Advanced Methods of PK/PD Systems Analysis - Biomedical ...
Advanced Methods of PK/PD Systems Analysis - Biomedical ...
Advanced Methods of PK/PD Systems Analysis - Biomedical ...
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Workshop Schedule<br />
Friday, June 22, 2001<br />
8:30 Introductory Remarks David Z. D'Argenio<br />
University <strong>of</strong> Southern California<br />
8:45 Tissue Pharmacokinetics Michael S. Roberts<br />
University <strong>of</strong> Queensland<br />
9:25 Compartmental vs. Distributed-in-Space Modeling <strong>of</strong><br />
Pharmacokinetics in Isolated Perfused Organs<br />
Michael Weiss<br />
Martin Lurther University Halle-<br />
Wittenberg<br />
10:05 Break<br />
10:35 Quantitative <strong>Analysis</strong> <strong>of</strong> Microdialysis Sheng Tong<br />
Duke University<br />
11:15 New Insights into the Pharmacokinetics and Metabolism <strong>of</strong><br />
(R,S)-Ifosfamide in Cancer Patients Using a Population<br />
Pharmacokinetic-Metabolism Model<br />
Murray P. Ducharme<br />
MDS Pharma Services<br />
12:00 Lunch<br />
1:30 Pharmacodynamics and Pharmacogenomics <strong>of</strong><br />
Corticosteroids<br />
2:10 Mechanism-Based Pharmacokinetic-Pharmacodynamic<br />
Modeling: Incorporation <strong>of</strong> Receptor Theory and Dynamic<br />
<strong>Systems</strong> <strong>Analysis</strong><br />
2:50 Population Pharmacokinetics/Pharmacodynamics <strong>of</strong> the Anti-<br />
CD11a Antibody hu1124 (Xanelim TM )<br />
William J. Jusko<br />
SUNY at Buffalo<br />
Meindert Danh<strong>of</strong><br />
Leiden University<br />
Robert J. Bauer<br />
Xoma (US) LLC<br />
3:30 Break<br />
4:00 Mechanism-Based Pharmacokinetic/Pharmacodynamic<br />
(<strong>PK</strong>/<strong>PD</strong>) Modeling for Biotechnology Products<br />
Yu-Nien (Tom) Sun<br />
Genentech, Inc.<br />
4:40 Applications <strong>of</strong> <strong>PK</strong>/<strong>PD</strong> Modeling in Drug Development Amy Racine-Poon<br />
Novartis Pharma Inc.<br />
5:30 Reception
Workshop Schedule<br />
Saturday, June 23, 2001<br />
8:30 Assessment <strong>of</strong> QTc Interval Prolongation in a Phase I Study<br />
Using Monte Carlo Simulation<br />
9:10 Bayesian Adaptive Trials for Pro<strong>of</strong>-<strong>of</strong>-Concept and Dose-<br />
Finding<br />
9:50 An Integrated Pharmacokinetic-Adherence Measure<br />
for Virologic Outcome<br />
Peter L. Bonate<br />
Quintiles Transnational Corp.<br />
William R. Gillespie<br />
Pharsight Corporation<br />
Richard C. Brundage<br />
University <strong>of</strong> Minnesota<br />
10:30 Break<br />
10:55 The Role <strong>of</strong> Pharmacokinetic/Pharmacodynamic (<strong>PK</strong>/<strong>PD</strong>)<br />
Modeling in HIV Therapy<br />
Ann Hsu<br />
Abbott Laboratories<br />
11:35 Concentration-Controlled Antiretroviral Therapy Courtney V. Fletcher<br />
University <strong>of</strong> Minnesota<br />
12:15 Lunch<br />
1:45 Unsupervised, Machine Learning Based Model Building in<br />
NONMEM<br />
2:25 Optimal Designs in Population Pharmacokinetics/<br />
Pharmacodynamics<br />
Mark Sale<br />
GlaxoSmithKline<br />
France Mentre<br />
University Hospital Bichat<br />
3:05 Break<br />
3:30 Pharmacodynamic Models with Multiple Inputs/Outputs William R. Greco<br />
Roswell Park Cancer Institute<br />
4:10 Bayesian <strong>Methods</strong> in Pharmacokinetic and<br />
Pharmacodynamic Modeling<br />
David Z. D'Argenio<br />
University <strong>of</strong> Southern California<br />
4:50 Closing Remarks David Z. D'Argenio<br />
University <strong>of</strong> Southern California
<strong>Biomedical</strong> Simulations Resource (BMSR)<br />
University <strong>of</strong> Southern California<br />
9 th Workshop on<br />
ADVANCED METHODS OF PHARMACOKINETIC &<br />
PHARMACODYNAMIC SYSTEMS ANALYSIS<br />
June 22-23, 2001<br />
Marina Beach Marriott<br />
Marina del Rey, California<br />
DIRECTORY OF PARTICIPANTS<br />
Agoram, Balaji<br />
Simulations Plus, Inc.<br />
1220 West Avenue J<br />
Lancaster, CA 93534<br />
Phone: (661) 723-7723<br />
Fax: (661) 723-5524<br />
Email: balaji@simulations-plus.com<br />
Anderson, Alan C.<br />
Texas Tech UHSC SOP<br />
Department <strong>of</strong> Phramacy Practice<br />
1300 Coulter Room 206<br />
Amarillo, TX 79106-1712<br />
Phone: (806) 356-4000 ext. 318<br />
Fax: (806) 356-4018<br />
Email: aca@cortex.ama.ttuhsc.edu<br />
Badawi, Hossam M.M.<br />
5 Shaki st. Off El-Eshreen St. Faisal<br />
Madkoor Giza<br />
Cairo, Haram 12111<br />
EGYPT<br />
Phone: 20 012 2738280<br />
Email: HMMB@S<strong>of</strong>tHome.net<br />
Al-Huniti, Nidal<br />
