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Cinnamomum verum J. Presl. (Lauraceae)

(Syns.: C. zeylanicum Nees.; Laurus cinnamomum L.)

  • Chapter
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Handbook of 200 Medicinal Plants

Abstract

The tree is native to Sri Lanka, south India, Seychelles, Martinique, Cayenne, Jamaica, Brazil and Malagasy Republic. Traditionally the infusion, decoction or powder of bark is used in India to treat digestive complaints, such as dyspepsia, flatulency, mild spasms, cramps, diarrhea, and vomiting. In Unani medicine, leaves are called Tezpaat or Sazaj Hindi, and the bark is called Darchini, and is regarded cardiorefrigerant, cardiotonic, cardiostimulant, carminative, antiseptic, antidote and phlegm liquefier (mucolytic). Therapeutic uses in Ayurveda include mukhasosa, trsna, kanthamukhroga, pinasa, krmiroga, vastiroga, arsa, and hrdroga. The bark is considered hot and irritating, and is a constituent of many prescriptions in TCM, and is used as abortifacient and oxytocic, and for the treatment of dysmenorrhea, adenopathy, rheumatism, dermatosis, dyspepsia, stroke, tumors, elephantiasis, and trichomonas, yeast, and viral infections; and in traditional Korean medicine, to improve blood circulation and Yang Qi. In southern Mexico state of Oaxaca, it is used by the indigenous community to treat women’s reproductive health problems, and is said to be effective as uteroactive at level II, also an emmenagogue, and tonic for stomach, intestine and liver; used externally in neuralgia, toothache and scorpion sting. In Austria, 85% of patients with type-1 diabetes and 70% with type-2 diabetes are aware of the positive effects of cinnamon on blood glucose. In Palestine, cinnamon is one of the most commonly used herbal products used by diabetic patients, especially the middle-aged and elderly. Cinnamomum contains eugenol, pinene, myristicine, cinnamaldehyde and camphor ; also contains volatile oil, phlobatannins, mucilage, calcium oxalate and starch. Animal studies showed that cinnamon reduced FBG, LDL-C and HbA1c, increased HDL-C and circulating insulin levels, and attenuated diabetes associated weight loss and metabolic derangements, with beneficial effects on diabetic neuropathy and nephropathy. Six-gram cinnamon with rice pudding reduced postprandial blood glucose and delayed gastric emptying without affecting satiety in healthy Swedish volunteers, and ingestion of 3 g cinnamon by healthy subjects reduced postprandial serum insulin and increased GLP-1 concentrations, without significantly affecting blood glucose, ghrelin, satiety, or gastric emptying rate.

Both Cinnamomum cassia and C. zeylanicum have identical properties, and share the same Indian vernacular names.

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Notes

  1. 1.

    Tayyab M: Personal communication.

References

  1. Achterrath-Tuckermann U, Kunde R, Flaskamp E, Isaac O, Thiemer K. Pharmacological investigations with compounds of chamomile. V. Investigations on the spasmolytic effect of compounds of chamomile and Kamillosan on the isolated guinea pig ileum. Planta Med. 1980;39:38–50 (German).

    Google Scholar 

  2. Ali-Shtayeh MS, Jamous RM, Jamous RM. Complementary and alternative medicine use amongst Palestinian diabetic patients. Complement Ther Clin Pract. 2012;18:16–21.

    PubMed  Google Scholar 

  3. Allen CM, Blozis GG. Oral mucosal reactions to cinnamon-flavored chewing gum. J Am Dent Assoc. 1988;116:664–7.

    CAS  PubMed  Google Scholar 

  4. Allen RW, Schwartzman E, Baker WL, Coleman CI, Phung OJ. Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis. Ann Fam Med. 2013;11:452–9.

    PubMed  PubMed Central  Google Scholar 

  5. Al-Mariri A, Safi M. In vitro antibacterial activity of several plant extracts and oils against some Gram-negative bacteria. Iran J Med Sci. 2014;39:36–43.

    PubMed  PubMed Central  Google Scholar 

  6. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care. 2007;30:813–6.

