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Neoplasms of the Skin and Immunodermatology

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Essentials of Anatomic Pathology

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Abstract

The skin is home to a wide variety of unique epithelial, mesenchymal, and hematopoietic neoplasms as well as a frequent site of involvement with systemic neoplasia. This chapter focuses on those entities that arise primarily in the skin, with distinction made between the often different biologic behavior of cutaneous neoplasms and their systemic counterparts, where applicable. The chapter concludes with a detailed examination of immunodermatology in the modern era with a focus on immunobullous and connective tissue diseases.

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Notes

  1. 1.

    Excludes CSCC of the eyelid.

  2. 2.

    High-risk features

    • Depth invasion: >2 mm thickness, Clark level ≥ IV, and perineural invasion

    • Anatomic locations: Primary sites – ear and hair-bearing lip

    • Differentiation: Poorly differentiated or undifferentiated

Suggested Reading

Cutaneous Neoplasms and Developmental Anomalies

  • Argenyi ZB. Newly recognized neural neoplasms relevant to the dermatopathologist. Dermatol Clin. 1992;10:219–34.

    Article  CAS  PubMed  Google Scholar 

  • Argenyi ZB. Cutaneous neural heterotopias and related tumors relevant for the dermatopathologist. Semin Diagn Pathol. 1996;13:60–71.

    CAS  PubMed  Google Scholar 

  • Beltraminelli H, Leinweber B, Kerl H, Derroni L. Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma: a cutaneous nodular proliferation of pleomorphic T lymphocytes of undetermined significance? A study of 136 cases. Am J Dermatopathol. 2009;31:317–22.

    Article  PubMed  Google Scholar 

  • Bobos M, Hytiroglou P, Kostopoulos I, Karkavelas G, Papadimitriou C. Immunohistochemical distinction between merkel cell carcinoma and small cell carcinoma of the lung. Am J Dermatopathol. 2006;28:99–104.

    Article  PubMed  Google Scholar 

  • Burg G, Kempf W, Cozzio A, et al. WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects. J Cutan Pathol. 2005;32:647–74.

    Article  PubMed  Google Scholar 

  • Cibull T, Thomas A, O’Malley D, Billings S. Myeloid leukemia cutis: a histologic and immunohistochemical review. J Cutan Pathol. 2008;35:180–5.

    PubMed  Google Scholar 

  • Cruz DJ. Sweat gland carcinomas: a comprehensive review. Semin Diagn Pathol. 1987;4:38–74.

    CAS  PubMed  Google Scholar 

  • Fabrizi G, Pagliarello C, Prente P, Massi G. Atypical nevi of the scalp in adolescents. J Cutan Pathol. 2007;34:365–9.

    Article  PubMed  Google Scholar 

  • Fetsch J, Laskin W, Hallman J, Lupton G, Miettinen M. Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information. Am J Surg Pathol. 2007;31:1103–14.

    Article  PubMed  Google Scholar 

  • González SB. Histopathologic diagnosis of pigmented lesions of the skin. Pathol Res Pract. 1991;187:387–431.

    Article  PubMed  Google Scholar 

  • Groben P, Harvell J, White W. Epithelioid blue nevus: neoplasm or Sui generis or variation on a theme? Am J Dermatopathol. 2000;22:473–88.

    Article  CAS  PubMed  Google Scholar 

  • Kempf W, Kasakov D, Kerl K. Cutaneous lymphomas: an update. Part 1: T-cell and Natural Killer/T-cell lymphomas and related conditions. Am J Dermatopathol. 2014;36:105–23.

    Article  PubMed  Google Scholar 

  • Olsen E, Vonderheid E, Pimpinelli N, et al. Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC). Blood. 2007;110:1713–22.

    Article  CAS  PubMed  Google Scholar 

  • Massa M, Medenica M. Cutaneous adnexal tumors and cysts: a review. II. Tumors with apocrine and eccrine glandular differentiation and miscellaneous cutaneous cysts. Pathol Annu. 1987;22:225–76.

    PubMed  Google Scholar 

  • Massone C, El-Shabrawi-Caelen L, Kerl H, Cerroni L. The morphologic spectrum of primary cutaneous anaplastic large T-cell lymphoma: a histopathologic study on 66 biopsy specimens from 47 patients with report of rare variants. J Cutan Pathol. 2008;35:46–53.