University <strong>of</strong> Iowa<br />
S 232 Pharmacy Building<br />
College <strong>of</strong> Pharmacy<br />
Iowa City, IA 52242<br />
Phone: (319) 335-9735<br />
Email: nidal-al-huniti@uiowa.edu<br />
Ariano, Robert<br />
St. Boniface General Hospital<br />
409 Tache Avenue<br />
Winnipeg, Manitoba R2H 2A6<br />
CANADA<br />
Phone: 204 237-2050<br />
Fax: 204 237-2165<br />
Email: rariano@sbgh.mb.ca<br />
Bashaw, Edward Dennis<br />
US Food & Drug Administration<br />
5600 Fishers Lane, HFD-880<br />
Rockville, MD 20857<br />
Phone: (301) 827-2534<br />
Fax: (301) 827-2531<br />
Email: bashaw@cder.fda.gov
Bauer, Robert<br />
Xoma Corporation<br />
2910 7th Street<br />
Berkeley, CA 94710<br />
Phone: (510) 644-1170 x2462<br />
Fax: (510) 704-8024<br />
Email: bobjbauer@home.com<br />
Berry, Brian<br />
Genpharm Inc.<br />
85 Advance Road<br />
Etobicoke, Ontario M8Z 2S9<br />
CANADA<br />
Phone: 416 924-0671 x5413<br />
Fax: 416 926-6529<br />
Email: bberry@inforamp.net<br />
Bies, Robert R.<br />
University <strong>of</strong> Pittsburgh<br />
805 N Salk Hall, School <strong>of</strong> Pharmacy<br />
U.P. 3501, Terrace St.<br />
Pittsburgh, PA 15213<br />
Phone: (412) 648-7219<br />
Fax: (412) 624-1850<br />
Email: biesrr@msx.upmc.edu<br />
Bonate, Peter L.<br />
Quintiles<br />
Clinical Pharmacokinetics<br />
P.O. Box 9708 (L4-M2828)<br />
Kansas City, MO 64134<br />
Phone: (816) 767-6084<br />
Fax: (816) 767-7378<br />
Email: peter.bonate@quintiles.com<br />
Bourne, David<br />
University <strong>of</strong> Oklahoma Health Sciences Center<br />
College <strong>of</strong> Pharmacy<br />
1110 N. Stonewall Avenue<br />
Oklahoma City, OK 73117<br />
Phone: (405) 271-6481<br />
Fax: (405) 271-7505<br />
Email: david-bourne@ouhsc.edu<br />
Beringer, Paul<br />
University <strong>of</strong> Southern California<br />
School <strong>of</strong> Pharmacy<br />
1985 Zonal Avenue<br />
Los Angeles, CA 90033<br />
Phone: (323) 442-1402<br />
Fax: (626)-628-3024<br />
Email: beringer@hsc.usc.edu<br />
Best, Brookie<br />
University <strong>of</strong> California, San Diego<br />
Pediatric Pharmacology Research Unit<br />
9500 Gilman Drive M/C 0979<br />
La Jolla, CA 92093-0979<br />
Email: brookie@usc.edu<br />
Blanchett, Dennis<br />
BioMedicines, Inc.<br />
1940 Rancho Verde Circle West<br />
Danville, CA 94526<br />
Phone: (510) 814-0112<br />
Fax: (510) 814-0170<br />
Email: blanchettd@aol.com<br />
Booker, Brent M.<br />
SUNY at UB<br />
Roswell Park Cancer Institute<br />
2194 Main Street Upper<br />
Buffalo, NY 14214<br />
Phone: (716) 845-3455<br />
Fax: (716) 845-2336<br />
Email: bmbooker@hotmail.com<br />
Brundage, Dianne Mary<br />
Park Nicollet Health Services<br />
Methodist Hospital Pharmacy<br />
6500 Excelsior Blvd.<br />
Minneapolis, MN 55426<br />
Phone: (952) 993-6374<br />
Fax: (952) 993-6813<br />
Email: brundd@parknicollet.com
Brundage, Richard<br />
University <strong>of</strong> Minnesota<br />
College <strong>of</strong> Pharmacy, WDH 7-150<br />
308 Harvard Street, S.E.<br />
Minneapolis, MN 55455<br />
Phone: (612) 624-3115<br />
Fax: (612) 626-5481<br />
Email: brund001@umn.edu<br />
Capparelli, Edmund<br />
University <strong>of</strong> California, San Diego<br />
Pediatric Pharm. Research Unit<br />
9500 Gilman Drive M/C 0979<br />
La Jolla, CA 92093-0979<br />
Phone: (858)-622-5729<br />
Fax: (858)-622-9213<br />
Email: ecapparelli@ucsd.edu<br />
Chawla, Jyoti<br />
12728 28th Avenue NE<br />
Apt. #508<br />
Seattle, WA 98125<br />
Phone: (206) 268-0281<br />
Email: chawla@u.washington.edu<br />
Burak, Eric<br />
Guilford Pharmaceuticals Inc.<br />
6611 Tributary Street.<br />
Baltimore, MD 21224<br />
Phone: (410) 631-6824<br />
Fax: (410) 631-6804<br />
Email: burak_e@guilforpharm.com<br />
Chapel, Sunny<br />
University <strong>of</strong> Iowa<br />
s232 Pharmacy Building<br />
Iowa City, IA 52242<br />
Phone: (319) 335-9735<br />
Fax: (319) 353-5646<br />
Email: sehong@blue.weeg.uiowa.edu<br />
Chen, Eric<br />
Princess Margaret Hospital<br />
University <strong>of</strong> Toronto<br />
Department <strong>of</strong> Medical Oncology<br />
610 University Avenue<br />
Toronto M5G 2M9, ON<br />
CANADA<br />
Phone: 416 946 2000<br />
Fax: 416 946 4520<br />
Email: eric.chen@uhn.on.ca<br />
Chen, Alin<br />
Medinox, Inc.<br />
11575 Sorrento Valley, Suite 201<br />
San Diego, CA 92121<br />
Phone: (858) 793-4820<br />
Fax: (858) 793-4823<br />
Email: aychen@medinox.com<br />
Chow, Fung-Sing Vincent<br />
GlaxoSmithKline<br />
Department <strong>of</strong> Clinical Pharmacology and<br />