    CAS  PubMed  Google Scholar 

  7. Anderson RA, Broadhurst CL, Polansky MM, et al. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem. 2004;52:65–70.

    CAS  PubMed  Google Scholar 

  8. Anderson RA. Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc. 2008;67:48–53.

    CAS  PubMed  Google Scholar 

  9. Arachchige SPG, Abeysekera WPKM, Ratnasooriya WD. Antiamylase, anticholinesterases, antiglycation, and glycation reversing potential of bark and leaf of Ceylon cinnamon (Cinnamomum zeylanicum Blume) in vitro. Evid Based Complement Alternat Med. 2017;2017:5076029.

    PubMed  PubMed Central  Google Scholar 

  10. Askari F, Rashidkhani B, Hekmatdoost A. Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients. Nutr Res. 2014;34:143–8.

    CAS  PubMed  Google Scholar 

  11. Atta AH, Alkofahi A. Antinociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. J Ethnopharmacol. 1998;60:117–24.

    CAS  PubMed  Google Scholar 

  12. Azimi P, Ghiasvand R, Feizi A, et al. Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: a randomized controlled clinical trial. Blood Press. 2016;25:133–40.

    CAS  PubMed  Google Scholar 

  13. Baker I, Chohan M, Opara EI. Impact of cooking and digestion, in vitro, on the antioxidant capacity and anti-inflammatory activity of cinnamon, clove and nutmeg. Plant Foods Hum Nutr. 2013;68:364–9.

    CAS  PubMed  Google Scholar 

  14. Baker WL, Gutierrez-Williams G, White CM, Kluger J, Coleman CI. Effect of cinnamon on glucose control and lipid parameters. Diabetes Care. 2008;31:41–3.

    PubMed  Google Scholar 

  15. Bandara T, Uluwaduge I, Jansz ER. Bioactivity of cinnamon with special emphasis on diabetes mellitus: a review. Int J Food Sci Nutr. 2012;63:380–6.

    CAS  PubMed  Google Scholar 

  16. Beejmohun V, Peytavy-Izard M, Mignon C, et al. Acute effect of Ceylon cinnamon extract on postprandial glycemia: alpha-amylase inhibition, starch tolerance test in rats, and randomized crossover clinical trial in healthy volunteers. BMC Complement Altern Med;14:351.

    Google Scholar 

  17. Blevins SM, Leyva MJ, Brown J, et al. Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes. Diabetes Care. 2007;30:2236–7.

    PubMed  Google Scholar 

  18. Broadhurst CL, Polansky MM, Anderson RA. Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric Food Chem. 2000;48:849–52.

    CAS  PubMed  Google Scholar 

  19. Campbell TM, Neems R, Moore J. Severe exacerbation of rosacea induced by cinnamon supplements. J Drugs Dermatol. 2008;7:586–7.

    PubMed  Google Scholar 

  20. Chaudhary SS, Tariq M, Zaman R, Imtiyaz S. The in vitro antiacne activity of two Unani drugs. Anc Sci Life. 2013;33:35–8.

    PubMed  PubMed Central  Google Scholar 

  21. Chen TW, Tsai KD, Yang SM, et al. Discovery of a novel anticancer agent targeting both topoisomerase I & II as well as telomerase activities in human lung adenocarcinoma A549 cells in vitro and in vivo: Cinnamomum verum component cuminaldehyde. Curr Cancer Drug Targets. 2016;16:796–806.

    CAS  PubMed  Google Scholar 

  22. Cheng DM, Kuhn P, Poulev A, et al. In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix. Food Chem. 2012;135:2994–3002.

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Chericoni S, Prieto JM, Iacopini P, et al. In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes. J Agric Food Chem. 2005;53:4762–5.

    CAS  PubMed  Google Scholar 

  24. Choi HM, Jung Y, Park J, et al. Cinnamomi cortex (Cinnamomum verum) suppresses testosterone-induced benign prostatic hyperplasia by regulating 5α-reductase. Sci Rep. 2016;6:31906.

