Nyctanthes arbor-tristis is popularly known as Night jasmine used extensively in the Ayurvedic system of medicine. To evaluate the anti-inflammatory potential of ethanolic bark extract of Nyctanthes arbor-tristis. Preliminary phytochemical analysis showed the presence of alkaloids, flavonoids, glycosides, tannin. Different concentrations viz 50, 100, 200, 400 and 800 µg/ml. Nyctanthes arbor-tristis were used to study the in vitro anti-inflammatory activities albumin denaturation and HRBC membrane stabilization activity. Aspirin was used as reference drug. It was found that ethanolic bark extract of Nyctanthes arbor-tristis was dose dependent RBC membrane stabilization and protein denaturation activity. The results suggested that anti-inflammatory activity of Nyctanthes arbor-tristis was reasonably due to the presence of flavonoid, quercetin. So, it can be used as a potential source of antiinflammatory agent.

Objective: Selected medicinal plants are either singly or in combination have been used traditionally for the management of variety of conditions especially against inflammatory disorders. They include Aegle marmelos (L.) Corr., Desmodium gangeticum (L.) DC., Gmelina arborea Roxb., Oroxylum indicum Vent., Premna optusifolia R. Br., Solanum anguivi Lam., Solanum virginianum L., Stereospermum colais Mabb. Tribulus terrestris L. and Uraria picta (Jacq.) Desv. ex DC. They are the constitutents of Ayurvedic Dashamoola which is a combination of roots of ten plants, owing to a unique combination of ten plants that play specific role in treatment of different conditions. Few of them are known to possess anti-inflammatory activity individualy but comparative study of these plants has never been carried out, therefore we have comparatively investigated these plants for their anti-inflammatory activity. Method: Water decoctions of roots were administered orally using in vivo Carrageenan induce...

It is evident from the literature and previous investigations that Nyctanthes arbortristis possesses antiinflammatory activity. On the basis of these reports, anti-inflammatory study was done on the water soluble fraction of the ethanolic extracts (WSFEE) of its flowers, barks, seeds and leaves at dose levels of 200, 400 and 600 mg/kg body weight which were selected from the study of LD50 value of the extracts. The antiinflammatory activity of the extracts was estimated using different inflammatory mediators like carrageenan, arachidonic acid, histamine and serotonin to induce paw oedema in rats. WSFEE of the flowers, seeds and leaves were found to possess anti-inflammatory activity against all the inflammatory mediators in a dose-dependent manner, whereas the barks exhibited activity at 600 mg/kg. From the study conducted it was concluded that the ethanolic extracts of the flowers, seeds, leaves and barks (600 mg/kg) of N. arbortristis L. might have the potential to inhibit cyclooxygenase pathway of arachidonic acid metabolism, which may be supplemented by antihistaminic and antiserotonergic property of the extracts. Keywords : Nyctanthes arbortristis , anti-inflammatory activity, carrageenan, arachidonic acid, histamine, serotonin Ethiopian Pharmaceutical Journal Vol. 24 (2) 2006: pp. 125-129

Abstract: The inflammatory process may be defined as a sequence of events that occurs in response to noxious stimuli, infection or trauma. Non-steroidal anti-inflammatory drugs (NSAIDS) are effective for the treatment of pain, inflammation and fever. The main factor that limits the use of NSAIDs is their gastrointestinal toxicity. Medicinal plants play an important role in the development of potent therapeutic agents. Medicinally important phytoconstituents obtained from plant barks exerted a wide range of pharmacological action on body. In this review an attempt has been made to highlight the work on medicinal plant barks having anti-inflammatory potential. The present paper involves various plant barks along with their chemical constituents and pharmacological profile which focus on the dose administered, bioactive extract involved in anti-inflammatory mechanism. This work stimulates the researchers for further research on the potential use of medicinal plant barks having anti-inflammatory property. Keywords: Inflammation, plants, bark, medicinal.

Water soluble fraction of ethanolic extract of flowers of yctanthes arbor-tristis Linn (NAT flower extract) was pharmacologically investigated for its analgesic potential in experimental models such as Tail flick latent period, Hot plate reaction in mice and Acetic acid induced writhing response in mice for analgesic activity. Extract was given orally at two different dose levels (250 and 500 mg/kg) once daily for three consecutive days, while Pentazocine (10 mg/kg, i.p.) and aspirin (25 mg/kg, i.p.) were administered respectively as positive control. Studies revealed that the flower extract have activity to prevent pains in the rodents. The analgesic effect was dose dependent and found to be statistically significant as compared to the control.