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Green Aspects of Flow Chemistry for Drug Discovery

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Flow Chemistry in Drug Discovery

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 38))

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Abstract

Flow chemistry is considered to be an enabling technology that covers many of the key principles of Green Chemistry. In this chapter, we review the main issues related to Green Chemistry, the use of green solvents, synergy with other enabling and green technologies that have been revitalized under flow conditions, in situ production and handling of hazardous reagents, and the possibility of telescoping, screening, optimization, automatization, and scale-up. We will finish with the topic of quantification of sustainability in comparison with batch conditions and the most important contributions for the design of greener processes.

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References

  1. Gomollón-Bel F (2019) Chem Int:12–17

    Google Scholar 

  2. Sharma S, Das J, Braje WM, Dash AK, Handa S (2020) ChemSusChem 13:2859–2875

    Article  CAS  PubMed  Google Scholar 

  3. Lummiss JAM, Morse PD, Beingessner RL, Jamison TF (2017) Chem Rec 17:667–680

    Article  CAS  PubMed  Google Scholar 

  4. Brandao P, Pineiro M, Pinho e Melo TMVD (2019) Eur J Org Chem:7188–7217

    Google Scholar 

  5. US Food and Drug Amministration. https://www.fda.gov/drugs/news-events-human-drugs/modernizing-way-drugs-are-made-transition-continuous-manufacturing. Accessed 15 Jul 2020

  6. Anastas PT, Warner JC (1998) Green chemistry: theory and practice. Oxford University Press, Oxford

    Google Scholar 

  7. Porta R, Benaglia M, Puglisi A (2016) Org Process Res Dev 20:2–25

    Article  CAS  Google Scholar 

  8. Mateos C, Nieves-Remacha MJ, Rincón JA (2019) Flow React Chem Eng 4:1536–1544

    Article  CAS  Google Scholar 

  9. Lapkin AA, Yaseneva P (2017) Life cycle assessment of flow chemistry processes. In: Vaccaro L (ed) Sustainable flow chemistry. Wiley-VCH, Weinheim, pp 249–276

    Chapter  Google Scholar 

  10. Koenig SG, Leahy DK, Wells AS (2018) Org Process Res Dev 22:1344–1359

    Article  CAS  Google Scholar 

  11. Vaccaro L (2020) Eur J Org Chem:4273–4283

    Google Scholar 

  12. Yaseneva P, Plaza D, Fan X, Loponov K, Lapkin A (2015) Catal Today 239:90–96

    Article  CAS  Google Scholar 

  13. Prat D, Hayler J, Wells A (2014) Green Chem 16:4546–4551

    Article  CAS  Google Scholar 

  14. https://www.acs.org/content/acs/en/greenchemistry/research-innovation/tools-for-green-chemistry/solvent-selection-tool.html. Accessed 7 Jul 2020

  15. Ley SV (2012) Chem Rec 12:378–390

    Article  CAS  PubMed  Google Scholar 

  16. Wong H, Cernak T (2018) Curr Opin Green Sus Chem 11:91–98

    Google Scholar 

  17. Newman SG, Jensen KF (2013) Green Chem 15:1456–1472

    Article  CAS  Google Scholar 

  18. Hall JFB, Bourne RA, Han X, Earley JH, Poliakoff M, George MW (2013) Green Chem 15:177–180

    Article  CAS  Google Scholar 

  19. Britton J, Majumdar S, Weiss GA (2018) Chem Soc Rev 47:5891–5918

    Google Scholar 

  20. Burguete MI, García-Verdugo E, Luis SV (2011) Beilstein J Org Chem 7:1347–1359

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Kristofkov D, Modrock V, Meciarov M, Sebesta R (2020) ChemSusChem 13:2828–2858