    Article  PubMed  Google Scholar 

  • McQuitty E, Curry JL, Teztlaff MT, Prieto VG, Duvic M, Torres-Cabala C. The differential diagnosis of CD8-positive (“type D”) lymphomatoid papulosis. J Cutan Pathol. 2014;41:88–100.

    Article  PubMed  Google Scholar 

  • Mentzel T, Kutzner H. Dermatomyofibroma: clinicopathologic and immunohistochemical analysis of 56 cases and reappraisal of a rare and distinct cutaneous neoplasm. Am J Dermatopathol. 2009;31:44–9.

    Article  PubMed  Google Scholar 

  • Plaza J, Torres-Cabala C, Evans H, Diwan A, Prieto V. Immunohistochemical expression of S100A6 in cellular neurothekeoma: clinicopathologic and immunohistochemical analysis of 31 cases. Am J Dermatopathol. 2009;31:419–22.

    Article  PubMed  Google Scholar 

  • Reichard K, Burks E, Foucar K, et al. CD4(+) CD56(+) lineage-negative malignancies are rare tumors of plasmacytoid dendritic cells. Am J Surg Pathol. 2005;29:1274–83.

    Article  PubMed  Google Scholar 

  • Requena C, Requena L, Kutzner H, Yus E. Spitz nevus: a clinicopathologic study of 349 cases. Am J Dermatopathol. 2009;31:107–16.

    Article  PubMed  Google Scholar 

  • Requena L, Sangueza OP. Cutaneous vascular anomalies. Part I. Hamartomas, malformations, and dilatation of preexisting vessels. J Am Acad Dermatol. 1997a;37:523–49.

    Article  CAS  PubMed  Google Scholar 

  • Requena L, Sangueza OP. Cutaneous vascular proliferations. Part II. Hyperplasias and benign neoplasms. J Am Acad Dermatol. 1997b;37:887–919.

    Article  CAS  PubMed  Google Scholar 

  • Requena L, Sangueza OP. Cutaneous vascular proliferations. Part III. Malignant neoplasms, other cutaneous neoplasms with significant vascular component, and disorders erroneously considered as vascular neoplasms. J Am Acad Dermatol. 1998;38:143–75.

    Article  CAS  PubMed  Google Scholar 

  • Singh R, Grayson W, Redston M, et al. Site and tumor type predicts DNA mismatch repair status in cutaneous sebaceous neoplasia. Am J Surg Pathol. 2008;32:936–42.

    Article  PubMed  Google Scholar 

  • Slater DN. The new World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: a practical marriage of two giants. Br J Dermatol. 2005;153:874–80.

    Article  CAS  PubMed  Google Scholar 

  • Swanson PE, Cherwitz DL, Neumann MP, Wick MR. Eccrine sweat gland carcinoma: an histologic and immunohistochemical study of 32 cases. J Cutan Pathol. 1987;14:65–86.

    Article  CAS  PubMed  Google Scholar 

  • Tardio J. CD34-reactive tumors of the skin. An updated review of an ever-growing list of lesions. J Cutan Pathol. 2008;35:1079–92.

    Article  PubMed  Google Scholar 

  • Walsh N, Crotty K, Palmer A, McCarthy S. Spitz nevus versus spitzoid malignant melanoma: an evaluation of the current distinguishing histopathologic criteria. Hum Pathol. 1998;29:1105–12.

    Article  CAS  PubMed  Google Scholar 

  • Wick MR, Goellner JR, Wolfe III JT, Su WPD. Adnexal carcinomas of the skin, I: eccrine carcinomas. Cancer. 1985a;56:1147–62.

    Article  CAS  PubMed  Google Scholar 

  • Wick MR, Goellner JR, Wolfe III JT, Su WPD. Adnexal carcinomas of the skin, II: extraocular sebaceous carcinomas. Cancer. 1985b;56:1163–72.

    Article  CAS  PubMed  Google Scholar 

  • Willemze R, Jaffe E, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood. 2005;105:3768–85.

    Article  CAS  PubMed  Google Scholar 

  • Zelger BWH, Sidoroff A, Orchard G, Cerio R. Non-Langerhans cell histiocytoses. Am J Dermatopathol. 1996;18:490–504.