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Chulasiri MU, Picha P, Rienkijkan M, Preechanukool K. The cytotoxic effect of petroleum ether and chloroform extracts from Ceylon cinnamon (Cinnamomum zeylanicum Ness) barks on tumor cells in vitro. Int J Crude Drug Res. 1984;22:177–80.

    Google Scholar 

  26. Couturier K, Qin B, Batandier C, et al. Cinnamon increases liver glycogen in an animal model of insulin resistance. Metabolism. 2011;60:1590–7.

    CAS  PubMed  Google Scholar 

  27. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1c in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med. 2009;22:507–12.

    PubMed  Google Scholar 

  28. Davis PA, Yokoyama W. Cinnamon intake lowers fasting blood glucose: meta-analysis. J Med Food. 2011;14:884–9.

    CAS  PubMed  Google Scholar 

  29. Endo H, Rees TD. Cinnamon products as a possible etiologic factor in orofacial granulomatosis. Med Oral Patol Oral Cir Bucal. 2007;12:E440–4.

    PubMed  Google Scholar 

  30. Endo H, Rees TD. Clinical features of cinnamon-induced contact stomatitis. Compend Contin Educ Dent. 2006;27:403–9.

    PubMed  Google Scholar 

  31. Fabian E, Töscher S, Elmadfa I, Pieber TR. Use of complementary and alternative medicine supplements in patients with diabetes mellitus. Ann Nutr Metab. 2011;58:101–8.

    CAS  PubMed  Google Scholar 

  32. Farnsworth NR, Bingel AS, Cordell GA, Crane FA, Fong HS. Potential value of plants as sources of new antifertility agents I & II. J Pharmaceut Sci. 1975;64:717–54.

    CAS  Google Scholar 

  33. Goh CL, Ng SK. Bullous contact allergy from cinnamon. Derm Beruf Umwelt. 1988;36:186–7.

    CAS  PubMed  Google Scholar 

  34. Guerra FQ, Mendes JM, Sousa JP, et al. Increasing antibiotic activity against a multidrug-resistant Acinetobacter spp. by essential oils of Citrus limon and Cinnamomum zeylanicum. Nat Prod Res. 2012;26:2235–8.

    CAS  PubMed  Google Scholar 

  35. Gunawardena D, Karunaweera N, Lee S, et al. Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts—identification of E-cinnamaldehyde and O-methoxycinnamaldehyde as the most potent bioactive compounds. Food Funct. 2015;6:910–9.

    Google Scholar 

  36. Gupta A, Duhan J, Tewari S, et al. Comparative evaluation of antimicrobial efficacy of Syzygium aromaticum, Ocimum sanctum and Cinnamomum zeylanicum plant extracts against Enterococcus faecalis: a preliminary study. Int Endod J. 2013;46:775–83.

    CAS  PubMed  Google Scholar 

  37. Hagenlocher Y, Bergheim I, Zacheja S, et al. Cinnamon extract inhibits degranulation and de novo synthesis of inflammatory mediators in mast cells. Allergy. 2013;68:490–7.

    CAS  PubMed  Google Scholar 

  38. Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr. 2007;85:1552–6.

    CAS  PubMed  Google Scholar 

  39. Hlebowicz J, Hlebowicz A, Lindstedt S, et al. Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr. 2009;89:815–21.

    CAS  PubMed  Google Scholar 

  40. Hong JW, Yang GE, Kim YB, et al. Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models. BMC Complement Altern Med. 2012;12:237.

    Google Scholar 

  41. Hong YJ, Bae YM, Moon B, Lee SY. Inhibitory effect of cinnamon powder on pathogen growth in laboratory media and oriental-style rice cakes (sulgidduk). J Food Prot. 2013;76:133–8.

    PubMed  Google Scholar 

  42. Jain S, Sangma T, Shukla SK, Mediratta PK. Effect of Cinnamomum zeylanicum extract on scopolamine-induced cognitive impairment and oxidative stress in rats. Nutr Neurosci. 2015;18:210–6.