Experimental Medicine<br />
Mail Code UW2730<br />
709 Swedeland Road, PO Box 1539<br />
King <strong>of</strong> Prussia, PA 19406<br />
Phone: (610) 270-5933<br />
Email: Vincent_2_Chow@gsk.com<br />
Chen, Sharon<br />
Protein Design Labs, Inc.<br />
34801 Campus Drive<br />
Fremont, CA 94555<br />
Phone: (510) 574-1624<br />
Fax: (510) 574-1616<br />
Email: schen@pdl.com<br />
Clardy, Darell<br />
Analytical & Forensic Toxicology, Inc.<br />
PO Box 5295<br />
Fullerton, CA 92838-0295<br />
Phone: (714) 993-2220<br />
Fax: (714) 993-1523<br />
Email: ydralcd@pacbell.net
Cornejo, Edson A. Meza<br />
Hospital Honorio Delgado<br />
Urb. Los Portales F-2, Cayma<br />
Arequipa, Pe<br />
PERU<br />
Phone: 051 54253620<br />
Email: emezacor@hotmail.com<br />
Dao, Le<br />
Genentech, Inc.<br />
1 DNA Way<br />
S. San Francisco, CA 94080-4990<br />
Phone: (650) 225-4618<br />
Fax: (650) 225-6452<br />
Email: le1@gene.com<br />
Del Rosario, Joselyn<br />
Medinox, Inc.<br />
11575 Sorrento Valley, Suite 201<br />
San Diego, CA 92121<br />
Phone: (858) 793-4820<br />
Fax: (858) 793-4823<br />
Email: j_del_rosario@hotmail.com<br />
DiStefano III, Joseph<br />
University <strong>of</strong> California, Los Angeles<br />
Computer Science<br />
4531 Boelter Hall<br />
Los Angeles, CA 90095-1596<br />
Phone: (310) 825-7482<br />
Fax: (310) 794-5057<br />
Email: joed@cs.ucla.edu<br />
Ebling, William F.<br />
Pharsight Corporation<br />
243 East Flagstone Dr.<br />
Newark, DE 19702<br />
Phone: (302) 731-1895<br />
Fax: (302) 731-1896<br />
Email: webling@pharsight.com<br />
Danh<strong>of</strong>, Meindert<br />
University <strong>of</strong> Leiden<br />
Division <strong>of</strong> Pharmacology<br />
Sylvius Lab. P.O. Box 9503<br />
2300 RA, Leiden<br />
NETHERLANDS<br />
Phone: 3171 5276211<br />
Fax: 31 71 5276292<br />
Email: m.danh<strong>of</strong>@CHEM.LeidenUniv.nl<br />
D'Argenio, David Z.<br />
University <strong>of</strong> Southern California<br />
<strong>Biomedical</strong> Engineering<br />
Olin Hall 500<br />
Los Angeles, CA 90089-1451<br />
Phone: (213) 740-0341<br />
Fax: (213) 740-0343<br />
Email: dargenio@bmsr.usc.edu<br />
DiCenzo, Robert<br />
University <strong>of</strong> Rochester Medical Center<br />
601 Elmgrove Avenue<br />
Rochester, NY 14534<br />
Phone: (716) 273-4317<br />
Email: robert_dicenzo@urmc.rochester.edu<br />
Ducharme, Murray P.<br />
MDS Pharma Services<br />
2350 Cohen Street<br />
St. Laurent BC, H4R 2N6<br />
CANADA<br />
Phone: 514 333-0042 ext 4520<br />
Fax: 514 333-7666<br />
Email: murray.ducharme@mdsps.com<br />
Egorin, Merrill J.<br />
University <strong>of</strong> Pittsburgh Cancer Institute<br />
E1040 <strong>Biomedical</strong> Sciences Tower<br />
200 Lothrop Street<br />
Pittsburgh, PA 15213<br />
Phone: (412) 624-9272<br />
Fax: (412) 648-9856<br />
Email: egorinmj@msx.upmc.edu
Endrenyi, Laszlo<br />
University <strong>of</strong> Toronto<br />
Department <strong>of</strong> Pharmacology<br />
Medical Sciences Building<br />
Toronto Ontario M5S 1A8<br />
CANADA<br />
Phone: 416 978-8620<br />
Fax: 416 978-6395<br />
Email: l.endrenyi@utoronto.ca<br />
Fletcher, Courtney V.<br />
University <strong>of</strong> Minnesota<br />
308 Harvard Street, SE<br />
WDH 7-151<br />
Minneapolis, MN 55455<br />
Phone: (612) 624-6489<br />
Fax: (612) 626-5481<br />
Email: fletc001@tc.umn.edu<br />
Fung, Dennis<br />
University <strong>of</strong> California, Davis<br />
2315 Stockton Blvd.<br />
PSSB 1231<br />
Sacramento, CA 95831<br />
Phone: (916) 734-5171<br />
Fax: (916) 734-7980<br />
Email: dlfung@ucdavis.edu<br />
Giangrandi, Enrico<br />
Padova University<br />
Via G.B. Piazzetta, 28<br />
Mestre-Venezia 30174<br />
ITALY<br />
Phone: 347 3158722<br />
Email: enrico.giangrandi@tin.it<br />
Granneman, Richard<br />
Abbott Laboratories<br />
100 Abbott Park Road<br />
D4CE, AP13A<br />
Abbott Park, IL 60064-6104<br />
Phone: (847) 937-5714<br />
Fax: (847) 938-5193<br />
Email: richard.g.granneman@abbott.com<br />
Fatima, Lakehl<br />
University <strong>of</strong> Washington<br />
4214 11th Avenue N.<br />
Seattle, WA 98105<br />
Fax: (206) 543-3204<br />
Email: lakehal@u.washington.edu<br />
Forrest, Alan<br />
Millard Filmore Hospital<br />
Clinical Pharmacokinetics Lab<br />
3 Gates Circle<br />
Buffalo, NY 14209<br />
Phone: (716) 887-5164<br />
Fax: (716) 887-4566<br />
Email: Jscott@mfhs.edu<br />
Garland, Marianne<br />
Columbia University<br />
622 West 168th Street<br />
PH4W-465<br />
New York, NY 10032<br />
Phone: (212) 305-0952<br />
Fax: (212) 305-0956<br />
Email: mg71@columbia.edu<br />
