A C20-diterpenoid alkaloid with an unprecedented carbon skeleton, acoapetaludine A, together with ten undescribed aconitine-type C19-diterpenoid alkaloids, acoapetaludines B-K, were isolated from the whole plants of Aconitum apetalum (Huth) B. Fedtsch. (Ranunculaceae). The structures were elucidated based on a comprehensive spectroscopic data analysis. The absolute configuration of acoapetaludine A was determined by quantum ECD calculation. Acoapetaludines D and E exhibited weak anti-Helicobacter pylori activity at a minimum inhibitory concentration (MIC) of 100 and 50 μg/mL, respectively.

中文翻译：

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Acopetaludine AK、C20 和 C19-二萜生物碱，来自乌头 (Huth) B.Fedtsch 全株

一种具有前所未有的碳骨架的 C20-二萜生物碱 acoapetaludine A，以及十种未描述的乌头碱型 C19-diterpenoid 生物碱 acoapetaludine BK，从乌头 (Huth) B. Fedtsch 的全株中分离出来。(毛茛科)。基于全面的光谱数据分析阐明了结构。acoapetaludine A 的绝对构型由量子 ECD 计算确定。Acoapetaludine D 和 E 在最小抑制浓度 (MIC) 分别为 100 和 50 μg/mL 时表现出较弱的抗幽门螺杆菌活性。