    Article  Google Scholar 

  22. Wasserscheid P, Welton T (2008) Ionic liquids in synthesis. Wiley-VCH, Weinheim

    Google Scholar 

  23. Lozano P, Alvarez E, Bernal JM, Nieto S, Gómez C, Sanchez-Gomez G (2017) Curr Green Chem 4:116–129

    CAS  Google Scholar 

  24. Reetz MT, Wiesenhöfer W, Franciò G, Leitner W (2002) Chem Commun:992–993

    Google Scholar 

  25. Lozano P, de Diego T, Carrié D, Vaultier M, Iborra JL (2002) Chem Commun:692–693

    Google Scholar 

  26. Stephenson P, Kondor B, Licence P, Scovell K, Ross SK, Poliakoff M (2006) Adv Synth Catal 348:1605–1610

    Article  CAS  Google Scholar 

  27. Lozano P, García-Verdugo E, Piamtongkam R, Karbass N, De Diego T, Burguete MI, Luis SV, Iborra JL (2007) Adv Synth Catal 349:1077–1084

    Article  CAS  Google Scholar 

  28. Villa R, Alvarez E, Porcar R, Garcia-Verdugo E, Luis SV, Lozano P (2019) Green Chem 21:6527–6544

    Article  CAS  Google Scholar 

  29. Zamani P, Khosropour AR (2016) Green Chem 18:6450–6455

    Article  CAS  Google Scholar 

  30. Grabner B, Schweiger AK, Gavric K, Kourist R, Gruber-Woelfler H (2020) React Chem Eng 5:263–269

    Article  CAS  Google Scholar 

  31. Guajardo N, Schrebler RA, Domínguez de María P (2019) Bioresour Technol 273:320–325

    Article  CAS  PubMed  Google Scholar 

  32. Iemhoff A, Sherwood J, McElroy CR, Hunt AJ (2018) Green Chem 20:136–140

    Article  CAS  Google Scholar 

  33. Ferlin F, Luque Navarro PM, Gu Y, Lanari D, Vaccaro L (2020) Green Chem 22:397–403

    Article  CAS  Google Scholar 

  34. Han S, Raghuvanshi K, Abolhasani M (2020) ACS Sustain Chem Eng 8:3347–3356

    Article  CAS  Google Scholar 

  35. Thompson CM, Poole JL, Cross JL, Akritopoulou-Zanze I, Djuric SW (2011) Molecules 16:9161–9177

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Vasudevan A, Bogdan AR, Koolman HF, Wang Y, Djuric SW (2017) Prog Med Chem 56:1–35

    Article  CAS  PubMed  Google Scholar 

  37. Hughes DL (2020) Org Process Res Dev 24:1850–1860

    Article  CAS  Google Scholar 

  38. Rehm TH (2020) Chem Eur J 71:16952–16974

    Google Scholar 

  39. Thomson CG, Lee A-L, Vilela F (2020) Beilstein J Org Chem 16:1495–1549

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Hommelsheim R, Guo Y, Yang Z, Empel C, Koenigs RM (2019) Angew Chem Int Ed 58:1203–1207

    Article  CAS  Google Scholar 

  41. Oelgemöller M (2016) Chem Rev 116:9664–9682

    Article  PubMed  Google Scholar 

  42. Cambié D, Dobbelaar J, Riente P, Vanderspikken J, Shen C, Seeberger PH, Gilmore K, Debije MG, Noël T (2019) Angew Chem Int Ed 58:14374–14378

    Article  Google Scholar 

  43. Lévesque F, Seeberger PH (2012) Angew Chem Int Ed 51:1706–1709

    Article  Google Scholar 

  44. Zuo Z, Ahneman DT, Chu L, Terret JA, Doyle AG, MacMillan DWC (2014) Science 345:437–440

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Abdiaj I, Alcázar J (2017) Bioorg Med Chem 25:6190–6196

    Article  CAS  PubMed  Google Scholar 

  46. Abdiaj I, Huck L, Mateo JM, de la Hoz A, Gómez MV, Díaz-Ortiz A, Alcázar J (2018) Angew Chem Int Ed 57:13231–13236

    Article  CAS  Google Scholar 

  47. Yan M, Kawamata Y, Baran PS (2018) Angew Chem Int Ed 57:4149–4155

    Article  CAS  Google Scholar 

  48. Pletcher D, Green RA, Brown RCD (2018) Chem Rev 118:4573–4591

    Article  CAS  PubMed  Google Scholar 

  49. Elsherbini M, Wirth T (2019) Acc Chem Res 52:3287–3296

    Article  CAS  PubMed  Google Scholar 

  50. Bärfacker L, Kuhl A, Hillisch A, Grosser R, Figueroa-Pérez S, Heckroth H, Nitsche A, Ergüden J-K, Gielen-Haertwig H, Schlemmer K-H, Mittendorf J, Paulsen H, Platzek J, Kolkhof P (2012) ChemMedChem 7:1385–1403