Gillespie, William R.<br />
Pharsight Corporation<br />
5520 Dillard Drive Suite 210<br />
Cary, NC 27511<br />
Phone: (919) 859-6868 x.4610<br />
Fax: (919) 859-6871<br />
Email: bgillespie@pharsigt.com<br />
Greco, William R.<br />
Roswell Park Cancer Institute<br />
Department <strong>of</strong> Pharmacology and Therapeutics<br />
Elm & Carlton Streets<br />
Buffalo, NY 14263<br />
Phone: (716) 845-8641<br />
Fax: (716) 845-8467<br />
Email: William.Greco@RoswellPark.org
Gries, Jean-Michel<br />
Aventis Pharmaceuticals Inc.<br />
Route 202-206<br />
P.O. Box 6800<br />
Bridgewater, NJ 08807-0800<br />
Phone: (908) 231-4467<br />
Fax: (908) 231-4754<br />
Email: Jean-Michel.Gries@aventis.com<br />
Guzy, Serge<br />
Xoma<br />
2 Anchor Drive #285<br />
Emeryville, CA 94608<br />
Phone: (510) 594-8704<br />
Email: guzy@xoma.com<br />
Harrold, John<br />
University <strong>of</strong> Pittsburgh<br />
Benedum Hall<br />
Room 1249<br />
Pittsburgh, PA 15261<br />
Phone: (412) 624-9630<br />
Fax: (412) 624-9639<br />
Email: jmh17@pitt.edu<br />
Hirankarn, Sarapee<br />
University <strong>of</strong> Iowa<br />
206 6th St.<br />
Apt.#A5<br />
Iowa City, IA 52241<br />
Phone: (319) 338-6583<br />
Email: sarapee@urech.com<br />
H<strong>of</strong>fman, Amnon<br />
The Hebrew University <strong>of</strong> Jerusalem<br />
Dept. <strong>of</strong> Pharmaceutics, School <strong>of</strong> Pharmacy<br />
PO Box 12065<br />
Jerusalem 91120<br />
ISRAEL<br />
Phone: 972 2 675 8667<br />
Fax: 972 2 6757246<br />
Email: ah<strong>of</strong>fman@cc.huji.ac.il<br />
Griffith, David<br />
Microcide Pharmaceutical Inc.<br />
850 Maude Avenue<br />
Mountain View, CA 94043<br />
Phone: (650)-428-3514<br />
Fax: (650)-428-3550<br />
Email: griffith@microcide.com<br />
Harms, Dan<br />
Amgen Inc.<br />
One Amgen Center Drive<br />
MS 29-2-A<br />
Thousand Oaks, CA 91320<br />
Phone: (805) 447-1583<br />
Fax: (805) 499-9955<br />
Heatherington, Anne<br />
Amgen Inc.<br />
One Amgen Center Drive<br />
M/S 1-1-A<br />
Thousand Oaks, CA 91320<br />
Phone: (805) 492-3209<br />
Fax: (805) 499-4868<br />
Email: anneh@amgen.com<br />
Hoem, Nils Ove<br />
University <strong>of</strong> Oslo<br />
Dept. <strong>of</strong> Pharmacology<br />
POB 1068 Blindern<br />
Oslo N-0316<br />
NORWAY<br />
Phone: 47 22 85 65 46<br />
Fax: 47 22 85 44 02<br />
Email: n.o.hoem@farmasi.uio.no<br />
Hoyo, Carlos<br />
Dept. Pharmacology Cinvestav<br />
IPN, Av.<br />
IPN 2508<br />
Mexico City 07360<br />
MEXICO<br />
Phone: 52 5747 3800 x.5438<br />
Fax: 52 5747 7095<br />
Email: carlosmail.cinvestav.mx
Hsei, Vanessa<br />
Genentech, Inc.<br />
1 DNA Way<br />
South San Francisco, CA 94080<br />
Phone: (650) 225-3902<br />
Fax: (650) 225-6452<br />
Email: hsei@gene.com<br />
Hughes, Michael<br />
Harvard School <strong>of</strong> Public Health<br />
Department <strong>of</strong> Biostatistics<br />
655 Huntington Avenue<br />
Boston, MA 02115<br />
Phone: (617) 432-3161<br />
Fax: (617) 432-2832<br />
Email: mhughes@sdac.harvard.edu<br />
Jensen, Bradford K.<br />
Aventis Pharmaceutical<br />
Route 202-206<br />
PO Box 6800<br />
Bridgewater, NJ 08807-0800<br />
Phone: (908) 231-2854<br />
Fax: (908) 231-3470<br />
Email: bradford.jensen@aventis.com<br />
Joshi, Amita<br />
Genentech Inc.<br />
DNA Way<br />
MS-70<br />
San Fransisco, CA 94080<br />
Phone: (650) 225-6434<br />
Fax: (650) 225-6452<br />
Email: amita@gene.com<br />
Jusko, William J.<br />
University at Buffalo/SUNY<br />
Department <strong>of</strong> Pharmaceutics<br />
565 Hochstetter Hall, North Campus<br />
Buffalo, NY 14260<br />
Phone: (716) 645-2855 ext. 225<br />
Fax: (716) 645-2842<br />
Email: wjjusko@acsu.buffalo.edu<br />
Hsu, Ann<br />
Abbott Laboratories<br />
100 Abbott Park Road<br />
D4CE, AP13A<br />
Abbott Park, IL 60064-6104<br />
Phone: (847) 937-5714<br />
Fax: (847) 938-5193<br />
Email: ann.hsu@abbott.com<br />
Jelliffe, Roger W.<br />
University <strong>of</strong> Southern California<br />
USC Laboratory <strong>of</strong> Applied Pharmacokinetics<br />
2250 Alcazar St., CSC 134-B- HSC<br />
Los Angeles, CA 90033<br />
Phone: (323) 442-1300<br />
Fax: (323) 442-1302<br />
Email: jelliffe@hsc.usc.edu<br />
Johansen, Mary J.<br />
University <strong>of</strong> Texas<br />
M.D. Anderson Cancer Center<br />
1515 Holcombe Blvd.<br />
Box 52<br />
Houston, TX 77030<br />
Phone: (713) 745-2805<br />
Fax: (713) 745-1453<br />
Email: mjohanse@mdanderson.org<br />
Jumbe, Nelson L.<br />
Microcide Pharmaceutical Inc.<br />
850 Maude Ave.<br />
Mountain View, CA 94043<br />
Phone: (650)-526-3044<br />
