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Botryosphaeran

An Unusual Exocellular Fungal (1→3)(1→6)-β-D-Glucan with Notable Biomedical Applications

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Polysaccharides of Microbial Origin

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Abstract

Botryosphaeran [(1→3)(1→6)-β-D-glucan] is an exopolysaccharide (EPS) produced by the ascomycete Botryosphaeria rhodina MAMB-05 when cultivated on glucose medium. Botryosphaeran has an unusual chemical structure in the sense that one of its two appendage residues (gentiobiose) attached to the (1→3)-linked backbone chain is rare, the other, glucose, is common to most β-glucans of this type. A family of botryosphaerans is produced on different carbohydrate substrates. Botryosphaeran is neither mutagenic nor genotoxic, and presents antioxidant, anticlastogenic, hypoglycemic, hypocholesterolemic, and hypotriglyceridemic activities and reduced the development of Walker-256 bearing tumors and cachexia syndrome in rats. Botryosphaeran exhibited antiproliferation of cancer cells that is associated with cell cycle arrest, apoptosis, necrosis, and oxidative stress in breast carcinoma MCF-7 cells, and cell cycle arrest in human T-lymphocyte tumorigenic cells. Botryosphaeran is commercially used in formulated cosmetic products to promote skin health and treat skin conditions.

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Acknowledgments

The authors are grateful to Danielle Geraldelli and Dr. Eveline Queiroz (Núcleo de Pesquisa e Apoio Didático em Saúde, Instituto de Ciências da Saúde, Universidade Federal de Mato Grosso, Sinop-MT, Brazil) for the provision of photographs of rats bearing the Walker-256 tumors.

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  1. Universidade Tecnológica Federal do Paraná (UTFPR), Programa de Pós-Graduação em Engenharia Ambiental, Câmpus Londrina, Londrina, Paraná, Brazil

    Robert F. H. Dekker

  2. Beta-Glucan Produtos Farmoquímicos - EIRELI, Lote 24A, Bloco Zircônia, Universidade Tecnológica Federal do Paraná, Avenida João Miguel Caram, Londrina, Paraná, Brazil

    Aneli M. Barbosa-Dekker

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  1. Robert F. H. Dekker
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Editors and Affiliations

  1. 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, Barco, Guimarães, Portugal

    Joaquim Miguel Oliveira

  2. 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, Barco, Guimarães, Portugal

    Hajer Radhouani

  3. 3B’s Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, Barco, Guimarães, Portugal

    Rui L. Reis

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Dekker, R.F.H., Barbosa-Dekker, A.M. (2022). Botryosphaeran. In: Oliveira, J.M., Radhouani, H., Reis, R.L. (eds) Polysaccharides of Microbial Origin. Springer, Cham. https://doi.org/10.1007/978-3-030-42215-8_63

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