    Article  PubMed  Google Scholar 

  51. Platzek KJ, Gottfried K, Assmann J, Lolli G (2017) WO 2017/032678 A1, March 2

    Google Scholar 

  52. Elsherbini M, Wirth T (2018) Chem Eur J 24:13399–13407

    Article  CAS  PubMed  Google Scholar 

  53. Francke R (2019) Curr Opin Electrochem 15:83–88

    Article  CAS  Google Scholar 

  54. Elsherbini M, Winterson B, Alharbi H, Folgueiras-Amador AA, Génot C, Wirth T (2019) Angew Chem Int Ed 58:9811–9815

    Article  CAS  Google Scholar 

  55. Qian X-Y, Li S-Q, Song J, Xu H-C (2017) ACS Catal 7:2730–2734

    Article  CAS  Google Scholar 

  56. Folgueiras-Amador AA, Qian X-Y, Xu H-C, Wirth T (2018) Chem Eur J 24:487–491

    Article  CAS  PubMed  Google Scholar 

  57. Laudadio G, Barmpoutsis E, Schotten C, Struik L, Govaerts S, Browne DL, Noël T (2019) J Am Chem Soc 141:5664–5668

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Tanaka K, Yoshizawa H, Atobe M (2019) Synlett 30:1194–1198

    Article  CAS  Google Scholar 

  59. Tamborini L, Fernandes P, Paradisi F, Molinari F (2018) Trend Biotechnol 36:73–88

    Article  CAS  Google Scholar 

  60. Zheng MM, Wang RF, Li CX, Xu JH (2015) Process Biochem 50:598–604

    Article  CAS  Google Scholar 

  61. Zheng MM, Chen FF, Li H, Li CX, Xu JH (2018) Chembiochem 19:347–353

    Article  CAS  PubMed  Google Scholar 

  62. De Vitis V, Dall’Oglio F, Pinto A, De Micheli C, Molinari F, Conti P, Romano D, Tamborini L (2017) Chem Open 6:668–673

    Google Scholar 

  63. de la Hoz A, Loupy A (2012) Microwaves in organic chemistry.2nd edn. Wiley-VCH Verlag GmbH, Weinheim

    Google Scholar 

  64. Glasnov TN, Kappe CO (2011) Chem Eur J 17:11956–11968

    Article  CAS  PubMed  Google Scholar 

  65. de la Hoz A, Díaz-Ortiz A (2017) Vaccaro L (ed) Sustainable flow chemistry: methods and applications. Wiley-VCH, Weinheim, pp 219–248

    Chapter  Google Scholar 

  66. Bálint E, Tajti Á, Keglevich G (2019) Materials 12:788

    Article  PubMed Central  Google Scholar 

  67. Fernandes RA, Chowdhury AK, Kattanguru P (2014) Eur J Org Chem 2014:2833–2871

    Article  CAS  Google Scholar 

  68. Egami H, Tamaoki S, Abe M, Ohneda N, Yoshimura T, Okamoto T, Odajima H, Mase N, Takeda K, Hamashima Y (2018) Org Process Res Dev 22:1029–1033

    Article  CAS  Google Scholar 

  69. Musio B, Mariani F, Śliwiński EP, Kabeshov MA, Odajima H, Ley SV (2016) Synthesis 48:3515–3526

    Article  CAS  Google Scholar 

  70. Calcio Gaudino E, Manzoli M, Carnaroglio D, Wu Z, Grillo G, Rotolo L, Medlock J, Bonrath W, Cravotto G (2018) RSC Adv 8:7029–7039