    CAS  PubMed  Google Scholar 

  43. Javed I, Faisal I, Rahman Z, et al. Lipid lowering effect of Cinnamomum zeylanicum in hyperlipidaemic albino rabbits. Pak J Pharm Sci. 2012;25:141–7.

    PubMed  Google Scholar 

  44. Kamath JV, Rana AC, Chowdhury AR. Prohealing effect of Cinnamomum zeylanicum bark. Phytother Res. 2003;17:970–2.

    PubMed  Google Scholar 

  45. Kanuri G, Weber S, Volynets V, et al. Cinnamon extract protects against acute alcohol-induced liver steatosis in mice. J Nutr. 2009;139:482–7.

    CAS  PubMed  Google Scholar 

  46. Keskin D, Toroglu S. Studies on antimicrobial activities of solvent extracts of different spices. J Environ Biol. 2011;32:251–6.

    PubMed  Google Scholar 

  47. Khan A, Safdar M, Ali Khan MM, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003;26:3215–8.

    PubMed  Google Scholar 

  48. Kim SH, Hyun SH, Choung SY. Antidiabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol. 2006;104:119–23.

    PubMed  Google Scholar 

  49. Kirton V, Wilkinson DS. Sensitivity to cinnamic aldehyde in a toothpaste. 2. Further studies. Contact Dermatitis. 1975;1:77–80.

    Google Scholar 

  50. Kong YC, Hu SY, Lau FK, et al. Potential antifertility plants from Chinese medicine. Am J Chinese Med. 1976;3:105–28.

    Google Scholar 

  51. Lamey PJ, Lewis MA, Rees TD, et al. Sensitivity reaction to the cinnamonaldehyde component of toothpaste. Br Dent J. 1990;168:115–8.

    CAS  PubMed  Google Scholar 

  52. Li J, Liu T, Wang L, et al. Antihyperglycemic and antihyperlipidemic action of cinnamaldehyde in C57BLKS/J db/db mice. J Tradit Chin Med. 2012;32:446–52.

    PubMed  Google Scholar 

  53. Lima EO, Gompertz OF, Giesbrecht AM, Paulo MQ. In vitro antifungal activity of essential oils obtained from officinal plants against dermatophytes. Mycoses. 1993;36:333–6.

    CAS  PubMed  Google Scholar 

  54. Lindeman Z, Waggoner M, Batdorff A, Humphreys TL. Assessing the antibiotic potential of essential oils against Haemophilus ducreyi. BMC Complement Altern Med. 2014;14:172.

    Google Scholar 

  55. Lu T, Sheng H, Wu J, et al. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32:408–12.

    CAS  PubMed  Google Scholar 

  56. Madhavadas S, Subramanian S. Cognition enhancing effect of the aqueous extract of Cinnamomum zeylanicum on nontransgenic Alzheimer’s disease rat model: biochemical, histological, and behavioural studies. Nutr Neurosci. 2017;20:526–37.

    PubMed  Google Scholar 

  57. Malik J, Munjal K, Deshmukh R. Attenuating effect of standardized lyophilized Cinnamomum zeylanicum bark extract against streptozotocin-induced experimental dementia of Alzheimer’s type. J Basic Clin Physiol Pharmacol. 2015;26:275–85.

    PubMed  Google Scholar 

  58. Mancini-Filho J, Van-Koiij A, Mancini DA, et al. Antioxidant activity of cinnamon (Cinnamomum zeylanicum, Breyne) extracts. Boll Chim Farm. 1998;137:443–7.

    CAS  PubMed  Google Scholar 

  59. Mandal S, Manisha Deb Mandal, Saha K, Pal NK. In vitro antibacterial activity of three Indian spices against methicillin-resistant Staphylococcus aureus. Oman Med J. 2011;26:319–23.

    Google Scholar 

  60. Mang B, Wolters M, Schmitt B, et al. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest. 2006;36:340–4.

    CAS  PubMed  Google Scholar 

  61. Markey O, McClean CM, Medlow P, et al. Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast. Cardiovasc Diabetol. 2011;10:78.

