Issue 7, 2023
From the journal:

Chemical Communications

Reversible dynamic optical sensing based on coumarin modified β-cyclodextrin for glutathione in living cells†

Zhixue Liu,a   Mengdi Tian,c   Heng Zhangc  and  Yu Liu ORCID logo *ab  

* Corresponding authors

a College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
E-mail: yuliu@nankai.edu.cn

b Haihe Laboratory of Sustainable Chemical Transformations, Tianjin 300192, China

c Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500, Yunnan, China

Abstract

Coumarin acting as an optical probe was modified on ethylenediamine β-cyclodextrin, which not only enhanced its molecular binding affinity to glutathione (GSH) by a reversible Michael addition, showing 113 times more affinity than that of coumarin itself, but also achieved dynamic real-time sensing of glutathione in living HeLa cells.

Graphical abstract: Reversible dynamic optical sensing based on coumarin modified β-cyclodextrin for glutathione in living cells

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Article information

DOI
https://doi.org/10.1039/D2CC06512F
Article type
Communication
Submitted
30 Nov 2022
Accepted
13 Dec 2022
First published
13 Dec 2022

Chem. Commun., 2023,59, 896-899

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Reversible dynamic optical sensing based on coumarin modified β-cyclodextrin for glutathione in living cells

Z. Liu, M. Tian, H. Zhang and Y. Liu, Chem. Commun., 2023, 59, 896 DOI: 10.1039/D2CC06512F

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