Abstract
The present volume is the third in a trilogy that documents naturally occurring organohalogen compounds, bringing the total number—from fewer than 25 in 1968—to approximately 8000 compounds to date. Nearly all of these natural products contain chlorine or bromine, with a few containing iodine and, fewer still, fluorine. Produced by ubiquitous marine (algae, sponges, corals, bryozoa, nudibranchs, fungi, bacteria) and terrestrial organisms (plants, fungi, bacteria, insects, higher animals) and universal abiotic processes (volcanos, forest fires, geothermal events), organohalogens pervade the global ecosystem. Newly identified extraterrestrial sources are also documented. In addition to chemical structures, biological activity, biohalogenation, biodegradation, natural function, and future outlook are presented.
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Acknowledgements
The author is indebted to Ms. Wendy Berryman who typed the manuscript and drew all of the structures, and to Professor Heinz Falk for his enormous assistance with the preparation of this manuscript. A special thanks goes to the several scientists who provided photographs of some of the organisms cited herein, and to Dartmouth College for the use of the facilities.
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Gribble, G.W. (2023). Naturally Occurring Organohalogen Compounds—A Comprehensive Review. In: Kinghorn, A.D., Falk, H., Gibbons, S., Asakawa, Y., Liu, JK., Dirsch, V.M. (eds) Naturally Occurring Organohalogen Compounds. Progress in the Chemistry of Organic Natural Products, vol 121. Springer, Cham. https://doi.org/10.1007/978-3-031-26629-4_1
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