calculated by comparing the disease rating in the treatment with the one of the untreated control. The sprayed plants were also assessed for plant damage by recording symptoms like necrosis, chlorosis and stunting. Compounds 52 57 58 85 104 122 at 500 ppm gave more than or equal to 70% control in these tests when compared to the untreated check which showed extensive disease development. Example 2: Alternaria solani test in Tomato Compounds were dissolved in 2 % dimethyl sulfoxide/acetone and then mixed with water containing an emulsifier to the calibrated spray volume of 50 mL. Each spray solution was poured into a spray bottle for further application. To test the preventive activity of the compound, healthy young tomato plants, raised in the greenhouse, were sprayed with the active compound preparation at the stated application rate inside the spray cabinets using hollow cone nozzles. One day after treatment, the plants were inoculated with a spore suspension containing 0.24 x 106 Alternaria solani inoculum. The inoculated plants were then kept in a greenhouse chamber at 22-24 °C temperature and 90-95 % relative humidity for disease expression. A visual assessment of the compound’s performance was carried out by rating the disease severity (0- 100% scale) on treated plants 3, 7, 10 and 15 days after application. Efficacy (% control) of the compound was calculated by comparing the disease rating in the treatment with the one of the untreated control. The sprayed plants were also assessed for plant damage by recording symptoms like necrosis, chlorosis and stunting. Compounds 80 107 108 122 126 at 500ppm gave more than or equal to 70% control in these tests when compared to the untreated check which showed extensive disease development. Example 3: Phytophthora infestans test in Tomato Compounds were dissolved in 2 % dimethyl sulfoxide/acetone and then mixed with water containing an emulsifier to the calibrated spray volume of 50 mL. Each spray solution was poured into a spray bottle for further application. To test the preventive activity of the compound, healthy young tomato plants, raised in the greenhouse, were sprayed with the active compound preparation at the stated application rate inside the spray cabinets using hollow cone nozzles. One day after treatment, the plants were inoculated with a sporangial suspension containing 0.24 x 106 Phytophthora infestans inoculum. After inoculation, the plants were kept in darkness at 15 ℃ during 24 h, and then transferred to a greenhouse chamber at 18 oC temperature and 95-100 % relative humidity for disease expression. A visual assessment of the compound’s performance was carried out by rating the disease severity (0- 100% scale) on treated plants 3, 7, 10 and 15 days after application. Efficacy (% control) of the compound was calculated by comparing the disease rating in the treatment with the one of the untreated control. The sprayed plants were also assessed for plant damage by recording symptoms like necrosis, chlorosis and stunting. Compounds 39 57 58 78 104 106 109 122 123 127 at 500 ppm gave more than or equal to 70% control in these tests when compared to the untreated check which showed extensive disease development. Having described the invention with reference to certain preferred embodiments, other embodiments will become apparent to one skilled in the art from the consideration of the specification. It will be apparent to those skilled in the art that many modifications, both to materials and methods, may be practiced without departing from the scope of the invention.

Claims

CLAIMS: 1) A compound of formula (I)
Figure imgf000131_0001
wherein, R1 is selected from the group consisting of hydroxy, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6- cycloalkyl, C1-C6-alkoxy, C3-C6-cycloalkyloxy, C1-C6-alkylthio, C1-C6-cycloalkylthio, -NHR13 and -N(R13)2; R1a is selected from the group consisting of hydroxy, halogen, C1-C6-alkyl, C3-C6-cycloalkyl, C1- C6-haloalkyl and C1-C6-alkoxy; R2 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6 haloalkyl, C1-C6-alkoxy- C1-C6-alkyl, -SOn-C1-C6-alkyl, -C(O)-R13, -C(O)-OR13, –(CH2)m-O-C(O)-R13, -C(O)-N(R13)2 and - (CH2)m-O-C(O)-N(R13)2; R3 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl, -(CH2)m-OR13, – (CH2)m-C(O)-R13, -(CH2)m-C(O)-OR13, -(CH2)m-C(O)-N(R13)2, -(CH2)m-O-C(O)-OR13, -(CH2)m-O- C(O)-N(R13)2 and –(CH2)m-C(O)-C1-C6-alkoxy ; or R2 and R3 together with the atoms to which they are attached may form a six membered heterocyclic ring; and one or more C atom/s of the ring may be optionally replaced by C(=O), C(=S), C=NR2a or CR2aN(R2a)2; wherein the heterocyclic ring may be optionally substituted with one or more identical or different groups of R2a; or R3 and R4 together with the atoms to which they are attached may form a 5 to 6 membered non- aromatic heterocyclic ring; wherein further heteroatom of said ring is selected from N, O or S(=O)0-2 and one or more C atom/s of the ring may be optionally replaced by C(=O) or C(=S); the ring may be optionally substituted with one or more identical or different groups of R3a; R2a is selected from the group consisting of halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6- alkoxy, C3-C8-cycloalkyl and C1-C4-alkoxy-C1-C4-alkyl; R3a is selected from the group consisting of halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6- alkoxy, C3-C8-cycloalkyl and C1-C4-alkoxy-C1-C4-alkyl; W represents O or S; R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6- cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl; each group of R4 and R5 may be optionally substituted by one or more groups selected from R4a; or R4 and R5 together with the atoms to which they are attached may form a 3 to 6 membered non- aromatic carbocyclic ring, or non-aromatic heterocyclic ring; wherein one or more heteroatoms of said ring are selected from N, O or S(=O)0-2 and one or more C atom/s of the ring may be optionally replaced by C(=O), C(=S) or C(=NR13); the ring may be optionally substituted with one or more identical or different groups of R4a; R4a is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1- C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6- haloalkylthio, C3-C8-cycloalkyl and C1-C4-alkoxy-C1-C4-alkyl; Z is selected from Z1 to Z4;
Figure imgf000132_0001
