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Biological potential of bioactive metabolites derived from fungal endophytes associated with medicinal plants

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Abstract

Endophytes are endosymbiotic fungi or bacteria that invade and colonize the plant tissue without harming their respective host. Since fungal endophytes live inside the host tissues, their effective isolation and identification is an important step. Endophytic fungi produce bioactive metabolites with unique chemical structures, which may help in improving the physiological condition of both the plants and endophytes. Endophytic fungi are a potent source of all major classes of secondary metabolites including terpenoids, non-ribosomal peptides, polyketides, and alkaloids. With the increase in the number of diseases and human health problems, an intensive search for new sources and effective metabolites is now in progress. The bioactive metabolites produced by the fungal endophytes are competent and effective against various diseases such as cancer, diabetes, infectious diseases, immunological disorders, and cardiovascular diseases. The present review summarizes the efficient approaches used for the screening of fungal endophytes, extraction, and purification of bioactive metabolites along with OMICS based study of endophytes. Along with this, the pharmaceutical importance of novel bioactive metabolites and their efficient production from fungal endophytes using various approaches like genetic engineering, use of elicitors, and precursor feeding are also discussed.

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Acknowledgements

PKK would like to thank Science and Engineering Research Board (SERB) India for Junior Research Fellowship under Empowerment and Equity Opportunities for Excellence in Science (EMEQ) scheme (EEQ/2019/000025). NR would like to thank University Grants Commission, New Delhi, India, for Junior Research Fellowship. Research in the VG laboratory is supported by the SERB-EMEQ project (EEQ/2019/000025), University Grants Commission, New Delhi, India and internal funding from Banaras Hindu University, Varanasi, India (under the Institute of Eminence Scheme).

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Research work in the VG laboratory is supported by the SERB-EMEQ project (EEQ/2019/000025), University Grants Commission, New Delhi, India, and internal funding from Banaras Hindu University, Varanasi, India (under the Institute of Eminence Scheme).

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  1. Priyanka Kumari Keshri and Nilesh Rai contributed equally to this work.

Authors and Affiliations

  1. Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India

    Priyanka Kumari Keshri, Nilesh Rai, Ashish Verma, Santosh Kumar Singh & Vibhav Gautam

  2. Department of Technology, Savitribai Phule Pune University, Ganeshkhind, Pune, 411007, India

    Swapnil C. Kamble

  3. Chemical Engineering Discipline, Indian Institute of Technology Gandhinagar, Gandhinagar, 382355, India

    Suvakanta Barik

  4. Division of Biochemistry, Department of Medical Biochemistry and Biophysics Karolinska Institute, Stockholm, Sweden

    Pradeep Mishra

  5. Agriculture Biotechnology Department, National Agri-Food Biotechnology Institute, Sector 81, SAS Nagar, Mohali, Punjab, 140306, India

    Prafull Salvi

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  1. Priyanka Kumari Keshri
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PKK, NR, SCK, SB, PM, and SKS wrote and compiled the manuscript. PKK, NR, AV, and PS revised the manuscript under the supervision of VG. Study and entire writing of the manuscript was supervised by VG (from the compilation of the first draft to the final draft).

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Keshri, P.K., Rai, N., Verma, A. et al. Biological potential of bioactive metabolites derived from fungal endophytes associated with medicinal plants. Mycol Progress 20, 577–594 (2021). https://doi.org/10.1007/s11557-021-01695-8

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