Abstract
Datura stramonium L., plant has been an exemplary source of folklore medicinal herb known for its mental stimulation and curative properties. The noteworthy pharmacological potential of this plant is utilized by Ayurvedic practitioners in the traditional system of Indian medicine. The major active principles contributing to remedying effects of this plant are ascribed to alkaloids, terpenoids, withanolides, steroids, flavonoids, triterpenes, phenolic compounds, carbohydrates, and tannins. These phytoconstituents bequeathed plant with anticancer, anti-inflammatory, antidiabetic, anticholinergic, antispasmodic, antioxidant, antidepressant, antimicrobial, cytotoxic, insecticidal, larvicidal, and herbicidal activity. So far, 64 tropane alkaloids characterized from the Datura plant are of prime importance to humankind. However, a variety of tropane alkaloids are neurotoxic, and their frequent recreational abuse may lead to delirium and even death. Recent studies have been directed toward the therapeutic efficacy of these metabolites and/or their derivatives as lead molecules offering new perspectives in biological, medicinal, and pharmaceutical research. This also encourages the cultivation and conservation of this highly valuable medicinal herb for its putative health benefits and sustainable use at commercial scale.
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Abbreviations
- ACh:
-
Acetylcholine
- CNS:
-
Central nervous system
- CT :
-
Computerized tomography
- DPPH:
-
1, 1-Diphenyl-2-picrylhydrazyl
- g:
-
Gram
- GPCR:
-
G-protein coupled receptor
- IC50:
-
Half maximal inhibitory concentration
- kg:
-
Kilogram
- L:
-
Liter
- m AchR:
-
Muscarinic acetylcholine receptor
- M(1–5):
-
Mammalian subtypes
- mg:
-
Milligram
- min:
-
Minute
- mL:
-
Milliliter
- MS:
-
Mass spectrometry
- nAChR:
-
Nicotinic acetylcholine receptor
- RBCs:
-
Red blood cells
- SA node:
-
Sinoatrial node
- Sp:
-
Species
- WBCs:
-
White blood cells
- μg:
-
Microgram
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Choudhary, M., Sharma, I., Agrawal, D.C., Dhar, M.K., Kaul, S. (2021). Neurotoxic Potential of Alkaloids from Thorn Apple (Datura stramonium L.): A Commonly Used Indian Folk Medicinal Herb. In: Agrawal, D.C., Dhanasekaran, M. (eds) Medicinal Herbs and Fungi. Springer, Singapore. https://doi.org/10.1007/978-981-33-4141-8_16
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