* represents point of attachment; R6 and R6a are independently selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6- haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C6- alkyl, -C(O)-R13, –(CH2)m-C(O)-R13 and –(CH2)m-C(O)-C1-C6-alkoxy; R7 is selected from the group consisting of hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6 cycloalkyl-C1- C6 alkyl, C1-C6-alkoxycarbonyl, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, C6-C10-aryl, C7-C14- aralkyl and C3-C10-heterocyclyl; each group of R7 may be optionally substituted by one or more groups selected from halogen, cyano, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C3-C8-cycloalkyl and C1- C4-alkoxy-C1-C4-alkyl; R7a is selected from the group consisting of hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6 cycloalkyl- C1-C6-alkyl; or R7 and R7a together with the atoms to which they are attached may form a 3- to 6- membered non- aromatic carbocyclic ring or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2 and one or more C atom/s of the ring may be optionally replaced by C(=O), C(=S) or C(=NR13); the ring may be optionally substituted with one or more identical or different groups of R7b; R7b is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1- C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C4-alkoxy-C1-C4-alkyl, C1-C6-haloalkoxy, C1-C6- alkylthio, C1-C6-haloalkylthio, C3-C8-cycloalkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10- heterocyclyl; R8, R8a, R9 and R9a are independently selected from the group consisting of hydrogen, hydroxy, halogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6 alkoxy- C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6 cycloalkyl-C1-C6-alkyl, C6-C10-aryl, C7-C14-aralkyl, C6-C10- aryloxy, C6-C10-arylthio, C6-C10-aryl-C1-C6-alkoxy, C3-C10-heterocyclyl and C3-C10- heterocyclyloxy; each group of R8, R8a, R9 and R9a may be optionally substituted by one or more groups selected from R10; or R8 and R9 together with the atoms to which they are attached may form a 3- to 10- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2 and one or more C atom/s of the ring may be optionally replaced by C(=O), C(=S) or C(=NR13); the ring may be optionally substituted with one or more identical or different groups of R11; provided that when R8 and R9 forms an aromatic ring then R12 is absent; or R7 and R9 together with the atoms to which they are attached may form a 3- to 10- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2 and one or more C atom/s of the ring may be optionally replaced by C(=O), C(=S) or C(=NR13); the ring may be optionally substituted with one or more identical or different groups of R11; R10 is selected from the group consisting of cyano, halogen, nitro, hydroxyl, thiol, amino, C1- C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6 alkoxy-C1-C6- alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl, phenyl, benzyl, phenylthio, phenyl-C1- C6-alkoxy, C3-C10-heterocyclyl and C3-C10-heterocyclyloxy; R11 is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1- C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C4-alkoxy-C1-C4-alkyl, C1-C6-haloalkoxy, C1-C6- alkylthio, C1-C6-haloalkylthio, C3-C8-cycloalkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10- heterocyclyl; R12 is selected from the group of hydrogen, halogen, hydroxy, C1-C6-alkyl, C1-C4-alkoxy, C1-C6- haloalkyl and C1-C4-haloalkoxy; R13 is selected from the group consisting of hydrogen, formyl, C1-C4-alkyl, C2-C4-alkenyl, C2-C4- alkynyl, C1-C4-haloalkyl, C3-C5-cycloalkyl, C3-C5-cycloalkyl-C1-C3-alkyl, C6-C10-aryl, C7-C14- aralkyl and C3-C10-heterocyclyl; each group of R1 to R13 and R1a, R2a, R3a, R4a, R5a, R6a, R7a, R7b, R8a, R9a may be optionally substituted by one or more groups selected from the group consisting of halogen, cyano, nitro, R’, OR’, SR’, N(R’)2, COR’ and CON(R’)2; R’ are independently selected from the group consisting of hydrogen, halogen, cyano, C1-C4- alkyl, C2-C4-alkenyl, C2-C4-alkynyl, C1-C4-haloalkyl, C2-C4-haloalkenyl, C2-C4-haloalkynyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C3-C6-cycloalkyl, C3-C6-halocycloalkyl, C6-C10-aryl-C1-C4- alkoxy, C6-C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl; n is an integer selected from 0 to 2 and m is an integer selected from 0 to 3; and/or N-oxides, metal complexes, isomers, polymorphs or the agriculturally acceptable salts thereof; provided that the following compounds are excluded from the definition of Formula (I), 2-(((2S)-1-((1-(4-cyclohexylphenyl)ethyl)(methyl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate; N-((2S)-1-((1-(4-cyclohexylphenyl)ethyl)(methyl)amino)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide; (S)-N-(1-(benzylamino)-1-oxo-3- phenylpropan-2-yl)-3,4-dihydroxypicolinamide; (S)-3,4-dihydroxy-N-(1-(isobutylamino)-1-oxo-3- phenylpropan-2-yl)picolinamide; (S)-N-(1-(benzylamino)-1-oxopropan-2-yl)-3,4- dihydroxypicolinamide; N-(2-(benzylamino)-2-oxoethyl)-3,4-dihydroxypicolinamide; (S)-3,4- dihydroxy-N-(1-(isobutylamino)-1-oxopropan-2-yl)picolinamide; 3,4-dihydroxy-N-(2- (isobutylamino)-2-oxoethyl)picolinamide; (S)-N-(1-(benzylamino)-1-oxo-3-phenylpropan-2-yl)- 3,4-dihydroxypicolinamide hydrochloride; (S)-3,4-dihydroxy-N-(1-(isobutylamino)-1-oxo-3- phenylpropan-2-yl)picolinamide hydrochloride; (S)-N-(1-(benzylamino)-1-oxopropan-2-yl)-3,4- dihydroxypicolinamide hydrochloride; N-(2-(benzylamino)-2-oxoethyl)-3,4- dihydroxypicolinamide hydrochloride; (S)-3,4-dihydroxy-N-(1-(isobutylamino)-1-oxopropan-2- yl)picolinamide hydrochloride and 3,4-dihydroxy-N-(2-(isobutylamino)-2-oxoethyl)picolinamide hydrochloride. 