Fax: (650) 428-3534<br />
Email: njumbe@microcide.com<br />
Kakuda, Thomas Naoki<br />
Abbott Laboratories<br />
338 Turks Head Lane<br />
Redwood City, CA 94065<br />
Phone: (650) 592-0962<br />
Email: thomas.kakuda@abbott.com
Kang, Wonku<br />
Martin-Luther University<br />
Fliederweg 36<br />
Hallle 06130<br />
GERMANY<br />
Phone: 49-345-557-4093<br />
Fax: 49-345-557-1835<br />
Email: won.kang@medizin.uni-halle.de<br />
Katz, Darryl<br />
519 Webster Street<br />
San Francisco, CA 94117-2616<br />
Phone: (415) 255-1611<br />
Fax: (415) 255-1632<br />
Email: DKStat@aol.com<br />
Kern, Steven E.<br />
University <strong>of</strong> Utah<br />
Dept. <strong>of</strong> Pharmaceutics & Anesthesiology<br />
421 Wakara Way Suite 318<br />
Salt Lake City, UT 84108<br />
Phone: (801) 585-5958<br />
Fax: (801) 585-3614<br />
Email: skern@remi.med.utah.edu<br />
Labbe, Line<br />
University <strong>of</strong> California, San Francisco<br />
521 Parnassus NONMEM Group<br />
Room C 250 Box 0626<br />
San Francisco, CA 94143<br />
Phone: (415) 502-1989<br />
Fax: (415) 476-2796<br />
Email: line@c255.ucsf.edu<br />
Landaw, Elliot M.<br />
University <strong>of</strong> California, Los Angeles<br />
School <strong>of</strong> Medicine<br />
Department <strong>of</strong> Biomathematics<br />
10833 Le Conte Avenue Box 951766<br />
Los Angeles, CA 90095-1766<br />
Phone: (310) 825-6743<br />
Fax: (310) 825-8685<br />
Email: elandaw@biomath.medsch.ucla.edu<br />
Kang, Dongwoo<br />
University <strong>of</strong> California, San Francisco<br />
Biopharmaceutical Sciences<br />
513 Parnassus Avenue<br />
San Francisco, CA 94143-0446<br />
Phone: (415) 502-6685<br />
Fax: (415) 476-1556<br />
Email: dongwoo@ariel1.ucsf.edu<br />
Kearns, Karen Ann<br />
Amgen Inc.<br />
One Amgen Center Drive<br />
MS 29-1-A<br />
Thousand Oaks, CA 91320<br />
Phone: (805) 447-1853<br />
Fax: (805) 447-1251<br />
Email: kkearns@amgen.com<br />
Kwon, Kwang-il<br />
Chungnam National University<br />
College <strong>of</strong> Pharmacy<br />
Daejeon 305-764<br />
KOREA<br />
Phone: 82 42 8215937<br />
Fax: 82 42 8236781<br />
Email: kwon@cnu.ac.kr<br />
Lai, Chii-Ming<br />
Du Pont Pharmaceutical Co.<br />
Stine-Haskell Research Center<br />
P.O. Box 30, Elkton Road<br />
Newark, DE 19714<br />
Phone: (302) 451-0026<br />
Fax: (302) 451-0054<br />
Email: Chii-Ming.LAI@DuPontpharma.com<br />
Lavigne, Jean<br />
MDS Pharma Services<br />
2350 Cohen Street<br />
St-Laurent H4R 2N6, Quebec<br />
CANADA<br />
Phone: 514 333-0042 x4234<br />
Fax: 514 333-7666<br />
Email: jean.lavigne@mdsps.com
Lee, Sue-Chih<br />
Food and Drug Administration<br />
9201 Corporate Blvd.<br />
HFD-880, Rm.N209<br />
Rockville, MD 20850<br />
Phone: (301) 827-2052<br />
Fax: (301) 827-2075<br />
Email: lees@cder.fda.gov<br />
Li, Jianguo<br />
Pfizer Inc.<br />
Groton Laboratories<br />
Eastern Point Road 8260/238<br />
Groton, CT 06340<br />
Phone: (860) 715-5950<br />
Fax: (860) 441-5302<br />
Email: Jianguo_li@groton.pfizer.com<br />
Liu, Mei-jen<br />
<strong>Advanced</strong> Medicine Inc.<br />
901 Gateway Blvd<br />
South San Francisco, CA 94080<br />
Phone: (650) 808-6176<br />
Fax: (650) 808-6441<br />
Email: mliu@advmedicine.com<br />
Looby, Michael<br />
Novartis AG<br />
Lichtstrasse 35<br />
Basel CH-4056<br />
SWITZERLAND<br />
Phone: 41 61 3242381<br />
Fax: 41 61 46112<br />
Email: michael.looby@pharma.novartis.com<br />
Lu, Jianfeng<br />
University <strong>of</strong> California, San Francisco<br />
521 Parnusus, Rm C255<br />
San Francisco, CA 94143-0626<br />
Phone: (415) 502-1989<br />
Fax: (415) 476-2796<br />
Email: jianfeng@c255.ucsf.edu<br />
Lee, Carlton K.K.<br />
Johns Hopkins University<br />
Department <strong>of</strong> Pharmacy Services<br />
600 North Wolfe St.<br />
Carnegie 180<br />
Baltimore, MD 21287-6180<br />
Phone: (410) 614-2949<br />
Fax: (410) 955-0287<br />
Email: ckklee@jhmi.edu<br />
Libertine, Lyn<br />
UCB Research, Inc.<br />
840 Memorial Drive<br />
Cambridge, MA 02139<br />
Phone: (617) 547-0033<br />
Fax: (617) 864-5961<br />
Email: lyn.libertine@ucb-research.com<br />
Long, Lina<br />
University <strong>of</strong> Chicago<br />
Dept. <strong>of</strong> Medicine, MC2115<br />
5841 S. Maryland Ave<br />
Chicago, IL 60637<br />
Phone: (773) 834-1350<br />
Fax: (773) 702-2770<br />
Email: llong@medicine.bsd.uchicago.edu<br />
Louie, Stan<br />
University <strong>of</strong> Southern California<br />
1985 Zonal Avenue<br />
Los Angeles, CA 90033<br />
Fax: (323) 442-1435<br />
Email: slouie@hsc.usc.edu<br />
Madden, Timothy<br />