    Google Scholar 

  62. Mertens M, Gilissen L, Goossens A, et al. Generalized systemic allergic dermatitis caused by Cinnamomum zeylanicum in a herbal tea. Contact Dermatitis. 2017;77:259–61.

    PubMed  Google Scholar 

  63. Mesripour A, Moghimi F, Rafieian-Kopaie M. The effect of Cinnamomum zeylanicum bark water extract on memory performance in alloxan-induced diabetic mice. Res Pharm Sci. 2016;11:318–23.

    PubMed  PubMed Central  Google Scholar 

  64. Mihail RC. Oral leukoplakia caused by cinnamon food allergy. J Otolaryngol. 1992;21:366–7.

    CAS  PubMed  Google Scholar 

  65. Miller AB, Cates RG, Lawrence M, et al. The antibacterial and antifungal activity of essential oils extracted from Guatemalan medicinal plants. Pharm Biol. 2015;53:548–54.

    CAS  PubMed  Google Scholar 

  66. Mishra A, Bhatti R, Singh A, Singh Ishar MP. Ameliorative effect of the cinnamon oil from Cinnamomum zeylanicum upon early stage diabetic nephropathy. Planta Med. 2010;76:412–7.

    CAS  PubMed  Google Scholar 

  67. Mohamed Sham Shihabudeen H, Hansi Priscilla D, Thirumurugan K. Cinnamon extract inhibits α-glucosidase activity and dampens postprandial glucose excursion in diabetic rats. Nutr Metab (Lond). 2011;8:46.

    Google Scholar 

  68. Moselhy SS, Ali HK. Hepatoprotective effect of cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats. Biol Res. 2009;42:93–8.

    PubMed  Google Scholar 

  69. Nayak IN, Chinta R, Jetti R. Antiatherosclerotic potential of aqueous extract of Cinnamomum zeylanicum bark against glucocorticoid induced atherosclerosis in Wistar rats. J Clin Diagn Res. 2017;11:FC19–23.

    Google Scholar 

  70. Nir Y, Potasman I, Stermer E, et al. Controlled trial of the effect of cinnamon extract on Helicobacter pylori. Helicobacter. 2000;5:94–7.

    CAS  PubMed  Google Scholar 

  71. Nyadjeu P, Dongmo A, Nguelefack TB, Kamanyi A. Antihypertensive and vasorelaxant effects of Cinnamomum zeylanicum stem bark aqueous extract in rats. J Complement Integr Med. 2011;8.

    Google Scholar 

  72. Nyadjeu P, Nguelefack-Mbuyo EP, Atsamo AD, et al. Acute and chronic antihypertensive effects of Cinnamomum zeylanicum stem bark methanol extract in L-NAME-induced hypertensive rats. BMC Complement Altern Med. 2013;13:27.

    PubMed  PubMed Central  Google Scholar 

  73. Ortiz de Montellano BR, Browner CH. Chemical bases for medicinal plant use in Oaxaca. Mexico. J Ethnopharmacol. 1985;13:57–88.

    Google Scholar 

  74. Pandey M, Chandra DR. Evaluation of ethanol and aqueous extracts of Cinnamomum verum leaf galls for potential antioxidant and analgesic activity. Indian J Pharm Sci. 2015;77:243–7.

    PubMed  PubMed Central  Google Scholar 

  75. Patton DW, Ferguson MM, Forsyth A, James J. Orofacial granulomatosis: a possible allergic basis. Br J Oral Maxillofac Surg. 1985;23:235–42.

    CAS  PubMed  Google Scholar 

  76. Pawar VC, Thaker VS. In vitro efficacy of 75 essential oils against Aspergillus niger. Mycoses. 2006;49:316–23.

    CAS  PubMed  Google Scholar 

  77. Perng DS, Tsai YH, Cherng J, et al. Discovery of a novel anticancer agent with both antitopoisomerase I and II activities in hepatocellular carcinoma SK-Hep-1 cells in vitro and in vivo: Cinnamomum verum component 2-methoxycinnamaldehyde. Drug Des Devel Ther. 2016;10:141–53.