2) The compound formula (I) according to claim 1, wherein R1 is selected from the group consisting of hydroxy, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6- cycloalkyl, C3-C6-cycloalkyloxy and C1-C6-alkoxy; R2 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6 haloalkyl, C1-C6-alkoxy- C1-C6-alkyl, -C(O)-R13, -C(O)-OR13, –(CH2)m-O-C(O)-R13 and -C(O)-N(R13)2; R3 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkyl-C1-C6-alkyl, -(CH2)m-OR13, - (CH2)m-C(O)-OR13 and –(CH2)m-C(O)-R13; R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6- cycloalkyl, C3-C6 -cycloalkyl-C1-C6-alkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl; each group of R4 and R5 may be optionally substituted by one or more groups selected from R4a; or R4 and R5 together with the atoms to which they are attached may form a 3 to 6 membered non- aromatic carbocyclic ring, or non-aromatic heterocyclic ring; wherein one or more heteroatoms of said ring are selected from N, O or S(=O)0-2; the ring may be optionally substituted with one or more identical or different groups of R4a; R4a is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6- alkylthio, C1-C6-haloalkylthio and C3-C8-cycloalkyl; R6 and R6a are independently selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6- haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6-cycloalkyl-C1- C6-alkyl; R7 is selected from the group consisting of hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6 cycloalkyl-C1- C6 alkyl, C1-C6-alkoxycarbonyl, C1-C6-alkylsulfinyl and C1-C6-alkylsulfonyl; each group of R7 may be optionally substituted by one or more groups selected from halogen, cyano, nitro, hydroxyl, thiol and amino; R7a is selected from the group consisting of hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl and C3- C6 cycloalkyl-C1-C6-alkyl; or R7 and R9 together with the atoms to which they are attached may form a 3- to 10- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2 and one or more C atom/s of the ring may be optionally replaced by C(=O), C(=S) or C(=NR13); the ring may be optionally substituted with one or more identical or different groups of R11; R8, R8a, R9 and R9a are independently selected from the group consisting of C1-C6-alkyl, C1-C6- haloalkyl, C1-C6-alkoxy, C1-C6 alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6 cycloalkyl-C1-C6- alkyl, phenyl, benzyl, phenyloxy and phenylthio; each group of R8, R8a, R9 and R9a may be optionally substituted by one or more groups selected from R10; or R8 and R9 together with the atoms to which they are attached may form a 3- to 6- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2 ; the ring may be optionally substituted with one or more identical or different groups of R11; provided that when R8 and R9 forms a ring then R12 is absent; R10 is selected from the group consisting of cyano, halogen, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6 alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6-cycloalkyl-C1-C6-alkyl; R11 is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C4-alkoxy-C1-C4-alkyl, C1- C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio and C3-C8-cycloalkyl; R12 is selected from the group of hydrogen, halogen, hydroxy, C1-C6-alkyl, C1-C4-alkoxy, C1-C6- haloalkyl and C1-C4-haloalkoxy; R13 is selected from the group consisting of hydrogen, formyl, C1-C4-alkyl, C2-C4-alkenyl, C2-C4- alkynyl, C1-C4-haloalkyl, C3-C5-cycloalkyl, C3-C5-cycloalkyl-C1-C3-alkyl, C6-C10-aryl, C7-C14- aralkyl and C3-C10-heterocyclyl; and/or N-oxides, metal complexes, isomers, polymorphs or the agriculturally acceptable salts thereof. 3) The compound formula (I) according to claim 1, wherein R1 is selected from the group consisting of hydroxy, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6- cycloalkyl and C1-C6-alkoxy; R2 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6 haloalkyl, C1-C6-alkoxy- C1-C6-alkyl, -C(O)-R13, -C(O)-OR13 and –(CH2)m-O-C(O)-R13; R3 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6-cycloalkyl-C1-C6-alkyl, -(CH2)m-C(O)- OR13; or W represents O; R4 and R5 are independently selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6- cycloalkyl, C3-C6 -cycloalkyl-C1-C6-alkyl, C6-C10-aryl, C7-C14-aralkyl and C3-C10-heterocyclyl; each group of R4 and R5 may be optionally substituted by one or more groups selected from R4a; or R4 and R5 together with the atoms to which they are attached may form a 3 to 6 membered non- aromatic carbocyclic ring; the ring may be optionally substituted with one or more identical or different groups of R4a; R4a is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkylthio and C1-C6- haloalkoxy; R6 and R6a are independently selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6- haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6-cycloalkyl-C1- C6-alkyl; R7 is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6 cycloalkyl-C1-C6 alkyl; each group of R7 may be optionally substituted by one or more groups selected from halogen, cyano, nitro, hydroxyl, thiol, amino; R7a is selected from the group consisting of hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl and C3- C6 cycloalkyl-C1-C6-alkyl; or R7 and R9 together with the atoms to which they are attached may form a 3- to 10- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2; the ring may be optionally substituted with one or more identical or different groups of R11; R8, R8a, R9 and R9a are independently selected from the group consisting of C1-C6-alkyl, C1-C6- haloalkyl, C1-C6-alkoxy, C1-C6 alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6 cycloalkyl-C1-C6- alkyl, phenyl, benzyl, phenyloxy, phenylthio; each group of R8, R8a, R9 and R9a may be optionally substituted by one or more groups selected from R10; or R8 and R9 together with the atoms to which they are attached may form a 3- to 6- membered aromatic or non-aromatic carbocyclic ring, or aromatic or non-aromatic heterocyclic ring; wherein heteroatom of said ring is selected from N, O or S(=O)0-2; the ring may be optionally substituted with one or more identical or different groups of R11; provided that when R8 and R9 forms a ring then R12 is absent; R10 is selected from the group consisting of cyano, halogen, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6 alkoxy-C1-C6-alkyl, C3-C6-cycloalkyl and C3-C6-cycloalkyl-C1-C6-alkyl; R11 is selected from the group consisting of halogen, cyano, nitro, hydroxyl, thiol, amino, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C4-alkoxy-C1-C4-alkyl, C1- C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio and C3-C8-cycloalkyl; R12 is selected from the group of hydrogen, halogen, hydroxy, C1-C6-alkyl, C1-C4-alkoxy, C1-C6- haloalkyl and C1-C4-haloalkoxy; R13 is selected from the group consisting of hydrogen, formyl, C1-C4-alkyl, C2-C4-alkenyl, C2-C4- alkynyl, C1-C4-haloalkyl, C3-C5-cycloalkyl, C3-C5-cycloalkyl-C1-C3-alkyl, C6-C10-aryl, C7-C14- aralkyl and C3-C10-heterocyclyl; n is an integer selected from 0 to 1 and m is an integer selected from 0 to 2; and/or N-oxides, metal complexes, isomers, polymorphs or the agriculturally acceptable salts thereof. 