University <strong>of</strong> Texas<br />
M.D. Anderson Cancer Center<br />
Dept. <strong>of</strong> Experimental Therapeutics<br />
1515 Holcombe Blvd., Box 90<br />
Houston, TX 77030<br />
Phone: (713) 794-4800<br />
Fax: (713) 797-9693<br />
Email: tmadden@mdanderson.org
Mager, Donald E.<br />
University at Buffalo, State University <strong>of</strong> New York<br />
528 Hochstetter Hall<br />
Buffalo, NY 14260<br />
Phone: (716) 645-2842<br />
Fax: (716) 645-3693<br />
Email: dmager@acsu.buffalo.edu<br />
Martin, Steven W.<br />
Amgen Inc.<br />
One Amgen Center Drive<br />
Thousand Oaks, CA 91320-1789<br />
Phone: (805) 447-4541<br />
Fax:<br />
Email: swmartin@amgen.com<br />
Montgomery, Megan<br />
University <strong>of</strong> Southern California<br />
School <strong>of</strong> Pharmacy<br />
11357 Wembley Road<br />
Los Alamito, CA 90720<br />
Phone: (562) 856-7958<br />
Email: mmontgom@usc.edu<br />
Nguyen, Linh T.<br />
Amgen Inc.<br />
1 Amgen Center Dr.<br />
<strong>PK</strong>DM Department<br />
Thousand Oaks, CA 91320<br />
Phone: (805) 447-5402<br />
Fax: (805) 499-4868<br />
Email: lnguyen@amgen.com<br />
Panetta, J. Carl<br />
St. Jude Children's Research Hospital<br />
332 North Lauderdale Street<br />
Memphis, TN 38105-2794<br />
Phone: (901) 495-3172<br />
Fax: (901) 525-6869<br />
Email: carl.panetta@stjude.org<br />
Marier, Jean Francois<br />
University <strong>of</strong> Montreal<br />
Faculty <strong>of</strong> Pharmacy<br />
P.O. Box 6128 Station Centre-Ville<br />
Montreal, Quebec H3C 3J7<br />
CANADA<br />
Phone: 514 333 0042<br />
Fax: 514 282-8472<br />
Email: jfmarier@hotmail.com<br />
Mentre, France<br />
Hopital Bichat - Claude Bernard<br />
Dpt de Biostatistiques et Epidemiologie<br />
46 rue Henri Huchard<br />
75018 Paris<br />
FRANCE<br />
Phone: 33 (0) 1 40 25 62 53<br />
Fax: 33 (0) 1 40 25 67 73<br />
Email: france.mentre@bch.ap-hop-paris.fr<br />
Ng, Juki Wing-Keung<br />
University <strong>of</strong> Minnesota<br />
7-158 Weaver Densford Hall<br />
College <strong>of</strong> Pharmacy<br />
308 Harvard Street S.E.<br />
Minneapolis, MN 55455<br />
Phone: (612) 626-3641<br />
Email: ngxx0035@umn.edu<br />
Nguyen, Thao<br />
1564 E. Muncie<br />
Fresno, CA 93720<br />
Phone: (559) 322-8167<br />
Email: Tng6728@mediaone.net<br />
Parker, Robert S.<br />
University <strong>of</strong> Pittsburgh<br />
Department <strong>of</strong> Chemical and Petroleum<br />
Engineering<br />
1249 Benedum Hall<br />
Pittsburgh, PA 15261<br />
Phone: (412) 624-7364<br />
Fax: (412) 624-2014<br />
Email: rparker@engrng.pitt.edu
Patel, Bela R.<br />
GlaxoSmithKline<br />
709 Swedeland Road<br />
King <strong>of</strong> Prussia, PA 19406<br />
Phone: (610) 270-5924<br />
Fax: (610) 270-5041<br />
Email: bela_r_patel@sbphrd.com<br />
Peterson, Mark C.<br />
Amgen Inc.<br />
One Amgen Center Drive<br />
Thousand Oaks, CA 91320-1799<br />
Phone: (805) 447-7222<br />
Fax: (805) 499-4868<br />
Email: markp@amgen.com<br />
Puchalski, Tom<br />
MGH Cancer Center<br />
Harvard Medical School<br />
55 Fruit Street<br />
GRJ 1025<br />
Boston, MA 02114<br />
Phone: (617) 724-4809<br />
Fax: (617) 726-5854<br />
Email: tpuchalski@partners.org<br />
Qian, Mingxin<br />
Dupont Pharmaceuticals Company<br />
Stine-Haskell Research Center<br />
P.O. Box 30<br />
1090 Elkton Road<br />
Newark, DE 19714<br />
Phone: (302) 366-6491<br />
Fax: (302) 366-5285<br />
Email: Mingxin.Qian@dupontpharma.com<br />
Racine-Poon, Amy<br />
Novartis Pharma Inc.<br />
WSJ 27 1013<br />
Basel CH 4001<br />
SWITZERLAND<br />
Phone: 41 61 324 4108<br />
Fax: 41 61 324 3039<br />
Email: amy.racine@pharma.Novartis.com<br />
Perotti, Beatrice<br />
Amgen Inc.<br />
One Amgen Center Drive<br />
M/S 1-1-A<br />
Thousand Oaks, CA 91320<br />
Phone: (805) 447-1759<br />
Fax: (805) 499-4868<br />
Email: bperotti@amgen.com<br />
Pfister, Marc<br />
University <strong>of</strong> California, San Francisco<br />
521 Parnassus NONMEM Group<br />
Room C255 Box 0626<br />
San Francisco, CA 94143<br />
Phone: (415) 502-1989<br />
Fax: (415) 476-2796<br />
Email: marc@c255.ucsf.edu<br />
Pumacayo, S<strong>of</strong>ia P. Salas<br />
Urb. J.P.V. y G. 2da Etapa L-3, J.L.B. y R<br />
Arequipa, Pe<br />
PERU<br />
Phone: 051 54425092<br />
Email: salass<strong>of</strong>ia@hotmail.com<br />
Raber, Susan<br />
Agouron Pharmaceuticals/Pfizer, Inc.<br />
11085 Torreyana Road<br />
San Diego, CA 92121<br />
Phone: (858) 622-8047<br />
Fax: (858) 678-8293<br />
Email: susan.raber@agouron.com<br />
Rayner, Craig<br />
Monash University<br />
Dept. Pharmacy Practice<br />
