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Novel secondary metabolites from endophytic fungi: synthesis and biological properties

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Abstract

Plant-associated endophytic fungi are rich sources of novel bioactive and structurally diverse secondary metabolites and other natural products. Newly synthesized secondary metabolites of endophytes in terrestrial plants and their biological properties are presented and reviewed herein. The review highlights natural products from plant-associated fungal endophytes that demonstrate significant inhibition against pathogenic strains, human cancer cell lines and other biological targets. We have summarized 221 recently isolated, structurally diverse and novel secondary metabolites. Secondary metabolites that failed to demonstrate activity in the bioassays are not included. The review is intended to assist scientists in the fields of phytochemistry, organic chemistry, and pharmacology.

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Acknowledgements

This work was supported by the grants the National Science and Technology Project “Major New Drug Creation-Research and Development of New Ethnic Drug Varieties and Its Key Innovation Technology” (Project number: 2017ZX09301045), and the Central Asian Drug Discovery and Development Center of the Chinese Academy of Science. The authors thank Dr. Ben Prickril for revisions of the manuscript.

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  1. Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 40-1 South Beijing Rd, Ürümqi, 830011, People’s Republic of China

    Nigora Rustamova, Khurshed Bozorov & Abulimiti Yili

  2. University of Chinese Academy of Sciences, 19 A Yuquan Rd, Beijing, 100049, People’s Republic of China

    Nigora Rustamova

  3. Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Mirzo Ulugbek Str. 77, 100170, Tashkent, Uzbekistan

    Khurshed Bozorov

  4. Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany

    Thomas Efferth

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  1. Nigora Rustamova
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  2. Khurshed Bozorov
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  3. Thomas Efferth
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  4. Abulimiti Yili
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Correspondence to Thomas Efferth or Abulimiti Yili.

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Rustamova, N., Bozorov, K., Efferth, T. et al. Novel secondary metabolites from endophytic fungi: synthesis and biological properties. Phytochem Rev 19, 425–448 (2020). https://doi.org/10.1007/s11101-020-09672-x

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