Abstract
Chemical examinations of Cleistanthus collinus Roxb., a poisonous tree from India, and Cleistanthus patulus Muell. Arg. have resulted in isolation of a number of arylnaphthalide lignans and their glycosides as well as some furofuranoid lignans. While Cleistanthus gracilis Hook. f. from Thailand afforded an unusual glucoside of 2-β-hydroxy-8-azabicyclo-(5,0,2)-4β, 9β-epoxynona-5,7-diene, C. schlechteri from South Africa was the first reported source of the pimarane diterpenes. Cleistanthin A and cleistanthin B, diphyllin glycosides isolated from C. collinus were reported to exhibit cytotoxicity on several cancer cell lines. Cleistanthin A was found to cause DNA strand breaks and induce apoptosis in cultured cells while cleistanthin B caused G1 arrest and induced apoptosis in mammalian cells.
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We thank Fundação para a Ciência e Tecnologia (FCT) and CIIMAR (Programa Plurianual) for support.
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Pinho, P.M.M., Kijjoa, A. Chemical constituents of the plants of the genus Cleistanthus and their biological activity. Phytochem Rev 6, 175–182 (2007). https://doi.org/10.1007/s11101-006-9027-z
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DOI: https://doi.org/10.1007/s11101-006-9027-z