2. Placenta
• The placenta is a temporary embryonic and
later fetal organ that begins developing from
the blastocyst shortly after implantation
• The placenta is an organ that develops in the uterus during
pregnancy.
• This structure provides oxygen and nutrients to a growing
baby. It also removes waste products from the baby's blood
• The placenta attaches to the wall of the uterus, and the
baby's umbilical cord arises from it.
3. Types of placenta
• Posterior placenta:
The placenta grows on the back
wall of uterus
• Anterior placenta:
The placenta grows on the front wall
of uterus closer to bladder
• Fundal placenta:
The placenta grows at the top of
uterus
• Lateral placenta:
The placenta grows on the right or
left wall of uterus
4. Development of placenta
• The placenta begins to develop
upon implantation of the blastocyst into
the maternal endometrium, very early on
in pregnancy at about week 4
• The outer layer of the late blastocyst, is
formed of trophoblasts, cells that form
the outer layer of the placenta.
• This outer layer is divided into two further
layers:
• the underlying cytotrophoblast layer and
the overlying syncytiotrophoblast layer.
• The syncytiotrophoblast is
a multinucleated continuous cell layer
that covers the surface of the placenta.
• The placenta grows throughout pregnancy
5. Placenta
• The placenta grows throughout pregnancy.
Development of the maternal blood supply to
the placenta is complete by the end of the
first trimester of pregnancy week 14
6. Placental circulation
• Placental circulation- maternal and
fetoplacental circulation
• maternal blood flow begins between days 5–
12, and is approximately 600–700 ml/min at
term.
7. Feto-placental circulation
• Deoxygenated fetal blood passes through umbilical arteries to the
placenta. At the junction of umbilical cord and placenta, the
umbilical arteries branch radially to form chorionic arteries.
• Chorionic arteries, in turn, branch into cotyledon arteries.
• In the villi, these vessels eventually branch to form an extensive
arterio-capillary-venous system, bringing the fetal blood extremely
close to the maternal blood; but no intermingling of fetal and
maternal blood occurs
• ("placental barrier")
• Endothelin and prostanoids cause vasoconstriction in placental
arteries, while nitric oxide causes vasodilation.
• On the other hand, there is no neural vascular regulation, and
catecholamines have only little effect.
8. Feto-placental circulation
• The fetoplacental circulation is vulnerable to
persistent hypoxia or intermittent hypoxia and
reoxygenation, which can lead to generation
of excessive free radicals. This may contribute
to pre-eclampsia and other pregnancy
complications.
• It is presumed that melatonin plays a role as
an antioxidant in the placenta.
9. Pathology of placenta
• Placenta accreta, when the placenta implants
too deeply, all the way to the actual muscle of
uterine wall (without penetrating it)
• Placenta praevia, when the placement of the
placenta is too close to or blocks the cervix
• Placental abruption, premature detachment
of the placenta
• Placentitis, inflammation of the placenta, such
as by TORCH infections
10. Placenta accreta
• Findings could be—
• focal thinning or absence of the myometrium
at the site of placental implantation
• a nodular interface between the placenta and
the uterus
• a mass effect of the placenta on the uterus
causing an outer bulge, heterogeneous signal
intensity within the placenta
11. Placenta increta and percreta
• Placenta increta is a condition where the
placenta attaches more firmly to the uterus
and becomes embedded in the organ's
muscle wall.
• Placenta percreta is a condition where
placenta attaches itself and grows through the
uterus and potentially to the nearby organs
(such as the bladder).
15. Placenta previa
• During pregnancy, the placenta provides the
growing baby with oxygen and nutrients from
the mother's bloodstream.
• Placenta previa means the placenta has
implanted at the bottom of the uterus, over
the cervix or close by, which means the baby
can't be born vaginally.
18. Placental abruption
• The placenta is an organ that develops in the
uterus during pregnancy.
• Placental abruption occurs when the placenta
separates from the inner wall of the uterus
before birth
• Placental abruption can deprive the baby of
oxygen and nutrients and cause heavy
bleeding in the mother.
20. Cause of placental abruption
• The cause is unknown in most cases,
• But risk factors may include maternal high
blood pressure, abdominal trauma and
substance misuse
21. Types of placental abruption
1. Subchorionic abruption - bleeding
between myometrium and placental
membranes.
2. Retroplacental abruption - bleeding
between myometrium and placenta
3. Preplacental abruption - bleeding
between placenta and amniotic fluid
4. Intraplacental abruption.