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Anisomycin: sc-3524
Anisomycin (CAS 22862-76-6)
See product citations (36)
Alternate Names:
Flagecidin; 2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
Application:
Anisomycin is activator of JNK (c-Jun N-terminal kinases) and p38
CAS Number:
22862-76-6
Purity:
≥98%
Molecular Weight:
265.30
Molecular Formula:
C14H19NO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Anisomycin is a phenylpyrolidine derivative shown to strongly activate the stress-induced MAP kinases JNK and p38. This activity results in the induction of the immediate-early genes: c-Fos, c-Jun, Fos B, Jun B and Jun D, and enhanced phosphorylation of p54/nrb, ATF-2, ERK, Caldesmon, IRS-1 and IRS-2. This compound behaves as a true signaling agonist, and has been implicated to play an important role in hyperosmolarity and UV-stimulated responses. Anisomycin has also been shown to increase the phosphorylation of p70 S6 kinase α.
References:
- Anisomycin treatment paradigm affects duration of long-term potentiation in slices of the amygdala. | Okulski, P., et al. 2002. Neuroscience. 114: 1-5. PMID: 12207948
- Anisomycin and the reconsolidation hypothesis. | Rudy, JW., et al. 2006. Learn Mem. 13: 1-3. PMID: 16452648
- Anisomycin abrogates repression of protooncogene c-fos transcription in E1A + cHa-ras-transformed cells through activation of MEK/ERK kinase cascade. | Kukushkin, AN., et al. 2008. J Cell Biochem. 103: 1005-12. PMID: 17647273
- A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis. | Mawji, IA., et al. 2007. Cancer Res. 67: 8307-15. PMID: 17804746
- Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNAMeg3/miR421/PDGFRA axis. | Ye, W., et al. 2019. Int J Oncol. 55: 1296-1312. PMID: 31638182
- Antiviral activity of the natural alkaloid anisomycin against dengue and Zika viruses. | Quintana, VM., et al. 2020. Antiviral Res. 176: 104749. PMID: 32081740
- Anisomycin protects against sepsis by attenuating I kappa B kinase-dependent NF- kappa B activation and inflammatory gene expression. | Park, GL., et al. 2021. BMB Rep. 54: 545-550. PMID: 34353427
- Anisomycin inhibits angiogenesis, growth, and survival of triple-negative breast cancer through mitochondrial dysfunction, AMPK activation, and mTOR inhibition. | Yang, W., et al. 2022. Can J Physiol Pharmacol. 100: 612-620. PMID: 35852219
- Modulation of the p38 MAPK Pathway by Anisomycin Promotes Ferroptosis of Hepatocellular Carcinoma through Phosphorylation of H3S10. | Chen, W., et al. 2022. Oxid Med Cell Longev. 2022: 6986445. PMID: 36466092
- Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. | Sánchez, I., et al. Nature. 372: 794-8. PMID: 7997269
- The stress-activated protein kinase subfamily of c-Jun kinases. | Kyriakis, JM., et al. 1994. Nature. 369: 156-60. PMID: 8177321
- Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction. | Kardalinou, E., et al. 1994. Mol Cell Biol. 14: 1066-74. PMID: 8289787
- DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis. | Kochi, SK. and Collier, RJ. 1993. Exp Cell Res. 208: 296-302. PMID: 8359223
- Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction. | Hazzalin, CA., et al. 1998. Mol Cell Biol. 18: 1844-54. PMID: 9528756