Abstract
Strains of the fungal genus Pestalotiopsis are reported as large promising sources of structurally varied biologically active metabolites. Many bioactive secondary metabolites with diverse structural features have been derived from Pestalotiopsis. Moreover, some of these compounds can potentially be developed into lead compounds. Herein, we have systematically reviewed the chemical constituents and bioactivities of the fungal genus Pestalotiopsis, covering a period ranging from January 2016 to December 2022. As many as 307 compounds, including terpenoids, coumarins, lactones, polyketides, and alkaloids, were isolated during this period. Furthermore, for the benefit of readers, the biosynthesis and potential medicinal value of these new compounds are also discussed in this review. Finally, the perspectives and directions for future research and the potential applications of the new compounds are summarized in various tables.
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References
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Acknowledgements
Zhi.Li. and Mei Wei revised the manuscript. We would like to thank Editage (www.editage.cn) for English language editing and to thank Dr. Weiliang Xiong (South China Sea Institute of Oceanology, Chinese Academy of Sciences), who made a diagram.
Funding
This work was funded by the National Natural Science Foundation of China (Grant No. 31900293), Department of Science and Technology of Sichuan Province (2022NSFSC0109), Sichuan Science and Technology Program (2022YFS0624), the Open Project of Sichuan Industrial Institute of Antibiotics, Chengdu University (ARRLKF20-04).
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Jiang, P., Fu, X., Niu, H. et al. Recent advances on Pestalotiopsis genus: chemistry, biological activities, structure–activity relationship, and biosynthesis. Arch. Pharm. Res. 46, 449–499 (2023). https://doi.org/10.1007/s12272-023-01453-2
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DOI: https://doi.org/10.1007/s12272-023-01453-2