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Comparative Evaluation of Antidiabetic and Antioxidant Activities of Methanol Fractions of Penicillium brevicaule alba CC200 and Aspergillus egypticus HT166S

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Abstract

The antioxidant activity of drugs used in the treatment of diabetes has been proven to be a beneficial property in reducing diabetes-related complications. Properties of secondary metabolites of fungal endophytes Penicillium brevicaule alba CC200 and Aspergillus egypticus HT166S isolated from native medicinal plants as pancreatic α-amylase inhibitors, and their antioxidant activity were investigated. P. brevicaule alba CC200 and A. egypticus HT166S methanol fractions at 25 mg/ml concentration were found to have high inhibitory activity and IC50 values were 0.49 and 0.68 mg/ml, respectively. Antioxidant activity was tested by 2,2-diphenyl-1-picrylhydrazine, hydrogen peroxide, and phospho molybdenum free radicals scavenging assays. Both endophytic strains in all tests exposed antioxidant activity. Still, the activity of A. egypticus HT166S extract was higher with IC50 values 1.14, 0.46, 0.46 mg/ml and comparable to ascorbic acid efficiency with IC50 values 0.91, 0.40, 0.40 mg/ml, correspondingly. The data obtained allowed us to consider that P. brevicaule alba CC200 and A. egypticus HT166S could be potential sources of complex drugs for type 2 diabetes.

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Authors and Affiliations

  1. Department of Zoology and Biochemistry, Andijan State University, 170100, Andijan, Uzbekistan

    I. I. Mukhammedov

  2. Institute of Microbiology, Academy of Sciences Republic of Uzbekistan, 100128, Tashkent, Uzbekistan

    D. M. Ruzieva & T. G. Gulyamova

Authors
  1. I. I. Mukhammedov
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  2. D. M. Ruzieva
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  3. T. G. Gulyamova
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Correspondence to I. I. Mukhammedov.

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Mukhammedov, I.I., Ruzieva, D.M. & Gulyamova, T.G. Comparative Evaluation of Antidiabetic and Antioxidant Activities of Methanol Fractions of Penicillium brevicaule alba CC200 and Aspergillus egypticus HT166S. Moscow Univ. Biol.Sci. Bull. 77, 245–250 (2022). https://doi.org/10.3103/S0096392522040137

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