4) The compound of formula (I) according to claim 1, wherein said compound of formula (I) is selected from N-((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)-3- hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((2S,3S)-1-(((S)-1,1-bis(4- methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((2S,3S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((2S,3S)-1-(((S)-1,1- bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate, N-((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, N-((S)-1-(((S)-1,1-bis(4- methoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-4-methyl-1- oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(4- ethoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((2S,3S)-1-(((S)-1,1-bis(4- ethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((2S,3S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2- yl)-3-hydroxy-4-methoxypicolinamide, 2-(((2S,3S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2- yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2- (((2S,3S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4- methoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3- yl acetate, 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4- ethoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((2S,3S)-1-(((S)-1,1-bis(4- methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3- yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan- 2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1- (((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4- methoxypyridin-3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2- yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, 2-(((S)- 1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate , ethyl (3-((ethoxycarbonyl)oxy)-4-methoxypicolinoyl)((2S)- 1-(((2S)-1-(4-ethoxyphenyl)-1-(4-methoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2- yl)carbamate, ethyl ((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-4-methyl-1- oxopentan-2-yl)(3-((ethoxycarbonyl)oxy)-4-methoxypicolinoyl)carbamate, N-((S)-1-(((S)-1,1- bis(4-methoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((2S,3S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-3- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((2S,3S)-1-(((S)-1,1- bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((2S,3S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-3- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((2S,3S)-1-(((S)-1,1- bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl ethyl carbonate , 2-((1-((1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, 2-((1-((1,1-bis(4- methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-((1-((1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-4- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1- bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3- yl acetate, N-((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)-3- hydroxy-4-methoxypicolinamide, 2-(((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)- 3-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((2S,3S)-1-((1,1-bis(4- fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxopentan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((2S,3S)-1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1- oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((2S,3S)-1-((1,1-bis(4- fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3- yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, N-((S)-1-(((S)-1,1-bis(4- ethoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-4- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(3,4- dimethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl ethyl carbonate, N-((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan-2-yl)amino)-3-methyl-1- oxobutan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((2S,3S)-1-((1,1-bis(4-chlorophenyl)prop- 1-en-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2- (((2S,3S)-1-((1,1-bis(4-chlorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxopentan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, N-((2S,3S)-1-((1,1-bis(4-chlorophenyl)prop-1- en-2-yl)amino)-3-methyl-1-oxopentan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((2S,3S)-1- ((1,1-bis(4-chlorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl ethyl carbonate , 2-(((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2- yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate , (S)-N-(1- ((1,1-bis(4-chlorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4- methoxypicolinamide, (S)-2-((1-((1,1-bis(4-chlorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(4-ethoxyphenyl)propan- 2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1- (((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate , 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-3- methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(4- fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3- yl isobutyrate, (S)-2-((1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxobutan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(3,4- dimethoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl ethyl carbonate , 2-(((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-4-methyl- 1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4- chlorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan- 2-yl)-3-hydroxy-4-methoxypicolinamide, N-((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2- yl)amino)-3-methyl-1-oxobutan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1-bis(4- fluorophenyl)prop-1-en-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3- yl acetate, 2-(((S)-1-(((S)-1,1-bis(3-fluoro-4-methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((S)-1-(((S)-1,1-bis(3-fluoro-4- methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2- (((S)-1-(((S)-1,1-bis(3-fluoro-4-methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4-fluorophenyl)prop-1-en- 2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2- ((1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyl carbonate, (S)-N-(1-((1,1-bis(4-fluorophenyl)prop-1-en-2- yl)amino)-4-methyl-1-oxopentan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1- bis(4-ethoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2- yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, 