Abstract
A new 10-hydroxycamptothecin (HCPT)-producing fungus was isolated from Camptotheca acuminata. The strain was classified as a Xylaria sp. based on the internal transcribed spacer and 18S rDNA gene analysis. All elicitors tested, except methyl jasmonate, increased HCPT production in submerged culture. The maximum yield was 5.4 mg HCPT/l−1, when salicylic acid was added at 0.1 mM to the culture medium
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Acknowledgments
The work was co-supported by projects from the Shaanxi Educational Committee (08JK244, 08JZ21, and 08JK248) and partially financed by grants from Shaanxi University of Technology (SLGQDO712, SLGQDO713).
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Liu, K., Ding, X., Deng, B. et al. 10-Hydroxycamptothecin produced by a new endophytic Xylaria sp., M20, from Camptotheca acuminata . Biotechnol Lett 32, 689–693 (2010). https://doi.org/10.1007/s10529-010-0201-4
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DOI: https://doi.org/10.1007/s10529-010-0201-4