381 Royal Parade<br />
Parkville Victoria 3052, Oceania<br />
AUSTRALIA<br />
Phone: 399 039108<br />
Fax: 61 399 039629<br />
Email: craig.rayner@vcp.monash.edu.au
Roberts, Michael S.<br />
University <strong>of</strong> Queensland<br />
Department <strong>of</strong> Medicine<br />
Princess Alexandra Hospital<br />
Wolloongabba, Queensland 4102<br />
AUSTRALIA<br />
Phone: 61 7 32402546<br />
Fax: 61 7 32405806<br />
Email: M.Roberts@mailbox.uq.edu.au<br />
Rodvold, Keith A.<br />
University <strong>of</strong> Illinois at Chicago<br />
College <strong>of</strong> Pharmacy, M/C 886<br />
833 South Wood Street, Room 164<br />
Chicago, IL 60612-7230<br />
Phone: (312) 996-3341<br />
Fax: (312) 413-1797<br />
Email: kar@uic.edu<br />
Scott, James D.<br />
Western University <strong>of</strong> Health Sciences<br />
College <strong>of</strong> Pharmacy<br />
309 E. 2nd Street<br />
Pomona, CA 91766<br />
Phone: (323) 993-7532<br />
Fax: (323) 993-7599<br />
Email: jdscott@westernu.edu<br />
Smith, Patrick (Pat)<br />
SUNY- Buffalo<br />
Hochstetter Hall<br />
Room 311<br />
Buffalo, NY 14260<br />
Phone: (716) 845-3281<br />
Fax: (716)-845-2336<br />
Email: pfsmith@acsu.buffalo.edu<br />
Spilker, Mary<br />
University <strong>of</strong> Washington<br />
Department <strong>of</strong> Bioengineering<br />
Box 352255<br />
Seattle, WA 98195<br />
Phone: (206) 616-9424<br />
Fax: (206) 543-3081<br />
Email: mspilker@u.washington.edu<br />
Rodman, John<br />
St. Jude Children's Research Hospital<br />
Pharmaceutical Dept.<br />
332 N. Lauderdale<br />
Memphis, TN 38138<br />
Phone: (901) 495-2237<br />
Fax: (901) 495-3111<br />
Email: john.rodman@stjude.org<br />
Sale, Mark<br />
GlaxoSmithKline<br />
Five Moore Drive<br />
P.O. Box 13398<br />
Research Triangle Park, NC 27709<br />
Phone: (919) 483-1808<br />
Fax: (919) 315-0092<br />
Email: ms93267@glaxowellcome.com<br />
Sheiner, Lewis B.<br />
University <strong>of</strong> California, San Francisco<br />
Department <strong>of</strong> Lab. Medicine and Med.<br />
School <strong>of</strong> Medicine and Pharm.<br />
Box 0626<br />
San Francisco, CA 94143<br />
Phone: (415) 476-1965<br />
Fax: (415) 476-2796<br />
Email: lbs@c255.ucsf.edu<br />
Smith, Judith A.<br />
UT MD Anderson Cancer Center<br />
Division <strong>of</strong> Cancer Medicine/ Division <strong>of</strong><br />
Pharmacy<br />
1515 Holcombe Blvd. - Box 401<br />
Houston, TX 77030-4009<br />
Phone: (713) 792-7972<br />
Fax: (713) 745-1541<br />
Email: jasmith@mdanderson.org<br />
Steinbach, Joseph H.<br />
University <strong>of</strong> California, San Diego<br />
VAMC Gastroenterology 111D<br />
3350 La Jolla Village Drive<br />
San Diego, CA 92161<br />
Phone: (858) 552-8585<br />
Fax: (858) 552-4327<br />
Email: jhsteinbach@ucsd.edu
Sun, Yu-Nien Tom<br />
Genentech, Inc.<br />
1 DNA Way<br />
S. San Francisco, CA 94080<br />
Phone: (650) 225-8212<br />
Fax: (650) 225-6452<br />
Email: ynsun@gene.com<br />
Tang, Tao<br />
Protein Design Labs, Inc.<br />
34801 Campus Dr.<br />
Fremont, CA 94555<br />
Phone: (510) 574-1621<br />
Fax: (510) 574-1616<br />
Email: ttang@pdl.com<br />
Thiessen, Jake J.<br />
University <strong>of</strong> Toronto<br />
Faculty <strong>of</strong> Pharmacy<br />
19 Russell Street<br />
Toronto, Ontario M5S 2S2<br />
CANADA<br />
Phone: 416 978-6483<br />
Fax: 416 978-8511<br />
Email: jj.thiessen@utoronto.ca<br />
Tran, Hai T.<br />
M.D. Anderson Cancer Center<br />
1515 Holcombe Blvd<br />
Box 90<br />
Houston, TX 77030<br />
Phone: (713) 794-4770<br />
Fax: (713) 745-2007<br />
Email: htran@mdanderson.org<br />
Udata, Chandrasekhar<br />
Wyeth-Ayerst Research<br />
Bioanalytical R&D (<strong>PK</strong>/<strong>PD</strong> Unit)<br />
Drug Safety and Metabolism<br />
Bldg/Rm. 205/315<br />
Pearl River, NY 10965<br />
Phone: (845) 732-3992<br />
Fax: (845) 732-5538<br />
Email: Udatac@war.wyeth.com<br />
Synold, Timothy W.<br />
City <strong>of</strong> Hope Medical Center<br />
1500 East Duarte Road<br />
Duarte, CA 91010<br />
Phone: (626) 359-8111<br />
Fax: (626) 301-8898<br />
Email: tsynold@coh.org<br />
Tee, Daniel<br />
University <strong>of</strong> California, Los Angeles<br />
BME Society<br />
1649 Lost Trail Drive<br />
Walnut, CA 91789<br />
Email: dtee@ucla.edu<br />
Tong, Sheng<br />
Duke University<br />
Department <strong>of</strong> <strong>Biomedical</strong> Engineering<br />
136 Hudson Hall<br />
P.O. Box 90281<br />
Durham, NC 27708-0281<br />
Phone: (919) 660-5131<br />
Fax: (919) 684-4488<br />
Email: sheng.tong@duke.edu<br />
Tran, Jonathan Q.<br />
Agouron Pharmaceuticals, Inc.<br />