2- (((S)-1-(((S)-1,1-bis(3-fluoro-4-methoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, N-((S)-1-(((S)-1,1-bis(3-fluoro-4- methoxyphenyl)propan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(3-fluoro-4-methoxyphenyl)propan-2-yl)amino)-4- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(4- chlorophenyl)prop-1-en-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl acetate, (S)-N-(1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxobutan-2- yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((2-((1,1-bis(4-methoxyphenyl)propan-2-yl)amino)- 2-oxoethyl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4- chlorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3- yl isobutyrate, (S)-2-((1-((1,1-bis(4-chlorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxobutan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N-(1-((1,1-bis(4-chlorophenyl)prop-1- en-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1- bis(4-fluorophenyl)prop-1-en-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl ethyl carbonate , (S)-2-((1-((1,1-bis(4-chlorophenyl)prop-1-en-2-yl)amino)- 3-methyl-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-N-(2-((1,1-bis(4- methoxyphenyl)propan-2-yl)amino)-2-oxoethyl)-3-hydroxy-4-methoxypicolinamide, (S)-N-(1- ((1,1-bis(4-chlorophenyl)prop-1-en-2-yl)amino)-3-methyl-1-oxobutan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(3,4-dimethoxyphenyl)propan-2-yl)amino)-4- methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, 2-(((S)-1-(((S)- 1,1-bis(4-chlorophenyl)-1-hydroxypropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4-chlorophenyl)-1- hydroxypropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4-methoxyphenyl)propan-2- yl)carbamoyl)cyclopropyl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(4- methoxyphenyl)propan-2-yl)amino)-2-methyl-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3- yl isobutyrate, N-(1-((1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)-3- hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1-bis(4-methoxyphenyl)propan-2- yl)carbamoyl)cyclopropyl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-N-(1-((1,1-bis(4- methoxyphenyl)propan-2-yl)carbamoyl)cyclopropyl)-3-hydroxy-4-methoxypicolinamide, (S)-2- ((1-((1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-2-methyl-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate , (S)-N-(1-((1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-2-methyl- 1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1-hydroxy-1,1-bis(4- (trifluoromethoxy)phenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl acetate, (S)-2-((1-((1,1-bis(4-methoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-N-(1-((1,1-bis(4-methoxyphenyl)prop-1-en-2- yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1-bis(4- methoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4-fluorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-N-(1-((1,1-bis(4-fluorophenyl)prop-1-en-2- yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1-bis(4- fluorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate , (S)-2-((1-((1,1-bis(4-(trifluoromethyl)phenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1-hydroxy-1,1-diphenylpropan-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1- hydroxy-1,1-diphenylpropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, 3-hydroxy-N-((S)-1-(((S)-1-hydroxy-1,1-diphenylpropan-2-yl)amino)-1- oxopropan-2-yl)-4-methoxypicolinamide, isobutyl (4-methoxy-2-(((2S)-1-((3-methylbutan-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)pyridin-3-yl) carbonate, 2-(((S)-1-(((S)-1-hydroxy-1,1- diphenylpropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 3- hydroxy-N-((S)-1-(((S)-1-hydroxy-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)-4-methoxypicolinamide, (S)-2-((1-(2-(diphenylmethylene)hydrazinyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-2-((1-(2- (diphenylmethylene)hydrazinyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-(2-(bis(4-methoxyphenyl)methylene)hydrazinyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(4-chlorophenyl)-1-hydroxypropan-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(4- chlorophenyl)-1-hydroxypropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3- yl isobutyl carbonate, 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-4- (methylthio)-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, N-((S)-1-(((S)-1,1- bis(4-methoxyphenyl)propan-2-yl)amino)-4-(methylthio)-1-oxobutan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(4-methoxyphenyl)propan-2-yl)amino)-4- (methylthio)-1-oxobutan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1- bis(4-methoxyphenyl)propan-2-yl)amino)-4-(methylthio)-1-oxobutan-2-yl)carbamoyl)-4- methoxypyridin-3-yl benzoate, (S)-N-(1-(2-(bis(4-methoxyphenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 4-methoxy-2-(((2S)-1-((3-methylbutan-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)pyridin-3-yl isobutyrate, 2-(((2S)-1-(((1s,3R)-adamantan- 1-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-N-(1-((4-(tert- butyl)cyclohexyl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)- 1,1-bis(4-fluorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((4-(tert-butyl)cyclohexyl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate, (S)-2-((1-((3,3-difluorocyclobutyl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(4-fluorophenyl)propan-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((3,3- difluorocyclobutyl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 4- methoxy-2-(((2S)-1-((3-methylbutan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)pyridin-3-yl butyrate, ethyl (4-methoxy-2-(((2S)-1-((3-methylbutan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)pyridin-3-yl) carbonate, (S)-2-((1-((4-(tert-butyl)cyclohexyl)amino)-1-oxopropan- 2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1-hydroxy-1,1-bis(4- (trifluoromethoxy)phenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl isobutyl carbonate, N-((S)-1-(((S)-1,1-bis(4-chlorophenyl)-1-hydroxypropan-2-yl)amino)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-(2-(bis(4- methoxyphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((R)-1,1-bis(4-fluorophenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, N-((S)-1-(((R)-1,1-bis(4-fluorophenyl)propan- 2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((R)-1,1-bis(4- fluorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl benzoate, 2-(((S)-1-(((R)-1,1-bis(4-fluorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate, 