Cephalosporins 

Cephalosporins are bactericidal beta-lactam antibiotics derived from the fungus Acremonlum— they disrupt peptidoglycan formation in the cell wall.

They have no activity against LAME: Listeria, Atypicals (Mycoplasma/Chlamydia), MRSA and enterococci

General Rule

1st Gen are predominantly active against gram-positives, with succeeding generations progressively more active against gram-negative strains (often with reduced gram-positive activity, except 4th, which are extended spectrum agents).



#Cephalosporins #Generations #Classification #pharmacology #Antibiotics