    Article  CAS  Google Scholar 

  71. Tagliapietra S, Calcio Gaudino E, Martina K, Barge A, Cravotto G (2019) Chem Rec 19:98–117

    Article  CAS  PubMed  Google Scholar 

  72. Christiaens S, Vantyghem X, Radoiu M, Vanden Eynde JJ (2014) Molecules 19:9986–9998

    Article  PubMed  PubMed Central  Google Scholar 

  73. He W, Fang Z, Zhang K, Tu T, Lv N, Qiu C, Guo K (2018) Chem Eng J 331:161–168

    Article  CAS  Google Scholar 

  74. Jin Y, Yang J, Feng X, Li J, Xu J, Chen X, Wang S, Lv Y, Yu J (2020) J Flow Chem 10:369–376

    Article  CAS  Google Scholar 

  75. Baumann M, Moody TS, Smyth M, Wharry S (2020) Org Process Res Dev 24:1802–1813

    Article  CAS  Google Scholar 

  76. O’Mahony RM, Lynch D, Hayes HLD, Ní Thuama E, Donnellan P, Jones RC, Glennon B, Collins SG, Maguire AR (2017) Eur J Org Chem:6533–6539

    Google Scholar 

  77. Carpentier F, Felpin F-X, Zammattio F, Le Grognec E (2020) Org Process Res Dev 24:752–761

    Article  CAS  Google Scholar 

  78. Mata A, Weigl U, Flögel O, Baur P, Hone CA, Kappe CO (2020) React Chem Eng 5:645–650

    Article  CAS  Google Scholar 

  79. Koo H, Kim HY, Oh K (2019) Org Lett 21:10063–10068

    Article  CAS  PubMed  Google Scholar 

  80. Sagandira CR, Watts P (2019) Beilstein J Org Chem 15:2577–2589

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Lehmann H (2017) Green Chem 19:1449–1453

    Article  CAS  Google Scholar 

  82. Yang H, Martin B, Schenkel B (2018) Org Process Res Dev 22:446–456

    Article  CAS  Google Scholar 

  83. Pieber B, Kappe CO (2016) Org Lett 18:1076–1079

    Article  CAS  PubMed  Google Scholar 

  84. Yu T, Jiao J, Song P, Nie W, Yi C, Zhang Q, Li P (2020) ChemSusChem 13:2876–2893

    Article  CAS  PubMed  Google Scholar 

  85. Gardiner J, Nguyen X, Genet C, Horne MD, Hornung CH, Tsanaktsidis J (2018) Org Process Res Dev 22:1448–1452

    Article  CAS  Google Scholar 

  86. Rahmana T, Wharry S, Smyth M, Manyar H, Moody TS (2020) Synlett 31:581–586

    Article  Google Scholar 

  87. Saito Y, Ishitani H, Ueno M, Kobayashi S (2017) Chem Open 6:211–215

    CAS  Google Scholar 

  88. Hansen SVF, Wilson ZE, Ulven T, Ley SV (2016) React Chem Eng 1:280–287

    Article  CAS  Google Scholar 

  89. Mata A, Hone CA, Gutmann B, Moens L, Kappe CO (2019) ChemCatChem 11:997–1001

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Chen Y, Hone CA, Gutmann B, Kappe CO (2017) Org Process Res Dev 21:1080–1087

    Article  CAS  Google Scholar 

  91. Hone CA, Lopatka P, Munday R, O’Kearney-McMullan A, Kappe CO (2019) ChemSusChem 12:326–337

    Article  CAS  PubMed  Google Scholar 

  92. Micic N, Polyzos A (2018) Org Lett 20:4663–4666

    Article  CAS  PubMed  Google Scholar 

  93. Osako T, Kaiser R, Torii K, Uozumi Y (2019) Synlett 30:961–966

    Article  CAS  Google Scholar 

  94. Dallinger D, Gutmann B, Kappe CO (2020) Acc Chem Res 53(7):1330–1341

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Johansen MB, Lindhardt AT (2018) Chem Commun 54:825–828

