Neurotrophic and Immunomodulatory Lanostane Triterpenoids from Wood-Inhabiting Basidiomycota
Abstract
:1. Introduction
2. Results
2.1. Isolation of Triterpenoids from L. sulphureus and Antrodia sp. (MUCL 56049)
2.2. Triterpenoids Induce Expression of ngf and bdnf in Astrocytoma Cells
2.3. Triterpenoids Enhance ngf-Induced Neurite Outgrowth in PC-12 Cells
3. Discussion
3.1. Previous Reports of Neurotrophic Activities of Extracts Derived from Other Basidiomycota and Selected Reports on Neurotropic Effects of Plant Metabolites
3.2. Known Biological Activities of Compounds 1–12 and Related Triterpenes
3.3. Previous Use of Laetiporus and Antrodia Species and Their Relatives in Traditional Medicine and for Other Applications
4. Materials and Methods
4.1. General Information
4.2. Fungal Material
4.3. Extraction and Isolation of the Secondary Metabolites
4.4. Cell Culture
4.5. cDNA Synthesis and Real-Time Quantitative RT-PCR
4.6. Neurite Outgrowth Assay
4.7. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Hassan, K.; Matio Kemkuignou, B.; Kirchenwitz, M.; Wittstein, K.; Rascher-Albaghdadi, M.; Chepkirui, C.; Matasyoh, J.C.; Decock, C.; Köster, R.W.; Stradal, T.E.B.; et al. Neurotrophic and Immunomodulatory Lanostane Triterpenoids from Wood-Inhabiting Basidiomycota. Int. J. Mol. Sci. 2022, 23, 13593. https://doi.org/10.3390/ijms232113593
Hassan K, Matio Kemkuignou B, Kirchenwitz M, Wittstein K, Rascher-Albaghdadi M, Chepkirui C, Matasyoh JC, Decock C, Köster RW, Stradal TEB, et al. Neurotrophic and Immunomodulatory Lanostane Triterpenoids from Wood-Inhabiting Basidiomycota. International Journal of Molecular Sciences. 2022; 23(21):13593. https://doi.org/10.3390/ijms232113593
Chicago/Turabian StyleHassan, Khadija, Blondelle Matio Kemkuignou, Marco Kirchenwitz, Kathrin Wittstein, Monique Rascher-Albaghdadi, Clara Chepkirui, Josphat C. Matasyoh, Cony Decock, Reinhard W. Köster, Theresia E. B. Stradal, and et al. 2022. "Neurotrophic and Immunomodulatory Lanostane Triterpenoids from Wood-Inhabiting Basidiomycota" International Journal of Molecular Sciences 23, no. 21: 13593. https://doi.org/10.3390/ijms232113593