Academia.edu no longer supports Internet Explorer.
To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade your browser.
2016, Notulae Scientia Biologicae
Diabetes mellitus is an endocrine and a metabolic disease resulting from the destruction of pancreatic beta cells; thus assessment of the pancreas in diabetic rats is important in monitoring therapy. The hereby study assessed pancreatic status of diabetic rats treated with methanol root bark extract of Cussonia arborea. A total of seventy two (72) male albino wistar rats weighting between 100-105 g were assigned into six (6) groups of twelve (12) rats per group. Groups 1-5 were diabetic infected by single intraperitoneal injection with alloxan monohydrate, at the dose of 160 mg/kg and treated with 62.5, 125, 250 mg/kg bw of the extract, 2 mg/kg bw glibenclamide and 10 ml/kg distilled water (DW) respectively, while the non diabetic rats, represented by Group 6, received 10 ml/kg DW and served as normal control rats. The treatment was applied daily through the oral route for 84 days. At the end of the experiment, the pancreas organs were acquired under light ether anaesthesia for hist...
Journal of Applied Animal Research
Glycosylated haemoglobin values of alloxan-induced diabetic rats treated with graded doses of Cussonia arborea extractClinical Phytoscience
Comparative studies on the hypoglycemic and antioxidant activities of Vernonia amygdalina delile and Baccharoides tenoreana olive in alloxan-induced hyperglycemic ratsBackground Vernonia amygdalina is a bitter culinary vegetable known to possess anti-diabetic principle. Baccharoides tenoreana belonging to the same species as V. amygdalina, is also used in cooking soup and it is comparatively non-bitter. However, its glycemic properties have not been studied. This study becomes imperative to find out if B. tenoreana possesses hypoglycemic and antioxidant properties and how it compares with V. amygdalina. Should B. tenoreana be better than V. amygdalina, it should be preferable since it is non-bitter and can comfortably be taken compared to V. amygdalina. This study investigated the comparative hypoglycemic and antioxidant potentials of V. amygdalina (VA) and B. tenoreana (BT). Methods Thirty male Albino wistar rats assigned into six groups of five rats per group were used for the study. Diabetes was induced in groups B-F rats by a single intraperitoneal injection of alloxan monohydrate at 160 mg/kg. Groups C-E rats were treated with VA (200 mg/kg)...
This study evaluated the pancreatic histomorphometry and possible hypolipidemic effects of graded concentrations of quail egg administration on alloxan-induced diabetic rats. Thirty adult male albino rats were assigned to 5 groups of 6 rats per group. Diabetes was induced in the rats of groups 2-5 by single intraperitoneal injection of alloxan monohydrate at the dose of 160 mg/kg. Group 1 rats were not injected with alloxan monohydrate. Rats with fasting blood glucose levels above 126 mg/dl were considered diabetic. Upon establishment of diabetes, rats in groups 2-4 were treated with 30, 15 and 7.5 mg/ml of quail egg solution respectively. Rats in groups 1 and 5 were administered with 10 ml/kg distilled water. At the end of the 21 days treatment, blood samples were collected for lipid profile analyses. The rats were euthanized using chloroform anaesthesia and the pancreases were then collected for histomorphometric assessment. Results of the study revealed that rats treated with 30 mg/ml of quail egg solution showed significant (P<0.05) reductions in the serum levels of total cholesterol, triglyceride, low density lipoprotein and very low density lipoprotein when compared with the negative control group while high density lipoprotein was not significantly increased compared to the negative control. The pancreas of diabetic untreated rats showed immense cytoplasmic vacuolation of the islet cells while the groups treated with quail egg solution especially those treated at the 30 mg/ml showed mild degeneration of the islet cells. In conclusion, administration of quail egg solution to alloxanized rats demonstrated hypolipidemia and ameliorated lesions in the pancreas.
