This is the first phytochemical investigation of Schisandra tomentella A. C. Smith. 11 lignans and 8 sesquiterpenoids, were isolated from the stems of S. tomentella, including two undescribed lignans, tomentaschinins A-B (1–2), and two new sesquiterpenoids, tomentaschinnes A-B (3–4). Their structures were elucidated based on the interpretation of their spectroscopic data. Cytotoxicity and MDR reversal effect of these compounds were screened on multidrug resistance cancer cell line MCF-7/ADR, and results showed gomisin M₂ (7) could promote the efficacy of adriamycin against MCF-7/ADR.

中文翻译：

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来自五味子 AC 史密斯的木脂素和倍半萜

这是五味子AC 史密斯的第一次植物化学研究。从S. tomentella的茎中分离出 11 种木脂素和 8 种倍半萜类化合物，包括两种未描述的木脂素 tomentaschinins AB ( 1-2 )和两种新的倍半萜类化合物 tomentaschinnes AB ( 3-4 )。根据对其光谱数据的解释，阐明了它们的结构。筛选了这些化合物对多药耐药癌细胞株MCF-7/ADR的细胞毒性和MDR逆转作用，结果表明gomisin M ₂ ( 7 )可以促进阿霉素对MCF-7/ADR的疗效。