2-(((S)-1-(((R)-1,1-bis(4-fluorophenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-((4,4- dimethylcyclohexyl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate , (S)-N-(1-((4,4-dimethylcyclohexyl)amino)-1-oxopropan-2-yl)-3-hydroxy-4- methoxypicolinamide, (S)-2-((1-((4,4-dimethylcyclohexyl)amino)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl acetate, (S)-N-(1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)- 3-hydroxy-4-methoxypicolinamide, (S)-2-((1-(2-(bis(4-fluorophenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-2-((1-(2-(bis(4- fluorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-(2-(bis(4-chlorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl isobutyl carbonate, (S)-2-((1-(2-(bis(4- methoxyphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, 2-(((S)-1-(((S)-1,1-diphenylpropan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, N-((S)-1-(((S)-1,1-diphenylpropan-2- yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1- diphenylpropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl benzoate , 2- (((S)-1-(((S)-1,1-diphenylpropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3- yl acetate, 2-(((S)-1-(((S)-1,1-diphenylpropan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl butyrate, (S)-N-(1-(2-(bis(4-fluorophenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-((4,4-dimethylcyclohexyl)amino)- 1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, 2-(((2S)-1-(((1s,3R)-adamantan-1- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((2S)-1-(((1s,3R)- adamantan-1-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, 2-(((S)-1- (((S)-1,1-bis(4-fluorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl benzoate, 2-(((S)-1-(((S)-1,1-bis(4-fluorophenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-((4-(tert- butyl)cyclohexyl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2- ((1-(2-(bis(4-fluorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(4-fluorophenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, N-((S)-1-(((S)-1,1-bis(4- fluorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)- 1-(((S)-1,1-bis(4-chlorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate, N-((S)-1-(((S)-1,1-bis(4-chlorophenyl)propan-2-yl)amino)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(4- chlorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, 2-(((S)-1-(((S)-1,1-bis(4-chlorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(4-chlorophenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl benzoate, (S)-2-((1-(2-(bis(4- chlorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(4-chlorophenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(4- fluorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-2-((1-(2-(bis(4-chlorophenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-(2-(diphenylmethylene)hydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2- (diphenylmethylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-N-(1-(2-(bis(4-chlorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)-3- hydroxy-4-methoxypicolinamide, (S)-2-((1-(2-(diphenylmethylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-2-((1-(2-benzhydryl-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-(2- benzhydryl-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N-(1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4- methoxypicolinamide, (S)-2-((1-(2-benzhydryl-2-methylhydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(4-fluorophenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-(2- (bis(4-fluorophenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyl carbonate, (S)-N-(1-(2-(bis(4-fluorophenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, N-((S)-1-(((S)-1,1- bis(3-cyclopropylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4- methoxypicolinamide, 2-(((S)-1-(((S)-1,1-bis(3-cyclopropylphenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(3- cyclopropylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, 2-(((S)-1-(((S)-1,1-bis(3-cyclopropylphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, 2-(((S)-1-(((S)-1,1-bis(3- cyclopropylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(3-cyclopropylphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N-((S)-1,1-bis(3- cyclopropylphenyl)propan-2-yl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)- yl)propanamide , 2-(((S)-1-(((S)-1,1-bis(4-isopropylphenyl)propan-2-yl)amino)-1-oxopropan- 2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, 2-(((S)-1-(((S)-1,1-bis(4- isopropylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, 2-(((S)-1-(((S)-1,1-bis(4-isopropylphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate , N-((S)-1-(((S)-1,1-bis(3- isopropylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, 2- (((S)-1-(((S)-1,1-bis(3-isopropylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1-bis(3-isopropylphenyl)propan-2-yl)amino)- 1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate , (S)-N-((S)-1,1- bis(3-isopropylphenyl)propan-2-yl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)- yl)propanamide, 2-(((S)-1-(((S)-1,1-bis(4-methylphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, 2-(((S)-1-(((S)-1,1-bis(4-methylphenyl)propan-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)-1,1- bis(4-methylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, 2-(((S)-1-(((S)-1,1-bis(3-methylphenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl propionate, 2-(((S)-1-(((S)-1,1-bis(3-methylphenyl)propan- 2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, 2-(((S)-1-(((S)- 1,1-bis(3-methylphenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3- yl isobutyl carbonate, 2-(((S)-1-(((S)-1,1-bis(3,5-difluorophenyl)propan-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, 2-(((S)-1-(((S)-1,1-bis(3,5- difluorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N-((S)-1,1-bis(3,5-difluorophenyl)propan-2-yl)-2-(8-methoxy-2,4-dioxo-2H- pyrido[2,3-e][1,3]oxazin-3(4H)-yl)propanamide, 2-(((S)-1-(((S)-1,1-bis(3,5- dichlorophenyl)propan-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, 