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The Family Myxococcaceae

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The Prokaryotes

Abstract

Myxococcaceae belong to the suborder Cystobacterineae in order Myxococcales and comprise three genera validly described as Myxococcus, Corallococcus, and Pyxidicoccus. Members of this family are widely distributed in soil and also occur in freshwater and marine environment. Myxococcus and Corallococcus appear to be the most commonly isolated myxobacterial genera in almost every soil sample. Myxococcaceae family covers the best explored and studied myxobacteria with a wide scope of research. The family’s pioneering and significant contributions to the order Myxococcales include (1) first genome to be sequenced, (2) discovery of first replicating plasmid, and (3) discovery of first bacteriophage. To date, several genomes are available belonging to Myxococcus and Corallococcus, and sequencing of Pyxidicoccus is ongoing. Albeit being common in the environment, metagenomics studies revealed that many members of this family still remain not cultivated. The important application of Myxococacceae family is reflected primarily on diverse secondary metabolites acting as antimicrobials, antiparasitics, antivirals, cytotoxins, and anti-blood coagulants. Bacteriocin-like activity and the potential application as biocontrol agent were also determined. Natural product discovery in this family appears promising as an important source of future drugs.

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Authors and Affiliations

  1. Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland – Helmholtz Centre for Infection Research and Pharmaceutical Biotechnology, Saarland University Campus, 15 11 50, 66041, Saarbrücken, Germany

    Ronald Garcia & Rolf Müller

Authors
  1. Ronald Garcia
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  2. Rolf Müller
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Corresponding author

Correspondence to Ronald Garcia .

Editor information

Editors and Affiliations

  1. Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Tel Aviv, Israel

    Eugene Rosenberg

  2. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

    Edward F. DeLong

  3. Center for Microbial Oceanography: Research and Education, University of Hawaii, Manoa, Honolulu, HI, USA

    Edward F. DeLong

  4. Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA

    Stephen Lory

  5. Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany

    Erko Stackebrandt

  6. Laboratory of Microbiology, Institute of Biology, Center for Health Sciences, Federal University of Rio de Janeiro (UFRJ), Ilha do Fundão, Rio de Janeiro, Brazil

    Fabiano Thompson

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Garcia, R., Müller, R. (2014). The Family Myxococcaceae. In: Rosenberg, E., DeLong, E.F., Lory, S., Stackebrandt, E., Thompson, F. (eds) The Prokaryotes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39044-9_303

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