    Article  CAS  PubMed  Google Scholar 

Immunodermatology

  • Abell E, Presbury DG, Marks R, et al. The diagnostic significance of immunoglobulin and fibrin deposition in lichen planus. Br J Dermatol. 1975;93:17–24.

    Article  CAS  PubMed  Google Scholar 

  • David-Bajar KM, Bennion SD, DeSpain JD, et al. Clinical, histologic and immunofluorescent distinctions between subacute cutaneous lupus erythemaatosus and discoid lupus erythematosus. J Invest Dermatol. 1992;99:251–7.

    Article  CAS  PubMed  Google Scholar 

  • Gammon WR, Briggaman RA, Woodley DT, et al. Epidermolysis bullosa acquisita: a pemphigoid-like disease. J Am Acad Dermatol. 1984;11:820–32.

    Article  CAS  PubMed  Google Scholar 

  • Gately LE, Nesbitt LT. Update on immunofluorescent testing in bullous diseases and lupus erythematosus. Dermatol Clin. 1994;1:133–42.

    Google Scholar 

  • Jones RR, Bhogal B, Dash A, et al. Urticaria and vasculitis: a continuum of histological and immunopathological changes. Br J Dermatol. 1983;108:695–703.

    Article  CAS  PubMed  Google Scholar 

  • Korman NJ. Pemphigus. Immunodermatology. 1990;8:689–700.

    CAS  Google Scholar 

  • Leonard JN, Tucker WFG, Fry JS, et al. Increased incidence of malignancy in dermatitis herpetiformis. Br J Med. 1983;286:16–8.

    Article  CAS  Google Scholar 

  • Logan RA, Bhogal B, Das AK, et al. Localization of bullous pemphigoid antigen: an indirect immunofluorescence study of 228 cases using a split-skin technique. Br J Dermatol. 1987;117:471–8.

    Article  CAS  PubMed  Google Scholar 

  • Mutasim DF, Pelc NJ, Anhalt GJ. Paraneoplastic pemphigus. Dermatol Clin. 1993;11:473–81.

    Article  CAS  PubMed  Google Scholar 

  • Olansky AJ, Briggaman RA, Gammon WR, et al. Bullous systemic lupus erythematosus. J Am Acad Dermatol. 1982;7:511–20.

    Article  CAS  PubMed  Google Scholar 

  • Person JR, Rogers III RS. Bullous and cicatricial pemphigoid: clinical, histologic, pathogenic and immunopathological correlations. Mayo Clin Proc. 1977;52:54–66.

    CAS  PubMed  Google Scholar 

  • Peters MS, Rogers III RS. Clinical correlations of IgA deposition at the cutaneous basement membrane zone. J Am Acad Dermatol. 1989;20:761–70.

    Article  CAS  PubMed  Google Scholar 

  • Schroeter AL, Copeman PWM, Hordon RE, et al. Immunofluorescence of cutaneous vasculitis associated with systemic disease. Arch Dermatol. 1971;104:254–9.

    Article  CAS  PubMed  Google Scholar 

  • Shornick JK. Herpes gestationis. Dermatol Clin. 1993;11:527–33.

    CAS  PubMed  Google Scholar 

  • Zone JJ, Taylor TB, Meyer LJ. Identification of the cutaneous basement membrane zone antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis. J Clin Invest. 1990;85:812.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Essential Health, St. Mary’s, 407 East Third Street, Duluth, MN, 55805, USA

    Daniel P. Vandersteen MD, FACP & Chris H. Jokinen MD

Authors
  1. Daniel P. Vandersteen MD, FACP
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  2. Chris H. Jokinen MD
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Corresponding author

Correspondence to Daniel P. Vandersteen MD, FACP .

Editor information

Editors and Affiliations

  1. Indiana University School of Medicine, Indianapolis, Indiana, USA

    Liang Cheng

  2. Granger Diagnostics, A Division of Granger Genetics, North Chesterfield, Virginia, USA

    David G. Bostwick

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Vandersteen, D.P., Jokinen, C.H. (2016). Neoplasms of the Skin and Immunodermatology. In: Cheng, L., Bostwick, D. (eds) Essentials of Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-23380-2_18

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  • DOI: https://doi.org/10.1007/978-3-319-23380-2_18

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-23379-6

  • Online ISBN: 978-3-319-23380-2

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