2-(((S)-1-(((S)-1,1-bis(3,5-dichlorophenyl)propan-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N-((S)-1,1-bis(3,5- dichlorophenyl)propan-2-yl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)- yl)propanamide, (S)-N-(1-((1,1-bis(3-cyclopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1-bis(3-cyclopropylphenyl)prop-1-en-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(3- cyclopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-((1,1-bis(3-cyclopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-((1,1-bis(3-cyclopropylphenyl)prop-1- en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1- bis(3-cyclopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl isobutyl carbonate, (S)-N-(1,1-bis(3-cyclopropylphenyl)prop-1-en-2-yl)-2-(8-methoxy-2,4- dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)propanamide, (S)-2-((1-((1,1-bis(4- isopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(4-isopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-((1,1-bis(4-isopropylphenyl)prop-1-en- 2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-N-(1-((1,1- bis(3-isopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4- methoxypicolinamide, (S)-2-((1-((1,1-bis(3-isopropylphenyl)prop-1-en-2-yl)amino)-1-oxopropan- 2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(3-isopropylphenyl)prop- 1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N- (1,1-bis(3-isopropylphenyl)prop-1-en-2-yl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3- e][1,3]oxazin-3(4H)-yl)propanamide, (S)-2-((1-((1,1-bis(4-methylphenyl)prop-1-en-2-yl)amino)- 1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-((1,1-bis(4- methylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(4-methylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-2-((1-((1,1-bis(3-methylphenyl)prop-1- en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-((1,1- bis(3-methylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(3-methylphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-2-((1-((1,1-bis(3,5- difluorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-((1,1-bis(3,5-difluorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N-(1,1-bis(3,5-difluorophenyl)prop-1- en-2-yl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)propanamide, (S)-2-((1- ((1,1-bis(3,5-dichlorophenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl propionate, (S)-2-((1-((1,1-bis(3,5-dichlorophenyl)prop-1-en-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N-(1,1-bis(3,5- dichlorophenyl)prop-1-en-2-yl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)- yl)propanamide, (S)-N-(1-(2-(bis(3-cyclopropylphenyl)methyl)-2-methylhydrazineyl)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-(2-(bis(3- cyclopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate, (S)-2-((1-(2-(bis(3-cyclopropylphenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1- (2-(bis(3-cyclopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(3-cyclopropylphenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate , (S)-2-((1- (2-(bis(3-cyclopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyl carbonate, (S)-N'-(bis(3-cyclopropylphenyl)methyl)-2-(8-methoxy- 2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)-N'-methylpropanehydrazide, (S)-2-((1-(2- (bis(4-isopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl acetate, (S)-2-((1-(2-(bis(4-isopropylphenyl)methyl)-2-methylhydrazineyl)- 1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(4- isopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl isobutyrate, (S)-N-(1-(2-(bis(3-isopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan- 2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-(2-(bis(3-isopropylphenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1- (2-(bis(3-isopropylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyl carbonate , (S)-N'-(bis(3-isopropylphenyl)methyl)-2-(8- methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)-N'-methylpropanehydrazide, (S)-2- ((1-(2-(bis(4-methylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(4-methylphenyl)methyl)-2-methylhydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(4- methylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3- yl ethyl carbonate, (S)-2-((1-(2-(bis(3-methylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan- 2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(3-methylphenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1- (2-(bis(3-methylphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyl carbonate, (S)-2-((1-(2-(bis(3,5-difluorophenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1- (2-(bis(3,5-difluorophenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl ethyl carbonate, (S)-N'-(bis(3,5-difluorophenyl)methyl)-2-(8-methoxy-2,4- dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)-N'-methylpropanehydrazide, (S)-2-((1-(2-(bis(3,5- dichlorophenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin- 3-yl propionate, (S)-2-((1-(2-(bis(3,5-dichlorophenyl)methyl)-2-methylhydrazineyl)-1-oxopropan- 2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N'-(bis(3,5-dichlorophenyl)methyl)- 2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)-N'-methylpropanehydrazide, (S)- N-(1-(2-(bis(3-cyclopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4- methoxypicolinamide, (S)-2-((1-(2-(bis(3-cyclopropylphenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-(2-(bis(3- cyclopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(3-cyclopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(3- cyclopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(3-cyclopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N'-(bis(3- cyclopropylphenyl)methylene)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)- yl)propanehydrazide, (S)-2-((1-(2-(bis(4-isopropylphenyl)methylene)hydrazineyl)-1-oxopropan- 2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-(2-(bis(4- isopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(4-isopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-N-(1-(2-(bis(3- isopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-(2-(bis(3-isopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate , (S)-2-((1-(2-(bis(3- isopropylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N'-(bis(3-isopropylphenyl)methylene)-2-(8-methoxy-2,4-dioxo-2H- pyrido[2,3-e][1,3]oxazin-3(4H)-yl)propanehydrazide, (S)-2-((1-(2-(bis(4- methylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-(2-(bis(4-methylphenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(4- methylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-2-((1-(2-(bis(3-methylphenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(3- methylphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(3-methylphenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-2-((1-(2-(bis(3,5- difluorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(3,5-difluorophenyl)methylene)hydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-N'-(bis(3,5-difluorophenyl)methylene)- 