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2006
Background: Fungi have a potential of using both as nutritive and medicinal food stuff. Because of containing several therapeutic agents, they are reported to be used for hundreds of years to treat several diseases caused by bacteria, fungi, viruses and parasites. The aim of this study is to determine the in vitro antimicrobial activity of Xylaria hypoxylon, which were collected from Yomra, Trabzon, Turkey. Materials and Methods: X. hypoxylon samples were air dried and extracted by using ethanol. Antimicrobial activity of X. hypoxylon ethanol extracts were investigated against 21 bacterial and 2 fungal strains, namely, Bacillus subtilis DSMZ Results: It is observed that ethanol extracts of X. hypoxylon has antimicrobial activity against several Gram positive and Gram negative microorganisms tested. As a result of the study, an antimicrobial activity of X. hypoxylon found against most of strains used in the study. Conclusion: The results of our study clearly puts forward that X. hypoxylon could have a possible medicinal use.
Applied Microbiology and Biotechnology
Antimicrobial activity of an endophytic Xylaria sp.YX-28 and identification of its antimicrobial compound 7-amino-4-methylcoumarin2008 •
An endophytic Xylaria sp., having broad antimicrobial activity, was isolated and characterized from Ginkgo biloba L. From the culture extracts of this fungus, a bioactive compound P3 was isolated by bioactivity-guided fractionation and identified as 7-amino-4-methylcoumarin by nuclear magnetic resonance, infrared, and mass spectrometry spectral data. The compound showed strong antibacterial and antifungal activities in vitro against Staphylococcus aureus [minimal inhibitory concentrations (MIC) 16 μg·ml−1], Escherichia coli (MIC, 10 μg·ml−1), Salmonella typhia (MIC, 20 μg·ml−1), Salmonella typhimurium (MIC, 15 μg·ml−1), Salmonella enteritidis (MIC, 8.5 μg·ml−1), Aeromonas hydrophila (MIC, 4 μg·ml−1), Yersinia sp. (MIC, 12.5 μg·ml−1), Vibrio anguillarum (MIC, 25 μg·ml−1), Shigella sp. (MIC, 6.3 μg·ml−1), Vibrio parahaemolyticus (MIC, 12.5 μg·ml−1), Candida albicans (MIC, 15 μg·ml−1), Penicillium expansum (MIC, 40 μg·ml−1), and Aspergillus niger (MIC, 25 μg·ml−1). This is the first report of 7-amino-4-methylcoumarin in fungus and of the antimicrobial activity of this metabolite. The obtained results provide promising baseline information for the potential use of this unusual endophytic fungus and its components in the control of food spoilage and food-borne diseases.
2014 •
During the course of a screening for novel anti-infective agents from cultures of tropical Xylariaceae originating from French Guiana and Thailand, pronounced antifungal activity was noted in extracts of cultures of Hypoxylon monticulosum. A bioassay-guided fractionation led to the known metabolite sporothriolide as active principle. In addition, three new derivatives of sporothriolide were isolated, for which we propose the trivial names sporothric acid, isosporothric acid and dihydroisosporothric acid. Their chemical structures were elucidated by high-resolution electrospray mass spectrometry in conjunction with two-dimensional nuclear magnetic resonance (2D-NMR) spectroscopy. From earlier studies on the biogenesis of the chemically similar canadensolides, we postulate that the new compounds were shunt products, rather than biogenetic precursors of sporothriolide. Interestingly, this compound class, as well as strong antifungal activities, was only observed in multiple cultures of...
In the present study, the fruiting body extracts of Xylaria sp. strain R006 were obtained from hexane, ethyl acetate and methanol. Among them, the ethyl acetate extract exhibited significant antimicrobial activities against bacterial and fungal pathogens. Based on the effective antimicrobial activity, the crude ethyl acetate extract was fractionized by two-step siliga gel column chromatography. All the fractions were tested for antibacterial activity against drug resistant Staphylococcus aureus strains (1–10) and Pseudomonas aeruginosa strains (1–8). The fraction E showed a maximum inhibition zone of 27.9 mm against drug resistant S. aureus strain 3 and 29.4 mm against drug resistant P. aeruginosa strain 4. Minimal inhibitory concentration of fraction E showed potential result against all the drug resistant strains however, the lowest concentration of 75 μg/mL –1 was observed against S. aureus strains 1 and 6 and P. aeruginosa strain 3. Further, 60 μg/mL of fraction E had significant cytotoxic activity of 54.9, 55.1 and 54.9% against MDA-MB-231 (breast carcinoma cells), A-549 (lung carcinoma cells) and MCF-7 (breast carcinoma cells) human cancer cell lines, respectively. The spectral data revealed that the fraction E has chromophoric groups in it and had the C = O stretching, C–C = C asymmetric stretch, N-H stretch and CO stretch as functional groups. The results indicate that the metabolites of fruiting bodies of Xylaria sp. R006 are the potential natural source for the development of new anticancer agents.
2010 •
Ptr Phytotherapy Research
An antibacterial and antifungal phenylpropanoid from Carum montanum (Coss. et Dur.) Benth. et Hook2009 •
Pharmaceutical Sciences and Research
Identification and Evaluation of Antibacterial Compounds from the Vibrio sp. associated with the Ascidian Pycnoclavella diminuta2019 •
2020 •
Encrucijadas Revista Critica De Ciencias Sociales
Metodología(s). Perspectivas, prácticas y desafíos2014 •
2016 •
Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology,and Health Informatics
Ranking Protein-Protein Binding Using Evolutionary Information and Machine Learning2017 •
2019 •
Jurnal Pendidikan Matematika Undiksha
Pengaruh Strategi College Bowl Terhadap Kemampuan Pemecahan Masalah Matematika Siswa Kelas XI Mipa Sma Negeri 3 Singaraja2019 •
Journal of Clinical Oncology
Prognostic significance of the neutrophil-lymphocyte ratio (NLR) in phase 1 clinical trial patients2014 •
Ciência & Educação (Bauru)
Cambio conceptual: análisis crítico y propuestas a la luz de la teoría del aprendizaje significativo2003 •
2023 •
Linköping Electronic Conference Proceedings
Monitoring a Secondary Settler using Gaussian Mixture Models2018 •
Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere
Evaluation of endometrial echotexture and cervical cytology in cows during and after treatment of endometritis2014 •
Biological Psychiatry
156. Inflammation Selectively Impairs Executive Function in Treatment-Resistant Depressed Outpatients: Findings From TREAD Study2018 •
2002 •
Cuadernos de Investigación Geográfica
Herramientas informáticas de gestión de terrenos agrarios : potencialidades del modelo AnnAGNPS en Navarra2012 •
Revista Interamericana de Investigación, Educación y Pedagogía
Desarrollo del pensamiento crítico en estudiantes universitarios2024 •
Ciência e Tecnologia de Alimentos
Difusão multicomponente durante a salga mista de queijo prato2005 •
Fertility and Sterility
Pregnancy and life after preimplantation genetic diagnosis of Smith-Lemli-Opitz syndrome2008 •
IEEE Transactions on Education
A state-wide senior parallel programming course1999 •
RePEc: Research Papers in Economics
A Comparison of Management Processes in Educational Hospitals Located in Isfahan, Iran2015 •
Jacques Roland Fournier