11085 Torreyana Road<br />
San Diego, CA 92121<br />
Phone: (858) 622-7448<br />
Fax: (858)-678-8293<br />
Email: Jonathan.Tran@agouron.com<br />
Urizar, Jose Perez<br />
CINVESTAV-IPN<br />
Av. Instituto Politecnico Nacional<br />
No. 2608<br />
Col. San Pedro Zacantero<br />
Mexico City 07360<br />
MEXICO<br />
Phone: 525 7473800<br />
Fax: 52 525 7477095<br />
Email: ppurizar@infosel.net.mx
Veng-Pedersen, Peter<br />
University <strong>of</strong> Iowa<br />
College <strong>of</strong> Pharmacy<br />
Iowa City, IA 52242<br />
Phone: (319) 335-8792<br />
Fax: (319) 335-9349<br />
Email: veng@uiowa.edu<br />
Weiss, Michael<br />
Martin Luther University Halle-Wittenberg<br />
Department <strong>of</strong> Pharmacology<br />
Halle/Saale D-06097<br />
GERMANY<br />
Phone: 49 345-557-1657<br />
Fax: 49 345-557-1835<br />
Email: michael.weiss@medizin.uni-halle.de<br />
Williams, Paul James<br />
University <strong>of</strong> the Pacific<br />
School <strong>of</strong> Pharmacy<br />
751 Brookside Road<br />
Stockton, CA 95211<br />
Phone: (209)-955-0170<br />
Fax: (209)-955-0170<br />
Email: pwilliams@uop.edu<br />
Wong, Shekman L.<br />
Amgen Inc.<br />
One Amgen Center Drive<br />
MS1-1-A<br />
Thousand Oaks, CA 91320<br />
Phone: (805) 447-4279<br />
Fax: (805) 449-4868<br />
Email: swang@amgen.com<br />
Woodworth, James R.<br />
Eli Lilly and Company<br />
Indiana University Hospital and Outpatient Center<br />
550 N. Universtiy Blvd.<br />
Indianapolis, IN 46202-5250<br />
Phone: (317) 276-1304<br />
Fax: (317) 276-8366<br />
Email: woody@lilly.com<br />
Vicini, Paolo<br />
University <strong>of</strong> Washington<br />
Department <strong>of</strong> Bioengineering<br />
Box 352255<br />
AERL 241<br />
Seattle, WA 98195-2255<br />
Phone: (206) 616-1133<br />
Fax: (206) 543-3081<br />
Email: vicini@u.washington.edu<br />
Whitfield, Lloyd<br />
Pfizer Global Research and Development<br />
2800 Plymouth Road<br />
Building 50/100<br />
Ann Arbor, MI 48105<br />
Phone: (734) 622-7023<br />
Fax: (734) 622-7937<br />
Email: lloyd.whitfield@pfizer.com<br />
Woltosz, Walter S.<br />
Simulations Plus, Inc. (SIMU)<br />
1220 W. Ave J<br />
Lancaster, CA 93534-2902<br />
Phone: (661) 723-7723<br />
Fax: (661) 723-5524<br />
Email: walt@simulations-plus.com<br />
Woo, Su-Kyung<br />
Chungnam National University<br />
College <strong>of</strong> Pharmacy<br />
Daejeon 305-764<br />
KOREA<br />
Phone: 82 42 8215937<br />
Fax: 82 42 8236566<br />
Email: wooosk@hanmail.net<br />
Xu, Lu<br />
University <strong>of</strong> Southern California<br />
2353 Portland Street<br />
Apt. 41<br />
Los Angeles, CA 90007<br />
Phone: (213) 749-0575<br />
Email: luxu@usc.edu
Xu, Chen<br />
Medinox<br />
7158 Caminito Zabala<br />
San Diego, CA 92121<br />
Phone: (858) 642-6898<br />
Email: chenxu@aol.com<br />
Yang, Joanna Y.<br />
Bristol-Myers Squibb<br />
Pharmaceutical Research Institute<br />
5 Research Parkway<br />
P.O. Box 5100<br />
Wallingford, CT 06492-7660<br />
Phone: (203) 677-7273<br />
Fax: (203) 677-7279<br />
Email: joanna.yang@bms.com<br />
Yu, Zhiling<br />
Allergan, Inc.<br />
2525 Dupont Drive, RD-2B<br />
Irvine, CA 92623-9534<br />
Phone: (714) 246-4832<br />
Fax: (714) 246-5850<br />
Email: yu_steve@allergan.com<br />
Zhai, Suoping<br />
Clinical Pharmacokinetic Section<br />
National Cancer Institute/NIH<br />
Building 10, Room 5A-01<br />
9000 Rockville Pike<br />
Bethesda, MD 20892<br />
Phone: (301) 402-3622<br />
Fax: (301) 402-8606<br />
Email: szhai@mail.nih.gov<br />
Xuan, Dawei<br />
Pharmacy Research/Hartford Hospital<br />
Department <strong>of</strong> Pharmacy Research<br />
80 Seymout Street<br />
Hartford, CT 06106<br />
Phone: (860) 545-3612<br />
Fax: (860) 545-3992<br />
Email: Dxuan@harthosp.org<br />
Yao, Amy<br />
Resource Facility for Population Kinetics<br />
Dept. <strong>of</strong> Bioengineering Box 352255<br />
University <strong>of</strong> Washington<br />
Seattle, WA 98195<br />
Phone: (206) 616-9424<br />
Fax: (206) 543-3081<br />
Email: ayao@u.washington.edu<br />
Zelenitsky, Sheryl<br />
Faculty <strong>of</strong> Pharmacy<br />
#50 Sifton Road<br />
Winnipeg, Manitoba R3T-2N2<br />
CANADA<br />
Phone: 204 474-8414<br />
Fax: 204 474-7617<br />
Email: zelenits@ms.umanitoba.ca<br />
Zhang, Liping<br />
University <strong>of</strong> California, San Francisco<br />
NONMEM Group<br />
521 Parnassus Avenue<br />
Room C 255 Box 0626<br />
San Francisco, CA 94131<br />
Phone: (415) 502-1989<br />
Fax: (415) 476-2796<br />
Email: lpz@itsa.ucsf.edu
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