2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)propanehydrazide, (S)-2-((1-(2- (bis(3,5-dichlorophenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(3,5-dichlorophenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate , (S)-N'-(bis(3,5- dichlorophenyl)methylene)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)- yl)propanehydrazide, (S)-N-(1-((1,1-bis(3,4-dimethoxyphenyl)prop-1-en-2-yl)amino)-1- oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1-bis(3,4- dimethoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(3,4-dimethoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1-((1,1-bis(3,4-dimethoxyphenyl)prop- 1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-((1,1- bis(3,4-dimethoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(3,4-dimethoxyphenyl)prop-1-en-2- yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyl carbonate, (S)-N-(1,1- bis(3,4-dimethoxyphenyl)prop-1-en-2-yl)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin- 3(4H)-yl)propanamide, (S)-2-((1-((1,1-bis(3-fluoro-4-methoxyphenyl)prop-1-en-2-yl)amino)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl acetate, (S)-2-((1-((1,1-bis(3-fluoro-4- methoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl butyrate, (S)-2-((1-((1,1-bis(3-fluoro-4-methoxyphenyl)prop-1-en-2-yl)amino)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-N-(1-((1,1-bis(phenyl)prop-1-en-2- yl)amino)-1-oxopropan-2-yl)-3-hydroxy-4-methoxypicolinamide, (S)-2-((1-((1,1- bis(phenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-((1,1-bis(phenyl)prop-1-en-2-yl)amino)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyl carbonate, (S)-N-(1,1-bis(phenyl)prop-1-en-2-yl)-2-(8-methoxy- 2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)propanamide, (S)-2-((1-(2-(bis(4- chlorophenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3- yl butyrate, (S)-2-((1-(2-(bis(4-chlorophenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2- yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate, (S)-2-((1-(2-(bis(4-chlorophenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate, (S)-2- ((1-(2-(bis(4-methoxyphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(4-methoxyphenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl isobutyrate , (S)-2-((1- (2-(bis(4-methoxyphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl isobutyl carbonate, (S)-2-((1-(2-(bis(3-fluoro,5-methoxyphenyl)methyl)-2- methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl propionate, (S)-2-((1- (2-(bis(3-fluoro,5-methoxyphenyl)methyl)-2-methylhydrazineyl)-1-oxopropan-2-yl)carbamoyl)- 4-methoxypyridin-3-yl ethyl carbonate, (S)-N'-(bis(3-fluoro,5-methoxyphenyl)methyl)-2-(8- methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)-yl)-N'-methylpropanehydrazide, (S)-2- ((1-(2-(bis(4-ethoxyphenyl)methylene)hydrazineyl)-1-oxopropan-2-yl)carbamoyl)-4- methoxypyridin-3-yl propionate, (S)-2-((1-(2-(bis(4-ethoxyphenyl)methylene)hydrazineyl)-1- oxopropan-2-yl)carbamoyl)-4-methoxypyridin-3-yl ethyl carbonate and (S)-N'-(bis(4- ethoxyphenyl)methylene)-2-(8-methoxy-2,4-dioxo-2H-pyrido[2,3-e][1,3]oxazin-3(4H)- yl)propanehydrazide. 5) A combination comprising the compound of formula (I) according to claim 1 and at least one further pesticidally active substance selected from the group consisting of fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, safeners, plant growth regulators, antibiotics, fertilizers and nutrients. 6) An agrochemical composition comprising the compound of formula (I) according to claim 1 and at least one agrochemically acceptable auxiliary. 7) The composition according to claim 6, wherein said composition may further comprises at least one additional active ingredient. 8) The composition according to claim 6, wherein said composition is applied to seed and the amount of compound of the formula (I) in said composition ranges from 0.1 g a.i. to 10 kg a.i .per 100 kg of seeds. 9) A method for controlling or preventing phytopathogenic microorganisms, wherein the method comprises treating the fungi or the materials, plants, plant parts, locus thereof, soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of formula (I) according to claim 1 or the combination according to claim 5 or the composition according to claim 6. 10) A method for controlling or preventing infestation of plants by phytopathogenic microorganisms in agricultural crops and/or horticultural crops wherein an effective amount of at least one compound of formula (I) according to claim 1 or the combination according to claim 5 or the composition according to claim 6, is applied to the plants, to parts thereof or locus thereof. 11) The method according to claim 10, wherein the phytopathogenic microorganisms are selected from the group comprising of wheat leaf blotch (Zymoseptoria tritici), wheat brown rust (Puccinia triticina), wheat stripe rust (Puccinia striiformis), scab of apple (Venturia inaequalis), powdery mildew of grapevine (Uncinula necator), barley scald (Rhynchosporium secalis), blast of rice (Pyricularia oryzae), rust of soybean (Phakopsora pachyrhizi), glume blotch of wheat (Leptosphaeria nodorum), powdery mildew of wheat (Blumeria graminis f. sp. tritici), powdery mildew of barley (Blumeria graminis f. sp. hordei), powdery mildew of cucurbits (Erysiphe cichoracearum), anthracnose of cucurbits (Colletotrichum lagenarium), leaf spot of beet and soybean (Cercospora beticola, Cercospora sojina), early blight of tomato (Alternaria solani), Gray mold (Botrytis cinerea), target spot (Corynespora cassiicola), Late blight of potato & tomato (Phytophthora infestans), rhizoctonia aerial, foliage, and web blight (Rhizoctonia solani), Septoria nodorum blotch on wheat (Parastagonospora nodorum), root rot, scab or head blight on cereals (e. g. wheat or barley) (Fusarium culmorum) and spot blotch of barley (Cochliobolus sativus).
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CN115927038B (en) * 2022-07-06 2024-04-30 西北农林科技大学 Streptomyces strain and application thereof in plant pathogenic fungi control

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