Natural Product Research
Natural Product Research
3 years ago

Three new andrastin derivatives from the endophytic fungus Penicillium vulpinum

Three new andrastin derivatives from the endophytic fungus Penicillium vulpinum
Yu-Yue Qin, Xi-Shan Huang, Xiao-Bo Liu, Tu-Xiang Mo, Zhao-Long Xu, Ben-Chao Li, Xiao-Ya Qin, Jun Li, Till F. Schӓberle, Rui-Yun Yang
Three new andrastin derivatives, 10-formyl andrastone A (1), 10-demethylated andrastone A (2) and andrastin G (3), together with four known andrastin analogues (4-7) were isolated from an endophytic fungus Penicillium vulpinum. Their structures were determined by 1 D, 2 D NMR, and the absolute configurations were further determined by experimental and calculated ECD spectra. Compound 5 exhibited significant antibacterial activity against Bacillus paratyphosus B with an MIC value of 6.25 µg·mL−1. Compounds 2 and 6 showed remarkable inhibitory activities against Bacillus megaterium with the MIC value of 6.25 µg·mL−1, respectively. Graphical

Publisher URL: https://www.tandfonline.com/doi/full/10.1080/14786419.2020.1853725

DOI: 10.1080/14786419.2020.1853725

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