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Flavonoids from Erythrina schliebenii
Journal of Natural Products ( IF 5.1 ) Pub Date : 2017-01-23 00:00:00 , DOI: 10.1021/acs.jnatprod.6b00839
Stephen S. Nyandoro 1, 2 , Joan J. E. Munissi 1, 2 , Msim Kombo 1 , Clarence A. Mgina 1 , Fangfang Pan 3 , Amra Gruhonjic 4 , Paul Fitzpatrick 4 , Yu Lu 5 , Bin Wang 5 , Kari Rissanen 3 , Máté Erdélyi 2, 6
Affiliation  

Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (24), and nineteen known natural products (523) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32–64 μg mL–1 and 36.9–101.8 μM, respectively. Evaluation of their toxicity against the aggressive human breast cancer cell line MDA-MB-231 indicated EC50 values of 13.0–290.6 μM (pure compounds) and 38.3 to >100 μg mL–1 (crude extracts).

中文翻译:

黄柏中的类黄酮

异戊二烯化和ö -methylflavonoids包括一个新pterocarpan(1),三个新的异黄酮(2 - 4),和19个已知的天然产物(5 - 23)的分离和从根识别,茎皮,和叶提取物刺桐schliebenii。评估了粗提物及其成分对结核分枝杆菌(H37Rv株)的抗结核活性,其MIC分别为32–64μgmL –1和36.9–101.8μM。评估其对侵袭性人类乳腺癌细胞MDA-MB-231的毒性表明EC 50值为13.0–290.6μM(纯化合物)和38.3至> 100μgmL –1(粗提取物)。
更新日期:2017-01-23
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