Nine new lignans (1–9) and ten known analogues (10–19) were isolated from the fruits of Schisandra bicolor var. tuberculata. The structures of compounds 1–9 were established on the basis of spectroscopic data analysis. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction analysis with Cu Kα irradiation techniques, and the absolute configurations of compounds 2–9 were deduced by comparing their experimental ECD spectra and optical rotations with those of compound 1 or similar compounds. All isolates were evaluated for their neuroprotective activities against CoCl₂, H₂O₂, and Aβ_25–35-induced SH-SY5Y cell injury, and were found to exhibit different degrees of neuroprotective effects. At a low concentration of 3.2 nM, compounds 3, 8, 9, and 14–19 in CoCl₂-induced, compounds 7, 8, 13, 17, and 18 in H₂O₂-induced, and compounds 2, 6, 7, 9, 10, and 12–19 in Aβ_25–35-induced SH-SY5Y cell injury models, showed statistically significant neuroprotective activities, when compared with each negative control group.

中文翻译：

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五味子五味子果实中的神经保护性木质素。结核菌

从五味子五味子的果实中分离出九个新的木脂素（1 – 9）和十个已知的类似物（10 – 19）。结核病。化合物1 – 9的结构是在光谱数据分析的基础上建立的。化合物的绝对构型1，通过用铜Kα照射技术，并且化合物的绝对构型的单晶X射线衍射分析测定2 - 9由他们的实验ECD谱和旋光与这些化合物的比较推导1或类似的化合物。评估所有分离株对CoCl ₂，H ₂ O ₂和_Aβ25-35诱导的SH-SY5Y细胞损伤的神经保护活性，发现它们表现出不同程度的神经保护作用。在3.2 nM的浓度低，化合物3，8，9，和14 - 19在氯化钴₂诱导的，化合物7，8，13，17，和18 H中₂ ö ₂诱导的，和化合物2，6，7，9，10，和12 - 19在Aβ _25-35诱导的SH-SY5Y细胞损伤模型中，当与每个阴性对照组相比有统计学显著神经保护活性。