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Natural Antifungal Agents Isolated from Argentine Plants. A Summary of Studies Developed in the Period 2000–2020

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Promising Antimicrobials from Natural Products

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Abstract

Fungal species are able to carry out beneficial actions on industrial processes that directly affect human being wellness. They can also be the cause of severe pathologies both in humans or food products. Fungicidal agents currently used to treat human or plant pathogens have many drawbacks after prolonged or inappropriate use, proving to be inefficient in a short term. Therefore, academics and the pharmaceutical or agrochemical industries are constantly encouraged to search for new chemical entities with antifungal action. In this sense, taking advantage of secondary plant metabolites to find out antifungal molecules could be of high interest. During the last 20 years, we have constituted a group of scientists that broach the subject related to antifungal products obtained from vegetable sources, and we have assayed hundreds of plant species and a considerable number of natural metabolites isolated from them, against the main fungal pathogens that affect humans and crops. The aim of this chapter is to update the plants that have demonstrated the best antifungal action during this period of time and the natural compounds responsible for this. In addition, new strategies like the evaluation of photoactive species and synergism, as well as comparisons with results obtained by other authors reported in the literature, will be discussed.

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Abbreviations

1-M-3-(3′,4’-DHP)-PC:

1-Methyl-3-(3′,4′-dihydroxyphenyl)-propyl caffeate

1-M-3-(4’-HP)-PC:

1-Methyl-3-(4′-hydroxyphenyl)-propyl caffeate

3,7-DHF:

3,7-Dihydroxy flavone

3-H-7,8-DMF:

3-Hydroxy-7,8-dimethoxy flavone

7-H-8-MF:

7-Hydroxy-8-methoxyflavanone

7-HF:

7-Hydroxy flavanone

AIDS:

Acquired immune deficiency syndrome

AMB:

Amphotericin B

APDT:

Antimicrobial photo dynamic therapy

BBT:

2,2′:5′,2″-Terthienyl (α-T); 5-(3-buten-1-ynyl)-2,2′-bithiophene

BBTOAc:

5-(4-Acetoxy-1-butynyl)-2,2′-bithiophene

BBTOH:

5-(4-Hydroxy-1-butynyl)-2,2′-bithiophene

CFU:

Colony forming units

DCM:

DiChloroMethane

DHC:

2′,4´-Dihydroxychalcone

DHMC:

2′,4´-Dihydroxy-3′-methoxychalcone

EtOH:

Ethanolic

FCZ:

Fluconazole

HTSS:

High-throughput synergy screening

ITZ:

Itraconazole

MeOH:

Methanolic

MFC:

Minimal fungicidal concentration

MIC:

Minimal inhibitory concentration

PBT:

5-(3-Penten-1-ynyl)-2,2′-bithiophene

PCM:

Paracoccidioidomycosis

PDT:

Photo dynamic therapy

PhytB:

Phytolaccoside B (3-O-β-D-xylopiranosylphytolaccagenin)

PhytE:

Phytolaccoside E (3-O-β-D-glucopyranosyl-(1,4)-β-D-xylopiranosyl-phytolaccagenin)

PhytF:

Phytolaccoside F [3-O-α-L-rhamnopyranosyl-(1,2)-β-D-glucopyranosyl-(1,2)-β-D-xylopyranosyl-phytolaccagenic acid]

PhytG:

Phytolaccagenin

PSs:

Photosensitizer

PtAqEb:

Phytolacca tetramera aqueous extract from berries

PtAqEl:

Phytolacca tetramera aqueous extract from leaves

PtAqEr:

Phytolacca tetramera aqueous extract from roots

PtBEb:

Phytolacca tetramera butanoic extract from berries

PtBEl:

Phytolacca tetramera butanoic extract from leaves

PtBEr:

Phytolacca tetramera butanoic extract from roots

PtDEb:

Phytolacca tetramera dichloromethane extract from berries

PtDEl:

Phytolacca tetramera dichloromethane extract from leaves

PtDEr:

Phytolacca tetramera dichloromethane extract from roots

PtMEb :

Phytolacca tetramera methanolic extract from berries

PtMEl:

Phytolacca tetramera methanolic extract from leaves

PtMEr:

Phytolacca tetramera methanolic extract from roots

ROS:

Reactive oxygen species

TLC:

Thin layer chromatography

UHPLC-ESI-MS:

Ultra-high performance liquid chromatography-electrospray ionization mass spectrometry

UVA:

Ultraviolet A radiation

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Acknowledgments

Authors gratefully acknowledge Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Agencia Nacional de Promoción Científica y Tecnológica (ANPCyT) and Universidad Nacional de Rosario (UNR) for financial support (PIP N° 2015-0524, PICT N° 2015-2259, PICT N° 2016-1833 and BIO571-UNR). GS, EB, MDL, EC, and AB are also thankful to CONICET for their doctoral fellowships.

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  1. ICiAgro Litoral, Universidad Nacional del Litoral-CONICET, Esperanza, Argentina

    Gisela Seimandi & Marcos Derita

  2. Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina

    Estefanía Butassi, Melina Di Liberto, Estefanía Cordisco, Alan Blanc, Maximiliano Sortino, Laura Svetaz & Marcos Derita

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  1. Gisela Seimandi
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  1. Sant Gadge Baba Amravati University, Department of Biotechnology, Amravati, Maharashtra, India

    Mahendra Rai

  2. University of Zagreb, Faculty of Pharmacy and Biochemistry, Institute for Microbiology, Zagreb, Croatia

    Ivan Kosalec

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Seimandi, G. et al. (2022). Natural Antifungal Agents Isolated from Argentine Plants. A Summary of Studies Developed in the Period 2000–2020. In: Rai, M., Kosalec, I. (eds) Promising Antimicrobials from Natural Products. Springer, Cham. https://doi.org/10.1007/978-3-030-83504-0_12

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