Tropical Journal of Pharmaceutical Research
Hypoglycemic, antidyslipidemic, hepatoprotective and antilipid peroxidation activities of hydromethanol leaf extract of Helianthus annuus in alloxan-induced diabetic rats2018 •
Asian Pacific Journal of Tropical Biomedicine
Histological changes and antidiabetic activities of Icacina trichantha tuber extract in beta–cells of alloxan induced diabetic rats2013 •
African Journal of Traditional, Complementary and Alternative medicines
Hexane Extract of Dacryodes Edulis Fruits Possesses Anti-Diabetic and Hypolipidaemic Potentials in Alloxan Diabetes of Rats2016 •
Pharmaceutical Biology
Antidiabetic, antilipidemic, and antioxidant activities of Gouania longipetala methanol leaf extract in alloxan-induced diabetic rats2015 •
Indian Journal of Animal Research
Effect of administration of methanol root bark extract of Cussonia arborea on serum lipid profile and oxidative biomarker parameters in alloxan-induced diabetic rats2016 •
This study investigated the effects of methanol extract of Cussonia arborea on serum lipid and oxidative stress biomarkers of alloxan-induced diabetic rats. A total of 72 male albino rats assigned into 6 groups of 12 rats per group were used. Groups 1-5 were made diabetic while group 6 were normal. Groups 1-4 were treated with 62.5, 125, 250 mg/kg of the extract and 2 mg/kg glibenclamide respectively while groups 5 and 6 received 10 ml/kg distilled water each. Total cholesterol, triglyceride, high density lipoprotein (HDL), malondiadehyde, catalase, and superoxide dismutase (SOD) were assayed on days 28, 56 and 84 post treatment. The results indicated that the extract significantly (p<0.05) reduced the levels of total cholesterol, triglyceride, malondialdehyde but significantly (p<0.05) increased the activities of SOD, catalase and the levels of HDL when compared to negative control. It was therefore concluded that methanol extract of C. arborea mitigated dyslipidaemia and oxi...
2018 •
Diabetes is both an endocrine and a metabolic disease affecting large numbers of individuals worldwide. The use of natural products such as herbs in the management of diseases dates back to the prehistoric era. Herbal therapy presents a less adverse side effect when compared with the synthetic orthodox counterpart. The phytochemical components of medicinal plants have been credited for the efficacy of herbal formulations. The aim of this study is to review some common anti-diabetic plants which have been tested experimentally using recent diabetes marker parameters and to highlight the bioactive anti-diabetic principles isolated from their phytochemicals. In addition, anti-diabetic compounds isolated in the process of research in our laboratory have been cited in the review. Such keywords like anti-diabetic medicinal plants, mechanism of actions, phytochemicals, alloxan, streptozotocin, glycosylated haemoglobin, were used on different search engines to generate secondary data used i...
Objective:Many of the available therapies for diabetes have a number of serious adverse effects; therefore the search for more effective and safer hypoglycaemic agents becomes a paramount. This research was set to investigate the antidiabetic potential and cytoprotective effect of ethanolic root extract of Salacianitida on alloxan induced hyperglyceamic rats. Method:Acute toxicity and phytochemical constituents were evaluated using standardized methods. The study lasted for a period of thirty days comprising of two phases: induction phase and treatment phase. Thirty animals were grouped into five groups of six rats each. Group 1 and 2 serve as normal and toxic control respectively while groups 3, 4, and 5 were treated with 750, 1500mg of S.nitidaand 5mg glibenclamide respectively. The BGL, food and fluid intake was monitored daily while the body weight was measured on weekly. The last day of the study after an overnight fast, the animals were loaded with glucose and the OGTT measured prior to and at 30minutes interval for two hours after which the animals were sacrificed under ether anaesthesia and the organs isolated for histological examination. Results/Conclusion:The results of the present study indicate that S.nitida possessantidiabetic potentials and cytoprotective effect noted in its significant percentage reduction in the glucose level, slight increase in body weight and restoration of the toxic organs to normal.
