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Phoma spp. an untapped treasure of cytotoxic compounds: current status and perspectives

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Abstract

The genus Phoma has been explored for a wide range of secondary metabolites signifying a huge range of bioactivities. Phoma sensu lato is a major group that secretes several secondary metabolites. The genus Phoma mainly includes Phoma macrostoma, P. multirostrata, P. exigua, P. herbarum, P. betae, P. bellidis, P. medicaginis, P. tropica, and many more species from the genus that are continuously being identified for their potential secondary metabolites. The metabolite spectrum includes bioactive compounds like phomenon, phomin, phomodione, cytochalasins, cercosporamide, phomazines, and phomapyrone reported from various Phoma spp. These secondary metabolites show a broad range of activities including antimicrobial, antiviral, antinematode, and anticancer. The present review is aimed to emphasize the importance of Phoma sensu lato fungi, as a natural source of biologically active secondary metabolites, and their cytotoxic activities. So far, cytotoxic activities of Phoma spp. have not been reviewed; hence, this review will be novel and useful for the readers to develop Phoma-derived anticancer agents.

Key points

• Different Phoma spp. contain a wide variety of bioactive metabolites.

• These Phoma spp. also secrete cytotoxic and antitumor compounds.

• The secondary metabolites can be used for the development of anticancer agents.

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Acknowledgements

Mahendra Rai wishes to acknowledge financial support from the Polish National Agency for Academic Exchange (NAWA) (Project No. PPN/ ULM/2019/1/00117/U/00001) to visit the Department of Microbiology, Nicolaus Copernicus University, Toruń, Poland.

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Authors and Affiliations

  1. Biotechnology Department, Sant Gadge Baba Amravati University, Amravati, 444 602, Maharashtra, India

    Mahendra Rai, Aniket Gade & Pramod Ingle

  2. Department of Microbiology, Nicolaus Copernicus University, 87-100, Torun, Poland

    Mahendra Rai

  3. Department of Plant Protection, University of Life Sciences in Lublin, Poland7 K. St. Leszczyńskiego Street, 20-069, Lublin, Poland

    Beata Zimowska

  4. Department of Biological Science and Biotechnology, Institute of Chemical Technology, Matunga, 400019, Mumbai, India

    Aniket Gade

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MR conceived and designed the review. BZ contributed substantially, and AG and PI co-wrote the manuscript. MR critically revised the mss. All authors read and approved the manuscript.

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Correspondence to Mahendra Rai.

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Rai, M., Zimowska, B., Gade, A. et al. Phoma spp. an untapped treasure of cytotoxic compounds: current status and perspectives. Appl Microbiol Biotechnol 107, 4991–5001 (2023). https://doi.org/10.1007/s00253-023-12635-9

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