    CAS  PubMed  PubMed Central  Google Scholar 

  78. Perry PA, Dean BS, Krenzelok EP. Cinnamon oil abuse by adolescents. Vet Hum Toxicol. 1990;32:162–4.

    CAS  PubMed  Google Scholar 

  79. Ping H, Zhang G, Ren G. Antidiabetic effects of cinnamon oil in diabetic KK-Ay mice. Food Chem Toxicol. 2010;48:2344–9.

    CAS  PubMed  Google Scholar 

  80. Pozzatti P, Scheid LA, Spader TB, et al. In vitro activity of essential oils extracted from plants used as spices against fluconazole-resistant and fluconazole-susceptible Candida spp. Can J Microbiol. 2008;54:950–6.

    CAS  PubMed  Google Scholar 

  81. Preuss HG, Echard B, Polansky MM, Anderson R. Whole cinnamon and aqueous extracts ameliorate sucrose-induced blood pressure elevations in spontaneously hypertensive rats. J Am Coll Nutr. 2006;25:144–50.

    CAS  PubMed  Google Scholar 

  82. Qin B, Panickar KS, Anderson RA. Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. J Diabetes Sci Technol. 2010;4:685–93.

    PubMed  PubMed Central  Google Scholar 

  83. Quale JM, Landman D, Zaman MM, et al. In vitro activity of Cinnamomum zeylanicum against azole resistant and sensitive Candida species and a pilot study of cinnamon for oral candidiasis. Am J Chin Med. 1996;24:103–9.

    CAS  PubMed  Google Scholar 

  84. Rafehi H, Ververis K, Karagiannis TC. Controversies surrounding the clinical potential of cinnamon for the management of diabetes. Diabetes Obes Metab. 2012;14:493–9.

    CAS  PubMed  Google Scholar 

  85. Raj RK. Screening of indigenous plants for anthelmintic action against human Ascaris lumbricoides: Part–II. Indian J Physiol Pharmacol. 1975;19:H53.

    Google Scholar 

  86. Ranasinghe P, Jayawardana R, Galappaththy P, et al. Efficacy and safety of ‘true’ cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med. 2012;29:1480–92.

    CAS  PubMed  Google Scholar 

  87. Ranasinghe P, Perera S, Gunatilake M, et al. Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model. Pharmacognosy Res. 2012;4:73–9.

    PubMed  PubMed Central  Google Scholar 

  88. Ranasinghe P, Pigera S, Premakumara GA, et al. Medicinal properties of ‘true’ cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complement Altern Med. 2013;13:275.

    Google Scholar 

  89. Rasheed A, Laekman G, Tottle J, et al. Eugenol and prostaglandin biosynthesis. New Eng J Med. 1984;310:50–1.

    CAS  PubMed  Google Scholar 

  90. Rasheed MU, Thajuddin N. Effect of medicinal plants on Moraxella catarrhalis. Asian Pac J Trop Med. 2011;4:133–6.

    CAS  PubMed  Google Scholar 

  91. Rathi B, Bodhankar S, Mohan V, Thakurdesai P. Ameliorative effects of a polyphenolic fraction of Cinnamomum zeylanicum l. Bark in animal models of inflammation and arthritis. Sci Pharm. 2013;81:567–89.

    Google Scholar 

  92. Revati S, Bipin C, Chitra PB, Minakshi B. In vitro antibacterial activity of seven Indian spices against high level gentamicin resistant strains of enterococci. Arch Med Sci. 2015;11:863–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  93. Roussel AM, Hininger I, Benaraba R, et al. Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese. J Am Coll Nutr. 2009;28:16–21.

    CAS  PubMed  Google Scholar 

  94. Sambaiah K, Srinivasan K. Effect of cumin, cinnamon, ginger, mustard and tamarind in induced hypercholesterolemic rats. Nahrung. 1991;35:47–51.