International Journal of Pharmacy and Pharmaceutical Sciences
Antihyperglycaemic Effect of Ficus Dalhousiae Miq Leaf Ethanolic Extract in Alloxan–Induced Diabetic Rats2014 •
2015 •
ARC Journal of Anesthesiology
Palliative Effects of Daonil Supplemented with Tryptophan on Alloxan Induced Diabetic Rats2017 •
Tropical Journal of Natural Product Research
Evaluation of Hypoglycaemic and Antioxidant Activity of Moringa oleifera Root in Normal and Alloxan-Induced Diabetic Rats2012 •
Recent Research in Science and Technology
Morphological Changes and Antihyperglycemic Effect of M. champaca Leaves Extract on Beta-cell in Alloxan Induced Diabetic Rats2010 •
2013 •
Bulletin of Pharmaceutical Research Institute
Evaluation of Anti-Diabetic Potential of the Syzygium Cuminii (Linn) Skeels by Reverse Pharmacological ApproachesJournal of Medicinal Plants Studies
Responses of liver and pancreatic cells to ethanolic seed extract of Aframomum Melegueta in alloxan-induced diabetic rats2016 •
International journal of Pharmaceutical sciences and research.ciences
ANTI-DIABETIC ACTIVITY OF METHANOLIC AND ETHYL ACETATE EXTRACTS OF WRIGHTIA TINCTORIA R.BR. FRUIT2012 •
Advances in Pharmacological Sciences
Antidiabetic Effects of the Ethanolic Root Extract ofUvaria chamaeP. Beauv (Annonaceae) in Alloxan-Induced Diabetic Rats: A Potential Alternative Treatment for Diabetes Mellitus2018 •
2012 •
Journal of Diabetic Complications & Medicine
In Vivo Antidiabetic Effect of Aqueous Leaf Extract of Azardirachta indica, A. juss in Alloxan Induced Diabetic MiceInternational Journal of Basic & Clinical Pharmacology
Effect of xylopic acid on alloxan-induced diabetic neuropathy in ratsJournal of Herbs, Spices & Medicinal Plants
Antidiabetic, Hypolipidemic, and Antioxidant Activities of Callistemon lanceolatus Leaves Extract2011 •
2015 •
International Journal of Basic & Clinical Pharmacology
Antidiabetic properties of Solanum villosum and Solanum nigrum var sarrachoides in a streptozotocin-induced diabetic mice modelAfrican Journal of Biological Sciences
Ameliorating effects of Cissus populnea aqueous stem bark extract on some parameters in diabetic Wistar ratsinternational food research journal
Effect of herbal combination of Andrographis paniculata (Burm.f) Ness and Gynura procumbens (Lour.) Merr ethanolic extracts in alloxan-induced hyperglycemic rats2015 •
BMC complementary and alternative medicine
Antidiabetic, renal/hepatic/pancreas/cardiac protective and antioxidant potential of methanol/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on streptozotocin induced diabetic rats2014 •
International Journal of Phytomedicine
Antidiabetic activity of leaves of Anthocephalus indicus A. Rich. in alloxan induced diabetic rats2013 •
Journal of Intercultural Ethnopharmacology
Musa sapientum with exercises attenuates hyperglycaemia and pancreatic islet cells degeneration in alloxan-diabetic rats2015 •
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Evaluation of Antihyperglycemic Effect of Extract of Moringa stenopetala (Baker f.) Aqueous Leaves on Alloxan-Induced Diabetic Rats2021 •
2002 •
Research Journal of Medicinal Plant
Anti-Diabetic Effect of Anthocleista vogelii Ethanolic Root Extract in Alloxan-Induced Diabetic Rats2016 •
Saudi Journal of Biological Sciences
Antidiabetic potential of Caralluma europaea against alloxan-induced diabetes in miceCurrent Issues in Pharmacy and Medical Sciences
Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats2019 •
Biology, Medicine, & Natural Product Chemistry
Acute Toxicity and Hypoglycemic Effect of a Polyherbal Formulation on Blood Glucose in Oral Glucose Tolerance Test (OGTT) and Alloxan-Induced Diabetic RatsJournal of Intercultural Ethnopharmacology
Cryptolepine, an indoloquinoline alkaloid, in the management of diabetes mellitus and its associated complications2016 •