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Chemistry and biology of Pestalotiopsis-derived natural products

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Abstract

Species within the fungal genus Pestalotiopsis have become a topic of research in many microbial-chemical and pharmacological laboratories because they contain structurally complex, biologically active metabolites. This article is a follow-up to a previous review (Xu, Ebada, and Proksch, Fungal Divers 44:15–31, 2010). It focuses particularly on new findings concerning the chemistry and bioactivity of Pestalotiopsis sp., covering a period ranging from August 2010 to August 2013. Some 160 metabolites were isolated from Pestalotiopsis species during this period and their structures are reported within a biogenetic context. Bioassays showed antitumor, antifungal, and antimicrobial activities to be the most notable bioactivities of secondary metabolites isolated from this genus. The biogenetic pathways associated with the alkaloids, sesquiterpenes, quinines, xanthones, and lactones covered in this review are highlighted.

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Acknowledgments

Co-Financed by grants of National Natural Science Foundation of China for Young Scholar (No. 81202456), the programs for New Century Excellent Talents in University (NCET-13-0760), and Special Social Service Fund of Hainan University (No. HDSF201301) are gratefully acknowledged.

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Authors and Affiliations

  1. Key Laboratory of Protection and Development Utilization of Tropical Crop Germplasm Resources, Ministry of Education, College of Material and Chemical Engineering, Hainan University, Haikou, 570228, People’s Republic of China

    Jing Xu & Xiaobo Yang

  2. Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, People’s Republic of China

    Jing Xu

  3. Key laboratory of water pollution treatment & resource reuse of Hainan province, Hainan Normal University, Haikou, 571158, People’s Republic of China

    Qiang Lin

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  1. Jing Xu
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  2. Xiaobo Yang
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  3. Qiang Lin
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Xu, J., Yang, X. & Lin, Q. Chemistry and biology of Pestalotiopsis-derived natural products. Fungal Diversity 66, 37–68 (2014). https://doi.org/10.1007/s13225-014-0288-3

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