    CAS  PubMed  Google Scholar 

  95. Sariözkan S, Türk G, Güvenç M, et al. Effects of cinnamon (C. zeylanicum) bark oil against taxanes-induced damages in sperm quality, testicular and epididymal oxidant/antioxidant balance, testicular apoptosis, and sperm dna integrity. Nutr Cancer. 2016;68:481–94.

    Google Scholar 

  96. Sartorius T, Peter A, Schulz N, et al. Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity. PLoS One. 2014;9:e92358.

    PubMed  PubMed Central  Google Scholar 

  97. Senhaji O, Faid M, Kalalou I. Inactivation of Escherichia coli O157:H7 by essential oil from Cinnamomum zeylanicum. Braz J Infect Dis. 2007;11:234–6.

    PubMed  Google Scholar 

  98. Shahverdi AR, Monsef-Esfahani HR, Tavasoli F, et al. Trans-cinnamaldehyde from Cinnamomum zeylanicum bark essential oil reduces the clindamycin resistance of Clostridium difficile in vitro. J Food Sci. 2007;72:S055–8.

    CAS  PubMed  Google Scholar 

  99. Shen Y, Fukushima M, Ito Y, et al. Verification of the antidiabetic effects of cinnamon (Cinnamomum zeylanicum) using insulin-uncontrolled type 1 diabetic rats and cultured adipocytes. Biosci Biotechnol Biochem. 2010;74:2418–25.

    CAS  PubMed  Google Scholar 

  100. Simić A, Soković MD, Ristić M, et al. The chemical composition of some Lauraceae essential oils and their antifungal activities. Phytother Res. 2004;18:713–7.

    PubMed  Google Scholar 

  101. Singh G, Maurya S, DeLampasona MP, Catalan CA. A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food Chem Toxicol. 2007;45:1650–61.

    CAS  PubMed  Google Scholar 

  102. Singh HB, Srivastava M, Singh AB, Srivastava AK. Cinnamon bark oil, a potent fungitoxicant against fungi causing respiratory tract mycoses. Allergy. 1995;50:995–9.

    CAS  PubMed  Google Scholar 

  103. Siqueira AS, Santos CC, Cristino MR, et al. Intraoral contact mucositis induced by cinnamon-flavored chewing gum—a case report. Quintessence Int. 2009;40:719–21.

    PubMed  Google Scholar 

  104. Sleha R, Mosio P, Vydrzalova M, et al. In vitro antimicrobial activities of cinnamon bark oil, anethole, carvacrol, eugenol and guaiazulene against Mycoplasma hominis clinical isolates. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014;158:208–11.

    PubMed  Google Scholar 

  105. Soliman KM, Badeaa RI. Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi. Food Chem Toxicol. 2002;40:1669–75.

    CAS  PubMed  Google Scholar 

  106. Solomon TP, Blannin AK. Effects of short-term cinnamon ingestion on in vivo glucose tolerance. Diabetes Obes Metab. 2007;9:895–901.

    CAS  PubMed  Google Scholar 

  107. Solomon TP, Blannin AK. Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans. Eur J Appl Physiol. 2009;105:969–76.

    CAS  PubMed  Google Scholar 

  108. Subash Babu P, Prabuseenivasan S, Ignacimuthu S. Cinnamaldehyde—a potential antidiabetic agent. Phytomedicine. 2007;14:15–22.

    CAS  PubMed  Google Scholar 

  109. Sultana S, Ripa FA, Hamid K. Comparative antioxidant activity study of some commonly used spices in Bangladesh. Pak J Biol Sci. 2010;13:340–3.

    CAS  PubMed  Google Scholar 

  110. Tabak M, Armon R, Neeman I. Cinnamon extracts’ inhibitory effect on Helicobacter pylori. J Ethnopharmacol. 1999;67:269–77.

    CAS  PubMed  Google Scholar 

  111. Tremblay S, Avon SL. Contact allergy to cinnamon: case report. J Can Dent Assoc. 2008;74:445–61.

    PubMed  Google Scholar 

  112. Ungsurungsie M, Paovalo C, Noonai A. Mutagenicity of extracts from Ceylon cinnamon in the rec assay (Cinnamomum zeylanicum). Food Chem Toxicol. 1984;22:109–12.

