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Bioactive Secondary Metabolites from Endophytic Phoma spp.

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Phoma: Diversity, Taxonomy, Bioactivities, and Nanotechnology

Abstract

Phoma is an exceptionally polyphyletic genus of rapidly growing soil fungi under the phylum of Ascomycota. The genus of Phoma includes more than 2000 species observed as phytopathogen or endophytes. The endophytic Phoma spp. have been isolated from a range of tropical/subtropical plants, arid climate of mangrove, mountain, desert, and forest. Wide varieties of plant like tree, herb, shrub, grass, palm, and climber inhabit exclusive endophytic Phoma spp. The isolated endophytic Phoma has been recognized as important source of many novel and natural products that exhibit a wide range of biological activities. Few of the chief bioactive secondary metabolites obtained from diverse species of Phoma are phomin, phomodione, sesquiterpenoid, cytochalasin B, deoxaphomin, usnic acid, trichodermin, beta-sitosterol, cercosporamide, sirodesmin, phomasetin, etc. Moreover, many novel secondary metabolites produced by Phoma sp. act as bio-herbicide, while some of them can produce indoleacetic acid that promotes the growth of that particular plant in which they reside. The biomolecules of endophytic Phoma are reported as antimicrobial, anti-inflammatory, bio-herbicidal, antiangiogenic, cytotoxic, and anti-HIV. Therefore, the chapter aims to present the secondary metabolites of Phoma, its identification tools, and its bioactivity in various areas.

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Abbreviations

BEAS-2B:

Human bronchial epithelial cells

COSY:

Correlated spectroscopy

DV-3:

Human dengue virus type 3

EtOAc:

Ethyl acetate

FT-IR:

Fourier-transform infrared spectroscopy

GC-MS:

Gas chromatography-mass spectrometry

H1N1:

Influenza A virus subtype

HeLa:

Henrietta Lacks (immortal cell line)

HIV:

Human immunodeficiency virus

HL:

Human leukemia cell line

HMBC:

Heteronuclear multiple bond correlation

HMQC:

Heteronuclear multiple quantum coherence

IL:

Interleukin

LC-MS:

Liquid chromatography-mass spectrometry

MCF-7:

Breast cancer cell line (MCF = Michigan Cancer Foundation)

NMR:

Nuclear magnetic resonance

NOESY:

Nuclear Overhauser effect spectroscopy

PAF:

Platelet-activating factor

ROS:

Reactive oxygen species

RS:

Reciprocal syncytial virus

SMMC:

Human hepatocarcinoma cell line

SW480:

Human colorectal cancer cell lines

VOCs:

Volatile organic compounds

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Authors and Affiliations

  1. Department of Biotechnology, Government Digvijay (Autonomous) P.G. College, Rajnandgaon, Chhattisgarh, India

    Pramod Kumar Mahish & Shweta Singh

  2. National Centre for Natural Resources (NCNR), Pandit Ravishankar Shukla University, Raipur, Chhattisgarh, India

    Ravishankar Chauhan

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  1. Pramod Kumar Mahish
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  2. Shweta Singh
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  3. Ravishankar Chauhan
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Editors and Affiliations

  1. Department of Biotechnology, SGB Amravati University, Amravati, Maharashtra, India

    Mahendra Rai

  2. Department of Plant Protection Institute of Plant Pathology and Mycology, University of Life Sciences in Lublin Lublin, Lubelskie, Poland

    Beata Zimowska

  3. Plant Protection Institute, University of Debrecen, Debrecen, Hungary

    György János Kövics

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Mahish, P.K., Singh, S., Chauhan, R. (2022). Bioactive Secondary Metabolites from Endophytic Phoma spp.. In: Rai, M., Zimowska, B., Kövics, G.J. (eds) Phoma: Diversity, Taxonomy, Bioactivities, and Nanotechnology. Springer, Cham. https://doi.org/10.1007/978-3-030-81218-8_11

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