1. Dr. V. RAMESH
Assistant Professor & Head i/c,
Department of Botany, Vivekananda College,
(Residential & Autonomous – Gurukula Institute of Life Training)
Tiruvedakam West – 625 234.
Madurai.
2.
3. REFERENCES
Kevin D. Hyde et al., (2019) The amazing potential of fungi: 50 ways we can exploit fungi
Industrially. Fungal Diversity, 97:1–136.
Luciana M. Elias et al., (2018) The potential of compounds isolated from Xylaria spp. as antifungal
agents against anthracnose. Brazilian Journal of Microbiology, 49: 840–847.
Tuan Noraida Tuan Hamzah et al., (2018) Diversity and Characterization of Endophytic Fungi Isolated
From the Tropical Mangrove Species, Rhizophora mucronata, and Identification of Potential Antagonists
Against the Soil-Borne Fungus, Fusarium solani. Frontiers in Microbiology, 9: 1-13
Rong Chen et al., (2018) Secondary Metabolites from the Endophytic Fungus Xylaria sp. hg1009.
Natural Products and Bioprospecting, 8:121–129.
Mohd Adnan et al., (2018) Formulation, evaluation and bioactive potential of Xylaria primorskensis
terpenoid nanoparticles from its major compound xylaranic acid. Scientific Reports, 8:1740 – 1752.
Ramesh et al., (2015) Novel Bioactive Wild Medicinal Mushroom—Xylaria sp. R006 (Ascomycetes)
against Multidrug Resistant Human Bacterial Pathogens and Human Cancer Cell Lines. International
Journal of Medicinal Mushrooms, 17(10): 1005–1017.
4. Why Xlaria spp.?
Xylaria is a large and the first described genus of the family Xylariaceae
They may be Lived as a Saprophytes or sometimes Parasitic or
Endophytes.
They may be found mostly on wood, sawdust, leaf, dung or soil.
It is a natural source of bioactive secondary metabolites like
Cytochalsins (Dagne et al., 1994), Xylaramides (Schneider et al., 1996),
Xanthones (Healy et al., 2004) and Griesofulvins (Park et al., 2005). etc.
9. Xylaria sp. (KC405623)
Morphology on PDA Fruiting bodies on PDB
Natural fruiting bodies Ascospores (100x)
Natural Habitat
Preparation of Extraction
10. Staphylococcus aureus (1-10) and Pseudomonas aeruginosa (1-8)
were obtained from Bose Clinical Laboratory, Madurai, Tamilnadu,
India.
Staphylococcus aureus Pseudomonas aeruginosa
HUMAN CANCER CELL LINES
A-549,
MCF-7
MDA-MB-231
CLINICAL STRAINS
12. nm
Abs
Absorption peak at 236 nm
indicates - alcohols, amines, halides,
ethers.
Absorption peak at 396 nm
indicates - chromophoric group.
UV spectrum
Wave number (cm-1)
Abs
The tentatively assigned peak at 3438 cm-1
indicates the presence of hydrogen bonding (OH
or NH).
The band around 2935 cm-1 is due to H-C-H
symmetric stretching.
The broad peak at 1699 cm-1 is due to C=O
stretching and the peaks at 1454, 1390-1228 &
1053 indicate C-C=C asymmetric, N-
H and C-O stretches.
IR spectrum
13. CONCLUSION
Present study revealed that the fruiting body extract of Xylaria sp.
(KC405623) had an effective broad spectrum antibacterial and cytotoxic
activity against drug resistant bacterial pathogens and human cancer
cell lines.
Xylaria sp. (KC405623) could be used as pharmaceutical substances
having diverse therapeutic applications once the nature of active
components will be elucidated.