    CAS  PubMed  Google Scholar 

  113. Unlu M, Ergene E, Unlu GV, et al. Composition, antimicrobial activity and in vitro cytotoxicity of essential oil from Cinnamomum zeylanicum Blume (Lauraceae). Food Chem Toxicol. 2010;48:3274–80.

    CAS  PubMed  Google Scholar 

  114. Uragoda CG. Asthma and other symptoms in cinnamon workers. Br J Ind Med. 1984;41:224–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  115. Urbaniak A, Głowacka A, Kowalczyk E, Lysakowska M, Sienkiewicz M. The antibacterial activity of cinnamon oil on the selected gram-positive and gram-negative bacteria. Med Dosw Mikrobiol. 2014;66:131–41 (Article in Polish).

    Google Scholar 

  116. Vanschoonbeek K, Thomassen BJ, Senden JM, et al. Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients. J Nutr. 2006;136:977–80.

    CAS  PubMed  Google Scholar 

  117. Voukeng IK, Kuete V, Dzoyem JP, et al. Antibacterial and antibiotic-potentiation activities of the methanol extract of some Cameroonian spices against Gram-negative multidrug resistant phenotypes. BMC Res Notes. 2012;5:299.

    PubMed  PubMed Central  Google Scholar 

  118. Wagner H. Phenolic compounds in plants of pharmaceutical interest. In: Swain T, Harborne JB, VanSumere CF, editors. Biochemistry of plant phenolics. New York: Plenum Press; 1978. p. 605, 608.

    Google Scholar 

  119. Wainstein J, Stern N, Heller S, Boaz M. Dietary cinnamon supplementation and changes in systolic blood pressure in subjects with type 2 diabetes. J Med Food. 2011;14:1505–10.

    CAS  PubMed  Google Scholar 

  120. Wang JG, Anderson RA, Graham GM 3rd, et al. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Fertil Steril. 2007;88:240–3.

    PubMed  Google Scholar 

  121. Westra WH, McMurray JS, Califano J, et al. Squamous cell carcinoma of the tongue associated with cinnamon gum use: a case report. Head Neck. 1998;20:430–3.

    CAS  PubMed  Google Scholar 

  122. Wong HY, Tsai KD, Liu YH, et al. Cinnamomum verum component 2-methoxycinnamaldehyde: a novel anticancer agent with both antitopoisomerase I and II activities in human lung adenocarcinoma A549 cells in vitro and in vivo. Phytother Res. 2016;30:331–40.

    CAS  PubMed  Google Scholar 

  123. Yap PS, Krishnan T, Chan KG, Lim SH. Some evidences on the mode of action of Cinnamomum verum bark essential oil, alone and in combination with piperacillin against a multidrug resistant Escherichia coli strain. J Microbiol Biotechnol. 2015;25:1299–306.

    CAS  PubMed  Google Scholar 

  124. Yüce A, Türk G, Çeribaşi S, et al. Effects of cinnamon (Cinnamomum zeylanicum) bark oil on testicular antioxidant values, apoptotic germ cell and sperm quality. Andrologia. 2013;45:248–55.

    PubMed  Google Scholar 

  125. Yüce A, Türk G, Ceribaşı S, et al. Effectiveness of cinnamon (Cinnamomum zeylanicum) bark oil in the prevention of carbon tetrachloride-induced damages on the male reproductive system. Andrologia. 2014;46:263–72.

    PubMed  Google Scholar 

  126. Zu Y, Yu H, Liang L, et al. Activities of ten essential oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 cancer cells. Molecules. 2010;15:3200–10.

    CAS  PubMed  PubMed Central  Google Scholar 

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    Shahid Akbar

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Akbar, S. (2020). Cinnamomum verum J. Presl. (Lauraceae). In: Handbook of 200 Medicinal Plants. Springer, Cham. https://doi.org/10.1007/978-3-030-16807-0_68

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