    Article  CAS  Google Scholar 

  96. Hirano K, Gondo S, Punna N, Tokunaga E, Shibata N (2019) Chem Open 8:406–410

    CAS  Google Scholar 

  97. Cantillo D, Wolf B, Goetz R, Kappe CO (2017) Org Process Res Dev 21:125–132

    Article  CAS  Google Scholar 

  98. Mata A, Cantillo D, Kappe CO (2017) Eur J Org Chem 2017:6505–6510

    Article  CAS  Google Scholar 

  99. Sagmeister P, Williams JD, Hone CA, Kappe CO (2019) React Chem Eng 4:1571–1578

    Article  CAS  Google Scholar 

  100. Brodmann T, Koos P, Metzger A, Knochel P, Ley SV (2012) Org Process Res Dev 16:1102–1113

    Article  CAS  Google Scholar 

  101. Zapata F, Ortega-Ojeda F, García-Ruiz C, González-Herráez M (2018) Sensors 18:2196–2205

    Article  PubMed Central  Google Scholar 

  102. Yao X, Deng Q, Wang S, Wang W, Hou Y, Gao Z, Wu Y, Guo Z (2019) Chem Select 4:5116–5121

    CAS  Google Scholar 

  103. Shokoufi N, Vosough M, Rahimzadegan-Asl M, Abbasi-Ahd A, Khatibeghdami M (2020) Int J Anal Chem:2921417

    Google Scholar 

  104. Gomez MV, de la Hoz A (2017) Beilstein J Org Chem 13:285–300

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  105. Jacquemmoz C, Giraudb F, Dumez J-N (2020) Analyst 145:478–485

    Article  CAS  PubMed  Google Scholar 

  106. Wang Y, Lin W-Y, Liu K, Lin RJ, Selke M, Kolb HC, Zhang N, Zhao X-Z, Phelps ME, Shen CKF, Faull KF, Tseng H-R (2009) Lab Chip 9:2281–2285

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. Weeranoppanant N, Adamo A (2020) ACS Med Chem Lett 11:9–15

    Article  CAS  PubMed  Google Scholar 

  108. Shukla CA, Kulkarni AA (2017) Beilstein J Org Chem 13:960–987

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. Trobe M, Burke MD (2018) Angew Chem Int Ed 57:4192–4214

    Article  CAS  Google Scholar 

  110. Adamo A, Beingessner RL, Behnam M, Chen J, Jamison TF, Jensen KF, Monbaliu J-CM, Myerson AS, Revalor EM, Snead DR, Stelzer T, Weeranoppanant N, Wong SY, Zhang P (2016) Science 352:61–67

    Article  CAS  PubMed  Google Scholar 

  111. Lehmann JW, Blair DJ, Burke MD (2018) Nat Rev 2:0115

    Google Scholar 

  112. Li J, Ballmer SG, Gillis EP, Fujii S, Schmidt MJ, Palazzolo AME, Lehmann JW, Morehouse GF, Burke MD (2015) Science 347:1221–1126

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  113. Reischl G, Ehrlichmann W, Bieg C, Solbach C, Kumar P, Wiebe LI, Machulla H-J (2005) Appl Radiat Isot 62:897–901

    Article  CAS  PubMed  Google Scholar 

  114. Parry DM (2019) ACS Med Chem Lett 10:848–856

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  115. Kitson PJ, Glatzel S, Chen W, Lin C-G, Song Y-F, Cronin L (2016) Nat Protoc 11:920

    Article  CAS  PubMed  Google Scholar 

  116. Rossi S, Puglisi A, Benaglia M (2018) ChemCatChem 10:1512–1525

    Article  CAS  Google Scholar 

  117. Parra-Cabrera C, Achille C, Kuhn S, Ameloot R (2018) Chem Soc Rev 47:209

    Article  CAS  PubMed  Google Scholar 

  118. Hartings MR, Ahmed Z (2019) Nat Rev Chem 3:305–314

    Article  Google Scholar 

  119. Rossi S, Porta R, Brenna D, Puglisi A, Benaglia M (2017) Angew Chem Int Ed 56:4290–4294

    Article  CAS  Google Scholar 

  120. Harding MJ, Brady S, O’Connor H, Lopez-Rodriguez R, Edwards MD, Tracy S, Dowling D, Gibson G, Girardg KP, Ferguson S (2020) Chem Eng 5:728–735

    CAS  Google Scholar 

  121. Zhang JM, Ji Q, Duan H (2019) Micromachines 10:754–777

    Article  CAS  PubMed Central  Google Scholar 

  122. Rodriguez AM, Juan A, Gomez MV, Moreno A, de la Hoz A (2012) Synthesis 44:2527–2530

    Article  CAS  Google Scholar 

  123. Lenstra DC, Rutjes FRJT (2017) Organic synthesis in flow: toward higher levels of sustainability. In: Vaccaro L (ed) Sustainable flow chemistry. Wiley-VCH, Weinheim, pp 103–134

    Chapter  Google Scholar 

  124. McMullen JP, Stone MT, Buchwald SL, Jensen KF (2010) Angew Chem Int Ed 49:7076–7080

    Article  CAS  Google Scholar 

  125. Sans V, Cronin L (2016) Chem Soc Rev 45:2032–2043

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  126. Akwi FM, Watts P (2018) Chem Commun 54:13894–13928

    Article  CAS  Google Scholar 

  127. Kilcher E, Freymond S, Vanoli E, Marti R, Schmidt G, Abele S (2016) Org Process Res Dev 20:432–439

    Article  CAS  Google Scholar 

  128. Bennett JA, Campbell ZS, Abolhasani M (2019) Curr Opin Chem Eng 26:9–19

    Article  Google Scholar 

  129. Zhang J, Wang K, Teixeira AR, Jensen KF, Luo G (2017) Annu Rev Chem Biomol Eng 8:285–305

    Article  PubMed  Google Scholar 

  130. Rossetti I, Compagnoni M (2016) Chem Eng J 296:56–70

    Article  CAS  Google Scholar 

  131. Pechlauer P, Skranc W (2017) Scale-up processes in the pharmaceutical industry. In: Vaccaro L (ed) Sustainable flow chemistry. Wiley-VCH, Weinheim, pp 73–94

    Chapter  Google Scholar 

  132. Thaisrivongs DA, Naber JR, Rogus NJ, Spencer G (2018) Org Process Res Dev 22:403–408

    Article  CAS  Google Scholar 

  133. Cole KP, Groh JM, Johnson MD, Burcham CL, Campbell BM, Diseroad WD, Heller MR, Howell JR, Kallman NJ, Koenig TM, May SA, Miller RD, Mitchell D, Myers DP, Myers SS, Phillips JL, Polster CS, White TD, Cashman J, Hurley D, Moylan R, Sheehan P, Spencer RD, Desmond K, Desmond P, Gowran O (2017) Science 356:1144–1150

    Article  CAS  PubMed  Google Scholar 

  134. Ott D, Borukhova S, Hessel V (2016) Green Chem 18:1096–1116

    Article  CAS  Google Scholar 

  135. Kralisch D, Kreisel G (2007) Chem Eng Sci 62:1094–1100

    Article  CAS  Google Scholar 

  136. Eckelman MJ (2016) Green Chem 18:3257–3264

    Article  CAS  Google Scholar 

  137. Yaseneva P, Hodgson P, Zakrzewski J, Falß S, Meadows RE, Lapkin AA (2016) React Chem Eng 1:229–238

    Article  CAS  Google Scholar 

  138. Morales-Gonzalez OM, Escribà-Gelonch M, Hessel V (2019) Int J Life Cycle Assess 24:2111–2127

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Facultad de Ciencias y Tecnologías Químicas, Universidad de Castilla-La Mancha, Ciudad Real, Spain

    Ángel Díaz-Ortiz & Antonio de la Hoz

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  1. Ángel Díaz-Ortiz
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  2. Antonio de la Hoz
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Correspondence to Antonio de la Hoz .

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Editors and Affiliations

  1. Discovery Chemistry, Janssen Pharmaceutical Companies of J&J, Janssen-Cilag, S.A., Toledo, Spain

    Jesus Alcazar

  2. Faculty of Chemistry, University of Castilla-La Mancha, Ciudad Real, Ciudad Real, Spain

    Antonio de la Hoz

  3. Faculty of Chemistry, University of Castilla-La Mancha, Ciudad Real, Spain

    Angel Díaz-Ortiz

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Ethical Approval: This manuscript is a review of previously published accounts, as such, no animal or human studies were performed.

Informed Consent: No patients were studied in this chapter.

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Díaz-Ortiz, Á., de la Hoz, A. (2021). Green Aspects of Flow Chemistry for Drug Discovery. In: Alcazar, J., de la Hoz, A., Díaz-Ortiz, A. (eds) Flow Chemistry in Drug Discovery. Topics in Medicinal Chemistry, vol 38. Springer, Cham. https://doi.org/10.1007/7355_2021_111

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